Su1035 Hyperplastic Polyps Predict the Subsequent Occurrence of Adenomatous Polyps on Follow-up Colonoscopy

The finding of adenomatous polyps of the gallbladder is a rare occurrence and an unusual clinical problem.Among 2,145 patients who underwent cholecystectomy for gallbladder disease only 9 (0.4 per cent) presented with adenomatous polyps. There were 6 women and 3 men, aged 17 to 70 years. Preoperative ultrasonographic diagnosis was made in only 1 of 7 patients with gallstones, in contrast polypoid lesions within a gallbladder without stones were easily confirmed by both ultrasonography and oral cholecystography in the remaining 2 patients. All polyps were 1.0 cm or less in size and without histologic evidence of malignant change. The clinical significance of this rare condition is discussed, with particular reference to a possible role in development of gallbladder carcinoma. Surgical treatment should be advocated regardless of clinical manifestation when the polyp exceeds 1.0 cm in diameter or rapid growth of the lesion is seen on ultrasonographic follow-up examinations.

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Methylation Status of miR-200b Promoter in Colorectal Polyp and Adenocarcinoma Tissues

10.32592/ircmj.2021.23.4.80 ◽

2021 ◽

Keyword(s):

Methylation Status ◽

Colorectal Polyp ◽

Cross Sectional Study ◽

Adenomatous Polyps ◽

Aberrant Methylation ◽

Hyperplastic Polyps ◽

Molecular Feature ◽

Cross Sectional ◽

Normal Tissues ◽

Specific Pcr

Background: Aberrant DNA methylation is a common molecular feature in colorectal cancer (CRC). Hypermethylation of miR-200b promoter, as an epigenetic factor, is involved in CRC tumorigenesis. The methylation status of miR-200b has been examined in CRC and adjacent normal tissues. Objectives: This study aimed to investigate miR-200b methylation in a series of colorectal adenomatous polyps, hyperplastic polyps, and adenocarcinoma tissues as precursors of CRC in the Iranian population for the first time. Materials and Methods: In this cross-sectional study (2017-2018), the methylation status of the miR-200b promoter was investigated using methylation-specific PCR in 131 fresh samples, including 30 adenocarcinoma specimens, 17 tumor-adjacent normal tissues, 78 primary lesions (55 adenomatous polyps and 23 hyperplastic polyps) and 6 healthy individuals. Results: Methylation of miR-200b was detected in adenocarcinoma samples (86%) and adenomatous polyps (85%); however, most of the hyperplastic polyps were unmethylated (69.6%). Neither control individuals nor tumor-adjacent normal tissues exhibited methylation in the miR-200b promoter. Aberrant methylation of miR-200b was significantly more common in tumor tissues and adenomatous polyps than in hyperplastic polyps (P<0.0001) and tumor-adjacent normal samples (P<0.0001). Conclusion: Methylation status of the miR-200b promoter was significantly altered during CRC development and may be identified as an attractive biomarker for the early detection of the disease.

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DOES FINDING RECTOSIGMOID DIMINUTIVE HYPERPLASTIC POLYPS ON SCREENING SIGMOIDOSCOPY (S) WARRANT FOLLOW-UP COLONOSCOPY (C)?

Southern Medical Journal ◽

10.1097/00007611-199009001-00096 ◽

1990 ◽

Vol 83 (Supplement) ◽

pp. 2S-25

Author(s):

Greg Gilbert ◽

Scott Wilhoite ◽

Ron Jackson ◽

Eapen Thomas

Keyword(s):

Hyperplastic Polyps

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A Case of Hyperplastic Polyposis of the Colon with Adenocarcinomas in Hyperplastic Polyps after Long-Term Follow-Up

Endoscopy ◽

10.1055/s-2002-32008 ◽

2002 ◽

Vol 34 (6) ◽

pp. 499-502 ◽

Cited By ~ 20

Author(s):

N. Koide ◽

Y. Saito ◽

T. Fujii ◽

H. Kondo ◽

D. Saito ◽

...

Keyword(s):

Hyperplastic Polyps ◽

Hyperplastic Polyposis ◽

Long Term Follow Up

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Increased incidence of colorectal adenomas in follow-up evaluation of patients with newly diagnosed hyperplastic polyps

Surgical Endoscopy ◽

10.1007/s004640000389 ◽

2001 ◽

Vol 15 (7) ◽

pp. 646-648 ◽

Cited By ~ 18

Author(s):

E.H. Huang ◽

R.L. Whelan ◽

N.R. Gleason ◽

J.S. Maeda ◽

M.B. Terry ◽

...

Keyword(s):

Colorectal Adenomas ◽

Newly Diagnosed ◽

Hyperplastic Polyps

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A prospective study of faecal immunochemical testing following polypectomy in a colorectal cancer screening population

Frontline Gastroenterology ◽

10.1136/flgastro-2017-100869 ◽

2017 ◽

Vol 9 (4) ◽

pp. 295-299 ◽

Cited By ~ 2

Author(s):

