scholarly journals Diuretic effect of co-administration of furosemide and albumin in comparison to furosemide therapy alone: An updated systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260312
Author(s):  
Tao Han Lee ◽  
George Kuo ◽  
Chih-Hsiang Chang ◽  
Yen Ta Huang ◽  
Chieh Li Yen ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Urine Output ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Diuretic Effect ◽  
Baseline Serum ◽  
Albumin Infusion ◽  
Link Type ◽  
Meta Analyses

Background It has been a matter of much debate whether the co-administration of furosemide and albumin can achieve better diuresis and natriuresis than furosemide treatment alone. There is inconsistency in published trials regarding the effect of this combination therapy. We, therefore, conducted this meta-analysis to explore the efficacy of furosemide and albumin co-administration and the factors potentially influencing the diuretic effect of such co-administration. Methods In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched the PubMed, Embase, Medline, and Cochrane databases. Prospective studies with adult populations which comparing the effect of furosemide and albumin co-administration with furosemide alone were included. The outcomes including diuretic effect and natriuresis effect measured by hourly urine output and hourly urine sodium excretion from both groups were extracted. Random effect model was applied for conducting meta-analysis. Subgroup analysis and sensitivity analysis were performed to explore potential sources of heterogeneity of treatment effects. Results By including 13 studies with 422 participants, the meta-analysis revealed that furosemide with albumin co-administration increased urine output by 31.45 ml/hour and increased urine excretion by 1.76 mEq/hour in comparison to furosemide treatment alone. The diuretic effect of albumin and furosemide co-administration was better in participants with low baseline serum albumin levels (< 2.5 g/dL) and high prescribed albumin infusion doses (> 30 g), and the effect was more significant within 12 hours after administration. Diuretic effect of co-administration was better in those with baseline Cr > 1.2 mg/dL and natriuresis effect of co-administration was better in those with baseline eGFR < 60 ml/min/1.73m2. Conclusion Co-administration of furosemide with albumin might enhance diuresis and natriuresis effects than furosemide treatment alone but with high heterogeneity in treatment response. According to the present meta-analysis, combination therapy might provide advantages compared to the furosemide therapy alone in patients with baseline albumin levels lower than 2.5 g/dL or in patients receiving higher albumin infusion doses or in patients with impaired renal function. Owing to high heterogeneity and limited enrolled participants, further parallel randomized controlled trials are warranted to examine our outcome. Registration PROSEPRO ID: CRD42020211002; https://clinicaltrials.gov/.

Mindfulness- and Acceptance-Based Interventions for Stroke Survivors: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 003435522110432
Author(s):  
Areum Han
Keyword(s):  
Systematic Review ◽  
Depressive Symptoms ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Mental Fatigue ◽  
Stroke Survivors ◽  
Positive Effects ◽  
Meta Analyses

Objective: Mindfulness- and acceptance-based intervention (MABI) is an emerging evidenced-based practice, but no systematic review incorporating meta-analyses for MABIs in stroke survivors has been conducted. The objective of this systematic review was to measure the effectiveness of MABIs on outcomes in people with stroke. Method: Three electronic databases, including PubMed, CINAHL, and PsycINFO, were searched to identify relevant studies published in peer-reviewed journals. The methodological quality of the included studies was assessed. Data were extracted and combined in a meta-analysis with a random-effect model to compute the size of the intervention effect. Results: A total of 11 studies met the eligibility criteria. Meta-analyses found a small-to-moderate effect of MABIs on depressive symptoms (standardized mean difference [SMD] = 0.39, 95% confidence interval [CI] = [0.12, 0.66]) and a large effect on mental fatigue (SMD = 1.22, 95% CI = [0.57, 1.87]). No statistically significant effect of MABIs on anxiety, quality of life, and mindfulness was found, but there was a trend in favor of MABIs overall. Conclusions: This meta-analysis found positive effects of MABIs on depressive symptoms and mental fatigue in stroke survivors, but future high-quality studies are needed to guarantee treatment effects of MABIs on varied outcomes in stroke survivors.

scholarly journals β lactam monotherapy versus β lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomised trials

BMJ ◽  
2004 ◽  
Vol 328 (7441) ◽  
pp. 668 ◽  
Author(s):  
Mical Paul ◽  
Ishay Benuri-Silbiger ◽  
Karla Soares-Weiser ◽  
Leonard Leibovici
Keyword(s):  
Relative Risk ◽  
Combination Therapy ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Cochrane Library ◽  
Randomised Trials ◽  
Intention To Treat ◽  
Relative Risks ◽  
Development Of Resistance

