COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review

Study Design: Systematic review. Objective: Spinal orthoses have been generally used in the management of osteoporotic vertebral fractures in the elderly population with purported positive biomechanical and functional effects. To our knowledge, this is the first systematic review of the literature examining the role of spinal orthoses in osteoporotic elderly patients who sustain low energy trauma vertebral fractures. Methods: A systematic literature review adherent to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted. Methodical searches utilizing MEDLINE, EMBASE, Google Scholar, and Cochrane Databases was performed. Results: Of the 2019 articles initially retrieved, 7 published articles (4 randomized controlled trials and 3 prospective cohort studies) satisfied the inclusion criteria. Five studies reported improvement in quantitative measurements of spinal column stability when either a rigid or semirigid orthosis was used, while 1 study was equivocal. The studies also showed the translation of biomechanical benefit into significant functional improvement as manifested by improved postural stability and reduced body sway. Subjective improvement in pain scores and quality of life was also noted with bracing. Conclusion: The use of spinal orthoses in neurologically intact elderly patients aged 60 years and older with osteoporotic compression vertebral fractures results in improved biomechanical vertebral stability, reduced kyphotic deformity, enhanced postural stability, greater muscular strength and superior functional outcomes.

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Disparities in a provision of in-hospital post-arrest interventions for out-of-hospital cardiac arrest (OHCA) in the elderly population—protocol for a systematic review

Systematic Reviews ◽

10.1186/s13643-016-0234-4 ◽

2016 ◽

Vol 5 (1) ◽

Cited By ~ 1

Author(s):

Joanna M. Bielecki ◽

Josephine Wong ◽

Nicholas Mitsakakis ◽

Prakesh S. Shah ◽

Murray D. Krahn ◽

...

Keyword(s):

Systematic Review ◽

Cardiac Arrest ◽

Elderly Population ◽

The Elderly ◽

Population Protocol ◽

Hospital Cardiac Arrest

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The Effect of Reminiscence on the Elderly Population: A Systematic Review

Public Health Nursing ◽

10.1046/j.1525-1446.2003.20407.x ◽

2003 ◽

Vol 20 (4) ◽

pp. 297-306 ◽

Cited By ~ 79

Author(s):

Yen-Chun Lin ◽

Yu-Tzu Dai ◽

Shiow-Li Hwang

Keyword(s):

Systematic Review ◽

Elderly Population ◽

The Elderly

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Tolerability of Duloxetine in the Elderly and in Young Adults: A Protocol and Preliminary Results of a Systematic Review and Individual Participant Data Meta-Analysis of Randomised Placebo-Controlled Trials.

10.21203/rs.3.rs-148334/v1 ◽

2021 ◽

Author(s):

Jean-Charles Roy ◽

Chloé Rousseau ◽

Alexis Jutel ◽

Florian Naudet ◽

Gabriel Robert

Keyword(s):

Systematic Review ◽

Adverse Events ◽

Elderly Population ◽

Meta Analysis ◽

The Elderly ◽

Search Term ◽

Individual Participant Data ◽

Younger Adults ◽

Individual Participant

Abstract BackgroundDuloxetine is an antidepressant that benefits from a wide range of approval in the elderly population, while its safety for use in the elderly population, compared to younger adults, is not clearly assessed. This protocol outlines a systematic review and individual participant data meta-analysis comparing the tolerability of duloxetine between elderly and younger adults. MethodsOnly randomised controlled clinical trials, comparing duloxetine to placebo, will be included in this meta-analysis. The studies will be selected if participants were adults of less and more than 65 years old, in conditions of use of duloxetine approved by the European Medical Agency (EMA) and the Food and Drug Administration (FDA). The primary outcome will be the rate ratio of serious adverse events under duloxetine compared to placebo, between participants at least 65 years old and younger adults. Second, the number of any adverse events, clinical efficacy and quality of life will be compared between elderly and younger adults under both interventions. The quality of evidence in the tolerability of duloxetine will be assessed using the GRADE system. A two-step random effect meta-analysis will be conducted. Preliminary searches and formal screening of search results against eligibility criteria on have been completed using predefined search term on electronic databases. DiscussionThis study represents the first meta-analysis investigating the safety of duloxetine in the elderly population across all conditions approved by European and American regulatory authorities. The results from this meta-analysis are intended to help prescribers to provide better care for the elderly population.Systematic review registrationThe protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42019130488).

