scholarly journals The Dynamics of Subcutaneous Tissue Response to Microorganisms Associated with the Extract of Araçá (Psidium cattleianum): An Edemogenic and Microscopic Analysis

2017 ◽  
Vol 20 (2) ◽  
pp. 93 ◽  
Author(s):  
Alessandra Cury Machado ◽  
Denise Belucio Ruviere ◽  
Renata Zoccal Novais ◽  
Carlos Roberto Emerenciano Bueno ◽  
Elerson Gaetti Jardim Jr ◽  
...  
Keyword(s):  
Subcutaneous Tissue ◽  
Tissue Response ◽  
Male Rats ◽  
Saline Control ◽  
Control Group ◽  
Dorsal Region ◽  
Hydroalcoholic Extract ◽  
Psidium Cattleianum ◽  
Significant Difference

<p><strong>Objective:</strong> To evaluate <em>in vivo </em>tissue reaction to the extract of araçá (<em>Psidium cattleianum</em>) associated with inactivated microorganisms. <strong>Material and Methods:</strong> A 0.1 mL suspension was used containing Porphyromonas gingivalis, Prevotella intermedia, <em>Fusobacterium nucleatum, Enterococcus faecalis, Peptostreptococcus micros</em>, and <em>Porphyromonas endodontalis,</em> which were inactivated by heat and mixed into a 1.0 mL saline (control group), an aqueous solution, or a hydroalcoholic extract of araçá. Eighteen male rats (<em>Rattus norvegiccus</em>) under general anesthesia received 0.2 mL of 1% intravenous Evans blue. Thirty minutes later, 0.1 mL of one of the associations was injected into the animals’ dorsal region. The animals were euthanized after 3 and 6 hours, and the materials obtained were placed in formamide for 72 hours then analyzed in a spectrophotometer (λ=630 hm). For the morphological analysis, 30 rats received polyethylene tubes implants with the extracts or the saline with the associations in the dorsal region and euthanized after 7 and 30 days to be analyzed according to an inflammation cell score. <strong>Results:</strong> No significant difference (p&gt;0.05) was observed in the edema among groups. The optical microscopy results showed a repair in the 30-day-period, which was higher when compared to the 7-day-period (p&lt;0.0001). Nevertheless, in the 7-day-period, the hydroalcoholic extract presented a significant response compared to the aqueous extract (p=0.05) and a trend for better results than the control group. <strong>Conclusion: </strong>The aqueous and hydroalcoholic araçá extracts associated with inactivated microorganisms showed similar responses to control, indicating no interference on the toxic effects of the bacterial components in tissue repair.</p><p><strong>Keywords</strong></p><p>Anaerobic bacteria; Edema; Inflammation; Plant extracts; <em>Psidium.</em></p>

scholarly journals Physical Properties, Antimicrobial Activity and In Vivo Tissue Response to Apexit Plus

Materials ◽  
2020 ◽  
Vol 13 (5) ◽  
pp. 1171 ◽  
Author(s):  
Roberto Alameda Hoshino ◽  
Guilherme Ferreira da Silva ◽  
Mateus Machado Delfino ◽  
Juliane Maria Guerreiro-Tanomaru ◽  
Mario Tanomaru-Filho ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Physical Properties ◽  
Enterococcus Faecalis ◽  
Subcutaneous Tissue ◽  
Setting Time ◽  
Tissue Reaction ◽  
Tissue Response ◽  
Control Group ◽  
Significant Difference

