scholarly journals Evaluation of a novel non-invasive preimplantation genetic screening approach

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0197262 ◽  
Author(s):  
Valeriy Kuznyetsov ◽  
Svetlana Madjunkova ◽  
Ran Antes ◽  
Rina Abramov ◽  
Gelareh Motamedi ◽  
...  
Keyword(s):  
Genetic Screening ◽  
Preimplantation Genetic Screening ◽  
Non Invasive ◽  
Screening Approach

scholarly journals Non-invasive preimplantation genetic screening of human blastocysts

2017 ◽  
Vol 108 (3) ◽  
pp. e277 ◽  
Author(s):  
V. Kuznyetsov ◽  
S. Madjunkova ◽  
R. Antes ◽  
R. Abramov ◽  
G. Motamedi ◽  
...  
Keyword(s):  
Genetic Screening ◽  
Preimplantation Genetic Screening ◽  
Non Invasive

scholarly journals Assessment of the embryo quality in the procedure of in vitro fertilization

2016 ◽  
Vol 69 (7-8) ◽  
pp. 241-246
Author(s):  
Artur Bjelica ◽  
Srna Subanovic
Keyword(s):  
Success Rate ◽  
Embryo Transfer ◽  
Genetic Screening ◽  
Embryo Quality ◽  
Genetic Diagnosis ◽  
Preimplantation Genetic Screening ◽  
Single Embryo Transfer ◽  
Elective Single Embryo Transfer ◽  
Non Invasive

Introduction. Since reproductive technologies are becoming increasingly popular among the couples with infertility problem, and having in mind that the success rate is still low, the clinicians tend to transfer more embryos in order to increase the probability of success. However, such a strategy increases the risk of multiple pregnancy, which brings about numerous risks to the health of both the mother and children. Therefore, an elective single-embryo transfer is set as imperative, which, on the other hand, would not be possible without selection and evaluation of the quality of embryos. Assessment of Embryo Quality. Embryos can be selected by various methods, from non-invasive to invasive methods. In non-invasive methods, the embryos are selected by their morphology or by the techniques based on the analysis of molecular components - analyses of the level of proteomes or metabolomes. A more detailed monitoring of the kinetics of the embryo development can be related to the introduction of time-lapse imaging and monitoring systems into laboratory practice. The invasive methods encompass the techniques such as preimplantation genetic diagnosis and preimplantation genetic screening. In preimplantation genetic diagnosis, the assisted reproduction technologies cycle is approached for the genetic reasons, whereas preimplantation genetic screening is used to enhance the success rate of the assisted reproduction cycles. Conclusion. In this paper we have shown that the application of elective single-embryo transfer requires the selection and assessment of the quality of embryos by the methods that have been developed in the last four decades, and still need further improvements.

Pre-implantation Screening and Diagnosis

2021 ◽  
Author(s):  
Kaylin O’Brien
Keyword(s):  
Preimplantation Genetic Diagnosis ◽  
Genetic Screening ◽  
Genetic Diagnosis ◽  
Preimplantation Genetic Screening ◽  
Diagnostic Methods ◽  
Vitro Fertilization ◽  
Blastomere Biopsy ◽  
Non Invasive ◽  
Gene Level

Through cellular biopsy of a developing embryo, genetic testing can be performed as part of the embryo selection phase of an in vitro fertilization (IVF) cycle. Preimplantation genetic screening (PGS) and preimplantation genetic diagnosis (PGD) allow embryos to be tested for genetic conditions on a chromosome and gene level, respectively, prior to implantation in the uterus and prior to pregnancy. Included in this review are indications for PGS and PGD, the biopsy and diagnostic methods that are most frequently utilized, advances in recent non-invasive technologies, and potential impacts that PGS/PGD and IVF may have on developing embryos. This review contains 5 figures, 1 table, and 53 references.  Keywords: Preimplantation genetic diagnosis, preimplantation genetic screening, blastocyst biopsy, blastomere biopsy, advances in PGS/PGD, indications for PGS/PGD, non-invasive embryo biopsy, infertility

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