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Cognitive and balance dysfunctions due to the use of zolpidem in the elderly: a systematic review

Dementia & Neuropsychologia ◽

10.1590/1980-57642021dn15-030013 ◽

2021 ◽

Vol 15 (3) ◽

pp. 396-404

Author(s):

Guilherme Tavares ◽

Gizela Kelmann ◽

Francisco Tustumi ◽

Catherine Nardini Tundisi ◽

Bárbara Regina Bruço Silveira ◽

...

Keyword(s):

Systematic Review ◽

Elderly Population ◽

Scientific Information ◽

The Elderly ◽

Acute Effect ◽

Controlled Trials ◽

Cognitive Changes ◽

Randomized Controlled ◽

Significant Difference ◽

The Mean

ABSTRACT. Zolpidem is one of the most widely prescribed hypnotic (non-benzodiazepine) agents for sleep disorder. Recently, an increase in the demand for this drug has been observed, mainly in the elderly population. Objective: This study aims to analyze the acute effect of zolpidem on cognitive and balance dysfunctions in the elderly population. Methods: A study was conducted by two independent researchers in four virtual scientific information bases and included randomized controlled trials. The studies evaluated elderly patients using zolpidem. Cognitive and balance dysfunctions were analyzed. Results: Six articles were included. The mean age of the participants in the studies was 69 years. The following zolpidem dosages were evaluated: 5, 6.25, 10, and 12.5 mg. Comparing zolpidem and placebo, relating to the cognitive dysfunctions, there is no statistically significant difference between the groups. However, in relation to balance dysfunctions, there is a statistically significant difference between the intervention and the comparison, favoring placebo. Conclusions: Zolpidem, even in usual doses (5 mg and 10 mg), has shown to increase the risk for balance dysfunctions. However, this does not occur in relation to cognitive changes.

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Efficacy of some Herbal Medicines in Osteoarthritis with a Focus on Topical Agents: A Systematic Review

Current Pharmaceutical Design ◽

10.2174/1381612826666200429013728 ◽

2020 ◽

Vol 26 (22) ◽

pp. 2676-2681

Author(s):

Sadra Ansaripour ◽

Morteza Dehghan

Keyword(s):

Systematic Review ◽

Elderly Population ◽

Collagen Type ◽

Nuclear Translocation ◽

Herbal Medicines ◽

The Elderly ◽

Nuclear Factor Κb ◽

Keywords Osteoarthritis ◽

Herbal Formulations

: Osteoarthritis (OA) is a leading cause of musculoskeletal disorders that mainly affects the elderly population. Some herbal medicines have the potential to alleviate the pain associated with OA and improve physical activity mostly through anti-inflammatory and anti-oxidative properties. The aim of this study was to investigate the effects of herbal medicines, especially topical types, on osteoarthritis. : In this systematic review, the keywords “osteoarthritis”, “herbal compounds”, “herbal medicine”, “topical drug”, “hydrogels”, “cream” and “treatment” were used to search publications published from 2010 to 2019 and indexed in databases including PubMed, SCOPUS, Web of Science and Google Scholar. After screening of titles and abstracts and detection of duplicate publications, 38 eligible articles were included in the main review. We also included herbal formulations in vivo. : Bioactive fractions of herbal medicines mostly worked on OA through suppression of interleukin-1β (IL-1β), inducing nuclear factor-κB (NF-κB) activation by inhibition of inhibitor of NF-κB (IκBα) phosphorylation, IκBα degradation, p65 phosphorylation, and p65 nuclear translocation, downregulation of NF-κB targets including COX-2 and MMPs, upregulation of collagen type II, cartilage-specific proteoglycans (CSPGs), β1-integrin, and expression of cartilage-specific transcription factor SOX-9 protein. Noticeably, herbal medicines do not produce desirable effects, thereby using their combinations with other therapeutic agents seem to exert substantial clinical outcomes. : Herbal gels have demonstrated robustly significant healing effects on knee pain, stiffness and mobility. It is worth considering that because OA is a chronic disease, longer duration of the studies/trials would even lead to obtaining more reliable judgments regarding topical treatment tolerability, safety and efficacy and clarify local or systemic adverse effects. Stability and standardization of a defined amount or concentrations of herbal gels would give promising effects on OA treatment and pain relief.

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