scholarly journals Incidence and factors associated with mortality of neonatal sepsis

2011 ◽  
Vol 51 (3) ◽  
pp. 144 ◽  
Author(s):  
I Made Kardana
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Mode Of Delivery ◽  
Developed Countries ◽  
Live Births ◽  
Factors Associated ◽  
Early Onset Sepsis

Background Neonatal sepsis is one of the major causes of mortality and long term morbidity in neonates, particularly in premature and low birth weight infants. The incidence of neonatal sepsis varies from 1 to 4 in 1000 live births in developed countries and 10 to 50 in 1000 live births in developing countries. The mortality rate of neonatal sepsis remains high, especially in developing countries.Objective To describe the incidence, mortality rate, and factors associated 'With mortality in neonatal sepsis in Sanglah Hospital, Denpasar.Methods A retrospective, cohort study was conducted in the Perinatology Ward, Department of Child Health, Sanglah Hospital, Denpasar, Bali from January to December 2008. One hundred thirty􀁄eight patients 'With neonatal sepsis were enrolled in this study. Patients' characteristic data were collected including sex, mode of delivery (spontaneous, non􀁄spontaneous), condition at birth (vigorous, asphyxic), gestational age (premature, full tenn), birth weight «2500 grams, > 2500 grams), and sepsis classifica􀁄tion (early onset sepsis, late onset sepsis). Outcomes were grouped into alive and dead.Results A total of 138 cases of neonatal sepsis were reviewed, 59.4% of whom were boys, 63.0% spontaneously delivered,39.1 % asphyxic, 53.6% 'With low birth weight, 50.7% premature, and84.8% with early onset sepsis. The incidence of neonatal sepsis was 5% of babies admitted, 'With a mortality rate of 28.3%. Low birth weight and prematurity were significantly associated withmortality in neonatal sepsis (RR8.4, 95% CI 2.4 to 29.0, P = 0.001 and RR3.4, 95% ClI.O to 11.0, P 􀀂 0.042, respectively). Conclusion The incidence of neonatal sepsis in Sanglah Hospital was 5% of babies admitted, with a mortality rate of 28.3%. Low birth weight and prematurity were significantly associated with mortality in neonatal sepsis. 2011;51:144-8].

scholarly journals Clinical profile and outcome of early onset sepsis in high risk very low birth weight neonates

2018 ◽  
Vol 5 (2) ◽  
pp. 389 ◽  
Author(s):  
Omprakash S. Shukla ◽  
Aditi Rawat
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Blood Culture ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Very Low Birth Weight ◽  
Gram Negative ◽  
Early Onset Sepsis ◽  
Culture Positive

Background: Neonatal sepsis is one of the main causes of mortality and morbidity, especially in very low birth weight neonates (birth weight <1499 grams) despite the progress in hygiene, introduction of new and potent antimicrobial agents for treatment and advanced measures for diagnosis. The aim of the study was to find correlation of clinical features and risk factors of neonatal sepsis in culture positive cases.Methods: A cross- sectional study was carried out in one hundred neonates with risk factors of septicemia after obtaining informed consent. Blood culture was done using Bactec Peds Plus/F Culture as a gold standard to diagnose septicaemia. Correlation of  risk factors, clinical features with laboratory findings was obtained by using chi-square test. p-value of less than 0.05 was considered as significant.Results: Out of 100 neonates with suspected sepsis, BACTEC culture proven sepsis was seen in 40% cases. Gram negative sepsis was seen in 62.5% cases. The most common bacteria for early onset sepsis were Klebsiella, Pseudomonas and MRSA contributing 17% each to the bacteriological profile. The most common predisposing factor and clinical feature in culture positive cases were Premature rupture of membrane >24 hours (67%) and bleeding/petechia/pupura (72%) respectively. The major cause of mortality was pulmonary hemorrhage.Conclusions: Gram negative organism were more common and associated with higher mortality. Blood culture positivity increases with increase in number of risk factors in neonatal septicemia. A detailed history and thorough clinical examination is vital for early recognition of sepsis. 

scholarly journals Patient characteristics, Bacteriological profile & outcome of Neonatal Sepsis: A Hospital Based Study

2013 ◽  
Vol 2 (1) ◽  
pp. 49-54
Author(s):  
Nasim Jahan ◽  
Zabrul SM Haque ◽  
Md Abdul Mannan ◽  
Morsheda Akhter ◽  
Sabina Yasmin ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Late Onset ◽  
Female Ratio ◽  
Gram Negative ◽  
Common Pathogen ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis

