Can Endoscopic Visualization Predict Histological Changes and Early Rejection of Small Intestine Grafts?

2008 ◽  
Vol 103 ◽  
pp. S115
Author(s):  
Ihab El Hajj ◽  
Tong Wu ◽  
Kareem Abu-Elmagd ◽  
Stephen Oʼ Keefe
Keyword(s):  
Small Intestine ◽  
Histological Changes

scholarly journals Adenocarcinomas of the Intestine Induced in Syrian Hamsters by N-methyl-N-nitrosourea

1969 ◽  
Vol 6 (5) ◽  
pp. 403-412
Author(s):  
Katherine McD. Herrold
Keyword(s):  
Small Intestine ◽  
Cytological Change ◽  
Histological Changes ◽  
Syrian Hamsters ◽  
Histological Types ◽  
Absorptive Cells ◽  
Cytological Features

The adenocarcinomas of the intestine induced in Syrian hamsters by N-methyl-N-nitrosourea (NMU) were of two histological types, superficial and intestinal. These types had distinctive characteristics regarding pattern, cytological features, secretion of mucus, and mode of growth. The histological changes induced by NMU in the mucosa of the small intestine differed from what has been described in enzootic intestinal adenocarcinoma and proliferative ileitis of Syrian hamsters. NMU produced alteration in the villous architecture and cytological change in the absorptive cells. There was marked shortening of the villi and reduced thickness of the mucosa. The villous absorptive cells were large and cuboidal with centrally placed nuclei.

Biochemical and histological changes in the small intestine of mice with dextran sulfate sodium colitis

2011 ◽  
Vol 226 (12) ◽  
pp. 3219-3224 ◽  
Author(s):  
Roger Yazbeck ◽  
Gordon S. Howarth ◽  
Ross N. Butler ◽  
Mark S. Geier ◽  
Catherine A. Abbott
Keyword(s):  
Small Intestine ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Histological Changes

scholarly journals Efficacy of oryzalin and associated histological changes in Cryptosporidium-infected neonatal rats

Parasitology ◽  
2002 ◽  
Vol 125 (2) ◽  
pp. 113-117 ◽  
Author(s):  
A. ARMSON ◽  
K. MENON ◽  
A. O'HARA ◽  
L. M. MACDONALD ◽  
C. M. READ ◽  
...  
Keyword(s):  
Small Intestine ◽  
Single Dose ◽  
Neonatal Rats ◽  
Intestinal Villus ◽  
Histological Changes ◽  
Distal Small Intestine ◽  
Maximum Inhibition

This paper reports the anti-cryptosporidial effects of, and concomitant amelioration of the histological changes in the gut of neonatal rats with intestinal cryptosporidiosis treated with the dinitroaniline, oryzalin. The ED50 was determined to be 7 mg/kg using twice daily doses administered for 3 consecutive days. A maximum inhibition of 85.5% was achieved at 25 mg/kg and this inhibition remained constant despite increasing the oryzalin dose to 200 mg/kg. Cryptosporidiosis significantly decreased the intestinal villus/crypt (VC) ratio by approximately 50% (duodenum = 2.3, jejunum = 2.5 and ileum = 1.7) when compared to uninfected untreated controls (duodenum = 4.3, jejunum = 5.9 and ileum = 4.5). Treatment with oryzalin doubled the VC ratio in the duodenum, jejunum and ileum following doses of 5 mg, 50 mg and 200 mg/kg respectively. Oryzalin concentrations in the small intestine contents and plasma were determined, using HPLC, at 0.5, 1 and 2 h after dosing. The much greater dose required to return VC ratios to normal in the ileum (200 mg/kg) compared to the duodenum (6.25 mg/kg) appeared to reflect the decreased concentration of the drug in the distal small intestine. Concentrations of oryzalin equivalent to the in vitro IC50 were maintained for 2 h in the first half of the small intestine following a single dose of 100 mg/kg.

Histological Changes in the Epithelium of the Small Intestine during Protein Absorption in the New-born Animal

Nature ◽  
1951 ◽  
Vol 168 (4263) ◽  
pp. 84-85 ◽  
Author(s):  
R. S. COMLINE ◽  
H. E. ROBERTS ◽  
D. A. TITCHEN
Keyword(s):  
Small Intestine ◽  
Histological Changes ◽  
Protein Absorption ◽  
New Born

scholarly journals Gambaran histologik usus halus pada hewan coba selama 24 jam postmortem

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Victori J. Theodore ◽  
Sunny Wangko ◽  
Sonny J.R. Kalangi
Keyword(s):  
Small Intestine ◽  
Observational Study ◽  
Histological Change ◽  
Time Intervals ◽  
Domestic Pig ◽  
Histological Changes

