scholarly journals Pulmonary valve tissue engineering strategies in large animal models

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258046
Author(s):  
M. Uiterwijk ◽  
D. C. van der Valk ◽  
R. van Vliet ◽  
I. J. de Brouwer ◽  
C. R. Hooijmans ◽  
...  
Keyword(s):  
Animal Models ◽  
Animal Studies ◽  
Meta Analysis ◽  
Control Group ◽  
Large Animal ◽  
Large Animal Models ◽  
Study Heterogeneity ◽  
Tissue Engineered Heart Valve ◽  
Synthetic Scaffolds ◽  
Study Designs

In the last 25 years, numerous tissue engineered heart valve (TEHV) strategies have been studied in large animal models. To evaluate, qualify and summarize all available publications, we conducted a systematic review and meta-analysis. We identified 80 reports that studied TEHVs of synthetic or natural scaffolds in pulmonary position (n = 693 animals). We identified substantial heterogeneity in study designs, methods and outcomes. Most importantly, the quality assessment showed poor reporting in randomization and blinding strategies. Meta-analysis showed no differences in mortality and rate of valve regurgitation between different scaffolds or strategies. However, it revealed a higher transvalvular pressure gradient in synthetic scaffolds (11.6 mmHg; 95% CI, [7.31–15.89]) compared to natural scaffolds (4,67 mmHg; 95% CI, [3,94–5.39]; p = 0.003). These results should be interpreted with caution due to lack of a standardized control group, substantial study heterogeneity, and relatively low number of comparable studies in subgroup analyses. Based on this review, the most adequate scaffold model is still undefined. This review endorses that, to move the TEHV field forward and enable reliable comparisons, it is essential to define standardized methods and ways of reporting. This would greatly enhance the value of individual large animal studies.

scholarly journals Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models

2015 ◽  
Vol 109 (2) ◽  
pp. 240-248 ◽  
Author(s):  
Gerardus P. J. van Hout ◽  
Sanne J. Jansen of Lorkeers ◽  
Kimberly E. Wever ◽  
Emily S. Sena ◽  
Lisanne H. J. A. Kouwenberg ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Animal Models ◽  
Meta Analysis ◽  
Large Animal ◽  
Large Animal Models ◽  
Anti Inflammatory

scholarly journals Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease

2011 ◽  
Vol 91 (4) ◽  
pp. 649-658 ◽  
Author(s):  
T. I. G. van der Spoel ◽  
S. J. Jansen of Lorkeers ◽  
P. Agostoni ◽  
E. van Belle ◽  
M. Gyongyosi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Heart Disease ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Large Animal ◽  
Large Animal Models

scholarly journals Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations

2019 ◽  
Vol 39 (3) ◽  
pp. 375-394 ◽  
Author(s):  
Andrea M Herrmann ◽  
Stephan Meckel ◽  
Matthew J Gounis ◽  
Leona Kringe ◽  
Edith Motschall ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ischemic Stroke ◽  
Animal Models ◽  
Translational Research ◽  
Arteriovenous Malformations ◽  
Vascular Malformations ◽  
Large Animal ◽  
Large Animal Models ◽  
Large Animals ◽  
Study Designs

Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular treatments. However, the availability and role of large animal models have not been systematically described so far. Based on comprehensive research in two databases, this systematic review describes current large animal models in neuroendovascular research including their primary use. It may therefore serve as a compact compendium for researchers entering the field or looking for opportunities to refine study concepts. It also describes particular applications for ischemic stroke and aneurysm therapy, as well as for the treatment of arteriovenous malformations. It focuses on most promising study designs and readout parameters, as well as on important pitfalls in endovascular translational research including ways to circumvent them.

scholarly journals Anti-inflammatory compounds to reduce infarct size in large-animal models of myocardial infarction: A meta-analysis

2014 ◽  
Vol 1 (1) ◽  
pp. e00004 ◽  
Author(s):  
G.P.J. van Hout ◽  
S.J. Jansen of Lorkeers ◽  
K.E. Wever ◽  
E.S. Sena ◽  
W.W. van Solinge ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Animal Models ◽  
Infarct Size ◽  
Meta Analysis ◽  
Large Animal ◽  
Reduce Infarct Size ◽  
Large Animal Models ◽  
Anti Inflammatory

The Utility of Animal Models in the Preclinical Study of Interventions to Prevent Human Coronary Artery Restenosis: Analysis and Recommendations

1999 ◽  
Vol 81 (05) ◽  
pp. 835-843. ◽  
Author(s):  
T. R. Griggs ◽  
L. Badimon ◽  
G. J. Johnson
Keyword(s):  
Animal Models ◽  
Animal Studies ◽  
Small Animal ◽  
Preclinical Study ◽  
Large Animal ◽  
Human Coronary Artery ◽  
Large Animal Models ◽  
Luminal Narrowing ◽  
Small Animal Models ◽  
Large Animals