AbstractObjective To compare β lactam monotherapy with β lactam-aminoglycoside combination therapy for severe infections.Data sources Medline, Embase, Lilacs, Cochrane Library, and conference proceedings, to 2003; references of included studies; contact with all authors. No restrictions, such as language, year of publication, or publication status.Study selection All randomised trials of β lactam monotherapy compared with β lactam-aminoglycoside combination therapy for patients without neutropenia who fulfilled criteria for sepsis.Data selection Two reviewers independently applied selection criteria, performed quality assessment, and extracted the data. The primary outcome assessed was all cause fatality by intention to treat. Relative risks were pooled with the random effect model (relative risk < 1 favours monotherapy).Results 64 trials with 7586 patients were included. There was no difference in all cause fatality (relative risk 0.90, 95% confidence interval 0.77 to 1.06). 12 studies compared the same β lactam (1.02, 0.76 to 1.38), and 31 studies compared different β lactams (0.85, 0.69 to 1.05). Clinical failure was more common with combination treatment overall (0.87, 0.78 to 0.97) and among studies comparing different β lactams (0.76, 0.68 to 0.86). There was no advantage to combination therapy among patients with Gram negative infections (1835 patients) or Pseudomonas aeruginosa infections (426 patients). There was no difference in the rate of development of resistance. Nephrotoxicity was significantly more common with combination therapy (0.36, 0.28 to 0.47). Heterogeneity was not significant for these comparisons.Conclusions In the treatment of sepsis the addition of an aminoglycoside to β lactams should be discouraged. Fatality remains unchanged, while the risk for adverse events is increased.

scholarly journals History and Spread of Viruses (COVID-19) and Associated Demographic and Clinical Parameters – A systematic review and meta-analysis

2021 ◽  
Vol 33 (1) ◽  
pp. 9-24
Author(s):  
Swambhavi Awasthi ◽  
Sunil Sharma ◽  
Saurav Attri ◽  
Sakshi Malik Attri ◽  
Rajesh Sharawat ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Fixed Effect Model ◽  
Primary Objective ◽  
Asymptomatic Patients ◽  
Effect Model ◽  
Co Morbidity ◽  
The Common ◽  
Meta Analyses

COVID-19 made a huge impact on the world due to its rapid transmission and no treatments being available for it. The virus affected more people and spread to various countries than what was predicted when COVID-19 initially began spreading. There have been numerous pandemics and epidemics in the 21st century yet COVID-19 has affected more people and spread widely. The primary objective of the study was to explore history, spread and associated parameters of existing viruses especially COVID-19. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed for a systematic search to identify eligible published articles. Clinical data, regarding COVID-19 patients, was obtained from previously published articles. The main cause of COVID-19 spreading rapidly was noted to be due to a high percentage of asymptomatic patients, transmission being air-borne, and the lack of knowledge and preventative measures being implemented when the virus began spreading. The common co-morbidity that found in patients was Diabetes Mellitus, Hypertension, and Coronary Heart Disease. The common symptoms, found through the Meta-analysis, that the patients faced included cough (55.4%), fever (68.4%), fatigue (20.3%), and shortness of breath (18.1%). The proportion of asymptotic positive cases was measured 58.3% (95%CI: 24.7% – 87.9%) while mortality proportion was found to be 6.7% (fixed-effect model) and 13.4% (random-effect model). The Meta-analysis indicated that a higher percentage of males were affected by COVID-19 than females and more patients are found to be asymptomatic. Moreover, the mortality rate of patients that have had COVID-19 was found to be low. 

scholarly journals A Bayesian Model-Averaged Meta-Analysis of the Power Pose Effect with Informed and Default Priors: The Case of Felt Power

2017 ◽  
Author(s):  
Quentin Frederik Gronau ◽  
Sara van Erp ◽  
Daniel W. Heck ◽  
Joseph Cesario ◽  
Kai Jonas ◽  
...  
Keyword(s):  
Bayesian Model ◽  
Bayesian Model Averaging ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Model Averaging ◽  
Fixed Effect Model ◽  
Body Postures ◽  
Effect Model ◽  
Meta Analyses

