A Case of Rapidly Progressing Gastric Hyperplastic Polyps to Adenomatous Polyps

2010 ◽  
Vol 105 ◽  
pp. S42-S43
Author(s):  
Supriya Tigadi ◽  
Micheal Tadros ◽  
Marcy Coach ◽  
John Birk ◽  
Joe Anderson
Keyword(s):  
Adenomatous Polyps ◽  
Hyperplastic Polyps

Methylation Status of miR-200b Promoter in Colorectal Polyp and Adenocarcinoma Tissues

2021 ◽  
Keyword(s):  
Methylation Status ◽  
Colorectal Polyp ◽  
Cross Sectional Study ◽  
Adenomatous Polyps ◽  
Aberrant Methylation ◽  
Hyperplastic Polyps ◽  
Molecular Feature ◽  
Cross Sectional ◽  
Normal Tissues ◽  
Specific Pcr

Background: Aberrant DNA methylation is a common molecular feature in colorectal cancer (CRC). Hypermethylation of miR-200b promoter, as an epigenetic factor, is involved in CRC tumorigenesis. The methylation status of miR-200b has been examined in CRC and adjacent normal tissues. Objectives: This study aimed to investigate miR-200b methylation in a series of colorectal adenomatous polyps, hyperplastic polyps, and adenocarcinoma tissues as precursors of CRC in the Iranian population for the first time. Materials and Methods: In this cross-sectional study (2017-2018), the methylation status of the miR-200b promoter was investigated using methylation-specific PCR in 131 fresh samples, including 30 adenocarcinoma specimens, 17 tumor-adjacent normal tissues, 78 primary lesions (55 adenomatous polyps and 23 hyperplastic polyps) and 6 healthy individuals. Results: Methylation of miR-200b was detected in adenocarcinoma samples (86%) and adenomatous polyps (85%); however, most of the hyperplastic polyps were unmethylated (69.6%). Neither control individuals nor tumor-adjacent normal tissues exhibited methylation in the miR-200b promoter. Aberrant methylation of miR-200b was significantly more common in tumor tissues and adenomatous polyps than in hyperplastic polyps (P<0.0001) and tumor-adjacent normal samples (P<0.0001). Conclusion: Methylation status of the miR-200b promoter was significantly altered during CRC development and may be identified as an attractive biomarker for the early detection of the disease.

scholarly journals Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies

2007 ◽  
Vol 44 (1) ◽  
pp. 14-17 ◽  
Author(s):  
Drausio Jefferson Morais ◽  
Ademar Yamanaka ◽  
José Murilo Robilotta Zeitune ◽  
Nelson Adami Andreollo
Keyword(s):  
Hyperplastic Polyp ◽  
Gastric Polyp ◽  
Adenomatous Polyps ◽  
Fundic Gland ◽  
Digestive Endoscopy ◽  
Gastric Lesions ◽  
Hyperplastic Polyps ◽  
Gastric Polyps ◽  
Fundic Gland Polyps ◽  
Upper Digestive Endoscopy

BACKGROUND: Gastric polyps are small gastric lesions, asymptomatic in most cases and are generally discovered inadvertently during upper digestive endoscopy. AIM: To retrospectively review the characteristics and frequency of gastric polyps, derived from the gastric mucosal epithelium in a large series of endoscopies. METHODS: One hundred and fifty three patients in a series of 26,000 consecutive upper digestive endoscopies done over a 5-year period, being that each patient had only one examination were analyzed and their histological and Yamada classification, as well as their location, size, histopathological findings and treatment studied. All patients had at least one gastric polyp, as confirmed by histological examination. RESULTS: The polyps were classified as hyperplastic, adenomatous and fundic gland polyps. The most of them measure less than 1 cm (hyperplastic polyps - 60,5%; adenomatous polyps - 73,6%; fundic gland polyps - 72%). Hyperplastic polyps were the most frequent and accounted for 71.3% of the cases, whereas fundic gland polyps accounted for 16.3% and adenomatous polyps for 12.4%. Hyperplastic and adenomatous polyps were primarily single, whereas fundic gland polyps tended to be multiple. A carcinoma was detected in one hyperplastic polyp (0.9%) and in two adenomatous polyps (10.5%). High grade dysplastic foci were found in four adenomatous polyps (21%). CONCLUSIONS: The digestive endoscopy is the safest and efficient method for the diagnosis of the gastric polyps, that in most of the patients does not show characteristic symptoms. The histopathological definition is not possible to the endoscopic glance being needed the pathologist's aid, once the conduct to be adopted will depend on the result of the biopsy.

scholarly journals Prevalence and Risk Factors of Asymptomatic Colorectal Polyps in Taiwan

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Fu-Wei Wang ◽  
Ping-I Hsu ◽  
Hung-Yi Chuang ◽  
Ming-Shium Tu ◽  
Guang-Yuan Mar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Alcohol Consumption ◽  
Body Mass ◽  
High Body Mass Index ◽  
Colorectal Polyps ◽  
Adenomatous Polyps ◽  
Hyperplastic Polyps ◽  
Current Smoking ◽  
Asymptomatic Subjects

