scholarly journals Characterization and Analysis of the Temporal and Spatial Dynamic of Several Enteritis Modeling Methodologies

2021 ◽  
Vol 12 ◽  
Author(s):  
Huangru Xu ◽  
Fangfang Cai ◽  
Ping Li ◽  
Xiaoyang Wang ◽  
Yingying Yao ◽  
...  
Keyword(s):  
Small Intestine ◽  
Complex Disease ◽  
Expression Profiles ◽  
Histological Changes ◽  
Acute Enteritis ◽  
Successful Establishment ◽  
Inflammatory Bowel ◽  
Temporal And Spatial ◽  
Conducting Research

Inflammatory bowel disease (IBD), such as Crohn’s disease and ulcerative colitis, is a complex disease involving genetic, immune, and microbiological factors. A variety of animal models of IBD have been developed to study the pathogenesis of human IBD, but there is no model that can fully represent the complexity of IBD. In this study, we established two acute enteritis models by oral 3% DSS or intraperitoneal injection of anti-CD3 antibody, and two chronic enteritis models by feeding 3 cycles of 1.5% DSS or 3 months of the high-fat diet, respectively, and then examined the clinical parameters, histological changes, and cytokine expression profiles after the successful establishment of the models. Our results indicated that in 3% DSS-induced acute enteritis, the colorectal injury was significantly higher than that of the small intestine, while in anti-CD3 antibody-induced acute enteritis, the small intestine injury was significantly higher than that of colorectal damage. Besides, in the 1.5% DSS-induced chronic enteritis, the damage was mainly concentrated in the colorectal, while the damage caused by long-term HFD-induced chronic enteritis was more focused on the small intestine. Therefore, our work provides a reference for selecting appropriate models when conducting research on factors related to the pathogenesis of IBD or evaluating the potential diagnosis and treatment possibilities of pharmaceuticals.

scholarly journals Ulcerative colitis indications and timing for surgery

2004 ◽  
Vol 51 (2) ◽  
pp. 123-126
Author(s):  
Goran Barisic ◽  
Zoran Krivokapic ◽  
V. Markovic ◽  
Djordjije Saranovic ◽  
Dragan Masulovic
Keyword(s):  
Ulcerative Colitis ◽  
Surgical Treatment ◽  
Complex Disease ◽  
Clinical Decision Making ◽  
Surgical Techniques ◽  
Clinical Decision ◽  
Optimal Timing ◽  
Inflammatory Bowel ◽  
Risk Of Cancer

Surgery continues to have a major role in the management of ulcerative colitis because it may save the patient?s life, eliminate the long-term risk of cancer, and most important, abolish the disease. Treatment of ulcerative colitis still remains the challenge despite growing knowledge about the disease, advances in medical treatment and surgical techniques. Indications and optimal timing for surgery are the mainstays of good outcome and are as important as the quality of medical therapy and surgery. Ulcerative colitis is a complex disease where medical and surgical treatment frequently overlap and clinical decision making should be in hands of well trained and experienced team consisting of surgeon, gastroenterologist, radiologist and pathologist. Recently developed drugs, with high potential in the treatment of severe attacks of ulcerative colitis brought some changes in therapy and indications for surgical treatment. Although as many as half of patients with inflammatory bowel disease require at least one surgical procedure to address complications derived from their disease, the decision in favor of a surgical approach and its timing is rarely an easy one.

Ultrosonogarphic and histological charac-teristics of the digestive tract in dogs with parvoviral enteritis

2020 ◽  
Vol 1 ◽  
pp. 115-123
Author(s):  
R.A. Tsyganski ◽  
◽  
A.N. Kvochko ◽  
V.V. Mikhailenko ◽  
◽  
...  
Keyword(s):  
Small Intestine ◽  
Chain Reaction ◽  
Histological Changes ◽  
Mucous Layer ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Polymerase Chain ◽  
Guang Dong ◽  
Number Of Publications ◽  
Ultrasound Parameters

