scholarly journals Early Cholecystectomy for Acute Cholecystitis in the Elderly Population: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 34 (5) ◽  
pp. 371-379 ◽  
Author(s):  
Charlotte S. Loozen ◽  
Bert van Ramshorst ◽  
Hjalmar C. van Santvoort ◽  
Djamila Boerma
Keyword(s):  
Systematic Review ◽  
Acute Cholecystitis ◽  
Elderly Population ◽  
Meta Analysis ◽  
The Elderly ◽  
Early Cholecystectomy

scholarly journals Tolerability of Duloxetine in the Elderly and in Young Adults: A Protocol and Preliminary Results of a Systematic Review and Individual Participant Data Meta-Analysis of Randomised Placebo-Controlled Trials.

2021 ◽  
Author(s):  
Jean-Charles Roy ◽  
Chloé Rousseau ◽  
Alexis Jutel ◽  
Florian Naudet ◽  
Gabriel Robert
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Elderly Population ◽  
Meta Analysis ◽  
The Elderly ◽  
Search Term ◽  
Individual Participant Data ◽  
Younger Adults ◽  
Individual Participant

Abstract BackgroundDuloxetine is an antidepressant that benefits from a wide range of approval in the elderly population, while its safety for use in the elderly population, compared to younger adults, is not clearly assessed. This protocol outlines a systematic review and individual participant data meta-analysis comparing the tolerability of duloxetine between elderly and younger adults. MethodsOnly randomised controlled clinical trials, comparing duloxetine to placebo, will be included in this meta-analysis. The studies will be selected if participants were adults of less and more than 65 years old, in conditions of use of duloxetine approved by the European Medical Agency (EMA) and the Food and Drug Administration (FDA). The primary outcome will be the rate ratio of serious adverse events under duloxetine compared to placebo, between participants at least 65 years old and younger adults. Second, the number of any adverse events, clinical efficacy and quality of life will be compared between elderly and younger adults under both interventions. The quality of evidence in the tolerability of duloxetine will be assessed using the GRADE system. A two-step random effect meta-analysis will be conducted. Preliminary searches and formal screening of search results against eligibility criteria on have been completed using predefined search term on electronic databases. DiscussionThis study represents the first meta-analysis investigating the safety of duloxetine in the elderly population across all conditions approved by European and American regulatory authorities. The results from this meta-analysis are intended to help prescribers to provide better care for the elderly population.Systematic review registrationThe protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42019130488).

scholarly journals Estimation of the prevalence of depression using diagnostic instruments in the elderly population in India, 2000–2019: a systematic review protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. e034330
Author(s):  
Priyamadhaba Behera ◽  
Manju Pilania ◽  
Vikas Yadav ◽  
Mohan Bairwa ◽  
Deepti Dabar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fixed Effects ◽  
Elderly Population ◽  
Common Mental Disorder ◽  
Meta Analysis ◽  
Temporal Trends ◽  
The Elderly ◽  
Elderly Persons ◽  
Diagnostic Instruments ◽  
Prevalence Of Depression

IntroductionDepression is a common mental disorder in the elderly population, which significantly impacts their quality of life. However, correct estimates of its magnitude are not available in the elderly in India. The present systematic review and meta-analysis would attempt to estimate the prevalence of depression using diagnostic instruments among elderly persons aged 60 years and above.Methods and analysisSearches will be performed in PubMed, Scopus, Embase, Web of Science, CINAHL and PsycINFO. Community-based cross-sectional and cohort studies (2001 to September 2019) reporting the prevalence of depression in the elderly, using diagnostic instruments will be included. Studies conducted among chronic disease patients, in-hospital patients and special groups such as with disaster-stricken populations, and studies reporting the only one or two subcategories of depression, will be excluded. Disagreements in study selection and data abstraction will be resolved by consensus and arbitration by a third reviewer. AXIS critical appraisal tool will be used for quality assessment of individual studies. Findings of eligible studies will be pooled using fixed-effects or random-effects meta-analysis whichever is appropriate. Heterogeneity between studies will be examined by Cochran’s Q test and quantified by I² statistic. A cumulative meta-analysis will be used to detect temporal trends in the prevalence of depression and the effect of poor-quality studies on the pooled estimate. Publication bias will be assessed by visual inspection of funnel plots and the Egger test.Ethics and disseminationNo ethical approval will be needed because it will be a systematic review. Data from previously published studies will be retrieved and analysed. Findings will be disseminated through a peer-reviewed publication in a scientific journal and conferences.PROSPERO registration numberCRD42019138453.

scholarly journals Fall and its association with the frailty syndrome in the elderly: systematic review with meta-analysis

