scholarly journals CLINICO - BACTERIOLOGICAL STUDY OF PYOGENIC MENINGITIS WITH SPECIAL REFFERANCE TO C - REACTIVE PROTEIN IN CEREBRO SPINAL FLUID

2015 ◽  
Vol 4 (77) ◽  
pp. 13459-13469
Author(s):  
Koteswara Rao K ◽  
Krishna Prasad A ◽  
Adi Reddy K ◽  
Solomon Saawan P ◽  
Krishna Kumari Agarwal ◽  
...  
Keyword(s):  
Spinal Fluid ◽  
C Reactive Protein ◽  
Pyogenic Meningitis ◽  
Bacteriological Study ◽  
Reactive Protein

Cerebrospinal Fluid and Serum C-Reactive Protein among Children with Acute Encephalitis Syndrome

2021 ◽  
Vol 16 (03) ◽  
pp. 111-115
Author(s):  
Durgesh Kumar ◽  
Dinesh Kumar ◽  
Alok Tiwari ◽  
Nishant Sharma ◽  
Rajesh Kumar Yadav ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cerebral Malaria ◽  
Tuberculous Meningitis ◽  
Viral Encephalitis ◽  
C Reactive Protein ◽  
Pyogenic Meningitis ◽  
Reactive Protein ◽  
Acute Encephalitis Syndrome ◽  
Acute Encephalitis ◽  
Serum Crp

Abstract Objectives This study aimed to evaluate the positivity of C-reactive protein (CRP) in cerebrospinal fluid (CSF) and serum in children presented with clinical diagnosis of acute encephalitis syndrome (AES). Methods A total of 164 children between 6 months and 14 years with clinical diagnosis of AES were investigated. Qualitative CRP (slide agglutination) was determined in CSF and serum sample of each patient. On the basis of clinical examination and investigations, all the patients were divided into four groups as pyogenic meningitis, viral encephalitis, tuberculous meningitis, and cerebral malaria. The positivity of CRP in CSF and serum were compared in these groups. Results CSF CRP was found to be positive in the majority of patients with pyogenic meningitis and a statistically significant (p ≤ 0.001) association was found between CSF CRP and final diagnosis of AES, while this association was nonsignificant (p = 0.141) in case of serum CRP. When we compared the CSF and serum CRP, serum CRP was found to be more suggestive of tuberculous meningitis, viral encephalitis, and cerebral malaria while CSF CRP was more sensitive and specific for the diagnosis of pyogenic meningitis. Conclusion The sensitivity and specificity of CSF CRP for pyogenic meningitis was quite high. Serum CRP with a high sensitivity can be used as a screening test for different types of meningitis and cerebral malaria; however, its diagnostic accuracy has yet to be established.

scholarly journals “Study of Estimation of Cerebrospinal Fluid C-Reactive Protein in Diagnosis of Acute Meningitis.”

2021 ◽  
Vol 8 (4) ◽  
pp. 175-181
Author(s):  
Dr. Keshav Bansal ◽  
◽  
Dr. Dhaval Bhatt ◽  
Dr. Sunil Kumar Dadhich ◽  
Dr. Deep Kariya ◽  
...  
Keyword(s):  
Mean Value ◽  
Latex Agglutination ◽  
C Reactive Protein ◽  
Pyogenic Meningitis ◽  
Group Iii ◽  
Reactive Protein ◽  
Group I ◽  
Diagnostic Role ◽  
Group Ii

Objectives:To assess the diagnostic role of CSF C-reactive protein quantitatively in acute meningitisand to evaluate the efficacy of CSF C-reactive protein in differentiating pyogenic meningitis fromnon-pyogenic meningitis.Material and Methods: It is a prospective observational study of total 102children with suspected meningitis allocated into three groups based on initial investigations; group-I Pyogenic meningitis, group-II Non-Pyogenic meningitis and group-III No meningitis (Controlgroup). Quantitative CSF C-reactive protein was detected by the latex agglutination method. Datawere analyzed to establish the diagnostic role of CSF-CRP and to evaluate the efficacy of CSF-CRP indifferentiating pyogenic meningitis from non-pyogenic meningitis.Results: A total of 102 clinicallysuspected meningitis patients were studied. Based on CSF findings, the study population (102cases) was categorized into 3 groups. Group I was pyogenic meningitis consist 53 cases (51.96%).Group II was Non-Pyogenic meningitis consists 27 cases (26.47%). Group III was normal CSFfindings consist 22 (21.56%). 98.1% cases of pyogenic meningitis had elevated CSF-CRP level >1.1μg/ml of CSF. In the case of Non-Pyogenic meningitis, 96.2% were found to have CSF- CRP in therange of 0.05-0.10 μg/ml. The mean value of CSF-CRP in groups I,II and III were 5.57±1.48,0.09±0.042 and 0.01±0.010 respectively. Conclusion: Detection of CSF-CRP provides a newdimension to establish the diagnosis of pyogenic meningitis. It is a rapid, reliable and sensitivediagnostic test. From this study it is concluded that CSF-CRP can be used to differentiate pyogenicfrom non-pyogenic meningitis. Early, accurate and appropriate therapy can ameliorate the morbidityand mortality rates in such cases.

C-Reactive protein in spinal fluid of children with meningitis

1981 ◽  
Vol 99 (3) ◽  
pp. 365-369 ◽  
Author(s):  
C. James Corrall ◽  
James M. Pepple ◽  
E. Richard Moxon ◽  
Walter T. Hughes
Keyword(s):  
Spinal Fluid ◽  
C Reactive Protein ◽  
Reactive Protein

Significance of C-reactive protein in spinal fluid.

1985 ◽  
Vol 31 (2) ◽  
pp. 345-345
Author(s):  
P H Trienekens ◽  
F T Willems ◽  
H C Zanen
Keyword(s):  
Spinal Fluid ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Early Ditection of Central Nervous System Infection by C-reactive Protein Examination of Cerebrospinal Fluid

2019 ◽  
Vol 32 (5-6) ◽  
pp. 144-52
Author(s):  
Tjipta Bahtera ◽  
Bagus Putu Ngurah Arsana ◽  
Maria Lidwina
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Bacterial Meningitis ◽  
Clinical Symptoms ◽  
Central Nervous System Infection ◽  
Spinal Fluid ◽  
Morbidity Rate ◽  
C Reactive Protein ◽  
Routine Examination ◽  
Reactive Protein

There are still many cases of bacterial meningitis in Indonesia. The highest morbidity rate are between 2 months until 2 years of age. The important factors that influence the success of treatment are early diagnosis and detection of the cause. C-reactive protein (=CRP) could be found in the spinal fluid of meningitis patients. The aim of this study is to judge the ability of CRP as a tool in making diagnosis as soon as possible whether there is a bacterial infection of the central nervous system and to compare it with the result of the spinal fluid culture. Also to compare the ability of it a conventional or routine examination of the spinal fluid was done. This was a prospective study on 30 children that were admitted in the child ward of Kariadi Hospital, Semarang during the first of April until the and of july 1990. The ages of the children were between one month until 14 years, with clinical symptoms such as fever, seizure and neurological disorders. CRP examination was done with Latex Agglutination method. The result of CRP examination on spinal fluid showed that the sensitivity was 91.6% , the specificity 94.4% , the positive prediction value 91.6% and the negative prediction value 94.4%. As a conclusion, CRP examination of spinal fluid gives better results than the conventional or routine examination in distinguishing bacterial meningitis from non bacterial meningitis.

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