scholarly journals Womb to womb: Maternal litter size and birth weight but not adult characteristics predict early neonatal death of offspring in the common marmoset monkey

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252093
Author(s):  
Julienne N. Rutherford ◽  
Corinna N. Ross ◽  
Toni Ziegler ◽  
Larisa A. Burke ◽  
Alana D. Steffen ◽  
...  
Keyword(s):  
Birth Weight ◽  
Litter Size ◽  
Pregnancy Outcomes ◽  
Early Life ◽  
Neonatal Death ◽  
Common Marmoset ◽  
Early Neonatal Death ◽  
Marmoset Monkey ◽  
Poisson Models ◽  
The Common

A singular focus on maternal health at the time of a pregnancy leaves much about perinatal mortality unexplained, especially when there is growing evidence for maternal early life effects. Further, lumping stillbirth and early neonatal death into a single category of perinatal mortality may obscure different causes and thus different avenues of screening and prevention. The common marmoset monkey (Callithrix jacchus), a litter-bearing nonhuman primate, is an ideal species in which to study the independent effects of a mother’s early life and adult phenotypes on pregnancy outcomes. We tested two hypotheses in 59 marmoset pregnancies at the Southwest National Primate Research Center and the Barshop Institute for Longevity and Aging Studies. We explored 1) whether pregnancy outcomes were predicted independently by maternal adult weight versus maternal litter size and birth weight, and 2) whether stillbirth and early neonatal death were differentially predicted by maternal variables. No maternal characteristics predicted stillbirth and no maternal adult characteristics predicted early neonatal death. In univariate Poisson models, triplet-born females had a significantly increased rate of early neonatal death (IRR[se] = 3.00[1.29], p = 0.011), while higher birth weight females had a decreased rate (IRR[se] = 0.89[0.05], p = 0.039). In multivariate Poisson models, maternal litter size remained an independent predictor, explaining 13% of the variance in early neonatal death. We found that the later in the first week those neonates died, the more weight they lost. Together these findings suggest that triplet-born and low birth weight females have distinct developmental trajectories underlying greater rates of infant loss, losses that we suggest may be attributable to developmental disruption of infant feeding and carrying. Our findings of early life contributions to adult pregnancy outcomes in the common marmoset disrupt mother-blaming narratives of pregnancy outcomes in humans. These narratives hold that the pregnant person is solely responsible for pregnancy outcomes and the health of their children, independent of socioecological factors, a moralistic framing that has shaped clinical pregnancy management. It is necessary to differentiate temporal trajectories and causes of perinatal loss and view them as embedded in external processes to develop screening, diagnostic, and treatment tools that consider the full arc of a mother’s lived experience, from womb to womb and beyond.

scholarly journals The common marmoset monkey: avenues for exploring the prenatal, placental, and postnatal mechanisms in developmental programming of pediatric obesity

2018 ◽  
Vol 314 (5) ◽  
pp. R684-R692 ◽  
Author(s):  
Laren Riesche ◽  
Suzette D. Tardif ◽  
Corinna N. Ross ◽  
Victoria A. deMartelly ◽  
Toni Ziegler ◽  
...  
Keyword(s):  
Early Life ◽  
World Monkey ◽  
Common Marmoset ◽  
Developmental Programming ◽  
Intrauterine Environment ◽  
Future Directions ◽  
Marmoset Monkey ◽  
Health And Disease ◽  
The Common

Animal models have been critical in building evidence that the prenatal experience and intrauterine environment are capable of exerting profound and permanent effects on metabolic health through developmental programming of obesity. However, despite physiological and evolutionary similarities, nonhuman primate models are relatively rare. The common marmoset monkey ( Callithrix jacchus) is a New World monkey that has been used as a biomedical model for well more than 50 years and has recently been framed as an appropriate model for exploring early-life impacts on later health and disease. The spontaneous, multifactorial, and early-life development of obesity in the common marmoset make it a valuable research model for advancing our knowledge about the role of the prenatal and placental mechanisms involved in developmental programming of obesity. This paper provides a brief overview of obesity in the common marmoset, followed by a discussion of marmoset reproduction and placental characteristics. We then discuss the occurrence and utility of variable intrauterine environments in developmental programming in marmosets. Evidence of developmental programming of obesity will be given, and finally, we put forward future directions and innovations for including the placenta in developmental programming of obesity in the common marmoset.

