DEPRESSIVE SYMPTOMS AND LEVEL OF 25-HYDROXYVITAMIN D IN FREE-LIVING OLDEST OLD

Background: Nowadays, the relation between hypovitaminosis D and depression has been reported and it is estimated that 1 billion people worldwide have vitamin D deficiency or insufficiency. However, the oldest old people are not included or are under-represented in most of the studies. Objective: To examine the association between depressive symptoms and 25-hydroxyvitamin D level (25(OH)Vit D) in elderly aged 80 and over who are physically more active and independent. Design: Cross-sectional study. Setting and Participants: Data collected from 182 oldest old people, aged 80 and over in the Geriatric Division from Federal University of São Paulo. Measurements: The functionality was evaluated by the Instrumental activities of their daily living (IADL). The approach of the depressive symptoms was done by the Geriatric Depression Scale (GDS) in its reduced 15 item version. 25-hydroxyvitamin D (25(OH)Vit D) analyses was done in serum sample refrigerated and protected from solar exposition. We considered deficiency serum level of 25(OH)Vit D <10ng/mL, insufficiency between 10 and 30ng/mL and sufficiency >30ng/mL. Results: According to blood level of 25(OH)Vit D we found difference between GDS score comparing the groups: “deficiency” (U=144,50; z=-3,126; p=0,002) and “insufficiency” groups (U=975,50; z=-2,793; p=0.005) are different than “sufficiency” group. Conclusion: In free-living independent oldest old people the goal of 25(OH)Vit D levels can be higher to avoid depressive symptoms, levels under 30ng/mL can be inadequate. Considering that the costs are low and side effects are not common, 25(OH)Vit D supplementation can be an important public health action.

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Effect of vitamin D supplement on depression scores in people with low levels of serum 25-hydroxyvitamin D: nested case—control study and randomised clinical trial

The British Journal of Psychiatry ◽

10.1192/bjp.bp.111.104349 ◽

2012 ◽

Vol 201 (5) ◽

pp. 360-368 ◽

Cited By ~ 108

Author(s):

Marie Kjærgaard ◽

Knut Waterloo ◽

Catharina E. A. Wang ◽

Bjørg Almås ◽

Yngve Figenschau ◽

...

Keyword(s):

Vitamin D ◽

Depressive Symptoms ◽

Rating Scale ◽

Seasonal Pattern ◽

Depression Scale ◽

High Serum ◽

High Dose ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Low Levels

AimsTo compare depressive symptoms in participants with low and high serum 25-hydroxyvitamin D (25(OH)D) levels and to examine whether supplementation with vitamin D3 would improve symptoms in those with low serum 25(OH)D levels.MethodParticipants with low 25(OH)D levels were randomised to either placebo or 40 000 IU vitamin D3 per week for 6 months. Individuals with high serum 25(OH)D levels were used as nested controls. Depressive symptoms were evaluated with the Beck Depression Inventory, Hospital Anxiety and Depression Scale, Seasonal Pattern Assessment Scale and Montgomery-Åsberg Depression Rating Scale. The study was registered at ClinicalTrials.gov (NCT00960232).ResultsParticipants with low 25(OH)D levels (n=230) at baseline were more depressed (P<0.05) than participants with high 25(OH)D levels (n=114). In the intervention study no significant effect of high-dose vitamin D was found on depressive symptom scores when compared with placebo.ConclusionsLow levels of serum 25(OH)D are associated with depressive symptoms, but no effect was found with vitamin D supplementation.

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Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults

Acta Endocrinologica ◽

10.1530/eje-18-0187 ◽

2018 ◽

Vol 179 (4) ◽

pp. 239-249 ◽

Cited By ~ 3

Author(s):

Liset E M Elstgeest ◽

Elisa J de Koning ◽

Ingeborg A Brouwer ◽

Natasja M van Schoor ◽

Brenda W J H Penninx ◽

...

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Depression Scale ◽

Population Based ◽

Epidemiologic Studies ◽

Time Points ◽

Hydroxyvitamin D ◽

Parallel Change ◽

Lower Baseline ◽

25 Hydroxyvitamin D

Objective Previous prospective studies on the association between vitamin D status and depression used a single 25-hydroxyvitamin D (25(OH)D) measurement. We investigated the association between change in serum 25(OH)D and parallel change in depressive symptoms over time in Dutch older adults. Design A population-based, prospective study in two cohorts of older men and women from the Longitudinal Aging Study Amsterdam. Methods Serum 25(OH)D concentrations were determined at two time points: in 1995/1996 and 13 years later in the older cohort (aged 65–88y, n = 173) and in 2002/2003 and 6 years later in the younger cohort (55–65 years, n = 450). At these time points, depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale (CES-D). Associations were tested by multiple linear regression analyses. Results During follow-up, serum 25(OH)D concentrations increased in 32.4% of the older cohort and in 69.8% of the younger cohort. In the older cohort, change in 25(OH)D was not associated with change in CES-D score. In the younger cohort, no associations were observed in participants with higher baseline 25(OH)D concentrations (>58.6 nmol/L), but in those with lower baseline 25(OH)D concentrations, an increase in 25(OH)D was associated with a decrease in CES-D score (adjusted B per 10 nmol/L 25(OH)D increase: −0.62 (95% CI: −1.17, −0.07)). Conclusions Our study suggests that over 6 years, an increase in serum 25(OH)D is associated with a small decrease in depressive symptoms in young older adults with lower baseline 25(OH)D. Well-designed intervention trials are required to determine causality.

