scholarly journals Endogenous erythropoietin concentrations and association with retinopathy of prematurity and brain injury in preterm infants

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252655
Author(s):  
Nancy M. Fahim ◽  
Michael K. Georgieff ◽  
Lei Zhang ◽  
Scott Naisbitt ◽  
Raghavendra B. Rao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Brain Injury ◽  
Preterm Infants ◽  
Retinopathy Of Prematurity ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Endogenous Erythropoietin ◽  
Lower Birth Weight ◽  
Increased Risk

Background Endogenous erythropoietin (EPO) concentrations vary widely in preterm infants and may be associated with perinatal risk factors and neurological outcomes. Erythropoietin is elevated in fetal hypoxia but is also a potential neuroprotectant. Methods In a prospective study of 27 infants ≤ 30 weeks gestation, serum erythropoietin concentrations were measured during the first month of life, on day 1 and weeks 1, 2, and 4, and related to perinatal risk factors and outcomes including retinopathy of prematurity and cerebral injury evaluated near term-equivalent post menstrual age using magnetic resonance imaging with quantitative scoring. Results Lower birth weight was associated with higher EPO concentrations throughout the first 2 weeks of life (r = -0.6, p < 0.01). Higher day 1 and week 1 EPO concentrations were associated with lower Apgar score at 1 minute (r = - 0.5) and 5 minutes (r = -0.7), respectively (p < 0.01). Higher day 1 EPO concentrations and 2-week area under the curve were associated with increased risk (p = 0.01) and severity (r = 0.5, p < 0.02) of retinopathy of prematurity. Higher EPO concentrations at 2 weeks were associated with increased total brain injury score (r = 0.5, p < 0.05). Conclusion Elevated endogenous erythropoietin concentrations in the first two weeks of life are associated with lower birth weight and increased risk of adverse outcomes.

scholarly journals Analysis of risk factors in the development of retinopathy of prematurity

2011 ◽  
Vol 139 (7-8) ◽  
pp. 433-438 ◽  
Author(s):  
Sanja Knezevic ◽  
Nadezda Stojanovic ◽  
Ana Oros ◽  
Dragana Savic ◽  
Aleksandra Simovic ◽  
...  
Keyword(s):  
Risk Factors ◽  
Central Nervous System ◽  
Nervous System ◽  
Birth Weight ◽  
Retinopathy Of Prematurity ◽  
Severe Form ◽  
Central Nervous System Damage ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Independent Risk Factors

Introduction. Retinopathy of prematurity (ROP) is a multifactorial disease that occurs most frequently in very small and very sick preterm infants, and it has been identified as the major cause of childhood blindness. Objective. The aim of this study was to evaluate ROP incidence and risk factors associated with varying degrees of illness. Methods. The study was conducted at the Centre for Neonatology, Paediatric Clinic of the Clinical Centre Kragujevac, Serbia, in the period from June 2006 to December 2008. Ophthalmologic screening was performed in all children with body weight lower than 2000 g or gestational age lower than 36 weeks. We analyzed eighteen postnatal and six perinatal risk factors and the group correlations for each of the risk factors. Results. Out of 317 children that were screened, 56 (17.7%) developed a mild form of ROP, while 68 (21.5%) developed a severe form. Univariate analysis revealed a large number of statistically significant risk factors for the development of ROP, especially the severe form. Multivariate logistical analysis further separated two independent risk factors: small birth weight (p=0.001) and damage of central nervous system (p=0.01). Independent risk factors for transition from mild to severe forms of ROP were identified as: small birth weight (p=0.05) and perinatal risk factors (p=0.02). Conclusion. Small birth weight and central nervous system damage were risk factors for the development of ROP, perinatal risk factors were identified as significant for transition from mild to severe form of ROP.

Perinatal Risk Factors for Retinopathy of Prematurity in Preterm and Low Birth Weight Neonates

2020 ◽  
Vol 12 (1) ◽  
pp. 32-38
Author(s):  
Reena Yadav ◽  
Sharad Gupta ◽  
Jyoti Baba Shrestha ◽  
Raveena Yadav ◽  
Tushar Bikram Sipaliya Yadav
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Birth Asphyxia ◽  
P Value ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Oxygen Exposure

Background: Retinopathy of prematurity (ROP) is emerging as a leading cause of childhood blindness. The incidence of ROP is likely to increase after improvement in neonatal care unit in premature neonates. This study is conducted to determine the perinatal risk factors for ROP in preterm and low birth weight neonates. Methods: This is a prospective, descriptive and clinical; hospital based study. A total of 92 preterm neonates with gestational age of 36 weeks or less and birth weight of 2000 grams or less admitted in Neonatal Intensive Care Unit (NICU) were screened. Detailed antenatal, perinatal and neonatal history; birth asphyxia and subsequent oxygen support records were noted. All the neonates underwent detailed anterior and posterior segment eye examination with indirect binocular ophthalmoscope after pupil dilatation within 4 weeks of life. Retinal vascular changes were classified according to the International Classification of Retinopathy of Prematurity. The Chi-square test with odds ratio was performed to derive the association between ROP and antenatal, perinatal and neonatal factors. A p-value was considered significant at 0.05. Result: Out of 92 neonates, 21(22.8%) developed ROP. Twelve neonates (13%) had stage-1 ROP, 6(6.5%) had stage-2 and 3(3.3%) had stage-3 ROP. Birth weight (OR=2.9; p=0.04; 95% CI=1.0-8.3), gestational age (OR=3.9; p=0.01; 95% CI=1.3-11.8) and time span of oxygen exposure (OR=2.9; p=0.05; 95% CI=1.0-8.4) had a strong association with ROP. Conclusion: The incidence of ROP is significantly high among preterm low birth weight neonates. The risk of developing ROP becomes even greater with lower gestational age and more duration of oxygen exposure.

