Correlation between High Serum Uric Acid Levels with Occurrence of Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus in Soetomo General Hospital

Background: The increased serum uric acid (SUA) levels have been linked to macro vascular disease in Type 2 Diabetes Melitus. The correlation between serum uric acid levels and diabetic peripheral neuropathy has not been addressed properly. Objective: The aim of this study was to determine the correlation between high serum uric acid levels and diabetic peripheral neuropathy. Methods: This was a case-control design study and the sampling was done consecutively by following the inclusion and the exclusion criteria. The diabetic peripheral neuropathy was evaluated using Electroneuromyography (EMNG) and the serum were taken for uric acid level examination. Chi square test was used for the correlation analysis. Result: Thirty subjects were enrolled and divided into an experimental group of 15 subjects and a control group of 15 subjects as well. We found that the diabetic peripheral neuropathy did not show a significant correlation with high serum uric acid levels, p=0,136 and OR 3,143 (CI 95% 0,681-14,503). Conclusions: There was no correlation between high serum uric acid levels with diabetic peripheral neuropathy.

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Correlation between High Serum Uric Acid Levels with Occurrence of Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes

Indian Journal of Forensic Medicine & Toxicology ◽

10.37506/ijfmt.v14i2.3132 ◽

2020 ◽

Keyword(s):

Type 2 Diabetes ◽

Uric Acid ◽

Peripheral Neuropathy ◽

Serum Uric Acid ◽

Diabetic Peripheral Neuropathy ◽

High Serum

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Serum Uric Acid Levels and Diabetic Peripheral Neuropathy in Type 2 Diabetes: a Systematic Review and Meta-analysis

Molecular Neurobiology ◽

10.1007/s12035-014-9075-0 ◽

2015 ◽

Vol 53 (2) ◽

pp. 1045-1051 ◽

Cited By ~ 16

Author(s):

Shuai Yu ◽

Ying Chen ◽

Xu Hou ◽

Donghua Xu ◽

Kui Che ◽

...

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Uric Acid ◽

Peripheral Neuropathy ◽

Serum Uric Acid ◽

Diabetic Peripheral Neuropathy ◽

Meta Analysis

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Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

Journal of Current and Advance Medical Research ◽

10.3329/jcamr.v4i2.36358 ◽

2018 ◽

Vol 4 (2) ◽

pp. 58-62

Author(s):

Roksana Yeasmin ◽

MA Muttalib ◽

Kazi Nazneen Sultana ◽

Nizamul Hoque Bhuiyan ◽

Md Jamil Hasan Karami ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Rheumatoid Factor ◽

Serum Uric Acid ◽

Control Group ◽

Healthy Male ◽

Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

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A STUDY OF SERUM URIC ACID LEVELS IN TYPE 2 DIABETES MELLITUS CASES AND ITS COMPARISON WITH THE SERUM CREATININE LEVELS

10.36106/paripex/0302859 ◽

2021 ◽

pp. 20-22

Author(s):

Shajahan Shajahan ◽

Koneru Sri Lahari ◽

P. Kiranmai

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Serum Creatinine ◽

Serum Uric Acid ◽

Fasting Blood Glucose ◽

Control Group ◽

P Value

BACKGROUND:Type 2 Diabetes Mellitus is a major non-communicable disease resulting from insulin resistance and is associated with cardiovascular,neurological and renal complications.Recent studies show association of hyperuricemia and Diabetes Mellitus.Uric acid increases oxidative stress that leads to vascular dysfunction and high intra glomerular pressure leading to renal complications.High serum creatinine is an indicator of renal compromise. OBJECTIVES: To evaluate serum uric acid and serum creatinine levels in type 2 diabetes mellitus patients and to find association between them. METHODOLOGY: The study was conducted in Osmania general hospital. Fifty cases of established Type 2 Diabetes Mellitus formed the study group and 50 normal healthy individuals formed the control group. Serum uric acid, Fasting Blood Glucose (FBS) and serum creatinine were estimated by colorimetric enzymatic methods on Beckman coulter AU5800.Mean values were compared in cases and controls using student t- test.Study group was further studied under 2 subgroups with serum Uric acid < 7 mg/dl and ≥7 mg/dl.In these 2 subgroups the association of Serum uric acid with FBS and creatinine was analysed statistically. RESULTS: Serum uric acid were found high in cases(7.63+/- 3.36)as compared to controls(4.48+/- 1.09) p value < 0.001.Serum creatinine were also high in cases(1.59+/- 1.39 )as compared to controls ( 0.87+/- 0.29) p value <0.005.Study subgroup with serum uric acid ≥7 mg/dl was associated with high creatinine and high fasting blood sugar levels when compared to subgroup with serum uric acid <7 mg/dl. CONCLUSION: Our study showed increased serum uric acid and serum creatinine levels in cases when compared to controls.There was significant association between high serum uric acid and high creatinine levels in cases.Therefore,it is important to measure serum uric acid and serum creatinine levels in diabetics for early detection of renal pathology.

