Correlates of Body Mass Index in Moderate to Severe Irritable Bowel Syndrome Patients

Recent research shows that the number of diseases associated with obesity has been increasing. In obese persons, association with functional constipation is noted in 24.0% of cases, and obesity is recorded in 60.0% of patients with functional constipation. Among the possible mechanisms for the development of such a combination are changes in serotonin level in the blood, although the existing data are ambiguous and sometimes controversial.The objective of the study is to investigate the changes in serotonin level in the blood of obese patients in combination with constipation and its relationship with the lipid profile of the blood.Materials and methods. 63 patients with obesity in combination with irritable bowel syndrome with constipation (IBSc), 24 patients with normal body mass index and 10 practically healthy people were examined. 25 patients with obesity and constipation had a body mass index of 32.8±0.24kg/m2, 28 patients – 37.8±kg/m2, and 10 patients – 42.6±0.5kg/m2. In patients with irritable bowel syndrome without obesity, the body mass index was 21.7±0.4kg/m2. The blood serotonin level and lipid profile of the blood was determined in all patients.Results. It was deermined that in case of irritable bowel syndrome with constipation, serotonin level in the blood was reduced. In obesity with IBSc, the concentration of serotonin, on the contrary, was elevated. All patients with IBSc and obesity were marked an elevated level of total cholesterol and triglycerides. A direct correlation between high levels of triglycerides and serotonin concentration in serum of such comorbid patients was detected. The increase in the degree of obesity in the presence of IBSc was accompanied by a decrease in the concentration of cholesterol of high density lipoprotein. Patients with IBSc without excessive body weight had no such deviations.Conclusions. With an increase in the degree of obesity, serotonin level in the blood increases and the lipid blood spectrum worsens.

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Partially hydrolyzed guar gum in the treatment of irritable bowel syndrome with constipation: Effects of gender, age, and body mass index

Saudi Journal of Gastroenterology ◽

10.4103/1319-3767.153835 ◽

2015 ◽

Vol 21 (2) ◽

pp. 104 ◽

Cited By ~ 13

Author(s):

Rosario Cuomo ◽

Luigi Russo ◽

Giovanni Sarnelli ◽

IvanaG Savino ◽

Letizia Vozzella ◽

...

Keyword(s):

Body Mass Index ◽

Irritable Bowel Syndrome ◽

Body Mass ◽

Guar Gum ◽

Irritable Bowel ◽

Partially Hydrolyzed Guar Gum

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Impact of irritable bowel syndrome and body mass index on mental health - A prospective cross sectional study

Journal of Integrated Health Sciences ◽

10.4103/jihs.jihs_10_20 ◽

2020 ◽

Vol 8 (1) ◽

pp. 14

Author(s):

Arvind Bamanikar ◽

Shivam Sharma ◽

Bhumika Vaishnav

Keyword(s):

Mental Health ◽

Body Mass Index ◽

Irritable Bowel Syndrome ◽

Body Mass ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Irritable Bowel

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A Conservative Weight Loss Intervention Relieves Bowel Symptoms in Morbidly Obese Subjects with Irritable Bowel Syndrome: A Prospective Cohort Study

Journal of Obesity ◽

10.1155/2018/3732753 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 7

Author(s):

Martin Aasbrenn ◽

Stian Lydersen ◽

Per G. Farup

Keyword(s):

Body Mass Index ◽

Morbid Obesity ◽

Weight Loss ◽

Irritable Bowel Syndrome ◽

Cohort Study ◽

Body Mass ◽

Prospective Cohort ◽

Weight Loss Intervention ◽

Bowel Symptoms ◽

Irritable Bowel

Background. Irritable bowel syndrome (IBS) is common in subjects with morbid obesity; the effect of weight loss programs on bowel symptoms is largely unknown. Methods. This prospective cohort study explored bowel symptoms, health scores, and biomarkers in subjects with morbid obesity during a six-month-long conservative weight loss intervention. Bowel symptoms were assessed with IBS-severity scoring system (IBS-SSS) and Gastrointestinal Symptom Rating Scale-IBS. Changes in all variables and associations between the changes in bowel symptoms and the other variables were analysed. Results. Eighty-eight subjects (81% females) were included. Body mass index was reduced from 42.0 (3.6) to 38.7 (3.5) (p<0.001). IBS-SSS was reduced from 116 (104) to 81 (84) (p=0.001). In all, 19 out of 25 variables improved significantly. In subjects with and without IBS at inclusion, the improvement in IBS-SSS was 88 (95% CI 55 to 121) and 10 (95% CI −9 to 29), respectively. Improved bowel symptoms were associated with improved subjective well-being, sense of humour, and vitamin D and negatively associated with reduced body mass index. Conclusion. Body mass index and health scores improved during a conservative weight loss intervention. Subjects with IBS before the intervention had a clinically significant improvement in bowel symptoms.

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