Atopic Dermatitis and Psoriasis as Overlapping Syndromes

Background/Objectives. Cooccurrence of atopic dermatitis (AD) and psoriasis (PS) is not common. However, both diseases are still of interest because of their comprehensive and diverse mechanisms. This study aimed to present the clinical and immunological profiles of patients with concomitant AD and PS and compare them with those of patients with only one of the diseases. Methods. In this observational study, 38 children with concomitant AD and PS with a mean age of 6.5 ± 3.2 yrs were compared with 41 similar patients with AD only ( 5.3 ± 5.1 yrs) and 28 patients with PS only ( 6.4 ± 4.3 yrs). All patients underwent dermatological examinations, including determination of SCORAD and PASI scores. TNF-α, IFN-γ, IL-2, IL-4, IL-5, IL-6, IL-8, IL-12, IL-17, IL-18, IL-22, I:-33, and TARC/CCL17 were measured by ELISA according to the manufacturer’s instructions. Results. Patients with concomitant AD and PS were frequently boys and overweight and had skin lesions equally distributed throughout the body. Children with concomitant AD and PS were more likely to report a family history of atopic disease than children with only AD or PS, and those with AD were more likely to report a family history of atopic disease than those with PS. Significant differences were observed in the concentration of IL-17 between patients with AD and PS and those with only AD or PS: 9.1 ± 3.7 pg/ml vs. 4.8 ± 2.9 pg/ml; and 9.1 ± 3.7 pg/ml vs. 5.2 ± 3.9 pg/ml, respectively (PD vs. AD, p = 0.01 ; PD vs. PS, p = 0.03 ). Conclusions. AD and PS can coexist. The role of T helper 17 cells may be more essential than believed.

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Atopic dermatitis and psoriasis as overlapping syndromes.

10.21203/rs.3.rs-57450/v1 ◽

2020 ◽

Author(s):

Andrzej Bozek ◽

Magdalena Zając ◽

Magdalena Krupka

Keyword(s):

Atopic Dermatitis ◽

Positive Family History ◽

Atopic Disease ◽

Skin Lesions ◽

T Helper 17 ◽

Dermatological Examination ◽

Area Distribution ◽

Tnf Α ◽

History Of

Abstract Background: Concomitant atopic dermatitis (AD) and psoriasis (PS) are not common. However, both diseases are still of interest because of their comprehensive and diverse mechanism. The aim of the study was to present the clinical and immunological profile of patients with concomitant AD and PS coexist in comparison to patients with one of these diseases.Methods: In this observational study, 38 children with concomitant AD and PS with a mean age of 6.5 ± 3.2 yrs. were compared with similar 41 patients with only AD (5.3± 5.1 yrs) and with 28 with PS (6.4± 4.3 yrs). All patients underwent the dermatological examination including SCORAD and PASI questionnaire. TNF-α, IFN-γ, Il-2, Il-4, Il-5, Il-6, Il-8, Il-12, I-17, Il-18, Il-22, Il-33, TARC/CCL17 were measured by the use ELISA method and according manufacturer (ThermoFischer Scientific, US).Results: Patients with concomitant AD and PS were frequently boys or with overweight and with a proportional area distribution of skin lesions. A positive family history of atopic disease was more frequently reported by children with concomitant AD and PS, and with AD vs. PS. Significant differences were observed in the concentration of Il-17 in patients with AD and PS compared with that in AD or PS patients as follows: 9.1±3.7 pg/ml vs. 4.8±2.9 pg/ml and 5.2±3.9 pg/ml (PD vs. AD, p = 0.01; PD vs. PS, p = 0.03).Conclusion: AD and PS might coexist as overlapping disease. The role of T-helper 17 may be more meaningful than it appeared.

