scholarly journals Association between immunization coverage and atopy in children with or without family history of atopic disease

2016 ◽  
Vol 48 (6) ◽  
pp. 358
Author(s):  
Isabella Riandani ◽  
Budi Setiabudiawan ◽  
Cissy B. Kartasasmita
Keyword(s):  
Family History ◽  
Environmental Factors ◽  
Immunization Coverage ◽  
Atopic Disease ◽  
Total Serum ◽  
Atopic Diseases ◽  
Chi Square ◽  
Prick Test ◽  
History Of ◽  
Genetic And Environmental Factors

Background Atopic diseases are determined by the interactionbetween genetic and environmental factors. The possible effectsof immunization, as one of environmental factors, on atopy remaina matter of controversy.Objective We conducted an observational clinical epidemiologyto find out the protective effect of high vaccination coverage toatopy in children.Methods During January through March 2006, 150 of749 childrenat Garuda, Padasuka, and Babakan Sari Primary Health Care inBandung were randomized from group with and without familyhistory of atopic disease. Atopy derived from skin prick test andtotal serum lgE was evaluated. Atopy was defined as a positiveskin test to any of the eight allergens tested. The immunizationswere recorded from Kartu Menuju Sehat (KMS). Statistical analysesincluded Chi square to compare prevalence, independent T-testand Mann-Whitney to compare mean.Results Atopy was found in 28.2% of284 subjects, of which 32.4%with and 23.9% without a family history of atopic disease. Themedian of total serum lgE level was higher in children with familyhistory of atopic disease and in atopy children. Children weregrouped according to total dose of basic immunizations (0-17 and2: 18) based on Program Pengembangan Imunisasi (PPI). There wasnonsignificant association between total doses of immunizationand atopy. Even though no statistically significant, the cumulativeimmunization doses were inversely related to the median of totalserum IgE level.Conclusions The immunization coverage has not decreased atopyrisk.

scholarly journals The association between fever in the first year of life and atopy in children with or without family history of atopic disease

2007 ◽  
Vol 47 (2) ◽  
pp. 65
Author(s):  
Susy P. Wihadi ◽  
Budi Setiabudiawan ◽  
Cissy B. Kartasasmita
Keyword(s):  
Family History ◽  
Skin Prick Test ◽  
Clinical Epidemiology ◽  
Atopic Disease ◽  
Total Serum ◽  
First Year ◽  
Prick Test ◽  
History Of ◽  
First Year Of Life

Background The role of repeated infection in early life in thedevelopment of childhood atopy is still controversy. Fever in thefirst year of life which is frequently associated with infections mightdecrease atopy.Objective The aim of this study was to investigate the associationbetween fever in the first year of life and atopy in children.Methods This was an observational clinical epidemiology studyperformed at Puskesmas Garuda, Padasuka, and Babakan Sari,Bandung, from January to March 2006. From 749 children, werandomly chose 150 subjects each from group with and withoutfamily history of atopic disease. Skin prick test and measurementof total serum immunoglobulin (Ig) E were performed on eachchildren. Atopy was defined as the skin prick test result waspositive to >1 allergen. The number of fever episodes in the firstyear of life was based on parents report. The relationship betweenfever and atopy was analyzed using Mantel Haenszel.Results From 284 subjects, atopy was found in 28.2% of children,of which 32.4% with and 23.9% without a family history of atopicdisease. Generally there was no significant association betweenfever and atopy. There was only decreased odds ratio withincreased fever episodes and trend analysis showed this decreasewas significant (P=0.01). The significant association betweenfever and atopy were found only in group without family historyof atopic disease (P=0.03, OR=0.43, CI 95% 0.18;1.01).Conclusion There is a relationship between fever and atopy inchildren without family history of atopic disease.

scholarly journals Correlation between obesity with atopy and family history of atopy in children

2011 ◽  
Vol 51 (4) ◽  
pp. 227
Author(s):  
Putria Rayani Apandi ◽  
Budi Setiabudiawan ◽  
Abdurachman Sukadi
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Atopic Disease ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Chi Square ◽  
Cross Sectional ◽  
Prick Test ◽  
Chi Square Test ◽  
History Of

