‘Abnormal’ Papanicolaou smears and colposcopy in pregnancy: ante- and post-partum findings

1993 ◽  
Vol 3 (4) ◽  
pp. 239-244 ◽  
Author(s):  
W. A. Nahhas ◽  
M. A. Clark ◽  
M. Brown
Keyword(s):  
Post Partum ◽  
Condylomata Acuminata ◽  
Intraepithelial Neoplasia ◽  
Genital Warts ◽  
Hpv Infection ◽  
Partial Regression ◽  
Abnormal Cytology ◽  
Papilloma Virus ◽  
Cytologic Smear ◽  
Papanicolaou Smears

Abnormal Papanicolaou smears and colposcopic findings suggesting human Papilloma virus (HPV) infection and cervical intraepithelial neoplasia (CIN) may occur during pregnancy. Condylomata acuminata often grow rapidly during pregnancy and may regress spontaneously following delivery. However, the post-partum outcome of the untreated ante-partum abnormal cytologic smear and colposcopy has not been defined clearly. Seventy-three pregnant patients were examined by colposcopy because of genital warts and/or abnormal Papanicolaou smears. Cytologic, colposcopic and histologic re-evaluation was conducted after delivery. Only one of the patients had a normal ante-partum colposcopic examination. This number increased to 15 after delivery. Forty-one patients had normal post-partum cytologic smears, but only 13 had normal histology. Abnormal post-partum cytology was highly predictive of abnormal colposcopy and histology. In contrast, normal post-partum cytology was not very accurate in predicting normal colposcopy and histology. It is concluded that a few pregnant patients may have partial regression of clinical HPV infection and abnormal cytology and colposcopy after delivery. However, the majority will continue to have abnormal findings 4 months following delivery in spite of normal post-partum cytology and even colposcopy.

5. Condylomata Acuminata in Pre-Pubertal Children

1993 ◽  
Vol 33 (1) ◽  
pp. 78-82 ◽  
Author(s):  
J D C Ross ◽  
G R Scott ◽  
A Busuttil
Keyword(s):  
Sexual Abuse ◽  
Case Reports ◽  
Sexual Transmission ◽  
Condylomata Acuminata ◽  
Genital Warts ◽  
Review Article ◽  
Anogenital Warts ◽  
Papilloma Virus ◽  
Modes Of Transmission

The medico-legal significance of anogenital warts as a marker of sexual abuse in children is unclear. This review article presents three case reports and discusses the possible modes of transmission of papilloma virus in children. Although genital warts can indicate sexual abuse, non-sexual transmission may also occur.

Characterization of high- and low-grade cervical intraepithelial neoplasia

1993 ◽  
Vol 3 (4) ◽  
pp. 203-207 ◽  
Author(s):  
M. I. Shafi ◽  
J. A. Dunn ◽  
C. B. Finn ◽  
S. Kehoe ◽  
E. J. Buxton ◽  
...  
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Surface Area ◽  
Univariate Analysis ◽  
Intraepithelial Neoplasia ◽  
Stepwise Logistic Regression ◽  
Low Grade ◽  
Abnormal Cytology ◽  
Stepwise Logistic Regression Analysis ◽  
Cytologic Smear ◽  
Cancer Precursors

A need exists to characterize the various grades of cervical intrapithelial neoplasia (CIN), and attempt to differentiate between high- and low-grade lesions, that may have different behavioral and progressive potentials. The identification of patients with high- or low-grade CIN is useful, as it may allow identification of those patients that have true cancer precursors. Fifty patients referred for colposcopy with abnormal cytology were studied. Univariate analysis identified three factors as important predictors of histologic grade; the colposcopic opinion, lesion surface area and the index cytology (P< 0.005). Colposcopic opinion was associated with the index cytology (P< 0.01) and the lesion surface area (P< 0.005). Only the colposcopic opinion and the index cytologic smear appeared in the final model using a stepwise logistic regression analysis, indicating their independent prognostic importance in prediction of grade of abnormality in cervical intraepithelial neoplasia. The study demonstrates the value of colposcopic training and experience being necessary prior to utilizing excisional treatment methods if overtreatment is to be avoided.