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The Role of Th17-Related Cytokines in Atopic Dermatitis

International Journal of Molecular Sciences ◽

10.3390/ijms21041314 ◽

2020 ◽

Vol 21 (4) ◽

pp. 1314 ◽

Cited By ~ 11

Author(s):

Makoto Sugaya

Keyword(s):

Atopic Dermatitis ◽

Skin Lesions ◽

Barrier Dysfunction ◽

T Helper 17 ◽

Bowel Diseases ◽

Th17 Cytokines ◽

Peptide Expression ◽

Inflammatory Bowel ◽

Antimicrobial Peptide Expression

T helper-17 (Th17) cells, which mainly produce IL-17, are associated with development of various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and psoriasis. IL-17 and related cytokines are therapeutic targets of these diseases. In atopic dermatitis (AD), Th2 cytokines such as IL-4 and IL-13 are regarded to be the main player of the disease; however, Th17 cytokines are also expressed in AD skin lesions. Expression of IL-22 rather than IL-17 is predominant in AD skin, which is contrary to cytokine expression in psoriasis skin. Relatively low IL-17 expression in AD skin can induce relatively low antimicrobial peptide expression, which may be a reason why bacterial infection is frequently seen in AD patients. Failure of clinical trials for investigating the efficacy of anti-IL-12/23 p40 in AD has suggested that IL-17 expressed in skin lesions should not be the main player but a bystander responding to barrier dysfunction.

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Relationship Between Concomitant Atopic Diseases With Atopic Dermatitis Severity And Persistence.

Journal of Clinical and Health Sciences ◽

10.24191/jchs.v6i2.9507 ◽

2021 ◽

Vol 6 (2) ◽

pp. 43-47

Author(s):

Adawiyah Jamil ◽

Siew Wen Goh ◽

Chon Sian Lee ◽

Mohan Arumugam

Keyword(s):

Atopic Dermatitis ◽

Family History ◽

Demographic Data ◽

Atopic Disease ◽

Cross Sectional Study ◽

Atopic Diseases ◽

Cross Sectional ◽

Face To Face ◽

Tertiary Hospitals ◽

History Of

Introduction: The atopic march consists of atopic dermatitis (AD), allergic rhinitis or sinusitis (AR), allergic conjunctivitis (AC) and bronchial asthma (BA). The influence of concomitant atopic diseases on AD is under-explored. We determined the relationship between personal and family history of atopic diseases with AD severity and persistence. Methods: A cross sectional study involving AD patients was performed at dermatology clinics of two tertiary hospitals. Inclusion criterion was all patients diagnosed with AD. Demographic data, personal and family history of atopy (BA, AR and AC) were obtained by face-to-face interview. AD severity was evaluated using Investigator’s Global Assessment (IGA). AD was considered persistent if continued beyond age 12 years. Results: Sixty patients aged 21.6±17.2 participated. There were 25(41.7%) with concomitant AR, 16(26.7%) BA and 12(20%) AC. Forty seven (78.3%) patients had family history of atopy, 25(41.7%) had eczema, 24(40%) AR, 19(31.7%) BA and 2(3.3%) AC. Patients with BA [OR=3.8, 95%CI 1.04 to 14.4)], BA and AR [OR=9.74, 95%CI 1.13 to 83.67) and family history of BA [OR= 4.00, 95%CI 1.20 to 13.27) were more likely to exhibit moderate-severe AD. Personal AR, AC and family history of AD and BA were significantly more prevalent in patients with persistent AD. Conclusions: AR was the most common atopic disease associated with AD. Family history of eczema and AR were common. Personal BA, BA with AR and family history of BA were predictors of severe AD. Personal AR, AC and family history of AD and BA were associated with AD persistence.

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Factors Influencing Atopic Dermatitis Incidence in Offspring

Iranian Journal of Allergy Asthma and Immunology ◽

10.18502/ijaai.v18i4.1413 ◽

2019 ◽

Author(s):

Siqi Ye ◽

Xiumei Mo ◽

Junfeng Liu ◽

Fenggen Yan ◽

Dacan Chen

Keyword(s):

Atopic Dermatitis ◽

Atopic Disease ◽

Skin Condition ◽

Breastfeeding Duration ◽

Protective Effects ◽

Short Period ◽

History Of ◽

Fundamental Research ◽

Genetic And Environmental Factors

Atopic dermatitis (AD) is a chronic, recurrent skin condition resulting from both genetic and environmental factors. In recent decades, the prevalence of AD has increased considerably in some countries. However, given that the role of genetics is unlikely to have changed over this short period, the increased prevalence is more likely to be explained by changes in environmental and maternal factors. The aim of this review is to comprehensively summarize the various factors impacting AD incidence in offspring and provide guidance for primary prevention. Recent research has demonstrated that environmental and climate factors, maternal history of allergies, gestational diabetes, and stress play essential roles in increasing the risk of AD in infants. Some factors have protective effects against the incidence of AD, including probiotic supplementation, fish intake, and moisturizers. This review also considers fundamental research into AD prevalence and factors that in the past were mistakenly thought to affect that prevalence, such as caesarean section and antigen avoidance. The potential influence of these factors on infant AD incidence remains inconclusive and needs further study. Furthermore, infants with a family history of atopic disease may benefit from early weaning or reduced breastfeeding duration.

