Prevalence of normal weight obesity and its associated cardio-metabolic risk factors – Results from the baseline data of the Kerala Diabetes Prevention Program (KDPP)

Introduction The American Heart Association created “Life’s Simple Seven” metrics to estimate progress toward improving US cardiovascular health in a standardized manner. Given the widespread use of federally funded Diabetes Prevention Program (DPP)-based lifestyle interventions such as the Group Lifestyle Balance (DPP-GLB), evaluation of change in health metrics within such a program is of national interest. This study examined change in cardiovascular health metric scores during the course of a yearlong DPP-GLB intervention. Methods Data were combined from 2 similar randomized trials offering a community based DPP-GLB lifestyle intervention to overweight/obese individuals with prediabetes and/or metabolic syndrome. Pre/post lifestyle intervention participation changes in 5 of the 7 cardiovascular health metrics were examined at 6 and 12 months (BMI, blood pressure, total cholesterol, fasting plasma glucose, physical activity). Smoking was rare and diet was not measured. Results Among 305 participants with complete data (81.8% of 373 eligible adults), significant improvements were demonstrated in all 5 risk factors measured continuously at 6 and 12 months. There were significant positive shifts in the “ideal” and “total” metric scores at both time points. Also noted were beneficial shifts in the proportion of participants across categories for BMI, activity, and blood pressure. Conclusion AHA-metrics could have clinical utility in estimating an individual’s cardiovascular health status and in capturing improvement in cardiometabolic/behavioral risk factors resulting from participation in a community-based translation of the DPP lifestyle intervention.

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Gestational weight gain in normal weight women and offspring cardio-metabolic risk factors at 20 years of age

International Journal of Obesity ◽

10.1038/ijo.2014.179 ◽

2014 ◽

Vol 39 (4) ◽

pp. 671-676 ◽

Cited By ~ 24

Author(s):

L Hrolfsdottir ◽

D Rytter ◽

S F Olsen ◽

B H Bech ◽

E Maslova ◽

...

Keyword(s):

Risk Factors ◽

Weight Gain ◽

Gestational Weight Gain ◽

Normal Weight ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

Gestational Weight

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Impact of Intensive Lifestyle and Metformin Therapy on Cardiovascular Disease Risk Factors in the Diabetes Prevention Program

Diabetes Care ◽

10.2337/diacare.28.4.888 ◽

2005 ◽

Vol 28 (4) ◽

pp. 888-894 ◽

Cited By ~ 355

Author(s):

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Prevention Program ◽

Diabetes Prevention ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Diabetes Prevention Program ◽

Cardiovascular Disease Risk Factors ◽

Metformin Therapy

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Impact of a Digital Diabetes Prevention Program on Risk Factors for Chronic Disease in a Workforce Cohort

Journal of Occupational and Environmental Medicine ◽

10.1097/jom.0000000000002044 ◽

2020 ◽

Vol 62 (12) ◽

pp. 1040-1045

Author(s):

Charles E. Birse ◽

Dov Shiffman ◽

Anita Satish ◽

Maren S. Fragala ◽

Andre R. Arellano ◽

...

Keyword(s):

Risk Factors ◽

Chronic Disease ◽

Prevention Program ◽

Diabetes Prevention ◽

Diabetes Prevention Program

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The association of interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular disease

Acta Endocrinologica ◽

10.1530/eje-07-0463 ◽

2007 ◽

Vol 157 (5) ◽

pp. 633-640 ◽

Cited By ~ 32

Author(s):