scholarly journals Significance of molecular diagnostics in human papilloma virus (HPV) determination

2014 ◽  
Vol 66 (1) ◽  
pp. 51-56 ◽  
Author(s):  
G. Kovacevic ◽  
V. Milosevic ◽  
I. Hrnjakovic-Cvjetkovic ◽  
V. Petrovic ◽  
S. Stefan-Mikic ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Hpv Infection ◽  
Molecular Techniques ◽  
Etiologic Factor ◽  
Abnormal Cytology ◽  
Normal Cytology ◽  
Papilloma Virus ◽  
Cervical Cancer Development ◽  
High Risk Hpv

HPV infection is considered to be the most important etiologic factor in cervical cancer development. In this retrospective study, which included the period from 2000 to 2012, the results of two molecular techniques used in the detection of HPV infection among women of the South Backa District were analyzed. By using the technique of in situ hybridization and the rPCR method, the proportion of high-risk HPV among women with normal cytology was determined to be 19.8% and 32.7%, respectively, and among women with abnormal cytology 43.1% and 61%, respectively. Among the analyzed women, HPV type 16 was the most prevalent, followed by HPV types 31, 51 and 18. Application of molecular HPV diagnosis is valuable because it increases the sensitivity of the screening test, so that the application of both tests to detect cervical cancer is a true prevention of malignancy.

Candidate HPV genotypes not included in the 9-valent vaccine for prevention of CIN 2–3

2020 ◽  
Vol 30 (7) ◽  
pp. 954-958
Author(s):  
Eduardo Gonzalez-Bosquet ◽  
Monica Gibert ◽  
Mariona Serra ◽  
Alicia Hernandez-Saborit ◽  
Alba Gonzalez-Fernandez
Keyword(s):  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Punch Biopsy ◽  
Single Infection ◽  
Abnormal Cytology ◽  
Test Analysis ◽  
Hpv 16 ◽  
Hpv Test ◽  
Two Samples ◽  
Qualitative Variables

ObjectivesTo identify the prevalence of human papillomavirus genotypes – as a single infection or co-infection – not included in the 9-valent (9v) HPV vaccine among women with cervical intraepithelial neoplasia (CIN 2–3).MethodsRetrospective study of 1700 women referred due to abnormal cytology to Sant Joan de Deu Hospital. We selected 849 patients with CIN 2 or CIN 3 diagnosis confirmed by biopsy. An HPV test, a second cytology, and colposcopy were performed on all patients.Those with abnormal colposcopy underwent cervical biopsy. Patients with abnormal cytology and normal colposcopy or transformation zone type 3 underwent endocervical curetage. Conization was performed if punch biopsy or endocervical curetage confirmed CIN 2–3 or if a CIN 1 lesion persisted (diagnosed by biopsy) over 2 years in patients over 25 years of age. Comparisons for qualitative variables were analyzed with the chi-squared test. Analysis of variance was used for comparisons involving more than two samples.ResultsHPV was detected in 746 of 849 patients (87.9%) and in 306 (41%) of those where more than one HPV genotype was present. The more frequent genotypes detected as single infection were: HPV-16 (267/849%–31.4%), HPV 31 (34/849–4%), HPV-33 (20/849%–2.4%), HPV-58 (17/849%–2%), HPV-51 (15/849%–1.8%), and HPV-53 (12/849%–1.4%). The more frequent genotypes isolated including multiple HPV infection were HPV-16 (427/849%–50.2%), HPV-31 (108/849%–12.7%), HPV-51 (79/849%–9.3%), HPV-33 (67/849%–7.8%), HPV-58 (67/849%–7.8%), and HPV-52 (59/849%–6.9%). In total, 78% of women diagnosed with CIN 2 or CIN 3 had an infection by a HPV genotype included in the 9v vaccine. Of the 849 women diagnosed with CIN 2 or CIN 3, 103 (12.1%) tested negative for HPV and 106 (12.4%) tested positive for low-risk HPV types.ConclusionsInclusion of HPV-51, 53, 66, and 35 in a new vaccine may not be advisable as most are detected as coinfection with other high-risk genotypes that are already included in the current vaccines.

