scholarly journals Influence of androgen deficiency on carbohydrate metabolism in men

2017 ◽  
Vol 14 (3) ◽  
pp. 19-24 ◽  
Author(s):  
Ashot M. Mkrtumyan ◽  
Lilit V. Egshatyan
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Carbohydrate Metabolism ◽  
Clinical Data ◽  
Current Literature ◽  
Androgen Deficiency ◽  
General Physicians ◽  
Deficiency Cases

The article provides an overview of the current literature integrating clinical data on the role of androgen deficiency in pathogenesis of metabolic malfunctions and diabetes mellitus. The combination of androgen deficiency and diabetes mellitus is a risk factor of cardiovascular diseases. Due to the fact that general physicians, endocrinologist dont have knowledge of this problem most of androgen deficiency cases are not only remained without treatment but also not revealed.

scholarly journals The role of nonesterified fatty acids in pathogenesis of cardiovascular diseases

2010 ◽  
Vol 16 (1) ◽  
pp. 93-103 ◽  
Author(s):  
M. V. Tsvetkova ◽  
V. N. Khirmanov ◽  
N. N. Zybina
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Sudden Death

The paper reviews publications concerned the role of nonesterifi ed fatty acids (NEFA) in pathogenesis of cardiovascular diseases. NEFAs are four and more carbons chain length carbonic acids and they are presented in free form (nonesterifi ed) in human body. Plasma NEFAs are produced by the adipose tissue triglyceride lipolysis, another source are lipoproteins such as chylomicrons, very low density lipoproteins and intermediate density lipoproteins. Elevated NEFA concentrations in plasma are the risk factor of cardiovascular diseases and type 2 diabetes mellitus and the independent risk factor of hypertension and sudden death. NEFA plasma concentration is elevated in atherosclerosis, acute myocardial infarction, diabetes mellitus, obesity, hypertension, and often in metabolic syndrome. A probable cause of NEFAs accumulation in plasma may be overeating and low physical activity, which result in increase of adipose tissue mass, lipolysis intensifi cation and elevation of NEFAs concentration in plasma. The role of elevated plasma NEFA concentration in a number of conditions (abdominal obesity, atherogenic dyslipidemia, insulin resistance, type 2 diabetes mellitus, endothelial dysfunction, vascular infl ammation, atherosclerosis, hypertension, ischemic heart disease, rhythm disturbances, sudden death) and possible ways of their correction are discussed.

Diabetic Retinopathy And Thromboxane Like Substance

1981 ◽  
Author(s):  
M A Lazzari ◽  
M Gimeno ◽  
N M Sutton ◽  
J R Lopez
Keyword(s):  
Diabetes Mellitus ◽  
Arachidonic Acid ◽  
Diabetic Retinopathy ◽  
Risk Factor ◽  
Platelet Aggregation ◽  
Platelet Rich Plasma ◽  
Thromboxane A2 ◽  
Initial Step ◽  
Platelet Activity

Diabetes Mellitus (DM) is a risk factor in the development of vasculopathies and its complications. It produces also its own microangiopathy. Evidence was reported of increased platelet activity in DM in different assays. Platelets aggregation and the arachidonic cycle could play a key role in the increased tendency to thrombosis. A disorder of ratio TXA2/PGI2, two opposing prostaglandin derivatives, could be the initial step. We intended to evaluate a thromboxane like substance (TLS) produced from platelet rich plasma (PRP) and to compare between normals and diabetic retinopathy (DR) patients. TLS was measured in 16 controls and 16 patients. Assay was done with the aggregating activity developed in PRP (considered TLS) after addition of arachidonic acid (f.c. 2 mM). The supernatant of the PRP (100 μl) was taken 40 sec. after the aggregation started and were added to a normal PRP treated with aspirin (f.c. 40 μl/ml) adjusted to 250.000 - 300.000 pl/μl and the degree of platelet aggregation measured in a Chrono Log Aggregometer. TLS was inactivated after its incubation during 2 min. at 37°C. This finding suggests this activity is due to TXA2.The results obtained (expressed in % of platelet aggregation) were: controls x 16.37% ± 6.28 and DR x 36.00% ± 9.72.The increase detected in the DR group supports previous experimental reports suggesting the role of the thromboxane A2 in vaso occlusive complication of diabetes mellitus.

