Type II Diabetes mellitus (TII DM) is a major global health problem. TII DM is characterized by the prothrombotic state
of platelets which owes to the persistent hyperglycemia and insulin resistance, causing injury to pericytes and
endothelium. Increased platelet activity is believed to be associated with the development of vascular complications in TII DM. Mean Platelet
Volume (MPV), a marker of platelet function which can be used to assess the vascular complications. This is an observational study including 150
TII DM patients attending Diabetology OPD in Coimbatore Medical College& Hospital. MPV, FBS, PPBS, HBA1c were signicantly elevated
in TII DM patients. Mean FBS, PPBS, HBA1c, MPV were 188.84±91.50mg/dL, 281.10±104.51mg/dL,8.56±2.25 %,9.66 ± 2.02fL, respectively.
MPV showed a signicant positive correlation with FBS, PPBS, HBA1c. MPV showed more strong correlation in patients with HBA1c >7% than
in patients with HBA1c ≤7%. Our study showed that in Type II Diabetes Mellitus patients, Mean Platelet Volume (MPV) is increased. MPV is
signicantly increased in patients with high HBA1c level. Thus, MPV can be taken as a simple and a cost-effective parameter in assessing the
Glycemic control in TII DM patients.
EVALUATION OF MEAN PLATELET VOLUME AS A PROGN OSTIC MARKER IN TYPE II DIABETES MELLITUS
