Pulmonary Vascular Responses to Hypoxia and Hyperoxia in Healthy Volunteers and COPD Patients Measured by Electrical Impedance Tomographya

Abstract Background: Chronic obstructive pulmonary disease (COPD) is the most common chronic respiratory disease which is expected to become the third leading cause of death worldwide in 2030. Series of susceptibility genes and single nucleotide polymorphism (SNPs) play an important role in the occurrence and development of COPD.Methods: In our study, 98 COPD patients and 90 healthy volunteers were enrolled. The +869 SNP (SNP, Single Nucleotide Polymorphisms) of TGF-β1 was detected in 98 COPD patients and 90 healthy volunteers by PCR-DNA sequencing. The effects of different genotypes of +869 locus on the susceptibility of COPD, pulmonary function and airflow limitation of COPD patients were analyzed.Results: Allele C of +869 locus was associated with the susceptibility of COPD (OR:1.913, 95% CI: 1.251-2.926). The predicted value of FEV1% (FEV1, Forced Expiratory Volume in One Second) in patients with CC of +869 locus was significantly lower than that in patients with TT (P < 0.05). The genotype frequencies of CC, CT and TT were 6.5%, 58.7% and 34.8% in Mild-to-Moderate airflow restriction patients. In severe airflow restriction patients, the genotype frequencies were CC 23.1%, CT 57.7% and TT 19.2%. The distribution of CC genotype in severe airflow restriction COPD patients was significantly higher than that in Mild-to-Moderate airflow restriction COPD patients (P = 0.037). Moreover, the frequency of C allele was significantly higher in patients with severe airflow restriction than that patients with Mild-to-Moderate airflow restriction (P = 0.024).Conclusions: The SNP of +869 T/C in TGF-β1 is closely related to the susceptibility of COPD and the airflow restriction of COPD patients.

Download Full-text

Non-invasive pulmonary artery pressure estimation by electrical impedance tomography in a controlled hypoxemia study in healthy subjects

Scientific Reports ◽

10.1038/s41598-020-78535-4 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Martin Proença ◽

Fabian Braun ◽

Mathieu Lemay ◽

Josep Solà ◽

Andy Adler ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Pulmonary Artery ◽

Healthy Volunteers ◽

Correlation Coefficient ◽

Electrical Impedance Tomography ◽

Pulmonary Artery Pressure ◽

Electrical Impedance ◽

Impedance Tomography ◽

Artery Pressure ◽

Non Invasive

AbstractPulmonary hypertension is a hemodynamic disorder defined by an abnormal elevation of pulmonary artery pressure (PAP). Current options for measuring PAP are limited in clinical practice. The aim of this study was to evaluate if electrical impedance tomography (EIT), a radiation-free and non-invasive monitoring technique, can be used for the continuous, unsupervised and safe monitoring of PAP. In 30 healthy volunteers we induced gradual increases in systolic PAP (SPAP) by exposure to normobaric hypoxemia. At various stages of the protocol, the SPAP of the subjects was estimated by transthoracic echocardiography. In parallel, in the pulmonary vasculature, pulse wave velocity was estimated by EIT and calibrated to pressure units. Within-cohort agreement between both methods on SPAP estimation was assessed through Bland–Altman analysis and at subject level, with Pearson’s correlation coefficient. There was good agreement between the two methods (inter-method difference not significant (P > 0.05), bias ± standard deviation of − 0.1 ± 4.5 mmHg) independently of the degree of PAP, from baseline oxygen saturation levels to profound hypoxemia. At subject level, the median per-subject agreement was 0.7 ± 3.8 mmHg and Pearson’s correlation coefficient 0.87 (P < 0.05). Our results demonstrate the feasibility of accurately assessing changes in SPAP by EIT in healthy volunteers. If confirmed in a patient population, the non-invasive and unsupervised day-to-day monitoring of SPAP could facilitate the clinical management of patients with pulmonary hypertension.

Download Full-text

Forced Expiratory Collapse Of The Central Airways: Comparison Between COPD Patients And Healthy Volunteers

10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5178 ◽

2011 ◽

Author(s):

Carl R. O'Donnell ◽

David H. Roberts ◽

Mary Pollock ◽

Stephen H. Loring ◽

Phillip M. Boiselle

Keyword(s):

Healthy Volunteers ◽

Copd Patients

Download Full-text

Late Breaking Abstract - The effectiveness of electrical impedance spirometry in heart insufficiency diagnostics in COPD patients

10.1183/13993003.congress-2018.pa2469 ◽

2018 ◽

Author(s):

Vitaly Mishlanov ◽

Andrew Zuev ◽

Ekaterina Koshurnikova

Keyword(s):

Electrical Impedance ◽

Heart Insufficiency ◽

Copd Patients

Download Full-text

Dyspnea affective response: comparing COPD patients with healthy volunteers and laboratory model with activities of daily living

BMC Pulmonary Medicine ◽

10.1186/1471-2466-13-27 ◽

2013 ◽

Vol 13 (1) ◽

Cited By ~ 19

Author(s):

Carl R O’Donnell ◽

Richard M Schwartzstein ◽

Robert W Lansing ◽

Tegan Guilfoyle ◽

Daniel Elkin ◽

...

Keyword(s):

Activities Of Daily Living ◽

Healthy Volunteers ◽

Daily Living ◽

Affective Response ◽

Laboratory Model ◽

Copd Patients

Download Full-text

FEATURES OF THE INTESTINAL MICROBIOTA IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2014-5-55-61 ◽

2014 ◽

Vol 13 (5) ◽

pp. 55-61

Author(s):

L. M. Ogorodova ◽

V. M. Govorun ◽

S. V. Fedosenko ◽

M. A. Karnaushkina ◽

I. V. Saltykova ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Healthy Volunteers ◽

Pulmonary Disease ◽

Intestinal Microbiota ◽

Taxonomic Composition ◽

Chronic Obstructive ◽

Metagenomic Sequencing ◽

Obstructive Pulmonary Disease ◽

Copd Patients ◽

Normal Composition

The article summarizes the results of studies on the composition of microbial communities in stool samples of patients with chronic obstructive pulmonary disease (COPD) compared with healthy volunteers using genome-metagenomic sequencing. It is shown that the microbial community of the intestine in COPD patients is characterized as diverse taxonomic composition of metagenomes that the healthy volunteers microbiota. In this case, the normal composition of intestinal microbiota in patients with COPD is exposed to the qualitative and quantitative modifications. In contrast to healthy volunteers, the intestinal microbiota in patients with COPD is characterized by the presence of representatives of the Proteobacteria, as Citrobacter, Enterobacter, Eggerthella,Proteus, Salmonella, Anaerococcus, Clostridium difficile, Pseudomonas, as well as higher insemination fungus genusCandida (Candida dubliniensis and Candida albicans).

Download Full-text