The association between fever in the first year of life and atopy in children with or without family history of atopic disease

Background The role of repeated infection in early life in thedevelopment of childhood atopy is still controversy. Fever in thefirst year of life which is frequently associated with infections mightdecrease atopy.Objective The aim of this study was to investigate the associationbetween fever in the first year of life and atopy in children.Methods This was an observational clinical epidemiology studyperformed at Puskesmas Garuda, Padasuka, and Babakan Sari,Bandung, from January to March 2006. From 749 children, werandomly chose 150 subjects each from group with and withoutfamily history of atopic disease. Skin prick test and measurementof total serum immunoglobulin (Ig) E were performed on eachchildren. Atopy was defined as the skin prick test result waspositive to >1 allergen. The number of fever episodes in the firstyear of life was based on parents report. The relationship betweenfever and atopy was analyzed using Mantel Haenszel.Results From 284 subjects, atopy was found in 28.2% of children,of which 32.4% with and 23.9% without a family history of atopicdisease. Generally there was no significant association betweenfever and atopy. There was only decreased odds ratio withincreased fever episodes and trend analysis showed this decreasewas significant (P=0.01). The significant association betweenfever and atopy were found only in group without family historyof atopic disease (P=0.03, OR=0.43, CI 95% 0.18;1.01).Conclusion There is a relationship between fever and atopy inchildren without family history of atopic disease.

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Prevalence of allergen sensitization, most important allergens and factors associated with atopy in children

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2013.1315502 ◽

2013 ◽

Vol 131 (5) ◽

pp. 301-308 ◽

Cited By ~ 7

Author(s):

Raquel Prudente de Carvalho Baldacara ◽

Maria de Fatima Marcelos Fernandes ◽

Leonardo Baldacara ◽

Wilson Tartuce Aun ◽

Joao Ferreira de Mello ◽

...

Keyword(s):

Family History ◽

Skin Prick Test ◽

Cesarean Delivery ◽

Atopic Disease ◽

Dermatophagoides Pteronyssinus ◽

Outpatient Clinics ◽

Positive Skin Prick Test ◽

Positive Skin ◽

Prick Test ◽

History Of

CONTEXT AND OBJECTIVE: Knowledge of the profile of allergen sensitization among children is important for planning preventive measures. The objective of this study was to assess the prevalence and profile of sensitization to inhaled allergens and food among children and adolescents in an outpatient population in the city of Palmas. DESIGN AND SETTING: Cross-sectional study at outpatient clinics in Palmas, Tocantins, Brazil. METHODS: Ninety-four patients aged 1-15 years who were attending two pediatric outpatient clinics were selected between September and November 2008. All of the subjects underwent clinical interviews and skin prick tests. RESULTS: A positive skin prick test was observed in 76.6% of the participants (72.3% for inhalants and 28.9% for food allergens). The most frequent allergens were Dermatophagoides pteronyssinus (34%), cat epithelium (28.7%), dog epithelium (21.3%), Dermatophagoides farinae (19.1%), Blomia tropicalis (18.1%), cow's milk (9.6%) and grasses (9.6%). A positive skin prick test correlated with a history of atopic disease (odds ratio, OR = 5.833; P = 0.002), a family history of atopic disease (OR = 8.400; P < 0.001), maternal asthma (OR = 8.077; P = 0.048), pet exposure (OR = 3.600; P = 0.012) and cesarean delivery (OR = 3.367; P = 0.019). CONCLUSION: Dermatophagoides pteronyssinus was the most frequent aeroallergen and cow’s milk was the most prevalent food allergen. There was a positive correlation between a positive skin prick test and several factors, such as a family history of atopic disease, maternal asthma, pet exposure and cesarean delivery.

