scholarly journals Uveal melanoma: Long-term survival

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0250939
Author(s):  
Tomas Radivoyevitch ◽  
Emily C. Zabor ◽  
Arun D. Singh
Keyword(s):  
Uveal Melanoma ◽  
Absolute Risk ◽  
Relative Survival ◽  
Population Based ◽  
Parametric Modeling ◽  
Primary Therapy ◽  
Term Survival ◽  
Long Term Survival ◽  
Melanoma Patients

Purpose The long-term survival of uveal melanoma patients in the US is not known. We compared long-term survival estimates using relative survival, excess absolute risk (EAR), Kaplan-Meier (KM), and competing risk analyses. Setting Population based cohort study. Study population Pooled databases from Surveillance, Epidemiology, and End Results data (SEER, SEER-9+SEER-13+SEER-18). Main outcome measure Overall Survival (OS), Metastasis Free Survival (MFS) and relative survival, computed directly or estimated via a model fitted to excess mortality. Results There were 10678 cases of uveal melanoma spanning a period of 42 years (1975–2016). The median age at diagnosis was 63 years (range 3–99). Over half the patients were still alive at the end of 2016 (53%, 5625). The KM estimates of MFS were 0.729 (0.719, 0.74), 0.648 (0.633, 0.663), and 0.616 (0.596, 0.636) at 10, 20, and 30 years, respectively. The cumulative probabilities of melanoma metastatic death at 10, 20 and 30 years were 0.241 (0.236, 0.245), 0.289 (0.283, 0.294), and 0.301 (0.295, 0.307). In the first 5 years since diagnosis of uveal melanoma, the proportion of deaths attributable to uveal melanoma were 1.3 with rapid fall after 10 years. Death due to melanoma were rare beyond 20 years. Relative survival (RS) plateaued to ~60% across 20 to 30 years. EAR parametric modeling yielded a survival probability of 57%. Conclusions Relative survival methods can be used to estimate long term survival of uveal melanoma patients without knowing the exact cause of death. RS and EAR provide more realistic estimates as they compare the survival to that of a normal matched population. Death due to melanoma were rare beyond 20 years with normal life expectancy reached at 25 years after primary therapy.

Long-term survival of uveal melanoma patients after surgery for liver metastases

2009 ◽  
Vol 93 (8) ◽  
pp. 1042-1046 ◽  
Author(s):  
S Frenkel ◽  
I Nir ◽  
K Hendler ◽  
M Lotem ◽  
A Eid ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Uveal Melanoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Melanoma Patients

scholarly journals Using Population-Based Cancer Registration Data and Period Analysis to Accurately Assess and Predict 5-Year Relative Survival for Lung Cancer Patients in Eastern China

2021 ◽  
Vol 11 ◽  
Author(s):  
Runhua Li ◽  
Min Zhang ◽  
Yongran Cheng ◽  
Xiyi Jiang ◽  
Huijuan Tang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Eastern China ◽  
Relative Survival ◽  
Population Based ◽  
Term Survival ◽  
Period Analysis ◽  
Long Term Survival ◽  
Lung Cancer Patients

BackgroundThe assessment of long-term survival of lung cancer patients based on data from population-based caner registries, using period analysis, was scarce in China. We aimed to accurately assess the long-term survival of lung cancer patients, and to predict the long-term survival in the future, using cancer registry data from Taizhou City, eastern China.MethodsFour cancer registries with high-quality data were selected. Patients diagnosed with lung cancer during 2004–2018 were included. The long-term survival was evaluated using period analysis, with further stratification by sex, age at diagnosis and region. Additionally, projected 5-year relative survival (RS) of lung cancer patients for 2019-2023 was evaluated, using model-based period analysis.ResultsThe 5-year RS of lung cancer patients diagnosed during 2014–2018 was 40.2% (31.5% for men and 56.2% for women). A moderate age gradient was observed for the period estimate, with the estimate decreasing from 50.5 to 26.5% in the age group of 15–44 years and ≥75 years, respectively. The 5-year RS of urban area was higher than that of rural area (52.3% vs. 38.9%). The overall projected 5-year RS of lung cancer patients was 52.7% for 2019–2023, with estimate of 43.0 and 73.2% for men and women, respectively. A moderate age gradient was also observed for the projected estimate. Moreover, estimate reached nearly 50% for rural and urban areas.ConclusionPeriod analysis tended to provide the up-to-date and precise survival estimates for lung cancer patients, which is worth further application, and provides important evidence for prevention and intervention of lung cancer.