2016 ◽  
Vol 50 (6) ◽  
pp. 1005-1013 ◽  
Author(s):  
Jack Roberto Silva Fhon ◽  
◽  
Rosalina Aparecida Partezani Rodrigues ◽  
Wilmer Fuentes Neira ◽  
Violeta Magdalena Rojas Huayta ◽  
...  
Keyword(s):  
Systematic Review ◽  
Data Collection ◽  
Odds Ratio ◽  
Elderly Population ◽  
Meta Analysis ◽  
The Elderly ◽  
Frailty Syndrome ◽  
Virtual Library ◽  
A Value ◽  
Data Collection Instrument

Abstract OBJECTIVE To analyze the prevalence of falls and frailty syndrome and the association between these two syndromes in the elderly population. METHOD Systematic review, without restriction of dates, in English, Portuguese and Spanish languages, in the databases PubMed, CINAHL, LILACS and in the SciElo virtual library. The association between both variables was extracted from the studies (Odds Ratio and 95% Confidence Intervals). RESULTS The review included 19 studies published between 2001 and 2015. The prevalence of falls in the frail elderly population was between 6.7% and 44%; in the pre-frail, between 10.0% and 52.0%, and in the non-frail, between 7.6% and 90.4%. The association between both variables presented a value of OR 1.80 (95% CI 1.51-2.13). CONCLUSION There is evidence that falls are associated to the frailty in the elderly. Other factors may influence this association, such as age, sex, data collection instrument of the studies, place where they live and the process of senescence.

scholarly journals Prevalence and determinants of depression among old age: a systematic review and meta-analysis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yosef Zenebe ◽  
Baye Akele ◽  
Mulugeta W/Selassie ◽  
Mogesie Necho
Keyword(s):  
Systematic Review ◽  
Publication Bias ◽  
Old Age ◽  
Elderly Population ◽  
Meta Analysis ◽  
Group Analysis ◽  
The Elderly ◽  
Effective Control ◽  
Prevalence Of Depression ◽  
The World

Abstract Background Depression is a leading cause of disability worldwide and is a major contributor to the overall global burden of disease. It is also one of the most common geriatric psychiatric disorders and a major risk factor for disability and mortality in elderly patients. Even though depression is a common mental health problem in the elderly population, it is undiagnosed in half of the cases. Several studies showed different and inconsistent prevalence rates in the world. Hence, this study aimed to fill the above gap by producing an average prevalence of depression and associated factors in old age. Objective This study aims to conduct a systematic review and meta-analysis to provide a precise estimate of the prevalence of depression and its determinants among old age. Method A comprehensive search of PubMed, Scopus, Web of sciences, Google Scholar, and Psych-info from database inception to January 2020. Moreover, the reference list of selected articles was looked at manually to have further eligible articles. The random-effects model was employed during the analysis. Stata-11 was used to determine the average prevalence of depression among old age. A sub-group analysis and sensitivity analysis were also run. A graphical inspection of the funnel plots and Egger’s publication bias plot test were checked for the occurrence of publication bias. Result A search of the electronic and manual system resulted in 1263 articles. Nevertheless, after the huge screening, 42 relevant studies were identified, including, for this meta-analysis, n = 57,486 elderly populations. The average expected prevalence of depression among old age was 31.74% (95% CI 27.90, 35.59). In the sub-group analysis, the pooled prevalence was higher among developing countries; 40.78% than developed countries; 17.05%), studies utilized Geriatrics Depression Scale-30(GDS-30); 40.60% than studies that used GMS; 18.85%, study instrument, and studies having a lower sample size (40.12%) than studies with the higher sample; 20.19%. Conclusion A high prevalence rate of depression among the old population in the world was unraveled. This study can be considered as an early warning and advised health professionals, health policymakers, and other pertinent stakeholders to take effective control measures and periodic care for the elderly population.

scholarly journals A systematic review protocol for estimation of the prevalence of depression using diagnostic instruments in the elderly population in India, 2000-2019

2020 ◽  
Author(s):  
Priyamadhaba Behera ◽  
Manju Pilania ◽  
Vikas Yadav ◽  
Mohan Bairwa ◽  
Deepti Dabar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fixed Effects ◽  
Elderly Population ◽  
Meta Analysis ◽  
The Elderly ◽  
List Type ◽  
Elderly Persons ◽  
Depression Prevalence ◽  
Diagnostic Instruments ◽  
Prevalence Of Depression

