scholarly journals Relationship between maternal global nutrient restriction during pregnancy and offspring kidney structure and function: a systematic review of animal studies

2019 ◽  
Vol 316 (6) ◽  
pp. F1227-F1235 ◽  
Author(s):  
Yu Qi Lee ◽  
Emma L. Beckett ◽  
Dean V. Sculley ◽  
Kym M. Rae ◽  
Clare E. Collins ◽  
...  
Keyword(s):  
Animal Models ◽  
Meta Analysis ◽  
Structure And Function ◽  
Nutrient Restriction ◽  
Large Animal ◽  
Kidney Weight ◽  
Kidney Structure ◽  
Large Animal Models ◽  
Glomerular Size ◽  
And Function

Maternal undernutrition during pregnancy is prevalent across the globe, and the origins of many chronic diseases can be traced back to in utero conditions. This systematic review considers the current evidence in animal models regarding the relationship between maternal global nutrient restriction during pregnancy and offspring kidney structure and function. CINAHL, Cochrane, EMBASE, MEDLINE, and Scopus were searched to November 2017. Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines were followed, and articles were screened by two independent reviewers. Twenty-eight studies met the inclusion criteria: 16 studies were on rats, 9 on sheep, 2 on baboons, and 1 on goats. The majority of the rat studies had maternal global nutrient restriction during pregnancy at 50% of ad libitum while restriction for sheep and baboon studies ranged from 50% to 75%. Because of the heterogeneity of outcome measures and the large variation in the age of offspring at followup, no meta-analysis was possible. Common outcome measures included kidney weight, nephron number, glomerular size, glomerular filtration rate, and creatinine clearance. To date, there have been no studies assessing kidney function in large animal models. Most studies were rated as having a high or unknown risk of bias. The current body of evidence in animals suggests that exposure to maternal global nutrient restriction during pregnancy has detrimental effects on offspring kidney structure and function, such as lower kidney weight, lower nephron endowment, larger glomerular size, and lower glomerular filtration rate. Further long-term followup of studies in large animal models investigating kidney function through to adulthood are warranted.

scholarly journals Large Animal Models of Vascularized Composite Allotransplantation: A Review of Immune Strategies to Improve Allograft Outcomes

2021 ◽  
Vol 12 ◽  
Author(s):  
Abraham J. Matar ◽  
Rebecca L. Crepeau ◽  
Gerhard S. Mundinger ◽  
Curtis L. Cetrulo ◽  
Radbeh Torabi
Keyword(s):  
Animal Models ◽  
Ex Vivo ◽  
Solid Organ Transplantation ◽  
Tolerance Induction ◽  
Large Animal ◽  
Solid Organ ◽  
Large Animal Models ◽  
Large Animals ◽  
And Function ◽  
Made In

Over the past twenty years, significant technical strides have been made in the area of vascularized composite tissue allotransplantation (VCA). As in solid organ transplantation, the allogeneic immune response remains a significant barrier to long-term VCA survival and function. Strategies to overcome acute and chronic rejection, minimize immunosuppression and prolong VCA survival have important clinical implications. Historically, large animals have provided a valuable model for testing the clinical translatability of immune modulating approaches in transplantation, including tolerance induction, co-stimulation blockade, cellular therapies, and ex vivo perfusion. Recently, significant advancements have been made in these arenas utilizing large animal VCA models. In this comprehensive review, we highlight recent immune strategies undertaken to improve VCA outcomes with a focus on relevant preclinical large animal models.

scholarly journals Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models

2015 ◽  
Vol 109 (2) ◽  
pp. 240-248 ◽  
Author(s):  
Gerardus P. J. van Hout ◽  
Sanne J. Jansen of Lorkeers ◽  
Kimberly E. Wever ◽  
Emily S. Sena ◽  
Lisanne H. J. A. Kouwenberg ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Animal Models ◽  
Meta Analysis ◽  
Large Animal ◽  
Large Animal Models ◽  
Anti Inflammatory

scholarly journals Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease

2011 ◽  
Vol 91 (4) ◽  
pp. 649-658 ◽  
Author(s):  
T. I. G. van der Spoel ◽  
S. J. Jansen of Lorkeers ◽  
P. Agostoni ◽  
E. van Belle ◽  
M. Gyongyosi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Heart Disease ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Large Animal ◽  
Large Animal Models

scholarly journals Effects of mesenchymal stromal cell-conditioned media on measures of lung structure and function: a systematic review and meta-analysis of preclinical studies

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Alvaro Moreira ◽  
Rija Naqvi ◽  
Kristen Hall ◽  
Chimobi Emukah ◽  
John Martinez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Lung Disease ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Human Lung ◽  
Meta Analysis ◽  
Structure And Function ◽  
Lung Structure ◽  
And Function