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The effects of a supportive-educational intervention on women with type 2 diabetes and diabetic peripheral neuropathy: a randomized controlled trial

Clinical Rehabilitation ◽

10.1177/0269215520914067 ◽

2020 ◽

Vol 34 (6) ◽

pp. 794-802

Author(s):

Zohre Ahrary ◽

Shahla Khosravan ◽

Ali Alami ◽

Mahdi Najafi Nesheli

Keyword(s):

Type 2 Diabetes ◽

Peripheral Neuropathy ◽

Educational Intervention ◽

Diabetic Peripheral Neuropathy ◽

Glycosylated Hemoglobin ◽

Self Care ◽

Control Group ◽

Trial Group ◽

Diabetes Clinic

Purpose: To determine the effect of a supportive educational intervention based on the Orem self-care model on women with type 2 diabetes and diabetic peripheral neuropathy. Design: A randomized controlled trial. Setting: Hospital outpatient diabetes clinic. Subjects: Adult women with type 2 diabetes and mild-to-moderate diabetic peripheral neuropathy. Out of 410 patients, 120 diabetic patients were recruited and randomly assigned to trial group ( N = 60) and control group ( N = 60). Intervention: The trial group received a designed intervention consist of one-month supportive educational program with three months of follow-up (totally four months), based on self-care requisites according to the Orem self-care regarding diabetic peripheral neuropathy. The control group only received a routine care program in the diabetes clinic. Main measurements: The main outcomes were symptoms and severity of diabetic neuropathy. Further outcomes were fasting blood sugar and glycosylated hemoglobin. Results: By the end of the intervention, the number of participants reduced from 60 to 58 in the trial group and to 57 in the control group (totally 115). The intervention significantly decreased mean score of diabetic neuropathy symptoms (trial group: 3.26 vs. control group: 9.57, P = 0.001), severity (trial group: 5.86 vs. control group: 9.02, P = 0.001), fasting blood sugar (trial group: 151 vs. control group: 204, P = 0.001), and glycosylated hemoglobin (trial group: 7.85 vs. control group: 8.62, P = 0.004). Conclusion: Delivering a supportive-educational intervention based on the Orem self-care model on outpatient diabetes clinic can decrease the symptoms and severity of diabetic peripheral neuropathy. Trial registration: It was registered in the Iranian Registry of Clinical Trials (IRCT2015021521095N1).

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The Effect of Sodium Channel Blocker, Mexiletine, on Body Weight in Type 2 Diabetes Patients with Visceral Obesity

Clinical Medicine Insights Endocrinology and Diabetes ◽

10.1177/1179551418825049 ◽

2019 ◽

Vol 12 ◽

pp. 117955141882504

Author(s):

Naohiko Ueno

Keyword(s):

Type 2 Diabetes ◽

Body Weight ◽

Uric Acid ◽

Waist Circumference ◽

Diabetic Neuropathy ◽

Serum Uric Acid ◽

Visceral Obesity ◽

Control Group ◽

Diabetes Patients

Objective: Mexiletine is an anti-arrhythmic agent also used for the treatment of painful diabetic neuropathy. In this study, the effect of mexiletine on body weight was evaluated in type 2 diabetes patients with diabetic neuropathy exhibiting visceral obesity. Methods: Type 2 diabetes patients with neuropathy exhibiting visceral obesity (n = 21) treated by mexiletine (300 mg/day) and a control group of type 2 diabetes patients with the same condition who received vitamin B12 (n = 12) were retrospectively evaluated. Body weight, waist circumference, hemoglobin A1c (HbA1c), blood pressure, liver function, serum lipids, and serum uric acid were assessed before and 6 months after the treatment. Results: Mexiletine significantly decreased body weight and waist circumference. The changes in body weight and waist circumference in 6 months in the mexiletine group were greater than in the control group. In metabolic parameters, there were significant decreases in triglyceride (TG) and serum uric acid. There were positive relationships between the change in body weight and the changes in TG, uric acid, alanine aminotransferase (ALT), and HbA1c. Conclusions: Mexiletine may affect body weight regulation. It ameliorated the metabolic parameters possibly by decreasing visceral fat. Further study should be performed to clarify the mechanism of the effect.

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The Relation between serum uric acid & HbA1c in geriatric patients of Type 2 Diabetes in Amravati, Maharashtra, India.

International Journal of Bioassays ◽

10.21746/ijbio.2016.06.009 ◽

2016 ◽

Vol 5 (06) ◽

pp. 4630 ◽

Cited By ~ 1

Author(s):

Jagtap M. W. ◽

Rohankar P. H. ◽

Shital Ashokrao Kale*

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Serum Uric Acid ◽

Geriatric Patients ◽

Control Group ◽

Cross Sectional ◽

Positive Correlation

Type 2 Diabetes mellitus (DM) is a heterogeneous disease which is characterized by variable degrees of insulin resistance or/and impaired insulin secretion as well as its deficiency (absolute/relative). The study was carried out to determine the relationship between serum concentration of uric acid and HbA1c among the geriatric group with type 2 diabetes mellitus in diabetic camps carried out at Amravati. We performed a cross sectional study on 30 patients of both genders of geriatric group, and a control group of 30 age and sex matched normal healthy individuals. Serum uric acid was tested by Uricase/PAP method [7, 15] and HbA1c by NycoCard READER II (color reflectometry) [6]. We observed the positive correlation between uric acid and HbA1c, as 0.080 which was found to be significant as 2.50 between the uric acid and HbA1c in geriatric patients of type 2 Diabetes. In healthy controls, we observed the positive correlation between uric acid and HbA1c as 0.074 which was not significant.

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