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The association between fever in the first year of life and atopy in children with or without family history of atopic disease

Paediatrica Indonesiana ◽

10.14238/pi47.2.2007.65-70 ◽

2007 ◽

Vol 47 (2) ◽

pp. 65

Author(s):

Susy P. Wihadi ◽

Budi Setiabudiawan ◽

Cissy B. Kartasasmita

Keyword(s):

Family History ◽

Skin Prick Test ◽

Clinical Epidemiology ◽

Atopic Disease ◽

Total Serum ◽

First Year ◽

Prick Test ◽

History Of ◽

First Year Of Life

Background The role of repeated infection in early life in thedevelopment of childhood atopy is still controversy. Fever in thefirst year of life which is frequently associated with infections mightdecrease atopy.Objective The aim of this study was to investigate the associationbetween fever in the first year of life and atopy in children.Methods This was an observational clinical epidemiology studyperformed at Puskesmas Garuda, Padasuka, and Babakan Sari,Bandung, from January to March 2006. From 749 children, werandomly chose 150 subjects each from group with and withoutfamily history of atopic disease. Skin prick test and measurementof total serum immunoglobulin (Ig) E were performed on eachchildren. Atopy was defined as the skin prick test result waspositive to >1 allergen. The number of fever episodes in the firstyear of life was based on parents report. The relationship betweenfever and atopy was analyzed using Mantel Haenszel.Results From 284 subjects, atopy was found in 28.2% of children,of which 32.4% with and 23.9% without a family history of atopicdisease. Generally there was no significant association betweenfever and atopy. There was only decreased odds ratio withincreased fever episodes and trend analysis showed this decreasewas significant (P=0.01). The significant association betweenfever and atopy were found only in group without family historyof atopic disease (P=0.03, OR=0.43, CI 95% 0.18;1.01).Conclusion There is a relationship between fever and atopy inchildren without family history of atopic disease.

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The role of a family history of adenocarcinomas in patients with Barrett oesophagus

Gastroenterology ◽

10.1016/s0016-5085(01)82192-2 ◽

2001 ◽

Vol 120 (5) ◽

pp. A442-A442

Author(s):

P TSIBOURIS ◽

M HENDRICKSE ◽

P ISAACS

Keyword(s):

Family History ◽

History Of ◽

Barrett Oesophagus

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Receptions of the Past: Commemoration, Racism, Desire

Somatechnics ◽

10.3366/soma.2017.0223 ◽

2017 ◽

Vol 7 (2) ◽

pp. 288-303

Author(s):

Michael Connors Jackman

Keyword(s):

Critical Point ◽

Social Relations ◽

White Privilege ◽

Body Politic ◽

The Body ◽

Race And Racism ◽

Lesbian And Gay ◽

The Past ◽

History Of

This article investigates the ways in which the work of The Body Politic (TBP), the first major lesbian and gay newspaper in Canada, comes to be commemorated in queer publics and how it figures in the memories of those who were involved in producing the paper. In revisiting a critical point in the history of TBP from 1985 when controversy erupted over race and racism within the editorial collective, this discussion considers the role of memory in the reproduction of whiteness and in the rupture of standard narratives about the past. As the controversy continues to haunt contemporary queer activism in Canada, the productive work of memory must be considered an essential aspect of how, when and for what reasons the work of TBP comes to be commemorated. By revisiting the events of 1985 and by sifting through interviews with individuals who contributed to the work of TBP, this article complicates the narrative of TBP as a bluntly racist endeavour whilst questioning the white privilege and racially-charged demands that undergird its commemoration. The work of producing and preserving queer history is a vital means of challenging the intentional and strategic erasure of queer existence, but those who engage in such efforts must remain attentive to the unequal terrain of social relations within which remembering forms its objects.

