Endoscopic Ultrasound Tissue Acquisition for Genomic Analysis of Pancreatic Cancer Using Liquid Next-Generation Sequencing

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S13
Author(s):  
Nadim Mahmud ◽  
Sherif Elhanafi ◽  
Michael L. Kochman ◽  
Gregory Ginsberg ◽  
Norge Vergara ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Next Generation Sequencing ◽  
Endoscopic Ultrasound ◽  
Genomic Analysis ◽  
Next Generation ◽  
Tissue Acquisition ◽  
Generation Sequencing

scholarly journals New Era of Endoscopic Ultrasound-Guided Tissue Acquisition: Next-Generation Sequencing by Endoscopic Ultrasound-Guided Sampling for Pancreatic Cancer

2019 ◽  
Vol 8 (8) ◽  
pp. 1173 ◽  
Author(s):  
Imaoka ◽  
Sasaki ◽  
Hashimoto ◽  
Watanabe ◽  
Ikeda
Keyword(s):  
Pancreatic Cancer ◽  
Next Generation Sequencing ◽  
Endoscopic Ultrasound ◽  
Next Generation ◽  
Ultrasound Guided ◽  
Tissue Samples ◽  
Genomic Biomarkers ◽  
Tissue Acquisition ◽  
Chemotherapy Patients ◽  
Generation Sequencing

Pancreatic cancer is a lethal cancer with an increasing incidence. Despite improvements in chemotherapy, patients with pancreatic cancer continue to face poor prognoses. Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is the primary method for obtaining tissue samples of pancreatic cancer. Due to advancements in next-generation sequencing (NGS) technologies, multiple parallel sequencing can be applied to EUS-TA samples. Genomic biomarkers for therapeutic stratification in pancreatic cancer are still lacking, however, NGS can unveil potential predictive genomic biomarkers of treatment response. Thus, the importance of NGS using EUS-TA samples is becoming recognized. In this review, we discuss the recent advances in EUS-TA application for NGS of pancreatic cancer.

scholarly journals Next-Generation Sequencing in Acute Lymphoblastic Leukemia

2019 ◽  
Vol 20 (12) ◽  
pp. 2929 ◽  
Author(s):  
Nicoletta Coccaro ◽  
Luisa Anelli ◽  
Antonella Zagaria ◽  
Giorgina Specchia ◽  
Francesco Albano
Keyword(s):  
Next Generation Sequencing ◽  
Acute Lymphoblastic Leukemia ◽  
Residual Disease ◽  
Age Of Onset ◽  
Lymphoblastic Leukemia ◽  
Genomic Analysis ◽  
Next Generation ◽  
Acute Leukemias ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for about a quarter of adult acute leukemias, and features different outcomes depending on the age of onset. Improvements in ALL genomic analysis achieved thanks to the implementation of next-generation sequencing (NGS) have led to the recent discovery of several novel molecular entities and to a deeper understanding of the existing ones. The purpose of our review is to report the most recent discoveries obtained by NGS studies for ALL diagnosis, risk stratification, and treatment planning. We also report the first efforts at NGS use for minimal residual disease (MRD) assessment, and early studies on the application of third generation sequencing in cancer research. Lastly, we consider the need for the integration of NGS analyses in clinical practice for genomic patients profiling from the personalized medicine perspective.

scholarly journals Final report of ENGAGE ‐ Establishing Next Generation sequencing Ability for Genomic analysis in Europe

2018 ◽  
Vol 15 (6) ◽  
Author(s):  
Rene S. Hendriksen ◽  
Susanne Karlsmose Pedersen ◽  
Pimlapas Leekitcharoenphon ◽  
Burkhard Malorny ◽  
Maria Borowiak ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Genomic Analysis ◽  
Final Report ◽  
Next Generation ◽  
Generation Sequencing
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