S2854 High-Risk Liver Transplants in Alcoholic Hepatitis: Case Series

Background: Many suicide risk factors have been identified, but traditional clinical methods do not allow the accurate prediction of suicide behaviors. To face this challenge, we developed emma, an app for Ecological Momentary Assessment/Intervention (EMA/EMI) and prediction of suicide risk in high risk patients.Objective: We wanted to test the feasibility of implementing this mHealth-based suicide risk assessment and prevention tool and its impact in subjects at high risk of suicide in real world conditions.Methods: The EMMA Study is an ongoing longitudinal interventional multicenter trial in which patients at high-risk for suicide (n=100) use emma for 6 months. During this period, they complete four EMA types (daily, weekly, monthly, spontaneous) and may use EMI modules. Participants undergo clinical assessment at month 0, 1, 3 and 6 after inclusion.Results: Among the 43 patients already recruited in the EMMA Study, 14 participants had completed the follow-up. Their data were analyzed to evaluate emma implementation and impact on suicide risk management. EMA completion rates were extremely heterogeneous among the 14 participants with a sharp decrease over time. The completion rates of the weekly EMA (25% to 87.5%) were higher than for the daily EMA (0% to 53.3%). Most patients (n=10/14) answered the EMA questionnaires spontaneously. Similarly, the Safety Plan Modules use was very heterogeneous (2 to 75 times). Specifically, 11 patients used the Call Module (1 to 29 times), designed by our team to help them to get in touch with healthcare professionals and/or relatives during a crisis. All patients used the Breathing Space Module and 8 the Emotion Regulation Module (1 to 46 times). The diversity of patient profiles and use of the EMA and EMI modules proposed by emma was highlighted by three case reports.Conclusions: These preliminary results suggest that it is possible and acceptable to collect longitudinal fine-grained contextualized data (EMA) and to offer personalized intervention (EMI) in real time to people at high risk of suicide. Patients have different clinical and digital profiles and needs that require a highly scalable, interactive and customizable app. To become a complementary tool for suicide prevention, emma should be integrated in the existing emergency procedures.

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COGNITIVE THERAPY FOR PREVENTING TRANSITION TO PSYCHOSIS IN HIGH RISK INDIVIDUALS: A CASE SERIES

Behavioural and Cognitive Psychotherapy ◽

10.1017/s1352465803001061 ◽

2003 ◽

Vol 31 (1) ◽

pp. 53-67 ◽

Cited By ~ 10

Author(s):

Paul French ◽

Anthony P. Morrison ◽

Lara Walford ◽

Alice Knight ◽

Richard P. Bentall

Keyword(s):

High Risk ◽

Cognitive Therapy ◽

Controlled Trial ◽

Intervention Strategy ◽

Cognitive Model ◽

Case Series ◽

First Episode ◽

Future Research ◽

Research Findings ◽

Further Development

Early interventions for psychosis have recently received a great deal of interest. This is because research findings have indicated the importance of duration of untreated psychosis (DUP) in influencing future prognosis. Most interventions have so far centered around the early identification of first episode cases in an attempt to minimize the DUP. A further development of the early intervention strategy aims to identify high-risk cases prior to the onset of psychosis. Treatment of this at risk group could potentially prevent the onset of psychosis. In this paper we describe three cases from a randomized controlled trial designed to test the feasibility of a cognitive therapy intervention, to prevent the onset of psychosis. These are presented with formulations based on a recent cognitive model conceptualizing the onset of psychosis. Implications of this approach for future research and clinical practice are also discussed.

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P-084: Venetoclax monotherapy is feasible and efficient in patients with bcl-2 overexpressing relapsed/refractory multiple myeloma at high-risk sites: a case series

Clinical Lymphoma Myeloma & Leukemia ◽

10.1016/s2152-2650(21)02218-7 ◽

2021 ◽

Vol 21 ◽

pp. S85

Author(s):

David Cordas dos Santos ◽

Elena Stauffer ◽

Tanja Paul ◽

Martina Rudelius ◽

Sebastian Theurich

Keyword(s):

Multiple Myeloma ◽

High Risk ◽

Case Series ◽

Refractory Multiple Myeloma

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Abstract 3772: Alternate Listing Transplantation is a Cost-Effective Treatment for End-Stage Heart Failure Patients

Circulation ◽

10.1161/circ.116.suppl_16.ii_858 ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

Mark J Russo ◽

Jonathan M Chen ◽

Kimberly N Hong ◽

Michael Argenziano ◽

Ryan R Davies ◽

...

