scholarly journals A prospective randomized controlled trial of bone metabolism in patients with charcot foot

2020 ◽  
Vol 23 (1) ◽  
pp. 12-18
Author(s):  
Ekaterina L. Zaitseva ◽  
Alla Y. Tokmakova ◽  
Viktor M. Zhilyaev ◽  
Natalia M. Malysheva ◽  
Natalia I. Sazonova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Controlled Trial ◽  
Type I ◽  
Metabolic Markers ◽  
Chronic Hyperglycemia ◽  
Vitamin D Levels ◽  
Patients With Diabetes ◽  
25 Oh Vitamin D

BACKGROUND: Diabetic neuroosteoarthropathy (DNOAP, Charcots foot) - is a progressive destructive inflammatory disease of the osteoarticular apparatus of the foot, untimely and inadequate treatment of which can lead to the formation of gross deformities. More often, DNOAP is unilateral, bilateral lesion is relatively rare. It is not always possible to trace the relationship between the debut of DNOAP with trauma and chronic hyperglycemia. There is data demonstrating the role of individual pro-inflammatory factors in the pathogenesis of DNOAP, however, studies combining the evaluation of various metabolic markers of Charcots foot formation are currently extremely poor. AIM: To evaluate the hormonal and metabolic markers of bone formation and resorption in patients with DNOAP and without this diabetic complication. METHODS: A prospective, controlled trial included 70 patients with type 2 diabetes mellitus (37 men and 43 women) who formed 2 groups: group 1 included patients with DNOAP, group 2 was formed by patients with diabetes without foot skeleton damage. All patients underwent a study of 1,25-OH-vitamin D, sclerostin, pro-MMP-1, C-terminal propeptide type 1 collagen (PICP), type 1 collagen, osteocalcin, PTH, 25-OH-vitamin D, beta-cross-slaps. RESULTS: The results of the studies confirmed the presence of vitamin D deficiency in all patients with diabetes mellitus included in the study, revealed the absence of statistically significant differences between the groups in the values of sclerostin, pro-MMP-1; 25-OH-vitamin D, type I collagen, and osteocalcin (p 0.05). However, significant differences were found in the 1.25-OH vitamin D levels: patients with DNOAP presented the lower rates of 1,25-OH-vitamin D in comparison to control group (p 0.05). Beta-cross and PICP levels were significantly higher in DNOAP patients as well (p 0.05). Those findings show the more severe collagen degradation in patients with DNOAP and can be the genetically predisposed cause of DNOAP development. Though further studies are needed. CONCLUSION: In patients with DNOAP a decrease in 1,25-OH-vitamin D levels was found, as well as the alteration of the synthesis and destruction of collagen (beta-cross-slaps and PICP) compared to patients with diabetes mellitus without osteoarticular disorders.

scholarly journals Evaluation of Vitamin D Metabolism in Patients with Type 1 Diabetes Mellitus in the Setting of Cholecalciferol Treatment

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3873
Author(s):  
Alexandra Povaliaeva ◽  
Ekaterina Pigarova ◽  
Artem Zhukov ◽  
Viktor Bogdanov ◽  
Larisa Dzeranova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Controlled Study ◽  
Affinity Constant ◽  
Vitamin D Metabolites ◽  
Vitamin D Metabolism ◽  
Vitamin D Levels

In this prospective controlled study, we examined 25 adults with adequately controlled (HbA1c level < 8.0%) type 1 diabetes mellitus (T1DM) and 49 conditionally healthy adults, intending to reveal the diversity of vitamin D metabolism in the setting of cholecalciferol intake at a therapeutic dose. All patients received a single dose (150,000 IU) of cholecalciferol aqueous solution orally. Laboratory assessments including serum vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3), free 25(OH)D, vitamin D-binding protein (DBP) and parathyroid hormone (PTH) as well as serum and urine biochemical parameters were performed before the intake and on Days 1, 3 and 7 after the administration. The studied groups had no significant differences in baseline parameters except that the patients with diabetes showed higher baseline levels of free 25(OH)D (p < 0.05). They also lacked a correlation between the measured and calculated free 25(OH)D in contrast to the patients from the control group (r = 0.41, p > 0.05 vs. r = 0.88, p < 0.05), possibly due to the glycosylation of binding proteins, which affects the affinity constant for 25(OH)D. The elevation of vitamin D levels after the administration of cholecalciferol was comparable in both groups, with slightly higher 25(OH)D3 levels observed in the diabetes group throughout the study since Day 1 (p < 0.05). Overall, our data indicate that in patients with adequately controlled T1DM 25(OH)D3 levels and the therapeutic response to cholecalciferol is similar to that in healthy individuals.