Colonization of collagen scaffolds by adipocytes derived from mesenchymal stem cells of the common marmoset monkey

2011 ◽  
Vol 411 (2) ◽  
pp. 317-322 ◽  
Author(s):  
Inga Bernemann ◽  
Thomas Mueller ◽  
Rainer Blasczyk ◽  
Birgit Glasmacher ◽  
Nicola Hofmann
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Common Marmoset ◽  
Collagen Scaffolds ◽  
Marmoset Monkey ◽  
The Common

scholarly journals The hormonal induction of cervical remodeling in the common marmoset monkey (Callithrix jacchus)

Reproduction ◽  
2009 ◽  
Vol 137 (3) ◽  
pp. 517-525 ◽  
Author(s):  
Christina Simon ◽  
Almuth Einspanier
Keyword(s):  
Morphological Changes ◽  
Common Marmoset ◽  
Cervical Ripening ◽  
Cervical Tissue ◽  
Ecm Remodeling ◽  
Marmoset Monkey ◽  
Gene And Protein Expression ◽  
The Common

Controversy still exists regarding the involvement of relaxin (RLX) in cervical reorganization throughout parturition in the human, despite its well-known role in facilitating extensive extracellular matrix (ECM) remodeling in diverse organs. Therefore, the aim of the present study was to examine the influence of RLX and estrogen (E2) on the cervical tissue of the common marmoset monkey. Two experimental designs were used: 1)in vivoanalysis of the intracervical diameter under locally applied RLX and 2) ovariectomized (ov) marmosets were treated systemically with either recombinant human (rh) RLX, E2 or rhRLX+E2 to examine their action on the cervix.In vivo-locally applied rhRLX induced a distinct and significant widening of the cervix (before: 4.8±1.1 mm versus after: 5.7±0.9 mm in diameter;P<0.030, MV±s.e.m.). This widening effect was most pronounced in animals without previous pregnancies.In vitroinvestigation of cervical tissue showed significantly increased wet weights after all three hormone treatments (E2: 0.27±0.07 g, RLX: 0.25±0.04 g, E2+RLX: 0.30±0.11 g; allP<0.05; MV±s.e.m.) versus controls (0.10±0.04 g). Furthermore, morphological changes such as loosening of the connective tissue structure and decline in collagen content, an increase in the number of eosinophils, increased the expression of matrix metalloproteinases (MMP1) and MMP2, as well as gene and protein expression of the RLX receptor RXFP1 could be detected in the cervical tissue after all hormone treatments, compared with controls. In summary, RLX has a potent widening effect on the cervix of the common marmoset monkey. Although E2 is not required for this RLX effect, a combined application of E2 and RLX induced the most prominent cervical ripening.

scholarly journals Analysis of Cardiotocography Findings in Pregnancy with Less Fetal Movement and Its Association with Perinatal Outcome

2018 ◽  
Vol 30 (1) ◽  
pp. 19-22
Author(s):  
Ummay Salma ◽  
Mahe Jabeen ◽  
Sabiha Shimul ◽  
Dilruba Akhter
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Perinatal Outcome ◽  
Neonatal Death ◽  
Birth Asphyxia ◽  
Fetal Movement ◽  
Neonatal Unit ◽  
Normal Vaginal Delivery ◽  
Early Neonatal Death ◽  
Medical College