Purpose. To investigate the prevalence and risk factors of hyperplastic and adenomatous colorectal polyps in a Taiwanese general population.Methods. From January 2009 to December 2011, consecutive asymptomatic subjects undergoing a routine health check-up were evaluated by colonoscopy. The colorectal polyps were assessed, and medical history and demographic data were obtained from each patient. Logistic regression analysis was conducted to search the independent risk factors for asymptomatic hyperplastic and adenomatous colorectal polyps.Results. Of the 1899 asymptomatic subjects, the prevalences of hyperplastic polyps and adenomatous polyps were 11.1% and 16.1%, respectively. Multivariate analysis revealed that high body mass index (BMI>25: OR, 1.32, 95% CI, 1.05–1.71) and current smoking (OR, 1.87, 95% CI, 1.42–2.71) were independent predictors for hyperplastic colorectal polyps. Age over 60 years old (OR, 3.49, 95% CI, 1.86–6.51), high body mass index (BMI>25: OR, 1.75, 95% CI, 1.21–2.71), heavy alcohol consumption (OR, 2.01, 95% CI, 1.02–3.99), and current smoking (OR, 1.31, 95% CI, 1.04–1.58) were independent predictors for adenomatous colorectal polyps.Conclusion. High BMI and smoking are common risk factors for both adenomatous and hyperplastic polyps. Old age and alcohol consumption are additional risk factors for the development of adenomatous polyps.

scholarly journals Spectrum of Colonic Polyps in a South Indian Urban Cohort

2017 ◽  
Vol 08 (03) ◽  
pp. 119-122
Author(s):  
Mayank Jain ◽  
Mukul Vij ◽  
M. Srinivas ◽  
Tom Michael ◽  
Jayanthi Venkataraman
Keyword(s):  
Colonic Polyps ◽  
Common Type ◽  
Left Colon ◽  
Adenomatous Polyps ◽  
Low Grade ◽  
Hyperplastic Polyps ◽  
Right Colon ◽  
South Indian ◽  
Low Grade Dysplasia ◽  
Almost All

ABSTRACT Background: The histological nature of polyps by site prevalence and size is unclear. Aim: To determine the prevalence of polyps in patients undergoing routine lower gastrointestinal (LGI) endoscopy and identify the histological types and their characteristics by age, location and size. Materials and Methods: For this retrospective study, patients undergoing ileocolonoscopy or sigmoidoscopy between 2014 and 2016 were included. Data on age, gender, test indication, site and size of polyps and histology type were collected. Results: Two hundred and ninety (12.7%) of 2303 patients who underwent LGI endoscopy had colonic polyps (n= 317; single in 272 patients). The median age was 61.1 years (range 5-99 years) and 223 (76.4%) were men. Polyps were rare <40 years age (7.3%). By site, the polyp frequency in right colon was 6.9%, 3.9% in left colon and 4.6% in the rectum. Two thirds of polyps (64%) were <1cm size. The 3 common polyp types were adenomatous (48.9%), hyperplastic (23.7%), and inflammatory (22.4%). Adenomatous polyps were common above 60 years (p <0.0002), located often in right (35.5%) or left colon (42.6%), large in size (54.2%) and showed low grade dysplasia (89.7%). Hyperplastic polyps were most common in the middle aged and in the rectum (p <0.00001). Inflammatory polyps were the most common type below 40 years age. Almost all hyperplastic and inflammatory polyps were <1cm size (93.3% and 87.3%). Conclusions: Adenomatous polyps were the commonest type; especially >60 years age. High grade dysplasia and carcinoma were rare (10.3%). While two-thirds of polyps <1cm size were inflammatory or hyperplastic, 86% of large polyps were adenomatous.

Identification of Colonic Dysplasia and Neoplasia by Diffuse Reflectance Spectroscopy and Pattern Recognition Techniques

1998 ◽  
Vol 52 (6) ◽  
pp. 833-839 ◽  
Author(s):  
Zhengfang Ge ◽  
Kevin T. Schomacker ◽  
Norman S. Nishioka
Keyword(s):  
Pattern Recognition ◽  
Diffuse Reflectance ◽  
Diffuse Reflectance Spectroscopy ◽  
Reflectance Spectroscopy ◽  
Adenomatous Polyps ◽  
Hyperplastic Polyps ◽  
Neoplastic Tissue ◽  
Tissue Samples ◽  
Linear Discriminant ◽  
The Mean

Diffuse reflectance spectroscopy of colonic tissue was employed to determine whether the spectra can be used to distinguish between neoplastic and non-neoplastic tissue in vivo. A total of 224 spectra were obtained in the wavelength range of 350–800 nm from 107 non-neoplastic tissue samples (84 normal mucosa, 23 hyperplastic polyps) and 53 neoplastic tissue samples (44 adenomatous polyps, 9 adenocarcinomas). Pattern recognition algorithms including multiple linear regression (MLR), linear discriminant analysis (LDA), and backpropagating neural network (BNN) were used to distinguish between the two tissue classes. The spectra were randomly separated into training and prediction sets for data analyses. The mean predictive accuracies of distinguishing neoplastic tissue from non-neoplastic tissue with MLR, LDA, and BNN were 85, 82, and 85%, respectively. In a similar fashion, the more clinically relevant problem of distinguishing adenomatous polyps from hyperplastic polyps was assessed. The mean predictive accuracies of distinguishing adenomatous polyps from hyperplastic polyps with MLR, LDA, and BNN were 85, 81, and 82%, respectively. The major spectral differences between tissues were attributed to changes in blood volume, oxygen saturation of hemoglobin, mean vessel depth within tissue, and tissue scattering.

scholarly journals Automated Measurement of Colorectal Polyp Height at CT Colonography: Hyperplastic Polyps Are Flatter Than Adenomatous Polyps

2009 ◽  
Vol 193 (5) ◽  
pp. 1305-1310 ◽  
Author(s):  
Ronald M. Summers ◽  
Jiamin Liu ◽  
Jianhua Yao ◽  
Linda Brown ◽  
J. Richard Choi ◽  
...  
Keyword(s):  
Ct Colonography ◽  
Colorectal Polyp ◽  
Adenomatous Polyps ◽  
Automated Measurement ◽  
Hyperplastic Polyps
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