We investigated the physical properties, antimicrobial activity, and tissue reaction to Apexit Plus in comparison to Sealapex. Flow, radiopacity, setting time, and solubility were evaluated in each material. The antimicrobial activity against Enterococcus faecalis was performed. Polyethylene tubes containing Apexit Plus or Sealapex, and without material (control group) were implanted into the subcutaneous tissue of rats. At 7, 15, 30, and 60 days of implantation, the specimens were paraffin-embedded and the number of inflammatory cells (ICs) and the amount of birefringent collagen (BC) were quantified. The von Kossa reaction followed by immunohistochemistry for detection of alkaline phosphatase (ALP) was also performed. Statistical analysis was performed with ANOVA and Tukey test (p ≤ 0.05). The flow value of Apexit Plus was greater than Sealapex, whereas the radiopacity (3.44 mm Al) was lower than Sealapex (6.82 mm Al). Apexit Plus showed lower solubility and shorter initial and final setting (p < 0.0001), whereas the antimicrobial activity was significantly greater than Sealapex. Although the number of ICs was higher in Apexit Plus (p = 0.0009) at 7 days, no significant difference was detected between Apexit Plus and Sealapex at 15, 30, and 60 days. All groups showed higher values for BC in the capsules over time. ALP-immunolabelled cells were observed, mainly around von Kossa-positive structures, either in the capsules of Apexit Plus or Sealapex. Therefore, our results revealed that Apexit Plus exhibited a greater effectiveness against Enterococcus faecalis and better physical properties than Sealapex, except for the radiopacity. In vivo findings indicate that Apexit Plus is biocompatible and presents potential bioactivity in the subcutaneous tissue.

scholarly journals Hepatoprotective Effect of Melatonin in Toxic Liver Injury in Rats

Medicina ◽  
2019 ◽  
Vol 55 (6) ◽  
pp. 304 ◽  
Author(s):  
Oleshchuk ◽  
Ivankiv ◽  
Falfushynska ◽  
Mudra ◽  
Lisnychuk
Keyword(s):  
Liver Injury ◽  
Hepatoprotective Effect ◽  
Male Rats ◽  
Saline Control ◽  
Control Group ◽  
Radical Scavenger ◽  
Thiobarbituric Acid Reactive Substance ◽  
Lipid Hydroperoxides ◽  
Significant Difference ◽  
Toxic Liver Injury

Background and objectives: toxic liver injury results in nitrooxidative stress. Melatonin is a potent free radical scavenger, an inducible nitric oxide synthase (iNOS) inhibitor and an activator of antioxidant enzymes. The aim of this study was to investigate the hepatoprotective effect of exogenous melatonin on animals with acute toxic hepatitis. Material and methods: 36 healthy Sprague-Dawley male rats were split into three equal groups and given carbon tetrachloride (CCl4), 2 g/kg (CCl4 group) or the same dose of CCl4 and melatonin, 10 mg/kg (CCl4/melatonin group) or saline (control group). The effect of melatonin on prooxidant and antioxidant system indexes, NO and NOS levels in serum and liver, data of mitochondrial chain functions and cytolysis in liver were evaluated in all three groups. Results: melatonin significantly decreased activities of AST, ALT, ceruloplasmine and thiobarbituric acid reactive substance (TBARS) in serum. Catalase activity was lowered in serum but not in the liver. Hepatic TBARS, lipid hydroperoxides and glutathione concentrations were decreased, while superoxide dismutase, mitochondrial cytochrome oxidase and succinate dehydrogenase activities increased. Melatonin inhibited synthesis of stable NO metabolites in serum: NO2-by 37.9%; NO3-by 29.2%. There was no significant difference in content NO2-in the liver, but concentration of NO3-increased by 32.6%. Melatonin significantly reduced iNOS concentrations both in serum (59.7%) and liver (57.8%) but did not affect endothelial isoform enzyme activities neither in serum, nor in liver. The histopathological liver lesions observed in the CCl4/melatonin group were less severe than those seen in the CCl4 group. Conclusions: we demonstrated an ameliorating effect of melatonin on prooxidants and antioxidants, NO-NOS systems balance, mitochondrial function and histopathological lesions in the liver in rats with CCl4-induced hepatitis.

scholarly journals Effects of Zataria multiflora Extract and Carvacrol on Doxorubicin-Induced Oxidative Stress in Rat Brain

2018 ◽  
Vol 24 (3) ◽  
pp. 187-192 ◽  
Author(s):  
Reza Mohebbati ◽  
Mohammad Jalili-Nik ◽  
Maryam Paseban ◽  
Mohammad Naser Shafei ◽  
Abolfazl Khajavirad Rad
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Antioxidant Enzyme ◽  
Antioxidant Defense System ◽  
Male Rats ◽  
Control Group ◽  
Hydroalcoholic Extract ◽  
Zataria Multiflora ◽  
Significant Difference ◽  
Thiol Content