scholarly journals Low Birth Weight Prevalence in Children Diagnosed with Neurodevelopmental Disorders in Dubai

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110317
Author(s):  
Faisal A. Nawaz ◽  
Meshal A. Sultan
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Mental Disorders ◽  
Low Birth Weight ◽  
Neurodevelopmental Disorders ◽  
Autism Spectrum ◽  
High Birth Weight ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
The Impact

The aim of this study is to evaluate the prevalence of low birth weight and other perinatal risk factors in children diagnosed with neurodevelopmental disorders. This is one of the first studies in the Arabian Gulf region focused on the contribution of these factors toward the development of various disorders such as attention-deficit/hyperactivity disorder, autism spectrum disorder, and other mental disorders. This descriptive study was based on qualitative data analysis. We reviewed retrospective information from the electronic medical records of 692 patients in Dubai, United Arab Emirates. The prevalence of low birth weight in children with mental disorders was significantly higher as compared to the general population (16% vs 6% respectively). Furthermore, other risk factors, including high birth weight and preterm birth were noted to have a significant association with neurodevelopmental disorders. Future research on the impact of perinatal risk factors will contribute to advancement of early intervention guidelines.

scholarly journals Perinatal Risk Factors for Postnatal Weight Loss in Late Preterm Infants

2019 ◽  
Vol 26 (4) ◽  
pp. 198-203
Author(s):  
Seong Phil Bae ◽  
Jun Hwan Song ◽  
Won-Ho Hahn ◽  
Ji Won Koh ◽  
Ho Kim
Keyword(s):  
Risk Factors ◽  
Weight Loss ◽  
Preterm Infants ◽  
Late Preterm ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Late Preterm Infants

Perinatal Risk Factors for the Retinopathy of Prematurity in Postnatal Growth and Rop Study

2019 ◽  
Vol 26 (4) ◽  
pp. 270-278 ◽  
Author(s):  
Gui-Shuang Ying ◽  
Edward F Bell ◽  
Pamela Donohue ◽  
Lauren A Tomlinson ◽  
Gil Binenbaum ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retinopathy Of Prematurity ◽  
Postnatal Growth ◽  
Perinatal Risk Factors ◽  
Perinatal Risk

scholarly journals The coagulation system of extremely preterm infants: influence of perinatal risk factors on coagulation

2011 ◽  
Vol 32 (11) ◽  
pp. 869-873 ◽  
Author(s):  
C Poralla ◽  
C Traut ◽  
H-J Hertfelder ◽  
J Oldenburg ◽  
P Bartmann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Coagulation System ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals Validation of The DIGIROP-Birth Model in A Chinese Cohort

2021 ◽  
Author(s):  
Sizhe Chen ◽  
Rong Wu ◽  
He Chen ◽  
Wenbei Ma ◽  
Shaolin Du ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Receiver Operating Characteristic ◽  
Preterm Infants ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Roc Curve ◽  
Operating Characteristic ◽  
Predictive Performance ◽  
Postnatal Risk Factors

Abstract Background We aimed to validate the predictive performance of the DIGIROP-Birth model for identifying treatment-requiring retinopathy of prematurity (TR-ROP) in Chinese preterm infants to evaluate its generalizability across countries and races. Methods We retrospectively reviewed the medical records of preterm infants who were screened for retinopathy of prematurity (ROP) in a single Chinese hospital between June 2015 and August 2020. The predictive performance of the model for TR-ROP was assessed through the construction of a receiver-operating characteristic (ROC) curve and calculating the areas under the ROC curve (AUC), sensitivity, specificity, and positive and negative predictive values. Results Four hundred and forty-two infants (mean (SD) gestational age = 28.8 (1.3) weeks; mean (SD) birth weight = 1237.0 (236.9) g; 64.7% males) were included in the study. Analyses showed that the DIGIROP-Birth model demonstrated less satisfactory performance than previously reported in identifying infants with TR-ROP, with an area under the receiver-operating characteristic curve of 0.634 (95% confidence interval = 0.564–0.705). With a cutoff value of 0.0084, the DIGIROP-Birth model showed a sensitivity of 48/93 (51.6%), which increased to 89/93 (95.7%) after modification with the addition of postnatal risk factors. In infants with a gestational age < 28 weeks or birth weight < 1000 g, the DIGIROP-Birth model exhibited sensitivities of 36/39 (92.3%) and 20/23 (87.0%), respectively. Conclusions Although the predictive performance was less satisfactory in China than in developed countries, modification of the DIGIROP-Birth model with postnatal risk factors shows promise in improving its efficacy for TR-ROP. The model may also be effective in infants with a younger gestational age or with an extremely low birth weight.

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