GRP78 expression in tumor and perinephric adipose tissue is not an optimal risk stratification marker for clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is widely acknowledged to be extremely sensitive to immunotherapy, emphasizing the tremendous impacts on which the tumor microenvironment (TME) has shown. However, the molecular subgroups characterized by the TME features scarcely serve as the risk stratification guides in clinical practice for survival outcomes and immunotherapy response prediction. This study generated fresh insights into a novel TME-related prognostic signature derived from The Cancer Genome Atlas database using integrated bioinformatics analyses. Subsequently, Kaplan–Meier survival analysis, receiver operating characteristic analysis, and univariate and multivariate Cox regression analysis were performed to evaluate and validate the efficacy and the accuracy of the signature in ccRCC prognosis. Furthermore, we discovered that the risk score presented an increased likelihood of correlation with miscellaneous clinicopathological characteristics, natural killer cell-mediated cytotoxicity, immune cell infiltration levels, and immune checkpoint expression. These findings highlighted the notion that the six-gene signature characterized by the TME features may have implications on the risk stratification for personalized and precise immunotherapeutic management.

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MP28-06 METASTATIC RISK STRATIFICATION OF CLEAR CELL RENAL CELL CARCINOMA PATIENTS BASED ON A GENOMIC SCORE

The Journal of Urology ◽

10.1016/j.juro.2018.02.906 ◽

2018 ◽

Vol 199 (4S) ◽

Author(s):

Julia Grimm ◽

MArtin Janssen ◽

Stefan Wagenpfeil ◽

Arndt Hartmann ◽

Christine Stöhr ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Risk Stratification ◽

Cell Carcinoma ◽

Renal Cell ◽

Clear Cell ◽

Cell Renal Cell Carcinoma ◽

Metastatic Risk

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Increased visceral adipose tissue in male patients with non-clear cell renal cell carcinoma

La radiologia medica ◽

10.1007/s11547-020-01146-6 ◽

2020 ◽

Vol 125 (6) ◽

pp. 538-543 ◽

Cited By ~ 4

Author(s):

Federico Greco ◽

Carlo Augusto Mallio ◽

Raffaele Grippo ◽

Laura Messina ◽

Silvia Vallese ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Adipose Tissue ◽

Cell Carcinoma ◽

Visceral Adipose Tissue ◽

Renal Cell ◽

Clear Cell ◽

Cell Renal Cell Carcinoma ◽

Male Patients ◽

Visceral Adipose

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Visceral Adiposity as a Significant Predictor of Sunitinib-Induced Dose-Limiting Toxicities and Survival in Patients with Metastatic Clear Cell Renal Cell Carcinoma

Cancers ◽

10.3390/cancers12123602 ◽

2020 ◽

Vol 12 (12) ◽

pp. 3602

Author(s):

Jee Soo Park ◽

Kyo Chul Koo ◽

Doo Yong Chung ◽

Sun Il Kim ◽

Jeongho Kim ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Body Composition ◽

Adipose Tissue ◽

Cell Carcinoma ◽

Renal Cell ◽

Clear Cell ◽

Univariate Analysis ◽

Progression Free Survival ◽

Visceral Adiposity ◽

Cell Renal Cell Carcinoma

Sunitinib is a first-line treatment for metastatic renal cell carcinoma (mRCC). Little is known about the predictive factors of sunitinib-induced dose-limiting toxicity (DLT) in Asian populations. We investigated whether body composition predicts sunitinib-induced DLT. We retrospectively reviewed sunitinib-treated Korean patients with clear cell mRCC from eight institutions. Body composition was measured using computed tomography. DLT was defined as any adverse event leading to dose reduction or treatment discontinuation. Univariate analysis was used to compare body composition indices, and logistic regression analyses were performed for factors predicting early DLT. Overall, 111/311 (32.5%) of patients experienced DLT. Significant differences were observed in the subcutaneous adipose tissue index (SATI; p = 0.001) and visceral adipose tissue index (VATI; p < 0.001) between patients with and without DLT. Multivariate analyses revealed that VATI (odds ratio: 1.013; p = 0.029) was significantly associated with early DLT. Additionally, 20% of patients who had a body mass index (BMI) greater than 23 kg/m2 and a low VATI experienced DLT, whereas 34.3% of the remaining groups had DLT (p = 0.034). Significant differences were observed for median progression-free survival (13.0 vs. 26.0 months, respectively; p = 0.006) between patients with low and high VATI. Visceral adiposity was a significant predictor of sunitinib-associated DLT and survival. Patients with a low VATI and a BMI greater than 23 kg/m2 experienced lower DLTs.

