scholarly journals Early Ditection of Central Nervous System Infection by C-reactive Protein Examination of Cerebrospinal Fluid

2019 ◽  
Vol 32 (5-6) ◽  
pp. 144-52
Author(s):  
Tjipta Bahtera ◽  
Bagus Putu Ngurah Arsana ◽  
Maria Lidwina
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Bacterial Meningitis ◽  
Clinical Symptoms ◽  
Central Nervous System Infection ◽  
Spinal Fluid ◽  
Morbidity Rate ◽  
C Reactive Protein ◽  
Routine Examination ◽  
Reactive Protein

There are still many cases of bacterial meningitis in Indonesia. The highest morbidity rate are between 2 months until 2 years of age. The important factors that influence the success of treatment are early diagnosis and detection of the cause. C-reactive protein (=CRP) could be found in the spinal fluid of meningitis patients. The aim of this study is to judge the ability of CRP as a tool in making diagnosis as soon as possible whether there is a bacterial infection of the central nervous system and to compare it with the result of the spinal fluid culture. Also to compare the ability of it a conventional or routine examination of the spinal fluid was done. This was a prospective study on 30 children that were admitted in the child ward of Kariadi Hospital, Semarang during the first of April until the and of july 1990. The ages of the children were between one month until 14 years, with clinical symptoms such as fever, seizure and neurological disorders. CRP examination was done with Latex Agglutination method. The result of CRP examination on spinal fluid showed that the sensitivity was 91.6% , the specificity 94.4% , the positive prediction value 91.6% and the negative prediction value 94.4%. As a conclusion, CRP examination of spinal fluid gives better results than the conventional or routine examination in distinguishing bacterial meningitis from non bacterial meningitis.

scholarly journals Characteristics and biomarkers of patients with central nervous system infection admitted to a referral hospital in Northern Vietnam

2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Cuong Chi Ngo ◽  
Shungo Katoh ◽  
Futoshi Hasebe ◽  
Bhim Gopal Dhoubhadel ◽  
Tomoko Hiraoka ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Bacterial Meningitis ◽  
Central Nervous System Infection ◽  
Cns Infection ◽  
High Morbidity ◽  
Tubercular Meningitis ◽  
Viral Pathogens ◽  
Number Of Patients ◽  
Csf Findings

Abstract Background Laboratory facilities for etiological diagnosis of central nervous system (CNS) infection are limited in developing countries; therefore, patients are treated empirically, and the epidemiology of the pathogens is not well-known. Tubercular meningitis is one of the common causes of meningitis, which has high morbidity and mortality, but lacks sensitive diagnostic assays. The objectives of this study were to determine the causes of meningitis in adult patients by using molecular assays, to assess the risk factors associated with them, and to explore whether biomarkers can differentiate tubercular meningitis from bacterial meningitis. Methods We conducted a cross-sectional study in the Department of Infectious Diseases, Bach Mai Hospital, Hanoi, Vietnam, from June 2012 to May 2014. All patients who were ≥ 16 years old and who had meningoencephalitis suggested by abnormal cerebrospinal fluid (CSF) findings (CSF total cell >5/mm3 or CSF protein ≥40 mg/dL) were included in the study. In addition to culture, CSF samples were tested for common bacterial and viral pathogens by polymerase chain reaction (PCR) and for biomarkers: C-reactive protein and adenosine deaminase (ADA). Results Total number of patients admitted to the department was 7506; among them, 679 were suspected to have CNS infection, and they underwent lumbar puncture. Five hundred eighty-three patients had abnormal CSF findings (meningoencephalitis); median age was 45 (IQR 31–58), 62.6% were male, and 60.9% were tested for HIV infection. Among 408 CSF samples tested by PCR, out of them, 358 were also tested by culture; an etiology was identified in 27.5% (n=112). S. suis (8.8%), N. meningitis (3.2%), and S. pneumoniae (2.7%) were common bacterial and HSV (2.2%), Echovirus 6 (0.7%), and Echovirus 30 (0.7%) were common viral pathogens detected. M. tuberculosis was found in 3.2%. Mixed pathogens were detected in 1.8% of the CSF samples. Rural residence (aOR 4.1, 95% CI 1.2–14.4) and raised CSF ADA (≥10 IU/L) (aOR 25.5, 95% CI 3.1–212) were associated with bacterial meningitis when compared with viral meningitis; similarly, raised CSF ADA (≥10 IU/L) (aOR 42.2, 95% CI 2.0–882) was associated with tubercular meningitis. Conclusions Addition of molecular method to the conventional culture had enhanced the identification of etiologies of CNS infection. Raised CSF ADA (≥10 IU/L) was strongly associated with bacterial and tubercular meningitis. This biomarker might be helpful to diagnose tubercular meningitis once bacterial meningitis is ruled out by other methods.

scholarly journals A Case of Brevibacillus brevis Meningitis and Bacteremia

2020 ◽  
Vol 2020 ◽  
pp. 1-2
Author(s):  
Parmvir Parmar ◽  
Milani Sivapragasam ◽  
Vicente Corrales-Medina
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Bacterial Meningitis ◽  
Clinical Cure ◽  
Surgical Repair ◽  
Central Nervous System Infection ◽  
Newly Diagnosed ◽  
Human Pathogens ◽  
Debulking Surgery ◽  
Brevibacillus Brevis

Brevibacillus species are environmental organisms that are rarely implicated as human pathogens. We present the case of postsurgical Brevibacillus brevis bacterial meningitis and an associated bacteremia after debulking surgery for a newly diagnosed pilocytic astrocytoma in a 19-year-old woman. The patient experienced clinical cure with a 4-week course of vancomycin, but her postinfectious course was complicated by the development of a pseudomeningocele that required surgical repair. To our knowledge, this is the first described case of a central nervous system infection caused by Brevibacillus brevis in the literature.

C-reactive protein, leukocytes, and fever after central IL 1 and alpha-MSH in aged rabbits

1988 ◽  
Vol 254 (3) ◽  
pp. R401-R409
Author(s):  
T. K. Dao ◽  
R. C. Bell ◽  
J. Feng ◽  
D. M. Jameson ◽  
J. M. Lipton
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Phase ◽  
Interleukin 1 ◽  
Buffy Coat ◽  
System Control ◽  
Central Administration ◽  
C Reactive Protein ◽  
Melanocyte Stimulating Hormone ◽  
Reactive Protein

Aged and young unanesthetized rabbits with intracerebroventricular cannulas were tested in experiments designed to determine whether increases in plasma C-reactive protein (CRP) level and leukocytosis can be rapidly induced by central administration of crude buffy-coat supernatant commonly called endogenous pyrogen or interleukin 1 (IL 1). The results indicate that both acute-phase responses occur during fever caused by central administration of this supernatant and that they are generally detectable within 2 h. Although the febrile response was smaller in aged female rabbits, there was no decline in CRP or leukocyte responses, an observation that was not predicted. The antipyretic neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) reduced fever caused by central IL 1 more effectively in the aged rabbits. alpha-MSH likewise inhibited the CRP and leukocyte responses to central IL 1. The results confirm that CRP and leukocyte responses can be driven by a central IL 1 signal and further indicate that the response can occur rapidly, consistent with direct central nervous system control of the acute-phase responses. The findings indicate that the acute-phase responses depend in part on the age of the host and that the responses can be modulated by an endogenous central nervous system peptide with known antipyretic and immune modulatory properties.

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