Background The prevalence of childhood obesity and atopy has increased in recent decades. Research on links between obesity and atopy has shown varied results. Few previous studies have reported on the significance of family history of atopic disease in children.Objective To determine correlation between obesity with atopy and family history of atopic disease in children.Methods This cross-sectional study was conducted from April to September 2010 in the Pediatric Allergy-Immunology subdivision, Hasan Sadikin Hospital. Children aged 6−11 years were divided into four groups of 40 each: obese subjects with and without family history of atopic disease, and normal weight subjects with and without family history of atopic disease. Skin prick test was performed to determine which subjects had atopy. Chi-square test was used to analyze mutual independence, and partial Chi-square test was used to analyze correlation of obesity to atopy and family history of atopic disease in children. Environmental factors, type of childbirth, and pregnancy history were also analyzed as risk factors for atopy.Results Of 80 obese children with and without family history of atopic disease, 40 (100%) and 38 (95%), respectively, were atopic. Of 80 normal weight children with and without family history of atopic disease, 39 (98%) and 9 (23%), respectively, were atopic. Thus atopy was observed in 126 subjects, while the remaining 34 subjects were non-atopic. Partial test showed a correlation between obesity with atopy and family history of atopic disease (P < 0.001). There were no significant differences in risk factors for atopy by group.Conclusion Obesity correlates with atopy and family history of atopic disease in children.

scholarly journals Prevalence of allergen sensitization, most important allergens and factors associated with atopy in children

2013 ◽  
Vol 131 (5) ◽  
pp. 301-308 ◽  
Author(s):  
Raquel Prudente de Carvalho Baldacara ◽  
Maria de Fatima Marcelos Fernandes ◽  
Leonardo Baldacara ◽  
Wilson Tartuce Aun ◽  
Joao Ferreira de Mello ◽  
...  
Keyword(s):  
Family History ◽  
Skin Prick Test ◽  
Cesarean Delivery ◽  
Atopic Disease ◽  
Dermatophagoides Pteronyssinus ◽  
Outpatient Clinics ◽  
Positive Skin Prick Test ◽  
Positive Skin ◽  
Prick Test ◽  
History Of

CONTEXT AND OBJECTIVE: Knowledge of the profile of allergen sensitization among children is important for planning preventive measures. The objective of this study was to assess the prevalence and profile of sensitization to inhaled allergens and food among children and adolescents in an outpatient population in the city of Palmas. DESIGN AND SETTING: Cross-sectional study at outpatient clinics in Palmas, Tocantins, Brazil. METHODS: Ninety-four patients aged 1-15 years who were attending two pediatric outpatient clinics were selected between September and November 2008. All of the subjects underwent clinical interviews and skin prick tests. RESULTS: A positive skin prick test was observed in 76.6% of the participants (72.3% for inhalants and 28.9% for food allergens). The most frequent allergens were Dermatophagoides pteronyssinus (34%), cat epithelium (28.7%), dog epithelium (21.3%), Dermatophagoides farinae (19.1%), Blomia tropicalis (18.1%), cow's milk (9.6%) and grasses (9.6%). A positive skin prick test correlated with a history of atopic disease (odds ratio, OR = 5.833; P = 0.002), a family history of atopic disease (OR = 8.400; P < 0.001), maternal asthma (OR = 8.077; P = 0.048), pet exposure (OR = 3.600; P = 0.012) and cesarean delivery (OR = 3.367; P = 0.019). CONCLUSION: Dermatophagoides pteronyssinus was the most frequent aeroallergen and cow’s milk was the most prevalent food allergen. There was a positive correlation between a positive skin prick test and several factors, such as a family history of atopic disease, maternal asthma, pet exposure and cesarean delivery.

scholarly journals Caesarean delivery and risk of developing atopic diseases in children

2014 ◽  
Vol 54 (2) ◽  
pp. 94
Author(s):  
Anak Agung Tri Yuliantini ◽  
Mohammad Juffrie ◽  
Ketut Dewi Kumara Wati
Keyword(s):  
Family History ◽  
Caesarean Section ◽  
Caesarean Delivery ◽  
Case Control Study ◽  
Demographic Data ◽  
Multiple Logistic Regression ◽  
Atopic Diseases ◽  
Prick Test ◽  
History Of ◽  
Control Study