Neonatal sepsis is a major cause of mortality and morbidity in newborn. The spectrum of bacteria which causes neonatal sepsis varies in different parts of the world. The organisms responsible for early onset and late onset sepsis are different. The objective of the study was undertaken to determine the pattern of bacterial isolates responsible for early and late onset neonatal sepsis. A prospective descriptive study over the period of one year was conducted at the Department of Neonatal Intensive care unit of Ad-din Women’s Medical College and Hospital, Dhaka, Bangladesh.Organisms were isolated from 8.7% of collected blood samples. The male female ratio of culture proven sepsis was 1.7:1. More than half (52.8%) of the evaluated neonates were preterm. & 56.3% had low birth weight. The gram positive and gram negative bacteria accounted for 24.1% and 75.9% of the isolates respectively. Around three fourth of the neonates (75.8%) presented with early onset sepsis, while 24.2% presented with late onset sepsis. Acinetobacter was the most common pathogen both in early onset (70%) and late onset (30%) sepsis. Pseudomonas (89.4%) was the second most common pathogen in early onset sepsis. Total mortality rate was 5.7%. Pre term, low birth weight and gram negative sepsis contributes majority of mortality.Gram negative organism especially Acinetobacter found to be commonest cause of sepsis. Pseudomonas was second most common but contributed highest in late onset sepsis and neonatal death due to sepsis. DOI: http://dx.doi.org/10.3329/cbmj.v2i1.14184 Community Based Medical Journal Vol.2(1) 2013 49-54

scholarly journals Clinical, Bacteriological Profile & Outcome of Neonatal Sepsis in a Tertiary Care Hospital

2014 ◽  
Vol 26 (1) ◽  
pp. 18-21 ◽  
Author(s):  
Biplob Kumar Raha ◽  
Md Abdul Baki ◽  
Tahmina Begum ◽  
Nazmun Nahar ◽  
Nasim Jahan ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Klebsiella Pneumoniae ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Late Onset ◽  
Gram Negative ◽  
Common Pathogen ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis

Neonatal sepsis is a major cause of mortality and morbidity in newborn, particularly in developing countries. The spectrum of bacteria which causes neonatal sepsis varies in different parts of the world. The organisms responsible for early onset and late onset sepsis are different. The objective of the study was undertaken to determine the pattern of bacterial isolates responsible for early and late onset neonatal sepsis based on the presence of one or more clinical signs, and its outcome. A cross- sectional prospective study was carried out in the special care baby unit (SCABU) from November 2008 to September 2009 under department of Paediatrics and Neonatology, BIRDEM General Hospital, Dhaka, Bangladesh. Organisms were isolated from 8.9% of collected blood samples. The male female ratio of culture proven sepsis was 1.7:1. Most of the culture proven septic neonates(71.88%) were preterm & 65.63% had low birth weight. The most frequent clinical presentations of patients with culture-proven sepsis were poor moro reflex (92.2%), feeding intolerance (90.6%), jaundice (87.5%), abdominal distention (76.6%), and lathergy (73.4%). The Gram positive and Gram negative bacteria accounted for 6 (9.4% ) and 58 (90.6%) of the isolates respectively. Around two third of the culture-proven septic neonates (70.3%) presented with early onset sepsis, while 29.7% presented with late onset sepsis. Klebsiella pneumoniae was the most common pathogen both in early onset (31.25%) and late onset (6.25%) sepsis. Serratia (18.75%) was the second most common pathogen in early onset sepsis. Total mortality rate was 9.38%. Preterm, low birth weight and Gram negative sepsis contributes majority of mortality. Gram negative organism especially Klebsiella pneumoniae contributed highest in early onset sepsis and neonatal death (6.25%) due to sepsis. DOI: http://dx.doi.org/10.3329/medtoday.v26i1.21306 Medicine Today 2014 Vol.26(1): 18-21

Changes in Pathogens Causing Early-Onset Sepsis in Very-Low-Birth-Weight Infants

2002 ◽  
Vol 347 (4) ◽  
pp. 240-247 ◽  
Author(s):  
Barbara J. Stoll ◽  
Nellie Hansen ◽  
Avroy A. Fanaroff ◽  
Linda L. Wright ◽  
Waldemar A. Carlo ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Early Onset ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Early Onset Sepsis

Very Low Birth Weight Preterm Infants With Early Onset Neonatal Sepsis

2005 ◽  
Vol 24 (7) ◽  
pp. 635-639 ◽  
Author(s):  
Barbara J. Stoll ◽  
Nellie I. Hansen ◽  
Rosemary D. Higgins ◽  
Avroy A. Fanaroff ◽  
Shahnaz Duara ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Very Low Birth Weight

Analysis of selected perinatological indicators in the Slovak Republic in the years 2007–2018

2021 ◽  
Vol 86 (2) ◽  
pp. 102-109
Author(s):  
Miroslav Korbeľ ◽  
◽  
Pavel Kaščák ◽  
zuzana Nižňanská
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Low Birth Weight ◽  
Perinatal Mortality ◽  
Total Fertility Rate ◽  
Very Low Birth Weight ◽  
Slovak Republic ◽  
In Utero ◽  
Fertility Rate ◽  
Live Births