Less fetal movement affects perinatal outcome. To examine association between antenatal CTG findings and perinatal outcome in women with less fetal movement. This prospective observational study was conducted in the department of Obstetrics and Gynecology, Kumudini Women's Medical College and Hospital, Mirzapur, Tangail over a period of six months from January 2015 to June 2015. It included 100 pregnant women after 34 weeks of gestation. They underwent a cardiotocogram (CTG) test. Data were collected by face-to-face interview, observation and document review. The mean age of the women was 24.37±4.62 (SD) years and mean gestational age was 38.48±2.15 weeks. In this study, 82.0% of the cases presented at term pregnancy, 42.0% of the women were primi gravida and rest falls between 2nd to 4th gravida. Normal vaginal delivery was in 59.0% cases and rest were undergone caesarean sections (41.0%). Late deceleration with decreased variability was (23.5%) most common. Incidence of low birth weight was 16.0% & macrosomia was 5.0%. Birth asphyxia was found in 52.0% cases, 49.0% needed immediate resuscitation, 35.0% were admitted into neonatal unit and early neonatal death was 8.0%. Birth asphyxia was significantly higher in non-reassuring [37(72.5%)] than reassuring [15(30.6%)] on CTG. Incidence of low birth weight was higher in non-reassuring [11(21.6%)] than in reassuring [5(10.2%)] on CTG (p>0.05). Early neonatal death was more in respondents with non-reassuring [5(9.8%)] on CTG than reassuring [3(6.1%)] on CTG (p>0.05). Twenty six (51.0%) neonatal of the non-reassuring were admitted into neonatal unit whereas only 9 (18.4%) neonatal of the reassuring were admitted into neonatal unit. It can be concluded that CTG may be the first line investigation for ante and intrapartum fetal assessment.Medicine Today 2018 Vol.30(1): 19-22

scholarly journals Cross-species comparison of behavioral neurodevelopmental milestones in the common marmoset monkey and human child

2017 ◽  
Vol 59 (7) ◽  
pp. 807-821 ◽  
Author(s):  
Karla K. Ausderau ◽  
Caitlin Dammann ◽  
Kathy McManus ◽  
Mary Schneider ◽  
Marina E. Emborg ◽  
...  
Keyword(s):  
Common Marmoset ◽  
Species Comparison ◽  
Marmoset Monkey ◽  
Human Child ◽  
The Common ◽  
Cross Species Comparison

Co-expression of calretinin and γ-aminobutyric acid in neurons of the entorhinal cortex of the common marmoset monkey

Hippocampus ◽  
2004 ◽  
Vol 14 (5) ◽  
pp. 615-627 ◽  
Author(s):  
Helen H.J. Pothuizen ◽  
Joram Feldon ◽  
Ana L. Jongen-Rêlo
Keyword(s):  
Entorhinal Cortex ◽  
Common Marmoset ◽  
Aminobutyric Acid ◽  
Marmoset Monkey ◽  
The Common

scholarly journals Cryopreservation of cells using defined serum-free cryoprotective agents

2016 ◽  
Vol 2 (1) ◽  
pp. 315-318
Author(s):  
Jan-Cedric Volbers ◽  
Lothar Lauterböck ◽  
Nicola Hofmann ◽  
Birgit Glasmacher
Keyword(s):  
Stress Shielding ◽  
Common Marmoset ◽  
Serum Free ◽  
Poloxamer 188 ◽  
Cryoprotective Agents ◽  
Marmoset Monkey ◽  
Microscopy Analysis ◽  
Fetal Bovine ◽  
The Common ◽  
Shielding Effects

AbstractFor regenerative purposes, there is a high demand for viable and active cells. A big issue is to have enough viable cells available at any given time. One solution is cryopreservation. In this context, DMSO is used as cryoprotective agent (CPA) along with fetal bovine serum for nutrient supply and stress shielding effects. To use these cells for human clinical studies, it is important to eliminate the serum to prevent foreign immune reactions and virus transmittance and DMSO for its toxic effect. In this study a serum free cryopreservation solution and protocol has been established. The combination of methylcellulose and poloxamer 188 provide the basis for the new CPA. Other additves are α-tocopherol, ectoine, prolin and ascorbic acid. The CPAs were examined with 3T3-cells and multipotent stromal cells from the common marmoset monkey (Callithrix jacchus). The cells were preserved with various CPA concentrations, incubation times and different cooling rates. To enable a higher throughput of encouraging conditions a fluorescence microscopy analysis was used. The use of methylcellulose, poloxamer 188 and α-tocopherol enables the reduction of DMSO [up to 2.5% (v/v)] and the elimination of serum without viability losses compared to control.

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