Extensive Genital Warts in Man Hampering Conjugal Life: A Case Report

2020 ◽  
Vol 11 (1) ◽  
pp. 82-85
Author(s):  
ATM Mostafizur Rahman ◽  
Tanvir Ahmed Chowdhury ◽  
Ali Nafisa ◽  
Mahbubur Rahman
Keyword(s):  
Case Report ◽  
Treatment Options ◽  
Genital Warts ◽  
Hpv Infection ◽  
Sexual Partners ◽  
Condyloma Acuminata ◽  
Skin Flaps ◽  
Scrotal Skin ◽  
Papilloma Virus ◽  
Medical College

Genital warts, commonly known as condyloma acuminata, caused by the proliferation of squamous epithelial cells in the presence of sexually transmission of human papilloma Virus (HPV) infection. In human, HPV infection results in simple condyloma acuminatum, giant condyloma or Buschke-LÖwenstein tumour, and seldom penile carcinoma. There are several modalities of treatment options available for genital warts- medical and surgical, alone or in combination. Sometimes extensive genital warts represent a district entity resulting from HPV infection and require surgical management. We present the case of a 42-year-old male; rickshaw puller had multiple professional female sexual partners, who presented with extensive genital warts in penoscrotal region. Lesions were treated due to failure of medical management, by wide electrosurgical excision and rotation scrotal skin flaps Anwer Khan Modern Medical College Journal Vol. 11, No. 1: Jan 2020, P 82-85

scholarly journals Vaccinations for Anal Squamous Cancer: Current and Emerging Therapies

2018 ◽  
Vol 31 (06) ◽  
pp. 321-327 ◽  
Author(s):  
Sean Glasgow ◽  
John Berry
Keyword(s):  
Human Papillomavirus ◽  
Adolescent Girls ◽  
Anal Cancer ◽  
Intraepithelial Neoplasia ◽  
Genital Warts ◽  
Hpv Infection ◽  
Hpv Vaccines ◽  
Emerging Therapies ◽  
Immune Therapies ◽  
Squamous Cancer

AbstractHuman papillomavirus (HPV) infection is responsible for 4.3% of the global cancer burden. Since 2006, current HPV vaccines have reduced the prevalence of the virus in adolescent girls, reduced the prevalence of genital warts, and been proven to reduce the progression of anal intraepithelial neoplasia in men. Herein, we review the epidemiology, virology, and immunology behind the prophylactic HPV vaccines and current recommendations for its use. We also review future immune therapies being trialed for use against HPV-related cancers including anal cancer.

scholarly journals Response of Bowenoid Papulosis to Combination Treatment of Oral Isotretinoin and Topical 1% 5-Fluorouracil

2021 ◽  
Vol 10 (35) ◽  
pp. 3067-3069
Author(s):  
Shravya Rimmalapudi ◽  
Sugat Jawade ◽  
Bhushan Madke ◽  
Adarsh Lata Singh
Keyword(s):  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Sexually Active ◽  
Female Ratio ◽  
Papilloma Virus ◽  
Bowenoid Papulosis ◽  
Oral Isotretinoin ◽  
Viral Wart ◽  
Male To Female

Bowenoid papulosis (BP) is a rare benign disease which can have spontaneous regression but can sometimes turn malignant.1 It is characterised by solitary or multiple verruca-like papules or plaques usually present on genitalia having a close histological resemblance to Bowen's disease and a predilection for sexually active young adults.2 It affects all races equally and has almost same male to female ratio. There are an estimated 5 cases per 100000 women. The exact prevalence is unknown.3 We hereby present a case report of bowenoid papulosis. Bowenoid papulosis is an uncommon form of intraepithelial neoplasia. It is caused by human papilloma virus (HPV) infection and clinically resembles viral wart while histologically resembling in situ squamous cell carcinoma (SCC). We hereby report a case of an adult male with multiple verrucous lesions on penis and scrotum. The histopathology showed features of bowenoid papulosis. The patient was treated with oral isotretinoin and topical 1 % 5 - fluorouracil following which the lesions reduced remarkably in the span of 3 weeks.