Background: Due to the antioxidant effects of Zataria multiflora (ZM) and Carvacrol (CAR) in various problems and the prominent role of the ROS in neurotoxicity induced by Doxorubicin (DOX), this study was designed to investigate the effects of ZM hydroalcoholic extract and CAR on DOX-induced oxidative stress in rat brain Methods: 24 male rats were randomly divided into four groups including: 1)Control ,2)Doxorubicin (DOX) that received DOX via a tail vein on the first day of the study, 3,4) ZM+DOX and CAR+DOX which received ZM and CAR by gavage for 28 consecutive days. Brain tissue removed for redox markers evaluation. Results: MDA level in the DOX group was significantly increased compared to control group while in treated groups did not show any significant changes in comparison with the DOX group. Also, Thiol content in DOX group showed significant reduction compared to control group. Thiol contents in treated groups showed no significant difference compared to DOX group. Catalase (CAT) activity, an antioxidant enzyme, in the DOX group were significantly decreased compared to control group and increased in treated rats in comparison with the DOX group. Activity of Superoxide dismutase (SOD), an antioxidant enzyme, in the DOX group was significantly reduced compared to control group and increased in treated rats in comparison with the DOX group. Conclusion: The present study showed that ZM hydroalcoholic extract and CAR could inhibit DOX induced oxidative stress of the brain mainly with effect on the enzymatic antioxidant defense system.

scholarly journals In vivo investigation of the tissue response to commercial Teflon insulin infusion sets in large swine for 14 days: the effect of angle of insertion on tissue histology and insulin spread within the subcutaneous tissue

2019 ◽  
Vol 7 (1) ◽  
pp. e000881 ◽  
Author(s):  
Gabriella Eisler ◽  
Jasmin R Kastner ◽  
Marc C Torjman ◽  
Abdurizzagh Khalf ◽  
David Diaz ◽  
...  
Keyword(s):  
Insulin Infusion ◽  
Subcutaneous Tissue ◽  
Pressure Profile ◽  
Tissue Response ◽  
Pressure Curve ◽  
Wear Time ◽  
Insertion Angle ◽  
Significant Difference ◽  
Design And Methods

ObjectiveThis study investigated the effects of the inflammatory tissue response (ITR) to an insulin infusion set (IIS) on insulin bolus spread over wear time, as well as the effect of cannula insertion angle on the ITR, bolus shape, and pump tubing pressure.Research design and methodsAngled or straight IISs were inserted every other day for 14 days into the subcutaneous tissue of 11 swine and insulin was delivered continuously. Prior to euthanasia, a 70 µL bolus of insulin/X-ray contrast agent was infused while recording a pressure profile (peak tubing pressure, pmax; area under the pressure curve, AUC), followed by the excision of the tissue-catheter specimen. Bolus surface area (SA) and volume (V) were assessed via micro-CT. Tissue was stained to analyze total area of inflammation (TAI) and inflammatory layer thickness (ILT) surrounding the cannula.ResultsA bolus delivered through an angled IIS had a larger mean SA than a bolus delivered through a straight cannula (314.0±84.2 mm2 vs 229.0±99.7 mm2, p<0.001) and a larger volume (198.7±66.9 mm3 vs 145.0±65.9 mm3, p=0.001). Both decreased significantly over wear time, independent of angle. There was a significant difference in TAI (angled, 9.1±4.0 mm2 vs straight, 14.3±8.6 mm2, p<0.001) and ILT (angled, 0.7±0.4 vs straight, 1.2±0.7 mm, p<0.001). pmax (p=0.005) and AUC (p=0.014) were lower using angled IIS. As ILT increased, pmax increased, while SA and V decreased.ConclusionsThe progression of the ITR directly affected bolus shape and tubing pressure. Although straight insertion is clinically preferred, our data suggest that an angled IIS elicits lower grades of ITR and delivers a bolus with lower tubing pressure and greater SA and V. The subcutaneous environment plays a crucial role in IIS longevity, and the insertion angle needs to be considered in future IIS designs and clinical trials.

scholarly journals Exploring with [18F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy

2020 ◽  
Vol 22 (5) ◽  
pp. 1197-1207 ◽  
Author(s):  
Maria Elisa Serrano ◽  
Mohamed Ali Bahri ◽  
Guillaume Becker ◽  
Alain Seret ◽  
Charlotte Germonpré ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Kainic Acid ◽  
Temporal Lobe ◽  
Rat Model ◽  
Chronic Phase ◽  
Male Rats ◽  
Saline Control ◽  
Control Group ◽  
Significant Group