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Analysis of Suicidal Behavior and Chronicity of Depressive Symptoms in the Presence of Hypovitaminosis D

Current Psychiatry Research and Reviews ◽

10.2174/2666082217666211122155401 ◽

2021 ◽

Vol 17 ◽

Author(s):

Catarina Magalhães Porto ◽

Natalia Santos Barbosa da Silva ◽

Cecília Magalhães Porto Lira ◽

Rayana Porpino Magalhães ◽

José Luiz Oliveira Magalhães ◽

...

Keyword(s):

Vitamin D ◽

Depressive Symptoms ◽

Suicidal Ideation ◽

Depressive Disorder ◽

Suicidal Behavior ◽

Suicide Risk ◽

Hypovitaminosis D ◽

Serum Levels ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

Background: One of the risk factors for suicide includes the presence of depressive disorder and symptoms, which may be related to the reduction of 25-hydroxyvitamin D serum levels. In this scenario, evidence shows vitamin D deficiency as an important aspect, directly related to depressive disorder chronicity. Objective: To assess the association between Vitamin D serum levels and the intensity of depressive symptoms and suicidal behavior in a clinical sample of depressed patients. Methods: A cross-sectional study with 146 patients aged between 18 and 59, seen in two psychiatry ambulatories. Data collection involved measurement of serum 25-hydroxyvitamin D levels and assessment of the intensity of depressive symptoms and suicide risk. Results: In the sample, 35% presented low Vitamin D serum levels and, in these individuals, the incidence of family history of Depressive Disorder (95.2%) and chronicity of severe depressive symptoms (47.8%) was higher. As to suicidal behavior, both groups presented high active suicide risk, with higher rates in the group with hypovitaminosis D. Only suicidal ideation was linked to lower Vitamin D levels (67.4% p= 0,005). Conclusion: In this study, hypovitaminosis D was associated with negative mental health outcomes, such as more severe chronicity of depressive symptoms and suicidal behavior, characterized by active suicidal ideation.

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Do the GDS and the GDS-15 adequately capture the range of depressive symptoms among older residents in congregate housing?

International Psychogeriatrics ◽

10.1017/s1041610210002425 ◽

2011 ◽

Vol 23 (6) ◽

pp. 950-960 ◽

Cited By ~ 1

Author(s):

Kathryn Betts Adams

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Oldest Old ◽

Geriatric Depression Scale ◽

Depression Scale ◽

Diagnostic Interview ◽

Geriatric Depression ◽

Roc Curve Analysis ◽

Cut Points ◽

Hit Rates

ABSTRACTBackground: In light of inconsistencies in cut points for identifying non-major depression, this study examined the classification efficiency of the Geriatric Depression Scale (GDS and GDS-15) total scores and individual items, and four additional depressive symptoms for identification of subthreshold, minor, or criterion depression among 166 vulnerable residents of congregate housing.Methods: Depression (combined categories of major depressive episode, minor, or subthreshold depression) was determined by the Mini-International Neuropsychiatric Interview (MINI) diagnostic interview depression module administered by telephone to 166 older residents of congregate housing facilities who also completed the 30-item GDS and four other yes/no potential indicators of geriatric depression. Classification agreement and ROC curve analysis for the full and 15-item GDS scale scores were calculated. Individual item hit rates for MINI criterion were calculated for GDS items and four new items.Results: GDS and GDS-15 at standard cut points had 70–75% agreement with MINI. Best sensitivity and specificity were obtained at lower than standard cut points. Some GDS Withdrawal, Apathy, lack of Vigor (WAV) and cognitive items obtained very low hit rates. New items “I just don't feel like myself” and “I feel I am a burden to others” better discriminated MINI depression than most GDS items and had good item-to-total correlations with the GDS.Conclusions: Diagnostic criteria and GDS screen had partial agreement. Some GDS items did not adequately represent depression among functionally impaired or oldest old older adults. Feeling one is a burden and the sense of feeling “different” from usual may be useful indicators of depression among vulnerable older adults.

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Plasma 25-hydroxyvitamin D level and the risk of frailty among Chinese community-based oldest-old: evidence from the CLHLS study

10.21203/rs.2.15995/v3 ◽

2020 ◽

Author(s):

Qi Xiao ◽

Meiliyang Wu ◽

Jinrui Cui ◽

Mengmei Yuan ◽

Ye Chen ◽

...