Background Caesarean delivery has been suggested to alterneonatal immune respon ses and increase the risk of atopicdiseases. Howevei; previous studies have reported inconsistentfindings.Objective To investigate a possible association between caesareandelivery and the development of atopic diseases in children.Methods This case-control study involved 100 children aged 3months-12 years, in Sanglah Hospital, Denpasai; Indonesia. Fiftyinfants and children with a confirmed diagnosis of atopic diseasesand 50 sex-paired controls (non-atopic infants and children)were enrolled. Demographic data was obtained, including modeof delivery and relevant history connected to atopic diseases.Skin prick test to four common aeroallergens was performed inall subjects. Possible confounding factors were considered in amultivariable logis tic regression model.Results Caesarean section was not significant as a risk factor foratopic diseases in a multivariate analysis [OR 2.4 (95%CI 0.7 to8.4; P=0.164)]. Howevei; multiple logistic regression analysisshowed that atopic diseases was significantly associated with apositive family history of atopy. Furthermore, caesarean sectionwas associated with a higher risk of atopic diseases in a subgroupanalysis for family history of atopy [OR= 4 (95%CI 1 to 16.2;P= 0.04)].Conclusion Children delivered by caesarean section and have afamily history of atopy have a 4-fo ld higher risk of atopic diseases.

scholarly journals 474 Relationship Between Total Serum IgE, Atopy, and Obesity in Children With or Without Family History of Atopic Disease

2012 ◽  
Vol 5 ◽  
pp. S150-S151
Author(s):  
Budi Setiabudiawan ◽  
Reni Ghrahani ◽  
Gartika Sapartini ◽  
Putria Rayani ◽  
Citra Amelinda ◽  
...  
Keyword(s):  
Family History ◽  
Atopic Disease ◽  
Total Serum ◽  
Serum Ige ◽  
History Of ◽  
Obesity In Children

scholarly journals Relationship between atopic manifestations, family history of atopic disease and cord blood IgE levels in children

2007 ◽  
Vol 47 (6) ◽  
pp. 278
Author(s):  
Tisnasari Hafsah ◽  
Myrna Soepriadi ◽  
Budi Setiabudiawan ◽  
Herry Garna
Keyword(s):  
Family History ◽  
Cord Blood ◽  
Atopic Disease ◽  
Mean Value ◽  
Inclusion Criteria ◽  
Chi Square ◽  
The Past ◽  
History Of ◽  
The Mean ◽  
The Relationship

Background The incidence of atopic disease tends to increaseover the past few decades and its morbidity interferes with thequality of life and health. Prediction of the disease is importantfor early prevention.Objective To evaluate the relationship between atopicmanifestations, family history (FH) of atopic disease and cordblood IgE (CB-IgE) levels.Methods We conducted an analytic observational study withcohort retrospective design on children with an average age of 3years whose CB-IgE had been measured at delivery inKiaracondong Primary Health Care during October–December2004. Manifestations of atopic disease were recorded using ISAACquestionaire for allergy. Chi-square, Mann-Whitney test, andlogistic regression analysis were used for analysis.Results Cord blood IgE was measured on 124 children after birth.Only 94 children (76%) fulfilled the inclusion criteria. Atopicdisease was found in 17 children (18%), consisting of 8 childrenwith atopic dermatitis, 4 with allergic rhinitis, and 5 suffered fromboth. There were significant differences in the mean value of CB-IgE (Z M-W =4.60; P<0.001) and FH (x 2 =19.059; P<0.001)between atopic and non atopic children. Cut off point of the CB-IgE concentration was 1.4 IU/mL (77.7%). The highest probabilityfor atopic manifestations was found in children who had highCB-IgE and positive FH (P=45%). Relative risk of children withhigh CB-IgE level in positive FH group was 3.636 (95% CI0.943;14.016).Conclusion CB-IgE level and family history of atopic disease arerisk factors for the development of atopic manifestation.

scholarly journals Relationship Between Concomitant Atopic Diseases With Atopic Dermatitis Severity And Persistence.