Carney, Cuddy, and Yap (2010) found that --compared to participants who adopted constrictive body postures-- participants who adopted expansive body postures reported feeling more powerful, showed an increase in testosterone and a decrease in cortisol, and displayed anincreased tolerance for risk. However, these power pose effects have recently come under considerable scrutiny. Here we present a Bayesian meta-analysis of six preregistered studies from this special issue, focusing on the effect of power posing on felt power. Our analysisimproves on standard classical meta-analyses in several ways. First and foremost, we considered only preregistered studies, eliminating concerns about publication bias. Second, the Bayesian approach enables us to quantify evidence for both the alternative and the null hypothesis. Third, we use Bayesian model-averaging to account for the uncertainty with respect to the choice for a fixed-effect model or a random-effect model. Fourth, based on a literature review we obtained an empirically informed prior distribution for the between-studyheterogeneity of effect sizes. This empirically informed prior can serve as a default choice not only for the investigation of the power pose effect, but for effects in the field of psychology more generally. For effect size, we considered a default and an informed prior. Our meta-analysis yields very strong evidence for an effect of power posing on felt power. However, when the analysis is restricted to participants unfamiliar with the effect, the meta-analysis yields evidence that is only moderate.

Metabolic syndrome in antipsychotic-naïve patients with first-episode psychosis: a systematic review and meta-analysis

2021 ◽  
pp. 1-14
Author(s):  
Nathalia Garrido-Torres ◽  
Idalino Rocha-Gonzalez ◽  
Luis Alameda ◽  
Aurora Rodriguez-Gangoso ◽  
Ana Vilches ◽  
...  
Keyword(s):  
Systematic Review ◽  
Metabolic Syndrome ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
First Episode ◽  
Effect Model ◽  
Caucasian Origin ◽  
Drug Naïve ◽  
Meta Analyses

Abstract Background It is unclear what the prevalence of metabolic syndrome (MetS) in drug-naïve first-episode of psychosis (FEP) is, as previous meta-analyses were conducted in minimally exposed or drug-naïve FEP patients with psychotic disorder at any stage of the disease; thus, a meta-analysis examining MetS in naïve FEP compared with the general population is needed. Methods Studies on individuals with FEP defined as drug-naïve (0 days exposure to antipsychotics) were included to conduct a systematic review. A meta-analysis of proportions for the prevalence of MetS in antipsychotic-naïve patients was performed. Prevalence estimates and 95% CI were calculated using a random-effect model. Subgroup analyses and meta-regressions to identify sources and the amount of heterogeneity were also conducted. Results The search yielded 4143 articles. After the removal of duplicates, 2473 abstracts and titles were screened. At the full-text stage, 112 were screened, 18 articles were included in a systematic review and 13 articles in the main statistical analysis. The prevalence of MetS in naïve (0 days) FEP is 13.2% (95% CI 8.7–19.0). Ethnicity accounted for 3% of the heterogeneity between studies, and diagnostic criteria used for MetS accounted for 7%. When compared with controls matched by sex and age, the odds ratio is 2.52 (95% CI 1.29–5.07; p = 0.007). Conclusions Our findings of increased rates of MetS in naïve FEP patients suggest that we are underestimating cardiovascular risk in this population, especially in those of non-Caucasian origin. Our findings support that altered metabolic parameters in FEPs are not exclusively due to antipsychotic treatments.

scholarly journals Prevalence of Mild Cognitive Impairment in Community-Dwelling Chinese Populations Aged over 55 years: A Meta-Analysis and Systematic Review

2020 ◽  
Author(s):  
Yuan Lu ◽  
Chaojie Liu ◽  
Dehua Yu ◽  
Sally Fawkes ◽  
Jia Ma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Intermediate Phase ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Community Dwelling ◽  
Bibliographic Databases ◽  
Meta Analyses

Abstract Background: Mild cognitive impairment (MCI) is an intermediate phase between normal cognitive ageing and overt dementia, with amnesic MCI (aMCI) being the dominant subtype. This study aims to synthesise the prevalence results of MCI and aMCI in community-dwelling populations in China through a meta-analysis and systematic review.Methods: The study followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) protocol. English and Chinese studies published before 1 March 2020 were searched from ten electronic bibliographic databases. Two reviewers screened for relevance of the studies against the pre-defined inclusion and exclusion criteria and assessed the quality of the included studies using the Risk of Bias Tool independently. A random-effect model was adopted to estimate the prevalence of MCI and aMCI, followed by subgroup analyses and meta-regression. Sensitivity and publication bias tests were performed to verify the robustness of the meta-analyses.Results: A total of 41 studies with 112,632 participants were included in the meta-analyses. The Chinese community-dwelling populations over 55 years old had a pooled prevalence of 12.2% [95% confidence interval (CI): 10.6%, 14.2%] for MCI and 10.9% [95% CI: 7.7%, 15.4%] for aMCI, respectively. The prevalence of MCI increased with age. The American Psychiatric Association’s Diagnostic tool (DSM-IV) generated the highest MCI prevalence (13.5%), followed by the Petersen criteria (12.9%), and the National Institute on Aging Alzheimer’s Association (NIA-AA) criteria (10.3%). Women, rural residents, and those who lived alone and had low levels of education had higher MCI prevalence than others. ​Conclusion：Higher MCI prevalence was identified in community-dwelling populations in China compared with some other countries, possibly due to more relaxed criteria being adopted for confirming the diagnosis. The study shows that aMCI accounts for 66.5% of MCI, which is consistent with findings of studies undertaken elsewhere.Systematic review registration number： PROSPERO CRD42019134686