AbstractIntroductionDepression is a common mental disorder in the elderly population, which significantly impacts their quality of life. However, correct estimates of its magnitude are not available in the elderly in India. The present systematic review and meta-analysis would attempt to estimate the prevalence of depression using diagnostic instruments among elderly persons aged 60 years and above.Methods and analysisSearches will be performed in PubMed, Scopus, Embase, Web of Science, CINAHL, and PsycINFO. Community-based cross-sectional and cohort studies (2001 – 9/2019) reporting the prevalence of depression in the elderly; using diagnostic instruments will be included. Studies conducted among chronic disease patients, in-hospital patients, and special groups such as with disaster-stricken populations, and studies reporting the only 1 or 2 subcategories of depression, will be excluded. Disagreements in study selection and data abstraction will be resolved by consensus and arbitration by a third reviewer. AXIS critical appraisal tool will be used for quality assessment of individual studies. Findings of eligible studies will be pooled using fixed-effects or random-effects meta-analysis whichever is appropriate. Heterogeneity between studies will be examined by Cochran’s Q test and quantified by I2 statistic. A cumulative meta-analysis will be used to detect temporal trends in the prevalence of depression and the effect of poor-quality studies on the pooled estimate. Publication bias will be assessed by visual inspection of funnel plots and the Egger test.Ethics and disseminationNo ethical approval will be needed because it will be a systematic review. Data from previously published studies will be retrieved and analyzed. Findings will be disseminated through a peer-reviewed publication in a scientific journal and conferences.PROSPEROregistration number CRD42019138453.Strengths and limitations of this studyIt is a first-ever systematic review of depression prevalence in India based on diagnostic instruments only.Meta-analytic techniques such as cumulative meta-analysis, leave-one-out (jack-knife estimation) meta-analysis, and meta-regression will enrich the analysis and provide the estimate of prevalence nearer to the population estimate.A comprehensive synthesis of all available depression prevalence data in India using a standardized risk of bias tool.The protocol adheres to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines.Heterogeneity in methodologies, such as diagnostic criteria, study duration, sampling design, and study locations may limit comparison across studies.

Sociodemographic determinants of edentulism in the elderly population: A systematic review and meta‐analysis

Gerodontology ◽  
2019 ◽  
Vol 36 (4) ◽  
pp. 325-337 ◽  
Author(s):  
Luana L. Roberto ◽  
Thaisa S. Crespo ◽  
Renato S. Monteiro‐Junior ◽  
Andréa M. E. B. L. Martins ◽  
Alfredo M. B. De Paula ◽  
...  
Keyword(s):  
Systematic Review ◽  
Elderly Population ◽  
Meta Analysis ◽  
The Elderly ◽  
Sociodemographic Determinants

scholarly journals Timing of early laparoscopic cholecystectomy for acute calculous cholecystitis revised: Protocol of a systematic review and meta-analysis of results

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Giuseppe Borzellino ◽  
Safi Khuri ◽  
Michele Pisano ◽  
Subhi Mansour ◽  
Niccolò Allievi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Laparoscopic Cholecystectomy ◽  
Early Intervention ◽  
Conservative Treatment ◽  
Acute Cholecystitis ◽  
Meta Analysis ◽  
Early Cholecystectomy ◽  
Early Laparoscopic Cholecystectomy ◽  
Pooled Data ◽  
Delayed Cholecystectomy

Abstract Background Early laparoscopic cholecystectomy has been adopted as the treatment of choice for acute cholecystitis due to a shorter hospital length of stay and no increased morbidity when compared to delayed cholecystectomy. However, randomised studies and meta-analysis report a wide array of timings of early cholecystectomy, most of them set at 72 h following admission. Setting early cholecystectomy at 72 h or even later may influence analysis due to a shift towards a more balanced comparison. At this time, the rate of resolving acute cholecystitis and the rate of ongoing acute process because of failed conservative treatment could be not so different when compared to those operated with a delayed timing of 6–12 weeks. As a result, randomised comparison with such timing for early cholecystectomy and meta-analysis including such studies may have missed a possible advantage of an early cholecystectomy performed within 24 h of the admission, when conservative treatment failure has less potential effects on morbidity. This review will explore pooled data focused on randomised studies with a set timing of early cholecystectomy as a maximum of 24 h following admission, with the aim of verifying the hypothesis that cholecystectomy within 24 h may report a lower post-operative complication rate compared to a delayed intervention. Methods A systematic review of the literature will identify randomised clinical studies that compared early and delayed cholecystectomy. Pooled data from studies that settled the early intervention within 24 h from admission will be explored and compared in a sub-group analysis with pooled data of studies that settled early intervention as more than 24 h. Discussion This paper will not provide evidence strong enough to change the clinical practice, but in case the hypothesis is verified, it will invite to re-consider the timing of early cholecystectomy and might promote future clinical research focusing on an accurate definition of timing for early cholecystectomy for acute cholecystitis.

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