2021 ◽  
Vol 6 (2) ◽  
pp. 43-47
Author(s):  
Adawiyah Jamil ◽  
Siew Wen Goh ◽  
Chon Sian Lee ◽  
Mohan Arumugam
Keyword(s):  
Atopic Dermatitis ◽  
Family History ◽  
Demographic Data ◽  
Atopic Disease ◽  
Cross Sectional Study ◽  
Atopic Diseases ◽  
Cross Sectional ◽  
Face To Face ◽  
Tertiary Hospitals ◽  
History Of

Introduction: The atopic march consists of atopic dermatitis (AD), allergic rhinitis or sinusitis (AR), allergic conjunctivitis (AC) and bronchial asthma (BA). The influence of concomitant atopic diseases on AD is under-explored. We determined the relationship between personal and family history of atopic diseases with AD severity and persistence. Methods: A cross sectional study involving AD patients was performed at dermatology clinics of two tertiary hospitals. Inclusion criterion was all patients diagnosed with AD. Demographic data, personal and family history of atopy (BA, AR and AC) were obtained by face-to-face interview. AD severity was evaluated using Investigator’s Global Assessment (IGA). AD was considered persistent if continued beyond age 12 years. Results: Sixty patients aged 21.6±17.2 participated. There were 25(41.7%) with concomitant AR, 16(26.7%) BA and 12(20%) AC. Forty seven (78.3%) patients had family history of atopy, 25(41.7%) had eczema, 24(40%) AR, 19(31.7%) BA and 2(3.3%) AC. Patients with BA [OR=3.8, 95%CI 1.04 to 14.4)], BA and AR [OR=9.74, 95%CI 1.13 to 83.67) and family history of BA [OR= 4.00, 95%CI 1.20 to 13.27) were more likely to exhibit moderate-severe AD. Personal AR, AC and family history of AD and BA were significantly more prevalent in patients with persistent AD. Conclusions: AR was the most common atopic disease associated with AD. Family history of eczema and AR were common. Personal BA, BA with AR and family history of BA were predictors of severe AD. Personal AR, AC and family history of AD and BA were associated with AD persistence.

scholarly journals Interleukin-4 and immunoglobulin E levels in newborns at risk of atopic diseases

2011 ◽  
Vol 51 (1) ◽  
pp. 12
Author(s):  
Frengky Sutanto ◽  
Rocky Wilar ◽  
Diana Devi Sondakh
Keyword(s):  
At Risk ◽  
Family History ◽  
Cord Blood ◽  
Immunoglobulin E ◽  
Atopic Disease ◽  
Interleukin 4 ◽  
Type I ◽  
Atopic Diseases ◽  
History Of ◽  
The Mean

Background The clinical syndrome of atopy is associated v.ith the production of immunoglobulin E (lgE) in response to antigenic stimulation as part of a type I hypersensitivity reaction. Since early prevention is regarded as an important cornerstone in the management of atopic diseases, the identification of reliable markers such as IgE and interleukin 4 (IL-4) in detecting individuals at risk are of major interest.Objective To determine whether cord blood IgE and IL-4 levels can be used as an predictor of atopy in newborns with a family history of atopic diseases.Methods We conducted a cross-sectional study on healthy-term newborns in the neonatal ward at R.D. Kandou Hospital from June to August 2010. A total of 50 healthy newborns in atopic and non-atopic groups were examined for cord blood IgE and IIA levels.Result The mean cord blood ILA levels in the atopic and non-atopic groups were 0.1 μg/mL (SD 0.08) and 0.1 μg/mL (SD 0.16) (P=0.359), respectively. The mean cord blood IgE levels in the atopic and non-atopic groups were 2.2 IU/mL (SD 1.98) and 0.5 IU/mL (SD 0.29) (P<0.00l), respectively. A point-biserial correlation coefficient analysis showed no significant correlation between ILA levels and family history of atopic disease (rpb=0.098), and a weak correlation between IgE levels and family history of atopic disease (rpb=0.54).Conclusions Cord blood IgE and IL-4 levels should not be used to distinguish newborns with a family history of atopic diseases from those without.

scholarly journals Distribution of atopic conditions among attendants to specialized allergy center/ Kirkuk/ Iraqi

2020 ◽  
Vol 3 (2) ◽  
pp. 139-153
Author(s):  
Chinar Kanbar ◽  
Abdulameer Samad ◽  
Ali Galleb
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Skin Prick Test ◽  
House Dust ◽  
House Dust Mite ◽  
Atopic Disease ◽  
Atopic Diseases ◽  
Prick Test ◽  
Dust Mite