Abstract Purpose The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. Procedures Twenty Sprague Dawley male rats were administered with multiple systemic doses of saline (control group, n = 5) or kainic acid (5 mg/kg/injection, epileptic group, n = 15). Both groups were scanned at the four phases of TLE (early, latent, transition, and chronic phase) with the [18F]UCB-H PET radiotracer and T2-structural magnetic resonance imaging. At the end of the scans (3 months post-status epilepticus), rats were monitored for 7 days with electroencephalography for the detection of spontaneous electrographic seizures. Finally, the immunofluorescence staining for SV2A expression was performed. Results Control rats presented a significant increase in [18F]UCB-H binding at the last two scans, compared with the first ones (p < 0.001). This increase existed but was lower in epileptic animals, producing significant group differences in all the phases of the disease (p < 0.028). Furthermore, the quantification of the SV2A expression in vivo with the [18F]UCB-H radiotracer or ex vivo with immunofluorescence led to equivalent results, with a positive correlation between both. Conclusions Even if further studies in humans are required, the ability to detect a progressive decrease in SV2A expression during the development of temporal lobe epilepsy supports the use of [18F]UCB-H as a useful tool to differentiate, in vivo, between healthy and epileptic animals along with the development of the epileptic disease.

scholarly journals Effect of Hydroalcoholic Extract of Hyssop on Acute Pain in Male Rats Using Tail Flick Test

2021 ◽  
Vol 2 (1) ◽  
pp. 15-19
Author(s):  
Amir Larki-Harchegani ◽  
Abbas Ehsanikia ◽  
Sara Ataei ◽  
Fakhriosadat Hosseini ◽  
Rasool Haddadi
Keyword(s):  
Analgesic Effect ◽  
Positive Control ◽  
Male Rats ◽  
Saline Control ◽  
Control Group ◽  
Tail Flick ◽  
Tail Flick Test ◽  
Hydroalcoholic Extract ◽  
Analgesic Effects ◽  
Iranian Traditional Medicine

Background: Iranian traditional medicine uses hyssop (Hyssopus officinalis) as an effective medicinal plant to reduce pain and inflammation in different diseases. Although the anti-inflammatory effect of this plant is proved, there is no study into its analgesic effects. Thus, this study aimed to investigate the analgesic effect of the hydroalcoholic extract from hyssop flowers and upper branches. Methods: This experimental study was conducted on 66 male rats that were divided into several groups including a saline control group, the groups of different doses of hyssop extract, morphine positive control group, the groups of hyssop extract plus morphine, and the most effective dose of the hyssop extract plus naloxone. All injections were administered intraperitoneally, and the pain was measured through the tail flick test. Results: Based on the results, 600 mg/kg was the most effective analgesic hyssop extract dose, and the most analgesic effect was observed at 45 minutes after administration. In addition, the administration of the most effective extract dose (600 mg/kg) plus morphine significantly improved the analgesic effects of morphine (P<0.001). Finally, the administration of naloxone plus the most effective extract dose (600 mg/kg) significantly reduced the analgesic effect of the extract (P<0.05). Conclusion: Overall, the hydroalcoholic extract of hyssop has analgesic effects that are probably applied through opioid receptors.

scholarly journals UJI ANTI INFLAMASI SECARA TOPIKAL EKSTRAK ETANOL UMBI SARANG SEMUT (Myrmecodia tuberosa Jack) PADA MENCIT PUTIH JANTAN

2017 ◽  
Vol 5 (1) ◽  
pp. 103-112
Author(s):  
Muhammad Islamoyo ◽  
Yufri Aldi ◽  
Surya Nelis
Keyword(s):  
Ethanol Extract ◽  
Negative Control ◽  
Fluid Volume ◽  
Tissue Response ◽  
Male Rats ◽  
Control Group ◽  
Treatment Groups ◽  
Edema Fluid ◽  
Significant Difference ◽  
Anti Inflammation