David J Gibson ◽

Blathnaid Nolan ◽

Joanna Rea ◽

Maire Buckley ◽

Gareth Horgan ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Screening ◽

Colorectal Cancer Screening ◽

Screening Programme ◽

Clinical Findings ◽

Adenomatous Polyps ◽

Screening Colonoscopy ◽

Cancer Screening Programme ◽

Advanced Adenomas

Introduction52% of faecal immunohistochemistry test (FIT)-positive clients in the Irish National Colorectal Cancer Screening Programme (BowelScreen) have adenomatous polyps identified at colonoscopy in round 1. Although it is known that advanced adenomas and cancers cause an elevated FIT, it is not known if small (<5 mm) adenomas cause a positive FIT.AimsDetermine if removal of small polyps in an FIT-based colorectal cancer (CRC) screening programme is associated with a negative FIT on follow-up.MethodsA single-centre prospective observational study of consecutive participants attending for first round screening colonoscopy who had a positive FIT (>45 µg Hb/g) as part of the Irish Colorectal Cancer Screening Programme. Subjects were consented at the time of colonoscopy and were sent a repeat FIT 4–6 weeks later. Precolonoscopy and postcolonoscopy FITs were compared and correlated with clinical findings and endoscopic intervention.Results112 consecutive first round participants were recruited. Eight (7%) had cancer, 75 (67%) adenomatous polyps, 17 (15%) a normal colonoscopy and 12 (11%) other pathology. There was a clear difference in median FIT levels between the four groups (P=0.006). Advanced pathology (tumour or adenomatous polyp >1 cm) was associated with higher FIT than non-advanced pathology (median FIT 346 vs 89 P=0.0003). 83% (86/104) of subjects completed a follow-up FIT. Follow-up FIT remained positive in 20% (17/86). Polypectomy was associated with a reduction in FIT from a median of 100 to 5 µg Hb/g (P<0.0001). Removal of polyps >5 mm was the only factor independently associated with a negative follow-up FIT on multivariate analysis (OR 3.9 (1.3–11.9, P=0.04)).ConclusionFIT is a sensitive test and levels increase with advanced colonic pathology. Polypectomy of advanced adenomas is associated with a negative follow-up FIT. However, alternative causes for a positive FIT should be considered in patients who have adenomas less than 5 mm detected or a normal colonoscopy.

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Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032007000100004 ◽

2007 ◽

Vol 44 (1) ◽

pp. 14-17 ◽

Cited By ~ 66

Author(s):

Drausio Jefferson Morais ◽

Ademar Yamanaka ◽

José Murilo Robilotta Zeitune ◽

Nelson Adami Andreollo

Keyword(s):

Hyperplastic Polyp ◽

Gastric Polyp ◽

Adenomatous Polyps ◽

Fundic Gland ◽

Digestive Endoscopy ◽

Gastric Lesions ◽

Hyperplastic Polyps ◽

Gastric Polyps ◽

Fundic Gland Polyps ◽

Upper Digestive Endoscopy

BACKGROUND: Gastric polyps are small gastric lesions, asymptomatic in most cases and are generally discovered inadvertently during upper digestive endoscopy. AIM: To retrospectively review the characteristics and frequency of gastric polyps, derived from the gastric mucosal epithelium in a large series of endoscopies. METHODS: One hundred and fifty three patients in a series of 26,000 consecutive upper digestive endoscopies done over a 5-year period, being that each patient had only one examination were analyzed and their histological and Yamada classification, as well as their location, size, histopathological findings and treatment studied. All patients had at least one gastric polyp, as confirmed by histological examination. RESULTS: The polyps were classified as hyperplastic, adenomatous and fundic gland polyps. The most of them measure less than 1 cm (hyperplastic polyps - 60,5%; adenomatous polyps - 73,6%; fundic gland polyps - 72%). Hyperplastic polyps were the most frequent and accounted for 71.3% of the cases, whereas fundic gland polyps accounted for 16.3% and adenomatous polyps for 12.4%. Hyperplastic and adenomatous polyps were primarily single, whereas fundic gland polyps tended to be multiple. A carcinoma was detected in one hyperplastic polyp (0.9%) and in two adenomatous polyps (10.5%). High grade dysplastic foci were found in four adenomatous polyps (21%). CONCLUSIONS: The digestive endoscopy is the safest and efficient method for the diagnosis of the gastric polyps, that in most of the patients does not show characteristic symptoms. The histopathological definition is not possible to the endoscopic glance being needed the pathologist's aid, once the conduct to be adopted will depend on the result of the biopsy.

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Follow up colonoscopy may be omissible in uncomplicated left-sided acute diverticulitis diagnosed with CT- a retrospective cohort study

Scientific Reports ◽

10.1038/s41598-019-56641-2 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

Nollaig O’Donohoe ◽

Pankaj Chandak ◽

Marina Likos-Corbett ◽

Janelle Yee ◽

Katherine Hurndall ◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Acute Diverticulitis ◽

Low Grade ◽

Hyperplastic Polyps ◽

Single Centre ◽

Advanced Adenomas ◽

First Time

AbstractInternational guidelines recommend colonoscopy following hospitalisation for acute diverticulitis. There is a paucity of evidence supporting the efficacy of colonoscopy in this context, particularly for patients with CT-diagnosed uncomplicated left-sided diverticulitis. This study aims to investigate the frequency that colorectal cancer (CRC) and advanced adenomas (AA) are identified during follow-up colonoscopy after hospitalisation with CT-proven left-sided diverticulitis for the first time in a UK population. In this single-centre retrospective-cohort study all patients presenting with CT-diagnosed uncomplicated left-sided diverticulitis between 2014 and 2017 were identified. The incidence of histologically confirmed CRC and AA identified at follow-up colonoscopy 4–6 weeks following discharge was assessed. 204 patients with CT proven uncomplicated left-sided diverticulitis underwent follow-up colonoscopy. 72% were female and the median age was 63 years. There were no major complications. 22% of patients were found to have incidental hyperplastic polyps or adenomas with low-grade dysplasia. No CRC or AA were found. Routine colonoscopy following acute diverticulitis in this cohort did not identify a single CRC or AA and could arguably have been omitted. This would significantly reduce cost and pressure on endoscopy departments, in addition to the pain and discomfort that is commonly associated with colonoscopy.

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