Juliet Evans ◽

Malcolm Collins ◽

Courtney Jennings ◽

Lize van der Merwe ◽

Ingegerd Söderström ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

South African ◽

Normal Weight ◽

Visceral Adiposity ◽

Metabolic Risk Factors ◽

African Women ◽

Metabolic Risk ◽

Black South African ◽

South African Women

AbstractObjectiveCirculating levels of interleukin (IL)-18 are associated with the metabolic syndrome and risk for the development of cardiovascular disease (CVD). This study investigated the association between the circulating IL-18 levels and the −137 G/C polymorphism within the IL-18 gene with metabolic risk factors for CVD in normal-weight and obese black South African women.MethodsBlood pressure (BP), body composition (dual-energy X-ray absorptiometer), visceral adiposity (computerized tomography), as well as fasting glucose, insulin, lipid profile, IL-18 levels, and IL-18 genotype were measured in 104 normal-weight (body mass index (BMI) ≤25 kg/m2) and 124 obese (BMI≥30 kg/m2) black South African women.ResultsSubjects with a GC genotype (23%) had a greater mean arterial pressure (MAP, 90.6±11.1 vs 85.5±10.3 mmHg, P<0.001) than the subjects with the GG genotype. Serum IL-18 levels were not associated with IL-18 genotype (P=0.985); however, they significantly correlated with percentage of body fat (r=0.25, P<0.001), visceral adiposity (r=0.32, P<0.001), MAP (r=0.22, P=0.001), HOMA-IR (r=0.33, P<0.001), fasting insulin (r=0.25, P<0.001), triglyceride (r=0.16, P<0.05), and high-density lipoprotein-cholesterol (r=−0.14, P<0.05) levels, after adjusting for age and body fatness.ConclusionsWe show for the first time that the GC genotype of the IL-18 −137 G/C polymorphism and the circulating IL-18 levels are independently associated with raised BP. Moreover, fasting IL-18 levels are associated with the other metabolic risk factors for CVD in normal-weight and obese black South African women.

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Nutritional status, dietary intake and adiposity of normal-weight individuals with clustered metabolic risk factors in the UK population

Proceedings of The Nutrition Society ◽

10.1017/s0029665116002524 ◽

2016 ◽

Vol 75 (OCE3) ◽

Author(s):

T. Harrison ◽

F. Amirabdollahian ◽

I.G. Davies

Keyword(s):

Risk Factors ◽

Nutritional Status ◽

Dietary Intake ◽

Normal Weight ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

The Uk

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Relationship between body fat percentage determined by bioelectrical impedance analysis and metabolic risk factors in Syrian male adolescents (18–19 years)

Anthropological Review ◽

10.1515/anre-2017-0006 ◽

2017 ◽

Vol 80 (1) ◽

pp. 103-113

Author(s):

Mahfouz Al-Bachir ◽

Mohamad Adel Bakir

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Density Lipoprotein ◽

Normal Weight ◽

Metabolic Risk Factors ◽

Body Fat Percentage ◽

Metabolic Risk ◽

Fat Percentage ◽

Male Adolescents ◽

Obese Subjects

Abstract The association between increasing obesity and metabolic syndrome among adolescent and the adverse consequences in adulthood including type-2 diabetes and coronary heart disease is well documented. The main objectives of this study were to evaluate the major metabolic risk factors and some clinical important parameters in Syrian male adolescents (18-19 years old), and to assess the correlations between BF% determined by BIA-man prediction equation and metabolic risk factors in the same group. The correlations between body fat percentage (BF%) based on BIA-man predictive equations, blood pressure, fasting blood sugar (FBS), cholesterol (Chol), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), Hematocrit (Ht), and hemoglobin (Hb) in 1596 healthy Syrian adolescents aged 18-19 years and the mean values of these parameters were examined. Data showed that, DBP, Chol, TG, LDL and TG/HDL-C were significantly (p<0.05) higher in overweight and obese subjects in compression to normal weight cases. Whereas, SBP, FBS and Ht were significantly (p<0.05) higher in obese subjects in compression to normal weight. However, all measured variable related to metabolic syndrome risk factors increased with increasing the BF% determined by BIA-man. The present study suggests that % BF by BIA-man is a good predictor of metabolic risks factors for Syrian adolescents.

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