Inflammation  is a tissue response  towards  damaging  physical  or chemical  stimulations.  One local sign of inflammation  is  edema  (tumor).  Usage  of  natural  herbal  medicine  has  become  an  alternative  way  to  prevent inflammation.  The extract of umbi sarang semut (Myrmecodia  tuberosa Jack) has anti-inflammation,  anti-bacterial and  antioxidant  properties.  This  study  is  to  determine  the  anti-inflammation  effect  of  the  topical  application  of Myrmecodia  tuberosa Jack ethanol extract. This study used 28 white male rats previously  induced with carragenin 2%  b/v  0,5ml  and  divided  into  4  treatment  groups.  Groups  1,2  dan  3  were  given  the  ethanol  extract  with  a concentration  of 0,5 %; 1%; 2% respectively  after induction and on 24, 48 and 72 hours after the first application. Group 4 was the untreated control group. Each treatment group were extracted for their inflammation  exudate fluid from their backs using a 1 ml syringe. Edema fluid volume was measured. The results showed a decrease of edema fluid volume on all treatment groups.   Statistical data analysis showed a significant difference between group 2 and the negative  control;  also between  group  3 and the negative  control.  In conclusion,  the topical  ethanol  extract  of Myrmecodia tuberosa Jack can reduce inflammation reactions. Keywords: Myrmecodia  tuberosa  Jack, anti-inflammation,  topical, edema fluid volume

scholarly journals Mixing failures of endodontic sealers: an in vivo biocompatibility study

2017 ◽  
Vol 20 (4) ◽  
pp. 85 ◽  
Author(s):  
Carlos Roberto Emerenciano Bueno ◽  
Gustavo Arcos Lopes ◽  
Diego Valentim ◽  
Vanessa Abreu Sanches Marques ◽  
Ana Maria Veiga Vasques ◽  
...  
Keyword(s):  
Subcutaneous Tissue ◽  
Male Rats ◽  
Maxillary Incisor ◽  
Control Group ◽  
Materials Testing ◽  
Polyethylene Tube ◽  
Root Canal Filling ◽  
Ah Plus ◽  
Endodontic Sealers

<p><strong>Objective:</strong> Evaluate, <em>in vivo</em>,<em> </em>the influence of mixing failures on endodontic sealers. <strong>Material and methods:</strong> To alveolus analysis, 80 rats were divided into Sealapex<sup>®</sup> and AH Plus<sup>®</sup> groups. Within each group, the sealer was subjected to either partial (incomplete homogenization—simulating handling failures) or total mixing (complete homogenization) over two periods of 7 and 30 days (n = 20). The maxillary incisor was extracted and a polyethylene tube containing the sealer was inserted. To quantify edema, 40 male rats were divided into four groups (n = 10). The animals received 2% Evans Blue intravenously, and either AH Plus<sup>®</sup> or Sealapex<sup>®</sup> was injected subcutaneously. The rats were euthanized after 3 or 6 hours and analyzed in a spectrophotometer (630 ƞm). To analyze the subcutaneous tissue, 20 rats received polyethylene tube implants with the sealers in the dorsal area (n=10), then euthanized after either 7 or 30 days, and inflammation was evaluated according to an inflammatory cells score. <strong>Results</strong>: In the alveolar 7-day group, control group presented an inflammation score 1, while all other groups presented a score 2, except AH plus<sup>®</sup> total mix group (3). After 30 days, all groups presented a score 1. The edemogenic test showed less edema in Sealapex<sup>®</sup> groups (p &lt; 0.5). In subcutaneous 7-day period, all groups presented score 2. In 30 days, all groups revealed score 1, except AH Plus<sup>®</sup> partial mix group (2). <strong>Conclusion: </strong>Regarding mixing of the sealers, there were no significant differences among the groups.</p><p><strong>Keywords</strong></p><p>AH Plus; Inflammation; Materials testing; Root canal filling materials; Sealapex.</p>

scholarly journals Biocompatibility, Biomineralization, and Maturation of Collagen by RTR®, Bioglass and DM Bone® Materials

2020 ◽  
Vol 31 (5) ◽  
pp. 477-484
Author(s):  
Francine Benetti ◽  
Carlos Roberto Emerenciano Bueno ◽  
Alexandre Henrique dos Reis-Prado ◽  
Marina Trevelin Souza ◽  
Juliana Goto ◽  
...  
Keyword(s):  
Collagen Fiber ◽  
Subcutaneous Tissue ◽  
Polarized Light ◽  
Collagen Fibers ◽  
Control Group ◽  
Tissue Replacement ◽  
Parametric Data ◽  
Significant Difference ◽  
Male Wistar Rats