Since the clinical manifestation of enteri-tis of various etiologies has a similar picture, and parvovirus enteritis has a high mortality rate, early diagnosis of this disease is im-portant. A number of publications demon-strate changes in ultrasound parameters dur-ing inflammatory bowel diseases. The article is devoted to comparison of ultrasound and histological changes in the wall of the stom-ach and small intestine with parvovirus en-teritis in order to distinguish the most spe-cific ultrasound markers. Object of the study – 53 dogs of mixed breeds of both sexe with a confirmed diagnosis of parvovirus enteri-tis by polymerase chain reaction in real time from the age of 6 weeks to 7 months. Re-search were conducted at the Stavropol Vet-erinary Center named after Pirogov and Vet-erinary Center of the Stavropol State Agrari-an University, by the use of SIUI Apogee 1100 Omni scanner (Shantou Institute of Ultrasonic Instruments Co., Ltd., Guang-dong, China), according to the generally accepted method using a multi-frequency linear sensor with a frequency of 5-13 MHz in B-mode. The most characteristic ultrason- ic manifestations of canine parvovirus enteri-tis are hypotension and ectasia of the stom-ach and loops of the small intestine with the presence of anechogenic fluid content in their cavity; thickening of the surface layer of the mucosa in the form of a hyperechoic strip, a decrease in the ratio of the mucous layer to the entire wall thickness of the duo-denum and jejunum by more than 2 times and increased echogenicity of the mucous layer. This picture is a result of the partial necrosis and desquamation of villi, prolifera-tion of cell infiltrate in the mucous layer itself, consisting of lymphocytes, macro-phages, a small number of histiocytes and fibroblasts.

scholarly journals CASE OF MULTIPLE ACUTE SMALL BOWEL PERFORATIONS IN A CHILD AGED 9 MONTHS OLD

2018 ◽  
Vol 22 (1) ◽  
pp. 52-54
Author(s):  
E. M. Ignatev ◽  
Artem M. Efremenkov ◽  
R. B. Trunova ◽  
N. I. Petrikova ◽  
N. A. Snitkin ◽  
...  
Keyword(s):  
Small Intestine ◽  
Surgical Treatment ◽  
Small Bowel ◽  
Clinical Observation ◽  
Total Duration ◽  
Unknown Etiology ◽  
Review Of The Literature ◽  
Acute Enteritis ◽  
Closure Of Ileostomy

The article presents the clinical observation of a child 9 months old with multiple perforations of the small intestine, which appeared against the background of acute enteritis of unknown etiology. Long-term surgical treatment was performed. At the first stage, a sanation laparotomy was performed with excision of jejuno- and ileostomy with the intubation of the small intestine. After the reversal phenomena of peritonitis, the closure of the jejunostomy with intubation of the small intestine was performed. The final stage was the closure of ileostomy. The total duration of the treatment is 2 months. A brief review of the literature devoted to multiple perforations of the small intestine in children with a description of the etiology, pathogenesis and treatment of this disease is given.

Novel Targets For Therapeutic Intervention in Inflammatory Bowel Disease. What is the Best Way to Assess the Safety Profile of a Drug?

2019 ◽  
Vol 25 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Clara Yzet ◽  
Stacy S. Tse ◽  
Maia Kayal ◽  
Robert Hirten ◽  
Jean-Frédéric Colombel
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Evaluation Process ◽  
Population Based ◽  
Stage Of Development ◽  
Remission Rates ◽  
Safety Parameters ◽  
Post Marketing ◽  
Inflammatory Bowel

The emergence of biologic therapies has revolutionized the management of inflammatory bowel disease (IBD) by halting disease progression, increasing remission rates and improving long-term clinical outcomes. Despite these well-described benefits, many patients are reluctant to commence therapy due to drug safety concerns. Adverse events can be detected at each stage of drug development and during the post-marketing period. In this article, we review how to best assess the safety parameters of new IBD medications, from the earliest stage of development to population-based registries, with a focus on the special populations often excluded from the evaluation process.