Overview Objective: Analysis of perinatal mortality in the Slovak Republic during the years 2007–2018. Methods: Analysis of prospectively collected selected perinatal data in the years 2007–2018. Results: In the year 2007, there were 63 obstetrics units, 51,146 deliveries and that of live births 51,650 in the Slovak Republic. The number of obstetrics units decreased to 51 in the years 2018, the total number of deliveries increased to 57,085 and that of live births increased to 57,773. The total fertility rate in the years 2007–2018 increased from 1.27 to 1.54. The preterm deliveries rate increased from 7.3% in the year 2007 to 8.5% in the year 2010 and decreased to 7% in the year 2018. The perinatal mortality rate decreased from 6.2 in the year 2007 to 4.4 in the year 2017, increased again in the years 2018 to 5.0 and according to the criteria of WHO (World Health Organization) to 6.6 per 1,000 still- and live-births. During the years 2007–2018 at perinatal mortality stillbirth participate with 65%, low birth weight with 63% and severe congenital anomalies with 19%. Transport in utero to perinatological centers in the years 2007–2018 has decreased from 57 to 56% for infants 1,000–1,499 g and from 75 to 73% for infants below 1,000 g. Conclusion: In the year 2017, perinatology in the Slovak Republic reached the best result in the perinatal mortality rate – 4.4‰ (0.44%), but has increased to over 5‰ next year. To further reduce perinatal mortality in the Slovak Republic, it is necessary to improve the prenatal dia­gnosis of severe congenital abnormalities, transport in utero of very low birth weight fetuses, centralization of high-risk pregnancies, obstetric personnel and material-technical equipment of obstetricians and neonatal intensive care units. Keywords: perinatal mortality – preterm delivery – multiple pregnancy – low birth weight – very low birth weight – total fertility rate

scholarly journals Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

Children ◽  
2020 ◽  
Vol 7 (12) ◽  
pp. 309
Author(s):  
Maura-Adelina Hincu ◽  
Gabriela-Ildiko Zonda ◽  
Gabriela Dumitrita Stanciu ◽  
Dragos Nemescu ◽  
Luminita Paduraru
Keyword(s):  
High Mortality ◽  
Early Onset ◽  
Clinical Signs ◽  
Developed Countries ◽  
Extremely Low Birth Weight ◽  
Invasive Infection ◽  
Acute Phase Reactants ◽  
Hematological Indices ◽  
Live Births ◽  
Early Onset Sepsis

Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first 72 h of life. The incidence of EOS varies from 0.5–2% live births in developed countries, up to 9.8% live births in low resource settings, generating a high mortality rate, especially in extremely low birth weight neonates. Clinical signs are nonspecific, leading to a late diagnosis and high mortality. Currently, there are several markers used for sepsis evaluation, such as hematological indices, acute phase reactants, cytokines, which by themselves do not show acceptable sensitivity and specificity for the diagnosis of EOS in neonates. Newer and more selective markers have surfaced recently, such as presepsin and endocan, but they are currently only in the experimental research stages. This comprehensive review article is based on the role of biomarkers currently in use or in the research phase from a basic, translational, and clinical viewpoint that helps us to improve the quality of neonatal early-onset sepsis diagnosis and management.

scholarly journals Neonatal and perinatal mortality trend among 23,000 babies delivered during three years at an urban university teaching hospital of Nepal

2019 ◽  
Vol 6 (2) ◽  
pp. 90-95
Author(s):  
Rateena Rajbhandari ◽  
Puja Amatya ◽  
Shova Shrestha
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Perinatal Mortality ◽  
Mode Of Delivery ◽  
Final Outcome ◽  
University Teaching ◽  
Microsoft Excel ◽  
Live Births ◽  
Perinatal Audit ◽  
Urban University

Introductions: Perinatal mortality rate (PMR) of Nepal is 31 deaths per 1000 pregnancies and neonatal mortality rate (NMR) is 21 deaths per 1000 live births according to Nepal Demographic and Health Survey (NDHS) 2016. This study aims to analyse the trend of PMR and NMR of babies delivered at Patan hospital, Nepal. Methods: This was a retrospective study done in the department of Pediatrics to analyse the trend of neonatal and perinatal outcome of babies delivered during three years from April 2016 to March 2019 at Patan Hospital, Patan Academy of Health Sciences, Nepal. Data was collected from hospital records and perinatal audit. The mode of delivery (vaginal, instrumental, caesarian), birth status (sex, premature, still, live, APGAR, birth weight) and final outcome (neonatal and perinatal mortalities) were analyzed descriptively using Microsoft Excel 2010. Results: The final outcome of total 22937 deliveries during three years were PMR 4.34, corrected PMR 10.85 per 1000 total births and NMR 3.62 per 1000 live births. There were 22913 (99%) live births, 3090 (13.3%) had low birth weight, 11898 (52%) spontaneous vaginal delivery, 10700 (47%) cesarean and 339 (1.5%) instrumental deliveries. Conclusions: The overall PMR was 4.34 per 1000 total births and NMR was 3.62 per 1000 live births at Patan Hospital.

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