scholarly journals BONE REMODELING IN WOMEN WITH DIABETES MELLITUS

2018 ◽  
Vol 2 (5) ◽  
pp. 33-36
Author(s):  
Татьяна Бардымова ◽  
Tatyana Bardymova ◽  
Максим Мистяков ◽  
Maksim Mistyakov ◽  
Юлия Башарина ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Bone Remodeling ◽  
Menstrual Function ◽  
Type 2 Dm ◽  
Bone Remodeling Markers ◽  
25 Oh Vitamin D ◽  
Post Menopausal

Background. It is known that the type 2 diabetes mellitus (DM) and osteoporosis are more often diagnosed in senior women. The condition of a bone tissue is accompanied by the metabolic violations that are typical for DM. The recent researches established the multidirectional changes of bone remodeling markers in women with type 2 DM at differ- ent age periods. Aims: to study the condition of bone remodeling in women with type 2 DM at different age periods. Materials and methods. We examined 27 women with type 2 DM, among them 15 were in the post-menopausal period and 12 with preserved menstrual function. Levels of osteocalcin, N-terminal propeptide of type 1 collagen (P1NP), C- terminal telopeptide of type 1 collagen (β-Crosslaps), 25-OH vitamin D, the ionized calcium were researched. Results. The analysis showed that increase in β-Crosslaps levels, P1NP, levels of osteocaltcin were observed in women with type 2 DM in the post-menopausal period, compared to parameters of women with type 2 DM with preserved menstrual function. Inverse correlation relation of osteocaltcin and 25-OH vitamin D was revealed in women with type 2 DM. Conclusion. Significant increase in markers of osteosynthesis and osteoresorption in women with type 2 DM was shown in the post-menopausal period compared with indicators of women with type 2 DM with preserved men- strual function.

Vitamin D levels in patients with diabetes mellitus in combination with chronic kidney disease

2021 ◽  
Vol 25 (6) ◽  
pp. 81-86
Author(s):  
A. P. Lichacheva ◽  
N. V. Agranovich ◽  
A. T. Klassova ◽  
A. S. Anopchenko ◽  
E. L. Solovyova
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Metabolic Effects ◽  
Control Group ◽  
Excretory Function ◽  
Vitamin D Levels ◽  
Wide Range ◽  
Patients With Diabetes

BACKGROUND. Vitamin D has been known since 1928. The wide range of its metabolic effects paradoxically contrasts with the high prevalence of insufficiency and deficiency in the population of different regions of the world. A number of publications have demonstrated information about the relationship between vitamin D and insulin production by beta cells of the pancreas, as well as the excretory function of the kidneys.THE AIM: to assess the level of vitamin D in patients with diabetes mellitus in combination with chronic kidney disease (CKD).PATIENTS AND METHODS. A questionnaire and a study of the level of 25-hydroxyvitamin D, creatinine, urea, and glucose in the blood were conducted in 117 patients aged 18 to 84 years who gave voluntary consent. All patients were divided into three study groups: group 1 - patients with long-term DM, group 2 - patients with newly diagnosed DM, and 3 - control group. The glomerular filtration rate (GFR) is calculated by the formula CKD-EPI.RESULTS. As a result of the study, it was found that patients with DM, regardless of the duration of its course, were more likely to suffer from vitamin D deficiency, compared with the control group, where D-deficiency and D-deficiency occurred with the same frequency. In addition, patients with DM were more likely to have stage 2-3A CKD, in contrast to the control group, where preserved kidney function prevailed. We also identified and confirmed the direct dependence of GFR on the level of vitamin D in the blood of patients with DM.CONCLUSION. In the patients studied by us, a clear association was found between a lower vitamin D index in the blood serum and the presence of a history of diabetes. They also showed a tendency to decrease the excretory function of the kidneys and the formation of CKD. Consequently, a full-fledged diagnosis of vitamin D-deficient conditions and timely initiated therapy can prevent or at least slow down the progression of CKD in these patients, which will certainly improve their quality of life and reduce the costs of health services for renal replacement therapy and rehabilitation of this group of patients.