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The Potential of Visceral Adipose Tissue in Distinguishing Clear Cell Renal Cell Carcinoma from Renal Angiomyolipoma with Minimal Fat

Cancer Management and Research ◽

10.2147/cmar.s336920 ◽

2021 ◽

Vol Volume 13 ◽

pp. 8907-8914

Author(s):

Jianhu Liu ◽

Jie Bao ◽

Weijie Zhang ◽

Qiaoxing Li ◽

Jianquan Hou ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Adipose Tissue ◽

Cell Carcinoma ◽

Visceral Adipose Tissue ◽

Renal Cell ◽

Clear Cell ◽

Renal Angiomyolipoma ◽

Cell Renal Cell Carcinoma ◽

Visceral Adipose ◽

Minimal Fat

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Identification of a hypoxia-associated long non-coding RNA signature and nomogram as a prognostic target for clear cell renal cell carcinoma

10.21203/rs.3.rs-126309/v1 ◽

2020 ◽

Author(s):

Hualin Chen ◽

Yang Pan ◽

Xiaoxiang Jin ◽

Gang Chen

Keyword(s):

Renal Cell Carcinoma ◽

High Risk ◽

Risk Stratification ◽

Cell Carcinoma ◽

Renal Cell ◽

Clear Cell ◽

Risk Group ◽

High Grade ◽

Advanced Stage ◽

Cell Renal Cell Carcinoma

Abstract Background To develop a hypoxia-associated long non-coding (lncRNA) signature for risk stratification in clear cell renal cell carcinoma (ccRCC). Methods The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA KIRC) dataset was downloaded and analyzed. Results Four prognostic hypoxia-associated lncRNAs were used for signature construction. The four lncRNAs were downregulated in high grade, advanced stage, and high-risk ccRCC. ccRCC patients in the high-risk group had a worse prognosis than those in the low-risk group. And the risk score was significantly higher in high grade and advanced stage. The signature had an independent and long-standing prognosis prediction ability up to 10-year follow-up. Notably, the risk score was significantly positively correlated with the infiltration abundances of six immune cells from the Tumor IMmune Estimation Resource (TIMER). The gene set enrichment analysis (GSEA) also suggested that the signature was involved in the metabolism and tumorigenesis, which were closely related to the hypoxic tumor microenvironment. Ultimately, a nomogram was built to predict the individual long-term survival possibility. Conclusions We have developed a new hypoxia-associated lncRNA signature, representing a promising tool for risk stratification tool in ccRCC. It might serve as a prognostic index to facilitate personalized counseling for treatment.

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Relationship between visceral adipose tissue and genetic mutations (VHL and KDM5C) in clear cell renal cell carcinoma

La radiologia medica ◽

10.1007/s11547-020-01310-y ◽

2021 ◽

Author(s):

Federico Greco ◽

Carlo Augusto Mallio

Keyword(s):

Renal Cell Carcinoma ◽

Adipose Tissue ◽

Cell Carcinoma ◽

Visceral Adipose Tissue ◽

Renal Cell ◽

Clear Cell ◽

Genetic Mutations ◽

Cell Renal Cell Carcinoma ◽

Visceral Adipose

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Subcutaneous Adipose Tissue Reduction in Patients with Clear Cell Renal Cell Carcinoma and Peritumoral Collateral Vessels: A Retrospective Observational Study

Applied Sciences ◽

10.3390/app11136076 ◽

2021 ◽

Vol 11 (13) ◽

pp. 6076

Author(s):

Federico Greco ◽

Luigi Giuseppe Quarta ◽

Aldo Carnevale ◽

Melchiore Giganti ◽

Rosario Francesco Grasso ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Adipose Tissue ◽

Cell Carcinoma ◽

Renal Cell ◽

Subcutaneous Adipose Tissue ◽

Clear Cell ◽

Cell Renal Cell Carcinoma ◽

Significant Difference ◽

Collateral Vessels ◽

Subcutaneous Adipose

Background: peritumoral collateral vessels adjacent to renal cell carcinoma (RCC) can be encountered in clinical practice. Cancer cachexia is defined as a decrease of adipose and skeletal muscle tissues. In this study we evaluated, using a quantitative CT imaging-based approach, the distribution of abdominal adipose tissue in clear cell RCC (ccRCC) male patients with and without collateral vessels. Methods: between November 2019 and February 2020, in this retrospective study we enrolled 106 ccRCC male Caucasian patients divided into two groups: a ccRCCa group without collateral vessels (n = 48) and a ccRCCp group with collateral vessels (n = 58). The total adipose tissue (TAT), visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were measured in both groups. Moreover, the VAT/SAT ratio was calculated for each subject. Results: a statistically significant difference between the two groups was found in the SAT area (p < 0.05), while no significant differences were found in the TAT area, VAT area and VAT/SAT ratio. Conclusion: this study demonstrates a reduction of SAT in ccRCC patients with peritumoral collateral vessels.

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