SummarySmall animal models have several advantageous characteristics, but those used in preclinical restenosis research have lacked efficacy in predicting the success of interventions to inhibit restenosis in humans.Large animal models have been more successful than small animal models in predicting efficacy of interventions to inhibit restenosis in humans, but the results of studies carried out with these models have not been uniformly predictive.Confirmation of the results of small animal studies in large animals has not always yielded information predictive of success in humans; however, the absence of such confirmation has had strong negative predictive value.Small animal models used for evaluation of interventions to inhibit luminal narrowing following arterial instrumentation have failed to closely simulate human atherosclerosis and the stenotic lesions subjected to instrumentation in humans.Transgenic, atherosclerotic animals hold promise for the development of more useful small animal models to study mechanisms of the response of diseased arteries to angioplasty and stents.The pig has been the most useful large animal to study stenosis/ restenosis, but more information is needed to overcome the limitations of this model.

scholarly journals CLINICAL RELEVANCE OF ISCHEMIC LARGE ANIMAL MODELS IN STEM CELL THERAPY; AN OVERVIEW AND META-ANALYSIS.

2011 ◽  
Vol 57 (14) ◽  
pp. E1011
Author(s):  
Tycho Van der Spoel ◽  
Sanne Jansen of Lorkeers ◽  
Pierfrancesco Agostoni ◽  
Eric Van Belle ◽  
Joost Sluijter ◽  
...  
Keyword(s):  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Clinical Relevance ◽  
Meta Analysis ◽  
Large Animal ◽  
Large Animal Models

scholarly journals Relationship between maternal global nutrient restriction during pregnancy and offspring kidney structure and function: a systematic review of animal studies

2019 ◽  
Vol 316 (6) ◽  
pp. F1227-F1235 ◽  
Author(s):  
Yu Qi Lee ◽  
Emma L. Beckett ◽  
Dean V. Sculley ◽  
Kym M. Rae ◽  
Clare E. Collins ◽  
...  
Keyword(s):  
Animal Models ◽  
Meta Analysis ◽  
Structure And Function ◽  
Nutrient Restriction ◽  
Large Animal ◽  
Kidney Weight ◽  
Kidney Structure ◽  
Large Animal Models ◽  
Glomerular Size ◽  
And Function

Maternal undernutrition during pregnancy is prevalent across the globe, and the origins of many chronic diseases can be traced back to in utero conditions. This systematic review considers the current evidence in animal models regarding the relationship between maternal global nutrient restriction during pregnancy and offspring kidney structure and function. CINAHL, Cochrane, EMBASE, MEDLINE, and Scopus were searched to November 2017. Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines were followed, and articles were screened by two independent reviewers. Twenty-eight studies met the inclusion criteria: 16 studies were on rats, 9 on sheep, 2 on baboons, and 1 on goats. The majority of the rat studies had maternal global nutrient restriction during pregnancy at 50% of ad libitum while restriction for sheep and baboon studies ranged from 50% to 75%. Because of the heterogeneity of outcome measures and the large variation in the age of offspring at followup, no meta-analysis was possible. Common outcome measures included kidney weight, nephron number, glomerular size, glomerular filtration rate, and creatinine clearance. To date, there have been no studies assessing kidney function in large animal models. Most studies were rated as having a high or unknown risk of bias. The current body of evidence in animals suggests that exposure to maternal global nutrient restriction during pregnancy has detrimental effects on offspring kidney structure and function, such as lower kidney weight, lower nephron endowment, larger glomerular size, and lower glomerular filtration rate. Further long-term followup of studies in large animal models investigating kidney function through to adulthood are warranted.

scholarly journals Longitudinal study of electrical, functional and structural remodelling in an equine model of atrial fibrillation

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Eva Zander Hesselkilde ◽  
Helena Carstensen ◽  
Mette Flethøj ◽  
Merle Fenner ◽  
Ditte Dybvald Kruse ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Animal Models ◽  
Ion Channel ◽  
Control Group ◽  
Large Animal ◽  
Large Animal Models ◽  
New Therapeutic Approaches ◽  
Atrial Remodelling ◽  
Channel Expression ◽  
Bona Fide

Abstract Background Large animal models are important in atrial fibrillation (AF) research, as they can be used to study the pathophysiology of AF and new therapeutic approaches. Unlike other animal models, horses spontaneously develop AF and could therefore serve as a bona fide model in AF research. We therefore aimed to study the electrical, functional and structural remodelling caused by chronic AF in a horse model. Method Nine female horses were included in the study, with six horses tachypaced into self-sustained AF and three that served as a time-matched sham-operated control group. Acceleration in atrial fibrillatory rate (AFR), changes in electrocardiographic and echocardiographic variables and response to medical treatment (flecainide 2 mg/kg) were recorded over a period of 2 months. At the end of the study, changes in ion channel expression and fibrosis were measured and compared between the two groups. Results AFR increased from 299 ± 33 fibrillations per minute (fpm) to 376 ± 12 fpm (p < 0.05) and atrial function (active left atrial fractional area change) decreased significantly during the study (p < 0.05). No changes were observed in heart rate or ventricular function. The AF group had more atrial fibrosis compared to the control group (p < 0.05). No differences in ion channel expression were observed. Conclusion Horses with induced AF show signs of atrial remodelling that are similar to humans and other animal models.

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