Corticosteroids in Inflammatory Bowel Disease patients: a practical guide for physicians.

2020 ◽  
Vol 15 ◽  
Author(s):  
Maria Carla Di Paolo ◽  
Cristiano Pagnini ◽  
Maria Giovanna Graziani
Keyword(s):  
Severe Disease ◽  
Unknown Etiology ◽  
History Of Disease ◽  
Bowel Diseases ◽  
Literature Evidence ◽  
History Of ◽  
Inflammatory Bowel ◽  
Favorable Safety ◽  
Pass Metabolism

: Inflammatory bowel diseases (IBDs) are chronic conditions characterized by unknown etiology and pathogenesis with deregulation of mucosal immunity. Among possible treatments, corticosteroids, already available from the 50’, are still the mainstay of treatment for moderate-severe disease. Nonetheless, the use of steroids is still largely empirical and solid evidence about therapeutic schemes are lacking. Moreover, due to the important side-effects and for the unsatisfactory impact on long-term natural history of disease, the steroid sparing has become an important therapeutic goal in IBD management. Besides conventional steroids, the so called “low bioavailability” steroids, which are steroids with high affinity for peripheral receptors and elevated hepatic first-pass metabolism, have demonstrated efficacy and more favorable safety profile. In the present review of the literature evidence of efficacy and safety of conventional and low bioavailability steroids in IBD patients are evaluated, and practical suggestions for a correct use in clinical practice are presented according to the current clinical guidelines.

Restoration of cylinder liners for automotive tractors engines in modern conditions

2020 ◽  
pp. 122-133
Author(s):  
Vyacheslav A. Denisov ◽  
Aleksandr Yu. Kostyukov ◽  
Roman N. Zadorozhniy
Keyword(s):  
Adhesion Strength ◽  
Electrode Materials ◽  
Research Purpose ◽  
Laboratory Studies ◽  
Term Operation ◽  
Operational Load ◽  
Operational Tests ◽  
Conducting Research ◽  
Cylinder Liners

One of the most promising technologies for restoring machine parts and cylinder liners is electric spark treatment as the most versatile technology that provides high-quality restoration of worn parts with wear up to 0.5 mm. (Research purpose) The research purpose is in developing a technology for restoring various cylinder liners by means of electric spark processing, selecting optimal modes and electrode materials that allow improving the quality of repair and increasing the post-repair life of the sleeve. (Materials and methods) It was taken into account when conducting research aimed at restoring the geometric parameters of the sleeve, that the coating must have sufficient adhesion strength to the surface of the sleeve under mechanical, thermal loads and long-term operation. Laboratory studies of the adhesion strength of electric spark coatings on the separation (adhesive) and on the cut, as well as tribotechnical studies of interfaces were conducted. Authors have found by analyzing the results of operational tests of restored and new cylinder liners the prospects for using electric spark treatment of worn parts, including diesel engine liners. (Results and discussion) It was shown by laboratory studies of the adhesion strength of electric spark coatings with a 0.2 mm thick BrMKc 3-1 electrode to the working surface of cylinder liners that their separation strength (adhesive) was 20-40 megapascals, and the shear strength (cohesive) was 50-80 megapascals. It was found that this provides the required functional strength of coatings with maximum operational load. The article presents the results of comprehensive research in graphs and tables. (Conclusions) The research conducted in the CCP "Nano-Center" of the FSAC VIM and operational tests in the 2nd bus fleet of Moscow confirmed the principal possibility of effectively restoring cast iron liners (blocks) using the technology of electric spark processing.

scholarly journals A long-term survivor of clear cell sarcoma-like tumor of the gastrointestinal tract with liver metastasis: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Takuhisa Okada ◽  
Yasumitsu Hirano ◽  
Shintaro Ishikawa ◽  
Hiroka Kondo ◽  
Toshimasa Ishii ◽  
...  
Keyword(s):  
Small Intestine ◽  
Lymph Node ◽  
Gastrointestinal Tract ◽  
Liver Metastasis ◽  
Surgical Resection ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma