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Association between immunization coverage and atopy in children with or without family history of atopic disease

Paediatrica Indonesiana ◽

10.14238/pi48.6.2008.358-63 ◽

2016 ◽

Vol 48 (6) ◽

pp. 358

Author(s):

Isabella Riandani ◽

Budi Setiabudiawan ◽

Cissy B. Kartasasmita

Keyword(s):

Family History ◽

Environmental Factors ◽

Immunization Coverage ◽

Atopic Disease ◽

Total Serum ◽

Atopic Diseases ◽

Chi Square ◽

Prick Test ◽

History Of ◽

Genetic And Environmental Factors

Background Atopic diseases are determined by the interactionbetween genetic and environmental factors. The possible effectsof immunization, as one of environmental factors, on atopy remaina matter of controversy.Objective We conducted an observational clinical epidemiologyto find out the protective effect of high vaccination coverage toatopy in children.Methods During January through March 2006, 150 of749 childrenat Garuda, Padasuka, and Babakan Sari Primary Health Care inBandung were randomized from group with and without familyhistory of atopic disease. Atopy derived from skin prick test andtotal serum lgE was evaluated. Atopy was defined as a positiveskin test to any of the eight allergens tested. The immunizationswere recorded from Kartu Menuju Sehat (KMS). Statistical analysesincluded Chi square to compare prevalence, independent T-testand Mann-Whitney to compare mean.Results Atopy was found in 28.2% of284 subjects, of which 32.4%with and 23.9% without a family history of atopic disease. Themedian of total serum lgE level was higher in children with familyhistory of atopic disease and in atopy children. Children weregrouped according to total dose of basic immunizations (0-17 and2: 18) based on Program Pengembangan Imunisasi (PPI). There wasnonsignificant association between total doses of immunizationand atopy. Even though no statistically significant, the cumulativeimmunization doses were inversely related to the median of totalserum IgE level.Conclusions The immunization coverage has not decreased atopyrisk.

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474 Relationship Between Total Serum IgE, Atopy, and Obesity in Children With or Without Family History of Atopic Disease

World Allergy Organization Journal ◽

10.1097/01.wox.0000411589.02905.d3 ◽

2012 ◽

Vol 5 ◽

pp. S150-S151

Author(s):

Budi Setiabudiawan ◽

Reni Ghrahani ◽

Gartika Sapartini ◽

Putria Rayani ◽

Citra Amelinda ◽

...

Keyword(s):

Family History ◽

Atopic Disease ◽

Total Serum ◽

Serum Ige ◽

History Of ◽

Obesity In Children

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Atopic Dermatitis and Psoriasis as Overlapping Syndromes

Mediators of Inflammation ◽

10.1155/2020/7527859 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

A. Bozek ◽

M. Zajac ◽

M. Krupka

Keyword(s):

Atopic Dermatitis ◽

Family History ◽

Atopic Disease ◽

Skin Lesions ◽

The Body ◽

T Helper 17 ◽

Tnf Α ◽

History Of

Background/Objectives. Cooccurrence of atopic dermatitis (AD) and psoriasis (PS) is not common. However, both diseases are still of interest because of their comprehensive and diverse mechanisms. This study aimed to present the clinical and immunological profiles of patients with concomitant AD and PS and compare them with those of patients with only one of the diseases. Methods. In this observational study, 38 children with concomitant AD and PS with a mean age of 6.5 ± 3.2 yrs were compared with 41 similar patients with AD only ( 5.3 ± 5.1 yrs) and 28 patients with PS only ( 6.4 ± 4.3 yrs). All patients underwent dermatological examinations, including determination of SCORAD and PASI scores. TNF-α, IFN-γ, IL-2, IL-4, IL-5, IL-6, IL-8, IL-12, IL-17, IL-18, IL-22, I:-33, and TARC/CCL17 were measured by ELISA according to the manufacturer’s instructions. Results. Patients with concomitant AD and PS were frequently boys and overweight and had skin lesions equally distributed throughout the body. Children with concomitant AD and PS were more likely to report a family history of atopic disease than children with only AD or PS, and those with AD were more likely to report a family history of atopic disease than those with PS. Significant differences were observed in the concentration of IL-17 between patients with AD and PS and those with only AD or PS: 9.1 ± 3.7 pg/ml vs. 4.8 ± 2.9 pg/ml; and 9.1 ± 3.7 pg/ml vs. 5.2 ± 3.9 pg/ml, respectively (PD vs. AD, p = 0.01 ; PD vs. PS, p = 0.03 ). Conclusions. AD and PS can coexist. The role of T helper 17 cells may be more essential than believed.