Abstract Background Lung disease is a leading cause of morbidity and mortality. A breach in the lung alveolar-epithelial barrier and impairment in lung function are hallmarks of acute and chronic pulmonary illness. This review is part two of our previous work. In part 1, we demonstrated that CdM is as effective as MSCs in modulating inflammation. Herein, we investigated the effects of mesenchymal stromal cell (MSC)-conditioned media (CdM) on (i) lung architecture/function in animal models mimicking human lung disease, and (ii) performed a head-to-head comparison of CdM to MSCs. Methods Adhering to the animal Systematic Review Centre for Laboratory animal Experimentation protocol, we conducted a search of English articles in five medical databases. Two independent investigators collected information regarding lung: alveolarization, vasculogenesis, permeability, histologic injury, compliance, and measures of right ventricular hypertrophy and right pulmonary pressure. Meta-analysis was performed to generate random effect size using standardized mean difference with 95% confidence interval. Results A total of 29 studies met inclusion. Lung diseases included bronchopulmonary dysplasia, asthma, pulmonary hypertension, acute respiratory distress syndrome, chronic obstructive pulmonary disease, and pulmonary fibrosis. CdM improved all measures of lung structure and function. Moreover, no statistical difference was observed in any of the lung measures between MSCs and CdM. Conclusions In this meta-analysis of animal models recapitulating human lung disease, CdM improved lung structure and function and had an effect size comparable to MSCs.

scholarly journals Effects of acid aspiration-induced acute lung injury on kidney function

2008 ◽  
Vol 294 (4) ◽  
pp. F900-F908 ◽  
Author(s):  
Jeffrey B. Hoag ◽  
Manchang Liu ◽  
R. Blaine Easley ◽  
Martin F. Britos-Bray ◽  
Priya Kesari ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
Small Animal ◽  
Kidney Injury ◽  
Structure And Function ◽  
Acid Aspiration ◽  
Kidney Structure ◽  
Small Animal Models ◽  
And Function

Acute lung injury (ALI) in combination with acute kidney injury carries a mortality approaching 80% in the intensive care unit. Recently, attention has focused on the interaction of the lung and kidney in the setting of ALI and mechanical ventilation (MV). Small animal models of ALI and MV have demonstrated changes in inflammatory mediators, water channels, apoptosis, and function in the kidney early in the course of injury. The purpose of this investigation was to test the hypothesis that ALI and injurious MV cause early, measurable changes in kidney structure and function in a canine HCl aspiration model of ALI when hemodynamics and arterial blood gas tensions are carefully controlled. Intratracheal HCl induced profound ALI as demonstrated by increased shunt fraction and airway pressures compared with sham injury. Sham-injured animals had similar mean arterial pressure and arterial Pco2 and HCO3 levels compared with injured animals. Measurements of renal function including renal blood flow, urine flow, serum creatinine, glomerular filtration rate, urine albumin-to-creatinine ratio, and kidney histology scores were not different between groups. With maintenance of hemodynamic parameters and alveolar ventilation, ALI and injurious MV do not alter kidney structure and function early in the course of injury in this acid aspiration canine model. Kidney injury in large animal models may be more similar to humans and may differ from results seen in small animal models.

scholarly journals Anti-inflammatory compounds to reduce infarct size in large-animal models of myocardial infarction: A meta-analysis

2014 ◽  
Vol 1 (1) ◽  
pp. e00004 ◽  
Author(s):  
G.P.J. van Hout ◽  
S.J. Jansen of Lorkeers ◽  
K.E. Wever ◽  
E.S. Sena ◽  
W.W. van Solinge ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Animal Models ◽  
Infarct Size ◽  
Meta Analysis ◽  
Large Animal ◽  
Reduce Infarct Size ◽  
Large Animal Models ◽  
Anti Inflammatory

scholarly journals CLINICAL RELEVANCE OF ISCHEMIC LARGE ANIMAL MODELS IN STEM CELL THERAPY; AN OVERVIEW AND META-ANALYSIS.

2011 ◽  
Vol 57 (14) ◽  
pp. E1011
Author(s):  
Tycho Van der Spoel ◽  
Sanne Jansen of Lorkeers ◽  
Pierfrancesco Agostoni ◽  
Eric Van Belle ◽  
Joost Sluijter ◽  
...  
Keyword(s):  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Clinical Relevance ◽  
Meta Analysis ◽  
Large Animal ◽  
Large Animal Models

scholarly journals Pulmonary valve tissue engineering strategies in large animal models

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258046
Author(s):  
M. Uiterwijk ◽  
D. C. van der Valk ◽  
R. van Vliet ◽  
I. J. de Brouwer ◽  
C. R. Hooijmans ◽  
...  
Keyword(s):  
Animal Models ◽  
Animal Studies ◽  
Meta Analysis ◽  
Control Group ◽  
Large Animal ◽  
Large Animal Models ◽  
Study Heterogeneity ◽  
Tissue Engineered Heart Valve ◽  
Synthetic Scaffolds ◽  
Study Designs

In the last 25 years, numerous tissue engineered heart valve (TEHV) strategies have been studied in large animal models. To evaluate, qualify and summarize all available publications, we conducted a systematic review and meta-analysis. We identified 80 reports that studied TEHVs of synthetic or natural scaffolds in pulmonary position (n = 693 animals). We identified substantial heterogeneity in study designs, methods and outcomes. Most importantly, the quality assessment showed poor reporting in randomization and blinding strategies. Meta-analysis showed no differences in mortality and rate of valve regurgitation between different scaffolds or strategies. However, it revealed a higher transvalvular pressure gradient in synthetic scaffolds (11.6 mmHg; 95% CI, [7.31–15.89]) compared to natural scaffolds (4,67 mmHg; 95% CI, [3,94–5.39]; p = 0.003). These results should be interpreted with caution due to lack of a standardized control group, substantial study heterogeneity, and relatively low number of comparable studies in subgroup analyses. Based on this review, the most adequate scaffold model is still undefined. This review endorses that, to move the TEHV field forward and enable reliable comparisons, it is essential to define standardized methods and ways of reporting. This would greatly enhance the value of individual large animal studies.

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