Abstract: Studies about histological changes in small intestine are still very limited. This study was aimed to obtain the histological changes of the small intestine in several time intervals during 24 hours postmortem. This was a descriptive observational study using domestic pig as model. Samples were obtained from the ileum section of the small intestine, taken at 0 hour, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, 12 hours, 14 hours, 16 hours, 18 hours, 20 hours, 22 hours, and 24 hours postmortem. The results showed that the earliest histological change was identified at 0 hours postmortem as congestion of the intestinal glands and formation of subepithelial cell spaces, followed by destruction of basal membranes of the glands at 3 hours postmortem, lysis of the glands at 16 hours postmortem. At 18-24 hours postmortem, almorst all intestinal glands could not be identified. Conclusion: The earliest histological change of small intestine was identified at 0 hours postmortem as congestion of the intestinal glands, followed by necrosis of the glands at 3 hours postmortem, and lysis of the glands at 16 hours postmortem.Keywords: small intestine, autolysis, histological changes, postmortem Abstrak: Studi mengenai perubahan gambaran histologik usus halus postmortem masih sangat terbatas. Penelitian ini bertujuan untuk mendapatkan gambaran histologik usus halus berdasarkan variasi waktu selama 24 jam postmortem. Jenis penelitian ialah deskriptif observasional dengan menggunakan babi domestik sebagai hewan coba. Sampel diambil dari bagian ileum usus halus pada interval waktu: 0 jam, 1 jam, 2 jam, 3 jam, 4 jam, 5 jam, 6 jam, 7 jam, 8 jam, 9 jam, 12 jam, 14 jam, 16 jam, 18 jam, 20 jam, 22 jam, dan 24 jam postmortem. Hasil penelitian ini memperlihatkan bahwa perubahan histologik usus halus babi mulai teridentifikasi pada 0 jam postmortem berupa kongesti kelenjar intestinal, diikuti oleh kerusakan struktur membran basalis kelenjar pada 3 jam postmortem, dan lisis sel-sel kelenjar pada 16 jam postmortem. Pada 18-24 jam postmortem, hampir seluruh kelenjar intestinal tidak dapat diidentifikasi. Simpulan: Perubahan histologik awal dari usus halus dapat diidentifikasi pada 0 jam postmortem berupa kongesti kelenjar intestinal, diikuti oleh kerusakan struktur membran basalis 3 jam postmortem, dan lisis kelenjar pada 16 jam postmortem. Kata kunci: usus halus, autolisis, postmortem, waktupostmortem, perubahan histologik postmortem

Ultrosonogarphic and histological charac-teristics of the digestive tract in dogs with parvoviral enteritis

2020 ◽  
Vol 1 ◽  
pp. 115-123
Author(s):  
R.A. Tsyganski ◽  
◽  
A.N. Kvochko ◽  
V.V. Mikhailenko ◽  
◽  
...  
Keyword(s):  
Small Intestine ◽  
Chain Reaction ◽  
Histological Changes ◽  
Mucous Layer ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Polymerase Chain ◽  
Guang Dong ◽  
Number Of Publications ◽  
Ultrasound Parameters

Since the clinical manifestation of enteri-tis of various etiologies has a similar picture, and parvovirus enteritis has a high mortality rate, early diagnosis of this disease is im-portant. A number of publications demon-strate changes in ultrasound parameters dur-ing inflammatory bowel diseases. The article is devoted to comparison of ultrasound and histological changes in the wall of the stom-ach and small intestine with parvovirus en-teritis in order to distinguish the most spe-cific ultrasound markers. Object of the study – 53 dogs of mixed breeds of both sexe with a confirmed diagnosis of parvovirus enteri-tis by polymerase chain reaction in real time from the age of 6 weeks to 7 months. Re-search were conducted at the Stavropol Vet-erinary Center named after Pirogov and Vet-erinary Center of the Stavropol State Agrari-an University, by the use of SIUI Apogee 1100 Omni scanner (Shantou Institute of Ultrasonic Instruments Co., Ltd., Guang-dong, China), according to the generally accepted method using a multi-frequency linear sensor with a frequency of 5-13 MHz in B-mode. The most characteristic ultrason- ic manifestations of canine parvovirus enteri-tis are hypotension and ectasia of the stom-ach and loops of the small intestine with the presence of anechogenic fluid content in their cavity; thickening of the surface layer of the mucosa in the form of a hyperechoic strip, a decrease in the ratio of the mucous layer to the entire wall thickness of the duo-denum and jejunum by more than 2 times and increased echogenicity of the mucous layer. This picture is a result of the partial necrosis and desquamation of villi, prolifera-tion of cell infiltrate in the mucous layer itself, consisting of lymphocytes, macro-phages, a small number of histiocytes and fibroblasts.

scholarly journals Characterization and Analysis of the Temporal and Spatial Dynamic of Several Enteritis Modeling Methodologies

2021 ◽  
Vol 12 ◽  
Author(s):  
Huangru Xu ◽  
Fangfang Cai ◽  
Ping Li ◽  
Xiaoyang Wang ◽  
Yingying Yao ◽  
...  
Keyword(s):  
Small Intestine ◽  
Complex Disease ◽  
Expression Profiles ◽  
Histological Changes ◽  
Acute Enteritis ◽  
Successful Establishment ◽  
Inflammatory Bowel ◽  
Temporal And Spatial ◽  
Conducting Research

Inflammatory bowel disease (IBD), such as Crohn’s disease and ulcerative colitis, is a complex disease involving genetic, immune, and microbiological factors. A variety of animal models of IBD have been developed to study the pathogenesis of human IBD, but there is no model that can fully represent the complexity of IBD. In this study, we established two acute enteritis models by oral 3% DSS or intraperitoneal injection of anti-CD3 antibody, and two chronic enteritis models by feeding 3 cycles of 1.5% DSS or 3 months of the high-fat diet, respectively, and then examined the clinical parameters, histological changes, and cytokine expression profiles after the successful establishment of the models. Our results indicated that in 3% DSS-induced acute enteritis, the colorectal injury was significantly higher than that of the small intestine, while in anti-CD3 antibody-induced acute enteritis, the small intestine injury was significantly higher than that of colorectal damage. Besides, in the 1.5% DSS-induced chronic enteritis, the damage was mainly concentrated in the colorectal, while the damage caused by long-term HFD-induced chronic enteritis was more focused on the small intestine. Therefore, our work provides a reference for selecting appropriate models when conducting research on factors related to the pathogenesis of IBD or evaluating the potential diagnosis and treatment possibilities of pharmaceuticals.

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