Abstract This study evaluated the biocompatibility, biomineralization, and collagen fiber maturation induced by Resorbable Tissue Replacement (RTR®; β-tricalcium phosphate [TCP]), Bioglass (BIOG; bioactive glass), and DM Bone® (DMB; hydroxyapatite and β-TCP) in vivo. Sixty-four polyethylene tubes with or without (control group; CG) materials (n=8/group/period) were randomly implanted in the subcutaneous tissue of 16 male Wistar rats (four per rat), weighting 250 to 280 g. The rats were killed after 7 and 30 days (n=8), and the specimens were removed for analysis of inflammation using hematoxylin-eosin; biomineralization assay using von Kossa (VK) staining and polarized light (PL); and collagen fiber maturation using picrosirius red (PSR). Nonparametric data were statistically analyzed by Kruskal-Wallis and Dunn tests, and parametric data by one-way ANOVA test (p<0.05). At 7 days, all groups induced moderate inflammation (p>0.05). At 30 days, there was mild inflammation in the BIOG and CG, and moderate inflammation in the RTR and DMB groups, with a significant difference between the CG and RTR (p<0.05). The fibrous capsule was thick at 7 days and predominantly thin at 30 days in all groups. All materials exhibited structures that stained positively for VK and PL. Immature collagen fibers were predominant at 7 and 30 days in all groups (p>0.05), although DMB exhibited more mature fibers than BIOG at 30 days (p<0.05). RTR, BIOG, and DMB were biocompatible, inducing inflammation that reduced over time and biomineralization in the subcutaneous tissue of rats. DMB exhibited more mature collagen fibers than BIOG over a longer period.

scholarly journals Biocompatibility nanostructured biomaterials based on calcium aluminate

2018 ◽  
Vol 146 (11-12) ◽  
pp. 634-640
Author(s):  
Ognjenka Jankovic ◽  
Smiljana Paras ◽  
Ljiljana Tadic-Latinovic ◽  
Renata Josipovic ◽  
Vukoman Jokanovic ◽  
...  
Keyword(s):  
Calcium Aluminate ◽  
Subcutaneous Tissue ◽  
Mineral Trioxide Aggregate ◽  
Nanostructured Material ◽  
Tissue Response ◽  
Fibrous Capsule ◽  
Control Group ◽  
Vascular Congestion ◽  
Significant Difference ◽  
The Difference

Introduction/Objective. The aim of this paper was to verify the biocompatibility of the newly synthesized nanostructured material based on calcium aluminate after implantation into the subcutaneous tissue of rats. Methods. The study included 18 rats aged 10?11 weeks, divided into two experimental groups (n = 9). In all animals, incision took place on the back and two pockets of 15 mm in depth were made, in which sterile polyethylene tubes with test materials [calcium aluminate cement (ALBO-CA), calcium silicate cement with the addition of hydroxyapatite (ALBO-CSHA), and mineral trioxide aggregate (MTA) for the control group) were implanted. Six rats of each group were sacrificed in three observational periods (seven, 15, 30 days). Pathohistological analysis included inflammation, bleeding, fibrous capsule, and tissue integrity around the implanted material. Results. After seven days of treatment, ALBO-CA and ALBO-CSHA showed better tissue response compared to MTA, with a statistically significant difference in inflammation intensity (p = 0.2781). The difference in vascular congestion and thickness of the fibrous capsule after implantation of ALBO-CA material compared to MTA was also statistically significant (p = 0.5567). At the end of the 30-day evaluation period, an identical inflammatory response of connective tissue at the site of implanting ALBO-CA, ALBO-CSHA, and MTA (score of 0.7) was recorded. The formation of thick or moderately thick fibrous capsule was found to be the thickest in ALBO-CA (grade 3.7). There were no statistically significant differences between the parameters analyzed after 30 days. Conclusion. Newly synthesized ALBO-CA showed a satisfactory tissue response and confirmed biocompatibility after implantation in subcutaneous tissue of rats.

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