Abstract Background Clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLTGT) is extremely rare. It is a mesenchymal neoplasm that usually forms in the small intestine of adolescents and young adults, is prone to local recurrence and metastasis, and has a high mortality rate. We report a patient with CCSLTGT with lymph node- and liver metastases, who continues to survive 6 years after initial surgical resection. Case presentation A 38-year-old woman presented with lightheadedness. Laboratory analysis revealed anemia (hemoglobin, 6.7 g/dL), and enhanced computed tomography (CT) demonstrated a mass in the small intestine, about 6 cm in diameter, with swelling of 2 regional lymph nodes. Double-balloon small intestine endoscopic examination revealed a tumor accompanied by an ulcer; the biopsy findings suggested a primary cancer of the small intestine. She was admitted, and we then performed a laparotomy for partial resection of the small intestine with lymph node dissection. Pathologic examination revealed CCSLTGT with regional lymph node metastases. About 3 years later, follow-up CT revealed a single liver metastasis. Consequently, she underwent a laparoscopic partial liver resection. Histopathologic examination confirmed that the liver metastasis was consistent with CCSLTGT. It has now been 3 years without a recurrence. Conclusion Repeated radical surgical resection with close follow-up may be the only way to achieve long-term survival in patients with CCLSTGT.

scholarly journals Long-Term Effectiveness of Oral Ferric Maltol vs Intravenous Ferric Carboxymaltose for the Treatment of Iron-Deficiency Anemia in Patients With Inflammatory Bowel Disease: A Randomized Controlled Noninferiority Trial

2021 ◽  
Author(s):  
Stefanie Howaldt ◽  
Eugeni Domènech ◽  
Nicholas Martinez ◽  
Carsten Schmidt ◽  
Bernd Bokemeyer
Keyword(s):  
Inflammatory Bowel Disease ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Primary Endpoint ◽  
Bowel Disease ◽  
Deficiency Anemia ◽  
Ferric Carboxymaltose ◽  
Inflammatory Bowel ◽  
Intent To Treat

Abstract Background Iron-deficiency anemia is common in inflammatory bowel disease, requiring oral or intravenous iron replacement therapy. Treatment with standard oral irons is limited by poor absorption and gastrointestinal toxicity. Ferric maltol is an oral iron designed for improved absorption and tolerability. Methods In this open-label, phase 3b trial (EudraCT 2015-002496-26 and NCT02680756), adults with nonseverely active inflammatory bowel disease and iron-deficiency anemia (hemoglobin, 8.0-11.0/12.0 g/dL [women/men]; ferritin, <30 ng/mL/<100 ng/mL with transferrin saturation <20%) were randomized to oral ferric maltol 30 mg twice daily or intravenous ferric carboxymaltose given according to each center’s standard practice. The primary endpoint was a hemoglobin responder rate (≥2 g/dL increase or normalization) at week 12, with a 20% noninferiority limit in the intent-to-treat and per-protocol populations. Results For the intent-to-treat (ferric maltol, n = 125/ferric carboxymaltose, n = 125) and per-protocol (n = 78/88) analyses, week 12 responder rates were 67% and 68%, respectively, for ferric maltol vs 84% and 85%, respectively, for ferric carboxymaltose. As the confidence intervals crossed the noninferiority margin, the primary endpoint was not met. Mean hemoglobin increases at weeks 12, 24, and 52 were 2.5 vs 3.0 g/dL, 2.9 vs 2.8 g/dL, and 2.7 vs 2.8 g/dL with ferric maltol vs ferric carboxymaltose. Treatment-emergent adverse events occurred in 59% and 36% of patients, respectively, and resulted in treatment discontinuation in 10% and 3% of patients, respectively. Conclusions Ferric maltol achieved clinically relevant increases in hemoglobin but did not show noninferiority vs ferric carboxymaltose at week 12. Both treatments had comparable long-term effectiveness for hemoglobin and ferritin over 52 weeks and were well tolerated.

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