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Early-Life Exposure to Antibiotics and Risk for Crohn’s Disease: A Nationwide Danish Birth Cohort Study

Inflammatory Bowel Diseases ◽

10.1093/ibd/izab085 ◽

2021 ◽

Author(s):

Anders Mark-Christensen ◽

Aksel Lange ◽

Rune Erichsen ◽

Trine Frøslev ◽

Buket Öztürk Esen ◽

...

Keyword(s):

Family History ◽

Early Life ◽

Intestinal Flora ◽

Antibiotic Use ◽

Hazard Ratio ◽

Adjusted Hazard Ratio ◽

First Year ◽

Increased Risk ◽

History Of ◽

First Year Of Life

Abstract Background Early-life antibiotic use can alter the intestinal flora and modify the risk of developing Crohn disease (CD), but rigorous epidemiological evidence is limited, with inconsistent results. Methods We identified all children born in Denmark from 1995 to 2009 and followed them from birth until death, emigration, a diagnosis of CD, or January 1, 2013. Using Cox regression, we assessed the association between antibiotic exposure in the first year of life and subsequent risk for CD, adjusting for sex, degree of urbanization, birth order, birth year, route of delivery, gestational age, smoking during pregnancy, intake of nonsteroidal anti-inflammatory drugs in the first year of life, and family history of CD. Results During a median 9.5 years (9.3 million total person-years), CD was diagnosed in 208 of 979,039 children. Antibiotic use in the first year of life was associated with a higher risk of CD (adjusted hazard ratio, 1.4; 95% confidence interval [CI], 1.1-1.8), with the highest risk with ≥6 courses of antibiotics (adjusted hazard ratio, 4.1; 95% CI, 2.0-8.5). A family history of CD did not modify these risk associations. The cumulative risk of CD at the 11th birthday for children exposed to antibiotics in their first year of life was 0.16‰ (95% CI, 0.11‰–0.22‰) compared to 0.11‰ (95% CI, 0.08‰–0.15‰) for children unexposed to antibiotics in their first year of life. Conclusions Antibiotic use in the first year of life is associated with a modestly increased risk for CD, although the absolute risk is very low.

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The association between duration of breastfeeding and atopy in children with or without family history of atopic disease

Paediatrica Indonesiana ◽

10.14238/pi47.4.2007.179-84 ◽

2007 ◽

Vol 47 (4) ◽

pp. 179

Author(s):

Riana Novy ◽

Budi Setiabudiawan ◽

Cissy B. Kartasasmita

Keyword(s):

Family History ◽

Exclusive Breastfeeding ◽

Clinical Epidemiology ◽

Atopic Disease ◽

Breastfeeding Duration ◽

History Of ◽

Skin Prick Tests ◽

The Difference ◽

Duration Of Breastfeeding ◽

Level Analysis

Background Atopic diseases (AD) are the most common chronicdiseases in childhood, and their incidence has a tendency to increaserecently. Tendency to have atopy could be triggered by many factorsoriginated in early life, including time of breastfeeding cessation.Objective To determine the association between exclusive andduration of breastfeeding and atopy in children with or withoutfamily history of atopic disease.Methods This was an observational clinical epidemiology studyperformed at Babakansari, Padasuka, Garuda Primary Health CareCenter in Bandung from January to March 2006. One hundredfifty of 749 children were randomized from group with and withoutfamily history of AD. They underwent skin prick tests and totalserum IgE level analysis. Atopy was defined as a positive skinprick test to any of the eight allergens tested. History of exclusiveand duration of breastfeeding was obtained from their parents.Significance tests for contingency tables were on the basis of x 2test for association odds ratio with 95% confidence interval.Results Atopy was found in 28.2% of children, of whom 32.4% withand 23.9% without family history of AD. Children exclusivelybreastfed exhibited a reduced risk of atopy (5.8% v 35.3%, OR=0.11,95%CI= 0.03;0.34, P<0.001). The difference of atopy was stronglysignificant between children who had exclusive breastfeeding andthose without exclusive breastfeeding whether or not the subjectshad family history of AD (P<0.001). There was a highly significantrisk reduction for atopy related to prolonged breastfeeding (=6months) (OR=0.37, 95%CI = 0.19 to 0.72, P=0.001). Thedifference of atopy was strongly significant between children whohad prolonged breastfeeding and short breastfeeding duration whetheror not the subjects had family history of AD (P<0.001)Conclusions Exclusive and prolonged breastfeeding decrease atopyin children with as well as without family history of AD.