scholarly journals Prevalence of mild cognitive impairment in community-dwelling Chinese populations aged over 55 years: a meta-analysis and systematic review

2020 ◽  
Author(s):  
Yuan Lu ◽  
Chaojie Liu ◽  
Dehua Yu ◽  
Sally Fawkes ◽  
Jia Ma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Intermediate Phase ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Community Dwelling ◽  
Bibliographic Databases ◽  
Meta Analyses

Abstract Background: Mild cognitive impairment (MCI) is an intermediate phase between normal cognitive ageing and overt dementia, with amnesic MCI (aMCI) being the dominant subtype. This study aims to synthesise the prevalence results of MCI and aMCI in community-dwelling populations in China through a meta-analysis and systematic review.Methods: The study followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) protocol. English and Chinese studies published before 1 March 2020 were searched from ten electronic bibliographic databases. Two reviewers screened for relevance of the studies against the pre-defined inclusion and exclusion criteria and assessed the quality of the included studies using the Risk of Bias Tool independently. A random-effect model was adopted to estimate the prevalence of MCI and aMCI, followed by sub-group analyses and meta-regression. Sensitivity and publication bias tests were performed to verify the robustness of the meta-analyses.Results: A total of 41 studies with 112,632 participants were included in the meta-analyses. The Chinese community-dwelling populations over 55 years old had a pooled prevalence of 12.2% [95% confidence interval (CI): 10.6%, 14.2%] for MCI and 10.9% [95% CI: 7.7%, 15.4%] for aMCI, respectively. The prevalence of MCI increased with age. The American Psychiatric Association’s Diagnostic tool (DSM-IV) generated the highest MCI prevalence (13.5%), followed by the Petersen criteria (12.9%), and the National Institute on Aging Alzheimer’s Association (NIA-AA) criteria (10.3%). Women, rural residents, and those who lived alone and had low levels of education had higher MCI prevalence than others. ​Conclusion：Higher MCI prevalence was identified in community-dwelling populations in China compared with some other countries, possibly due to more relaxed criteria being adopted for confirming the diagnosis. The study shows that aMCI accounts for 66.5% of MCI, which is consistent with findings of studies undertaken elsewhere.Systematic review registration number：PROSPERO CRD42019134686

scholarly journals A Bayesian Model-Averaged Meta-Analysis of the Power Pose Effect with Informed and Default Priors: The Case of Felt Power

2017 ◽  
Author(s):  
Quentin Frederik Gronau ◽  
Sara van Erp ◽  
Daniel W. Heck ◽  
Joseph Cesario ◽  
Kai Jonas ◽  
...  
Keyword(s):  
Bayesian Model ◽  
Bayesian Model Averaging ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Model Averaging ◽  
Fixed Effect Model ◽  
Body Postures ◽  
Effect Model ◽  
Meta Analyses

Carney, Cuddy, and Yap (2010) found that --compared to participants who adopted constrictive body postures-- participants who adopted expansive body postures reported feeling more powerful, showed an increase in testosterone and a decrease in cortisol, and displayed an increased tolerance for risk. However, these power pose effects have recently come under considerable scrutiny. Here we present a Bayesian meta-analysis of six preregistered studies from this special issue, focusing on the effect of power posing on felt power. Our analysis improves on standard classical meta-analyses in several ways. First and foremost, we considered only preregistered studies, eliminating concerns about publication bias. Second, the Bayesian approach enables us to quantify evidence for both the alternative and the null hypothesis. Third, we use Bayesian model-averaging to account for the uncertainty with respect to the choice for a fixed-effect model or a random-effect model. Fourth, based on a literature review we obtained an empirically informed prior distribution for the between-study heterogeneity of effect sizes. This empirically informed prior can serve as a default choice not only for the investigation of the power pose effect, but for effects in the field of psychology more generally. For effect size, we considered a default and an informed prior. Our meta-analysis yields very strong evidence for an effect of power posing on felt power. However, when the analysis is restricted to participants unfamiliar with the effect, the meta-analysis yields evidence that is only moderate.