Keyword(s):

Cost Effectiveness ◽

High Risk ◽

Cost Model ◽

Case Series ◽

Cost Effective ◽

Intention To Treat ◽

Cost Effective Treatment ◽

Number Of Patients ◽

Transplant Candidates ◽

End Stage

BACKGROUND: In order to offer the benefit of heart transplantation to a greater number of patients some centers match high-risk recipients (HR) with non-standard or ”marginal” donors (MD) in a strategy known as Alternate Listing Transplantation (ALT). However, pairing sicker recipients with lower quality donor organs remains both clinically and ethically controversial. The purpose of this study was to determine the cost-effectiveness of this strategy. METHODS: The United Network of Organ Sharing provided deidentified patient-level data. UNOS data was used to determine clinical outcomes, including waiting time, post-transplant survival, length of stay, re-hospitalizations, episodes of rejection, and infection, based on all adult heart transplant candidates (age [gt] 18 yo) and listed between 1995–2005 (n=35,049). Through a systematic literature review of randomized controlled trials and case series that estimated related costs, a cost model (see Table ) using an intention-to-treat assumption was developed to calculate the incremental cost-effectiveness ratio (ICER) for HR candidates who subsequently received marginal donor hearts (HTR) compared with candidates who were not transplanted (NTXP). High-risk recipient criteria included age [gt] 65yo, retransplantation, HepC+, HIV+, CrCl <30 ml/min, DM with PVD, DM with Crcl <40 ml/min. MD criteria included age [gt] 55yo, DM, HIV+, HepC+, EF<45%, and donor:recipient weight <0.7. RESULTS: Median survival from listing was 0.55 yrs and 5.1 yrs in the HTR and NTXP groups, respectively. The estimated ICER was $66,645($34,046–$127,491) ICER varied by HR recipient criteria. CONCLUSIONS: The ICER for ALT falls at the upper limits acceptability for being cost-effective. However, stratified analysis by HR group suggests that this strategy is not appropriate for all groups. Cost Model Assumptions

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Noninvasive Ventilation for Awake Percutaneous Aortic Valve Implantation in High-Risk Respiratory Patients: A Case Series

Journal of Cardiothoracic and Vascular Anesthesia ◽

10.1053/j.jvca.2010.06.032 ◽

2011 ◽

Vol 25 (6) ◽

pp. 1109-1112 ◽

Cited By ~ 29

Author(s):

Fabio Guarracino ◽

Luca Cabrini ◽

Rubia Baldassarri ◽

Sonia Petronio ◽

Marco De Carlo ◽

...

Keyword(s):

High Risk ◽

Aortic Valve ◽

Noninvasive Ventilation ◽

Case Series ◽

Aortic Valve Implantation ◽

Valve Implantation

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Outcomes and risk factors of cholecystectomy in high risk patients: A case series

Annals of Medicine and Surgery ◽

10.1016/j.amsu.2019.12.003 ◽

2020 ◽

Vol 50 ◽

pp. 35-40 ◽

Cited By ~ 1

Author(s):

A. Musbahi ◽

P. Abdulhannan ◽

J. Bhatti ◽

R. Dhar ◽

M. Rao ◽

...

Keyword(s):

Risk Factors ◽

High Risk ◽

Case Series ◽

High Risk Patients ◽

Risk Patients

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Detection of Silent Type I Choroidal Neovascular Membrane in Chronic Central Serous Chorioretinopathy Using En Face Swept-Source Optical Coherence Tomography Angiography

Journal of Ophthalmology ◽

10.1155/2017/6913980 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 8

Author(s):

Magdy Moussa ◽

Mahmoud Leila ◽

Hagar Khalid ◽

Mohamed Lolah

Keyword(s):

High Risk ◽

Case Series ◽

Detection Algorithm ◽

Type I ◽

Chronic Central Serous Chorioretinopathy ◽

Swept Source ◽

Bivariate Correlation ◽

Risk Patients ◽

Flow Detection

Purpose. To evaluate the efficacy of SS-OCTA in the detection of silent CNV secondary to chronic CSCR compared to that of FFA and SS-OCT. Patients and Methods. A retrospective observational case series reviewing the clinical data, FFA, SS-OCT, and SS-OCTA images of patients with chronic CSCR, and comparing the findings. SS-OCTA detects the CNV complex and delineates it from the surrounding pathological features of chronic CSCR by utilizing the blood flow detection algorithm, OCTARA, and the ultrahigh-definition B-scan images of the retinal microstructure generated by swept-source technology. The bivariate correlation procedure was used for the calculation of the correlation matrix of the variables tested. Results. The study included 60 eyes of 40 patients. Mean age was 47.6 years. Mean disease duration was 14.5 months. SS-OCTA detected type 1 CNV in 5 eyes (8.3%). In all 5 eyes, FFA and SS-OCT were inconclusive for CNV. The presence of foveal thinning, opaque material beneath irregular flat PED, and increased choroidal thickness in chronic CSCR constitutes a high-risk profile for progression to CNV development. Conclusion. Silent type 1 CNV is an established complication of chronic CSCR. SS-OCTA is indispensable in excluding CNV especially in high-risk patients and whenever FFA and SS-OCT are inconclusive.

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