Keyword(s):

Vitamin D ◽

Oldest Old ◽

Osteoporotic Fractures ◽

Threshold Effect ◽

Spline Smoothing ◽

Chinese Community ◽

Community Based ◽

Effect Analysis ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

Abstract Background: Vitamin D deficiency has been linked to the risk of frailty. However, there are limited methods for evaluations of the potential association of vitamin D with frailty in a longevous (80+) population. The aim of this study was to examine the association between plasma 25-hydroxyvitamin D [25(OH)D] levels and the risk of frailty among the Chinese community based oldest-old. Methods: Secondary analysis of data compiled in the 2011 wave of the Chinese Longitudinal Healthy Longevity Survey (n=1324) was performed. Frailty was assessed by the Study of Osteoporotic Fractures (SOF) index. Multivariate logistic regression and spline smoothing with threshold effect analysis were performed to investigate the association between 25(OH)D level and the risk of frailty after adjusting for socio-demographic variables, health characteristics and confounding biomarkers. Results: The mean age was 92.89 ± 7.92 years, and 844 (63.7%) participants were women. In all, data from 426 (33.2%, 95% confidence interval, CI: 29.66-34.69) frail participants were recorded. After adjustment for confounding covariates, the level of 25(OH)D was significantly related to frailty. By spline smoothing with threshold effect analysis, a monotonically negative association between 25(OH)D and frailty was identified. Subgroup analyses revealed that the association did not differ by sex or age. Conclusions: The 25(OH)D level was inversely associated with the risk of frailty among the Chinese community-based oldest-old.

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Serum 25-hydroxyvitamin D concentrations of free-living subjects consuming olestra

American Journal of Clinical Nutrition ◽

10.1093/ajcn/53.5.1281 ◽

1991 ◽

Vol 53 (5) ◽

pp. 1281-1287 ◽

Cited By ~ 33

Author(s):

D Y Jones ◽

K W Miller ◽

B P Koonsvitsky ◽

M L Ebert ◽

P Y T Lin ◽

...

Keyword(s):

Free Living ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Serum 25-Hydroxyvitamin D and Depressive Symptoms in Older Women and Men

Obstetrical & Gynecological Survey ◽

10.1097/ogx.0b013e3182022107 ◽

2010 ◽

Vol 65 (11) ◽

pp. 706-708

Author(s):

Yuri Milaneschi ◽

Michelle Shardell ◽

Anna Maria Corsi ◽

Rosamaria Vazzana ◽

Stefania Bandinelli ◽

...

Keyword(s):

Depressive Symptoms ◽

Older Women ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Is serum 25-hydroxyvitamin D associated with depressive symptoms and suicidal ideation in Korean adults?

The International Journal of Psychiatry in Medicine ◽

10.1177/0091217415621042 ◽

2015 ◽

Vol 51 (1) ◽

pp. 31-46 ◽

Cited By ~ 8

Author(s):

Jong-Il Park ◽

Jong-Chul Yang ◽

Tae Won Park ◽

Sang-Keun Chung

Keyword(s):

Depressive Symptoms ◽

Suicidal Ideation ◽

Hydroxyvitamin D ◽

Korean Adults ◽

25 Hydroxyvitamin D

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Relationship between dual task walking, cognition, and depression in oldest old people

International Psychogeriatrics ◽

10.1017/s1041610215000915 ◽

2015 ◽

Vol 28 (1) ◽

pp. 31-38 ◽

Cited By ~ 9

Author(s):

Juliana Hotta Ansai ◽

Thais Rabiatti Aurichio ◽

José Rubens Rebelatto

Keyword(s):

Dual Task ◽

Cognitive Task ◽

Oldest Old ◽

Depression Scale ◽

Community Dwelling ◽

Cognitive Tests ◽

Cognitive Screening ◽

Old People ◽

Timed Up And Go ◽

Cross Sectional

ABSTRACTBackground:The purpose of the study was to investigate the relationship between dual task walking, cognition, and depression in oldest old people living in the community.Methods:We conducted an observational cross-sectional study at Federal University of São Carlos (Brazil). We assessed 67 community-dwelling older adults aged 80 years and over, who were able to walk alone and did not present with a risk of dementia (assessed by Mini-Mental State Examination, MMSE). The assessment consisted of anamnesis, dual task using the Timed Up and Go test associated with a motor task (TUGT-motor) and a cognitive task (TUGT-cognitive); cognitive measures using MMSE, Montreal Cognitive Assessment (MoCA), Clock Drawing test (CDT) and verbal fluency, and depressive measures by the Geriatric Depression Scale (GDS).Results:There was a correlation with higher magnitude between cognitive tests and TUGT-cognitive, compared to TUGT-motor. For TUGT-motor, the highest correlations with cognitive tests were found between time and MMSE, MoCA (total score), and MoCA visuospatial/executive domain. For TUGT-cognitive, the highest correlations with cognitive tests were between number of steps and MMSE and between time and MMSE. GDS showed a significant weak correlation with number of steps taken in TUGT-motor, wrong words, and correct/time of TUGT-cognitive.Conclusions:Dual task performances are associated with cognition in oldest old. Furthermore, dual task tests have less influence of educational level, are functional, fast, and easily applicable in clinical practice. Future studies are needed to confirm if dual task test is useful for cognitive screening in oldest old.

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