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The role of pubertal timing in the link between family history of alcohol use disorder and late adolescent substance use

Drug and Alcohol Dependence ◽

10.1016/j.drugalcdep.2020.107955 ◽

2020 ◽

Vol 210 ◽

pp. 107955

Author(s):

Alexander S. Weigard ◽

Jillian E. Hardee ◽

Robert A. Zucker ◽

Mary M. Heitzeg ◽

Adriene M. Beltz

Keyword(s):

Substance Use ◽

Family History ◽

Alcohol Use ◽

Alcohol Use Disorder ◽

Pubertal Timing ◽

Adolescent Substance Use ◽

Late Adolescent ◽

Adolescent Substance ◽

History Of

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Impressic Acid Ameliorates Atopic Dermatitis-Like Skin Lesions by Inhibiting ERK1/2-Mediated Phosphorylation of NF-κB and STAT1

International Journal of Molecular Sciences ◽

10.3390/ijms22052334 ◽

2021 ◽

Vol 22 (5) ◽

pp. 2334

Author(s):

Jae Ho Choi ◽

Gi Ho Lee ◽

Sun Woo Jin ◽

Ji Yeon Kim ◽

Yong Pil Hwang ◽

...

Keyword(s):

Atopic Dermatitis ◽

Skin Lesions ◽

Histopathological Analysis ◽

Mrna Levels ◽

Chemokine Production ◽

Dermal Thickness ◽

Skin Symptoms ◽

Tnf Α ◽

Ifn Γ ◽

In Cells

Impressic acid (IPA), a lupane-type triterpenoid from Acanthopanax koreanum, has many pharmacological activities, including the attenuation of vascular endothelium dysfunction, cartilage destruction, and inflammatory diseases, but its influence on atopic dermatitis (AD)-like skin lesions is unknown. Therefore, we investigated the suppressive effect of IPA on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin symptoms in mice and the underlying mechanisms in cells. IPA attenuated the DNCB-induced increase in the serum concentrations of IgE and thymic stromal lymphopoietin (TSLP), and in the mRNA levels of thymus and activation regulated chemokine(TARC), macrophage derived chemokine (MDC), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13), tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in mice. Histopathological analysis showed that IPA reduced the epidermal/dermal thickness and inflammatory and mast cell infiltration of ear tissue. In addition, IPA attenuated the phosphorylation of NF-κB and IκBα, and the degradation of IκBα in ear lesions. Furthermore, IPA treatment suppressed TNF-α/IFN-γ-induced TARC expression by inhibiting the NF-κB activation in cells. Phosphorylation of extracellular signalregulated protein kinase (ERK1/2) and the signal transducer and activator of transcription 1 (STAT1), the upstream signaling proteins, was reduced by IPA treatment in HaCaT cells. In conclusion, IPA ameliorated AD-like skin symptoms by regulating cytokine and chemokine production and so has therapeutic potential for AD-like skin lesions.

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Young Male with Bilateral ICA Dissection: Beyond CADISS Trial

Journal of Stroke Medicine ◽

10.1177/2516608520984289 ◽

2021 ◽

pp. 251660852098428

Author(s):

Vikas Bhatia ◽

Chirag Jain ◽

Sucharita Ray ◽

jay Kumar

Keyword(s):

Management Strategies ◽

Young Male ◽

Acute Onset ◽

The Body ◽

Artery Dissection ◽

Cervical Artery Dissection ◽

Stroke Study ◽

History Of

Objective: To report a case of young male with stroke and bilateral internal carotid artery (ICA) dissection. Background: Cervical Artery Dissection in Stroke Study trial has provided some insight on management of patients with ICA dissection. However, there is a need to modify the management strategies as per specific clinical scenario. Design/Methods: Case report and literature review. Results: A 45-year-old male presented with 1 month old history of acute onset numbness of right half of the body with slurring of speech. Computed tomography angiography showed complete occlusion of left cervical ICA just beyond origin with presence of fusiform dilatation and spiral flap in right extracranial cervical ICA. The patient was started on antiplatelets and taken for endovascular procedure using 2-mesh-based carotid stents. Patient was discharged after 3 days on antiplatelet therapy. At 1-year follow-up, there were no fresh symptoms. Conclusion: This case emphasizes the role of successful endovascular management of carotid dissection in a young male. These clinical situations may not be fully represented in trials, and a case-based approach is required.

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