scholarly journals P50.11 Long-Term Survival after Surgical Resection of Carcinoid Tumors in a Population-Based Cohort

2021 ◽  
Vol 16 (3) ◽  
pp. S516-S517
Author(s):  
M. Taylor ◽  
M. Smeltzer ◽  
R. Ramirez ◽  
C. Fehnel ◽  
O. Akinbobola ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Population Based ◽  
Carcinoid Tumors ◽  
Term Survival ◽  
Long Term Survival

Octogenarian Patients with Colon Cancer – Postoperative Morbidity and Mortality are the Major Challenges

2021 ◽  
Author(s):  
Øystein Høydahl ◽  
Tom-Harald Edna ◽  
Athanasios Xanthoulis ◽  
Stian Lydersen ◽  
Birger Henning Endreseth
Keyword(s):  
Colon Cancer ◽  
Survival Rate ◽  
Emergency Surgery ◽  
Relative Survival ◽  
Curative Intent ◽  
Term Survival ◽  
Younger Patients ◽  
Long Term Survival ◽  
Over Time

Abstract Background Few studies have addressed colon cancer surgery outcomes in an unselected cohort of octogenarian patients. The present study aimed to evaluate the relative survival of octogenarian patients after a major resection of colon cancer with a curative intent. Methods All patients diagnosed with colon cancer at Levanger Hospital between 1980 and 2016 were included. We performed logistic regression to test for associations between 100-day mortality and explanatory variables. We performed a relative survival analysis to identify factors associated with short- and long-term survival.Results Among 239 octogenarian patients treated with major resections with curative intent, the 100-day mortality was 10.1%. Among 215 patients that survived the first 100 days, the five-year relative survival rate was 99.7%. The 100-day mortality of octogenarian patients was significantly shorter than that of younger patients, but the long-term survival converged with that of younger patients. Among octogenarian patients, the incidence of colon cancer more than doubled during our 37-year observation period. The relative increase in patients undergoing surgery exceeded the increase in incidence; hence, more patients were selected for surgery over time. A high 100-day mortality was associated with older age, a high American Society of Anaesthesiologists (ASA) score, and emergency surgery. Moreover, worse long-term survival was associated with a high Charlson Comorbidity Index, a high ASA score, a worse TNM stage, emergency surgery and residual tumours. Both the 100‑day and long-term survival rates improved over time. Conclusion Among octogenarian patients with colon cancer that underwent major resections with curative intent, the 100-day mortality was high, but after surviving 100 days, the relative long-term survival rate was comparable to that of younger patients. Further improvements in survival will primarily require measures to reduce the 100-day mortality risk.

scholarly journals Long-term Survival of Stage IV Melanoma Patients Treated with BOLD Combination Chemotherapy and Intermediate-dose Subcutaneous Interferon-alpha

2018 ◽  
Vol 38 (11) ◽  
pp. 6393-6397 ◽  
Author(s):  
KALLE MATTILA ◽  
PIRITA RAANTA ◽  
VALTTERI LAHTELA ◽  
SEPPO PYRHÖNEN ◽  
ILKKA KOSKIVUO ◽  
...  
Keyword(s):  
Interferon Alpha ◽  
Combination Chemotherapy ◽  
Stage Iv ◽  
Term Survival ◽  
Long Term Survival ◽  
Melanoma Patients ◽  
Stage Iv Melanoma ◽  
Intermediate Dose

METHODS FOR DETERMINING LONG-TERM SURVIVAL IN A POPULATION BASED STUDY1

1979 ◽  
Vol 110 (6) ◽  
pp. 747-752 ◽  
Author(s):  
MELISSA A. AUSTIN ◽  
SUSAN BERREYESA ◽  
JENNIE LEA ELLIOTT ◽  
ROBERT B. WALLACE ◽  
ELIZABETH BARRETT-CONNOR ◽  
...  
Keyword(s):  
Population Based ◽  
Term Survival ◽  
Long Term Survival
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