scholarly journals Genotyping of High-risk Human Papilloma virus (HPV) among Iraqi women in Baghdad by Multiplex PCR

2015 ◽  
Vol 9 (1) ◽  
pp. 38-45
Author(s):  
Ashna J. Faik Faik ◽  
Mudhafar Q. Saber Saber ◽  
Wisam J. Mohammed Mohammed ◽  
Bashar Z. Ibraheem Ibraheem ◽  
Kawther R. Lateef Lateef ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Human Papilloma Virus ◽  
Multiplex Pcr ◽  
Dna Amplification ◽  
Hpv Infection ◽  
Abnormal Cytology ◽  
Normal Cytology ◽  
Papilloma Virus ◽  
Hpv Types

Human papilloma virus (HPV) infection is a causative factor for cervical cancer. Early detectionrisk HPV types might help to identify women at high risk of cervical cancer. The aim of of highHPV infection in population of rgir hgih determine the occurrence of the present study was toIraqi women in Baghdad by using Multiplex PCR determine the percentage and genotyping ofHuman Papilloma Virus and to put the best prevention and control program in Iraqi women.Study started at January 2009 to March 2010, cervical samples were collected from 856 womenaged 16–70. HPV DNA amplification was performed using HPV High Risk Typing PCR Kit testfor qualitative detection and genotyping of HPV types 16, 18, 31, 33, 35, 39, 45, 52, 56, 58, 59, 66 inHPV was detected in 106 ( 12,38% ) of the study population, with a range of the cervical swabs.16-70 years age groups. Results showed that the overall HPV prevalence twelve genotypes wereidentified, including HPV-33 (18.60%), HPV-35 (18.60%), HPV-56 (18.60%) ,HPV-39(10.85%),HPV-52 (10.08%), HPV-18 (7.75%), HPV-16 (4.65%), HPV-59 (4.65%), HPV-58(2.32%), HPV-31(1.55%), HPV-45(1.55% ) and HPV-66( 0.77%). Of 856, 218 women was also tested by pap smearith normal cytology was 198 ( 90.83%), 24(12.12%) of them were HPV positive, those with w,abnormal cytology was 20 (9.17 %), 5( 25%)of them was HPV positive. In this study unlike otherepidemiological studies, HPV33,35,56 was the most frequent type (55.8%) in Baghdad, followedby HPV39, HPV52, HPV18, HPV16.

scholarly journals Determination of papilloma-virus infection reproductive phase in algorithm of monitoring patients with cervical displasia

2021 ◽  
Vol 51 (4) ◽  
pp. 61-63
Author(s):  
S. A. Selkov ◽  
G. N. Vedeneeva ◽  
I. A. Baskakova ◽  
S. R. Baur
Keyword(s):  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
Hpv Dna ◽  
Virus Activity ◽  
Polymerase Chain

HPV 16 and 18 are known to be the main cause of cervical intraepithelial neoplasia (CIN) and cervical cancer. The terms of HPV persistence in the host and, coordinately, the risk of cervical neoplasia development and progression are determined in much extent by virus activity. The purpose of this investigation was the detection of HPV DNA presence in cervical epithelium as well as confirmation of its activity by means of immunocytochemistry and reverse transcriptase polymerase chain reaction. The level of HPV inf ection by oncogenic and nononcogenic types in 181 women with different cervical pathology was 55,8%. The active stage of HPV infection was confirmed in 27,5% of HPV-inf ected women mainly with low grades of CIN. The proof of reproductive general HPV infection was more informative with RT PCR just as for HPV 16 and 18 immunocytochemistry and RT PCR completed each anothe.

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