Atopy is a syndrome characterized by genetic tendency to develop allergic diseases, such as asthma, allergic rhinitis and atopic dermatitis. The risk factors of atopic diseases can be placed in two categories, namely host and environmental factors. The host factors of allergy include genetics, race, gender, age… etc. The environmental factors include exposure to environmental pollution and allergens. To define the distribution of atopic conditions (asthma, allergic rhinitis and atopic dermatitis) according to age, residence and available skin prick test. This cross-sectional study included (100) patients, representing research sample. It was conducted in specialized allergy center in Kirkuk city during the period from first January .2016 to the end of December 2016 All patients included in this study were referred from primary health centers, complaining from signs and symptoms of atopic diseases. Depending on medical history and clinical examinations, the sample was classified into (3) groups (asthma, allergic rhinitis and atopic dermatitis). Skin prick test was used to identify patients allergy to house dust mite and pollen. Regarding the distribution of samples according to residence, most patients (about 91%) were from urban areas compared with (9%) of them were from rural areas. Also, it was found that the frequency of atopic diseases decreases by age advancement. The frequency distribution of asthma, allergic rhinitis and atopic dermatitis was 49%, 26% and 25%, respectively. The skin test data revealed the frequency of 2 aeroallergen mite and pollen in all patients under study. .Hence, 65% were sensitive to house dust mite, 26% to pollen and 9% to both mite and pollen In conclusion this study confirmed that most patients complaining from atopic disease were from urban area. Also, the frequency of atopic diseases decreased by age advancement. The most common atopic disease was asthma followed by allergic rhinitis and atopic dermatitis. Most patients were sensitive to house dust mite.

Combined Effects of Lung Disease History, Environmental Exposures, and Family History of Lung Cancer to Susceptibility of Lung Cancer in Chinese Non-smokers

2021 ◽  
Author(s):  
Fanglin Yu ◽  
Rendong Xiao ◽  
Xu Li ◽  
Zhijian Hu ◽  
Lin Cai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Family History ◽  
Environmental Factors ◽  
Lung Disease ◽  
Environmental Exposures ◽  
Collective Effects ◽  
Combined Effects ◽  
Cancer History ◽  
Increased Risk ◽  
History Of

Abstract Background: Although cigarette smoking is a major risk factor for lung cancer, the incidence rate of lung cancer among non-smokers is notable. The etiology and potential mechanism of non-smoker lung cancer are worthy of further research. This study was designed to explore the collective effects of environmental factors and the relationship between environmental exposure index (EEI) and lung cancer among non-smokers by evaluating the joint effects among lung disease history, environmental factors, and family history of lung cancer without smoking confounders.Methods: A total of 767 never-smoked lung cancer cases and 767 sex- and age-matched controls were selected from the department of Thoracic Surgery and Respiratory Medicine of three hospitals in Fujian, China. We used two methods to develop the EEI according to 12 statistically significant environmental risk factors. Restricted cubic spline (RCS) was applied to analyze the non-linear relationship between EEI and lung cancer in non-smokers. Combined effects, additive interaction, and multiplicative interaction were assessed among lung disease history, EEI, and family history of lung cancer to estimate susceptibility to develop lung cancer.Results: Lung disease history, especially asthma, was significantly associated with an increased risk of lung cancer with an odds ratio (OR) for asthma history of 14.720 (95% CI: 1.877–115.449). Family history of lung cancer was related to susceptibility of lung cancer (OR = 3.347, 95% CI: 1.930–5.806). According to type of relatives and cancer, a parental or children’s history and a sibling’s history of lung cancer were significantly associated with an increased risk of lung cancer. The positive association between EEI and lung cancer was apparently stronger in those with lung disease history or family lung cancer history. Furthermore, there was a addictive interaction between EEI and lung disease history, and a possibly addictive interaction between EEI and family lung cancer history on development of lung cancer.Conclusions: There were combined effects among lung disease history, environmental exposures, and family history of lung cancer toward susceptibility to lung cancer in Chinese non-smokers. Non-smokers who had a family history of lung cancer were at higher risk of lung cancer than non-smokers who had lung disease history. Non-smokers with family cancer history may obtain benefits from removal of environmental exposures and active treatment of lung disease.

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