scholarly journals TP6.1.7 Systematic review and meta-analyses of cholecystectomy as a treatment of biliary hyperkinesia

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Hazim A. Eltyeb ◽  
Dhya Al-Leswas ◽  
Mutwakil O. Abdalla ◽  
John Wayman
Keyword(s):  
Ejection Fraction ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Symptomatic Improvement ◽  
Cochrane Library ◽  
Biliary Colic ◽  
Cochrane Central Register ◽  
Mean Differences ◽  
Meta Analyses

Abstract Aims Biliary hyperkinesia is typically diagnosed in patients with biliary like pain and no evidence of gall stones on imaging modalities but who have had biliary scintigraphy scan (HIDA) that shows ejection fraction ≥80%. This study aims to identify whether the removal of the gall bladder can alleviate the symptoms associated with Biliary Hyperkinesia. Methods Systematic search following PRISMA guidelines was done from inception to January 2020 using PubMed/Medline, OVID, Embase, Cochrane database of systemic reviews, Cochrane central register of controlled trials, The Database of Abstracts of Reviews of Effects (DARE) and Cochrane library databases. Results were expressed as risk ratios (RR) for dichotomous outcomes together with 95% confidence intervals (CI) or mean differences (MD) or standardized MD (SMD) for continuous outcomes. A meta-analysis done using random-effect model in RevMan 5.4® software. Results Thirteen studies met the inclusion criteria and were included in the review. A total of 332 patients diagnosed with biliary hyperkinesia underwent cholecystectomy, of whom 303 (91.3%) reported symptomatic improvement RR 8.67 [95% CI 4.95, 15.16] P = 0.01. Six studies described abnormal histological features in 163/181 (90.05%) with high GB EF. RR 7.88 [95% CI 3.94, 15.75] P = 0.08. Chronic cholecystitis n = 155 (95%), cholesterolosis n = 7 (4.3%), and one showed features of acute cholecystitis. Conclusion Patients with typical biliary colic symptoms without gallstones and markedly high ejection fraction might benefit from having cholecystectomy to alleviate their symptoms.

Vital Bleaching Influences the Bond Strength of Adhesive Systems to Enamel and Dentin: A Systematic Review and Meta-Analysis of In Vitro Studies

2021 ◽  
Author(s):  
TG Savian ◽  
J Oling ◽  
FZM Soares ◽  
RO Rocha
Keyword(s):  
Systematic Review ◽  
Bond Strength ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
In Vitro Studies ◽  
Adhesive Systems ◽  
Inverse Variance ◽  
Meta Analyses

Clinical Relevance Vital bleaching impairs the bonding of adhesive systems to enamel and dentin. Thus, restoration placement should be delayed for at least two weeks after completion of bleaching procedures. SUMMARY Objective: This systematic review evaluates the influence of vital bleaching on the bond strength of adhesive systems to enamel and dentin. Methods: This review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). In vitro studies comparing the bond strength of bleached and unbleached enamel and dentin were searched at the electronic databases—PubMed/MEDLINE, Scopus, and Web of Science—with no limit on year or language. The studies were screened and had data extracted by two reviewers independently. Bond strength data were meta-analyzed using the inverse variance method and the random effect model (p≤0.05). Results: The electronic search provided 4941 eligible studies, and 52 were included in the systematic review and the meta-analysis. The global meta-analysis showed that bleaching impairs the bond strength of adhesive systems to enamel and dentin (p&lt;0.001; mean difference [MD]: –0.96; confidence interval [CI]: −1.18 to −0.73), regardless of the bleaching agent (p&lt;0.001; MD: −9.98; CI: −1.37 to −0.58) or substrate (p&lt;0.001; MD: −0.89; CI: −1.12 to −0.66). The detrimental effect of bleaching on bond strength was not observed after two and three weeks after bleaching (p=0.1; MD: −0.39; CI: −0.84 to 0.65; and p=0.18; MD: −0.99; CI: −2.45 to 0.47, respectively). Conclusion: This systematic review and meta-analysis demonstrated that vital bleaching impairs the bonding of adhesive systems to enamel and dentin, and this adverse effect persists for two weeks.

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