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Epilepsy in children with cerebral palsy

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2001000100008 ◽

2001 ◽

Vol 59 (1) ◽

pp. 35-39 ◽

Cited By ~ 31

Author(s):

Isac Bruck ◽

Sérgio Antônio Antoniuk ◽

Adriane Spessatto ◽

Ricardo Schmitt de Bem ◽

Romeu Hausberger ◽

...

Keyword(s):

Cerebral Palsy ◽

Family History ◽

First Year ◽

Neonatal Seizures ◽

Tertiary Center ◽

History Of ◽

History Of Epilepsy ◽

First Year Of Life ◽

Patients With Epilepsy

OBJECTIVE: To describe the prevalence and characteristics of epilepsy in patients with cerebral palsy in a tertiary center. METHODS: a total of 100 consecutive patients with cerebral palsy were retrospectively studied. Criteria for inclusion were follow-up period for at least 2 years. Types and incidence of epilepsy were correlated with the different forms of cerebral palsy. Other factors associated with epilepsy such as age of first seizure, neonatal seizures and family history of epilepsy were also analysed. RESULTS: follow-up ranged between 24 and 151 months (mean 57 months). The overall prevalence of epilepsy was 62%. Incidence of epilepsy was predominant in patients with hemiplegic and tetraplegic palsies: 70.6% and 66.1%, respectively. First seizure occurred during the first year of life in 74.2% of patients with epilepsy. Generalized and partial were the predominant types of epilepsy (61.3% and 27.4%, respectively). Thirty-three (53.2%) of 62 patients were seizure free for at least 1 year. Neonatal seizures and family history of epilepsy were associated with a higher incidence of epilepsy. CONCLUSIONS: epilepsy in cerebral palsy can be predicted if seizures occur in the first year of life, in neonatal period and if there is family history of epilepsy.

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Correlation between obesity with atopy and family history of atopy in children

Paediatrica Indonesiana ◽

10.14238/pi51.4.2011.227-33 ◽

2011 ◽

Vol 51 (4) ◽

pp. 227

Author(s):

Putria Rayani Apandi ◽

Budi Setiabudiawan ◽

Abdurachman Sukadi

Keyword(s):

Risk Factors ◽

Family History ◽

Atopic Disease ◽

Cross Sectional Study ◽

Normal Weight ◽

Chi Square ◽

Cross Sectional ◽

Prick Test ◽

Chi Square Test ◽

History Of

Background The prevalence of childhood obesity and atopy has increased in recent decades. Research on links between obesity and atopy has shown varied results. Few previous studies have reported on the significance of family history of atopic disease in children.Objective To determine correlation between obesity with atopy and family history of atopic disease in children.Methods This cross-sectional study was conducted from April to September 2010 in the Pediatric Allergy-Immunology subdivision, Hasan Sadikin Hospital. Children aged 6−11 years were divided into four groups of 40 each: obese subjects with and without family history of atopic disease, and normal weight subjects with and without family history of atopic disease. Skin prick test was performed to determine which subjects had atopy. Chi-square test was used to analyze mutual independence, and partial Chi-square test was used to analyze correlation of obesity to atopy and family history of atopic disease in children. Environmental factors, type of childbirth, and pregnancy history were also analyzed as risk factors for atopy.Results Of 80 obese children with and without family history of atopic disease, 40 (100%) and 38 (95%), respectively, were atopic. Of 80 normal weight children with and without family history of atopic disease, 39 (98%) and 9 (23%), respectively, were atopic. Thus atopy was observed in 126 subjects, while the remaining 34 subjects were non-atopic. Partial test showed a correlation between obesity with atopy and family history of atopic disease (P < 0.001). There were no significant differences in risk factors for atopy by group.Conclusion Obesity correlates with atopy and family history of atopic disease in children.

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