A STUDY ON THE CORRELATION OF DIABETIC RETINOPATHY IN TYPE II DIABETES MELLITUS WITH SERUM VITAMIN D LEVELS

2021 ◽  
pp. 78-80
Author(s):  
Barnali Bhattacharyya Thakur ◽  
Keshab Bora ◽  
Sherin Gogoi
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Diabetic Retinopathy ◽  
Type Ii Diabetes ◽  
Serum Vitamin ◽  
Diabetic Patients ◽  
Type I ◽  
Type Ii ◽  
Serum Vitamin D ◽  
Vitamin D Levels

INTRODUCTION: Diabetes mellitus is a major public health problem with signicant morbidity and mortality. Diabetic retinopathy is one of the most common microvascular complications of Diabetes mellitus causing blindness. Vitamin D is a fat soluble vitamin involved in maintenance of mineral homeostasis and bone remodelling. Vitamin D deciency is highly prevalent in type I and type II Diabetes. 38 diabetic without ocular disease a METHOD: nd 30 diabetic with retinopathy were taken as cases and 38 age sex matched healthy persons were taken as controls. Serum Vit D and glucose were estimated and retinopathy was diagnosed by fundus examination. The results were statistically analysed. Statistica RESULTS: l analysis of the results shows a negative correlation between FBS and HbA1C with Vitamin D level in diabetic retinopathy patients. Patients CONCLUSION: with Diabetic retinopathy has lower serum Vitamin D level than diabetic patients without retinopathy.

scholarly journals Deficiency of Vitamin D: Influence on Diabetic Retinopathy and Hearing Loss Among Patients with Diabetes Mellitus Type 2

2020 ◽  
Vol 10 (4) ◽  
pp. 282-286
Author(s):  
Mashhood Farooq ◽  
Syed Inamullah ◽  
Shama Mashhood ◽  
Mahmood Rana ◽  
Muhammad Fahim
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Hearing Loss ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
P Value ◽  
Hearing Status ◽  
Vitamin D Levels ◽  
Patients With Diabetes

Objective: To find a relationship between serum level of vitamin D with diabetic retinopathy and hearing loss in patients with diabetes mellitus type2. Study design and setting: This cross-sectional study was carried out at Ophthalmology, ENT and family physician Outpatient clinic of Mohsin Consultant Clinic Federal B Area, Karachi from study was April 2019 to December 2019. Methodology: Total 181 eligible type 2 diabetes mellitus patients. Complete ophthalmological, ENT and physical evaluation was carried out. Retinopathy and hearing status were recorded and were compared to serum 25-OH Vitamin D levels to find any association. SPSS version 23.0 was used to analyze the data. Results: Mean age of participants were found to be 60.56±7.3 (SD). When diabetic retinopathy status and hearing status was compared, non-proliferative diabetic retinopathy patients with normal hearing were 24(42.1%), with mild hearing 32(56.1%) and only 1(1.8%) with moderate-severe hearing loss was observed with P-value of <0.0001. Retinopathy status was compared with vitamin D levels. Insufficiency was seen in 14(38.9%) non-proliferative diabetic retinopathy, 2(5.6%) proliferative diabetic retinopathy patients and deficiency level was found in 33(32.7%) non-proliferative diabetic retinopathy and 15(14.9%) proliferative diabetic retinopathy patients. Level of vitamin D was compared to DR and HL status. Significantly low level of vitamin D was found with increasing severity of DR and HL with P-value <0.0001. Conclusions: Low level of vitamin D was associated with the severity of diabetic retinopathy and hearing loss in patients suffering from diabetes mellitus type2

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