scholarly journals Cardiovascular diseases in diabetic patients

2010 ◽  
Vol 1 (1) ◽  
pp. 46-50
Author(s):  
I. Y Yarek-Martynova ◽  
M. V Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Cerebrovascular Diseases ◽  
Diabetic Patients ◽  
Metabolic Disturbances ◽  
Lower Extremity Ischemia ◽  
Traditional Risk Factors ◽  
Extremity Ischemia

The review pays attention to a considerable rise in the incidence of diabetes mellitus (DM) and to its association with cardiovascular diseases (CVD) and events. It is noted that these events may be present much earlier than DM is diagnosed. The paper also discusses in detail a role of hyperglycemia, postprandial one in particular, hyperinsulinemia, insulin resistance, endothelial dysfunction, impaired blood rheological properties, lipid metabolic disturbances, and genetic and traditional risk factors in the development of atherosclerosis, coronary heart disease, chronic heart failure, cerebrovascular diseases, and lower extremity ischemia in DM.

scholarly journals Role of angiostatins in diabetic complications

2015 ◽  
Vol 61 (1) ◽  
pp. 41-56 ◽  
Author(s):  
A.A. Tykhomyrov ◽  
S.I. Shram ◽  
T.V. Grinenko
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Diseases ◽  
Diabetic Complications ◽  
Causative Factor ◽  
Vascular Abnormalities ◽  
Number Of Factors ◽  
First Time ◽  
Review Current ◽  
Diagnostics And Therapy

Angiogenesis is a process through which new blood vessels form from pre-existing vessels. Angiogenesis is regulated by a number of factors of peptide nature. Disbalance of angiogenic system appears to be the major causative factor contributing vascular abnormalities in diabetes mellitus, resulting in various complications. Angiostatins, which are kringle-containing fragments of plasminogen/plasmin, are known to be powerful physiological inhibitors of neovascularization. In the present review, current literature data on peculiarities of production of angiostatins and their functioning at diabetes mellitus are summarized and analyzed for the first time. Also, role of angiostatins in the pathogenesis of typical diabetic complications, including retinopathies, nephropathies and cardiovascular diseases, is discussed. Data presented in this review may be useful for elaboration of novel effective approaches for diagnostics and therapy of vascular abnormalities in diabetes mellitus.

Prognostic role of intrathecal IgM synthesis in multiple sclerosis: Results from a clinical series

2020 ◽  
pp. 135245852090791
Author(s):  
Mattia Fonderico ◽  
Tiziana Biagioli ◽  
Luisa Lanzilao ◽  
Angelo Bellinvia ◽  
Roberto Fratangelo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Regression Analysis ◽  
Risk Factor ◽  
Clinical Data ◽  
Cox Regression ◽  
Oligoclonal Bands ◽  
Prognostic Role ◽  
Cox Regression Analysis ◽  
Clinical Series

Background: There is emerging evidence that intrathecal IgM synthesis (ITMS) is a risk factor for conversion to clinically defined multiple sclerosis (CDMS) in clinically isolated syndrome (CIS) patients. Objectives: The objective of this study is to verify the prognostic role of ITMS as a risk factor for the second clinical attack in patients after the first demyelinating event. Methods: Monocentric observational study performed on prospectively acquired clinical data and retrospective evaluation of magnetic resonance imaging (MRI) data. ITMS was assessed according to Reiber’s non-linear function. We compared time to the second attack by using Kaplan–Meier curves and performed adjustment by Cox regression analysis. Results: Demographics and clinical data were collected prospectively in a cohort of 68 patients. ITMS occurred in 40% (27/68) of patients who had a higher T1-hypointense lesion load at brain MRI ( p = 0.041). In multivariate Cox regression analysis (adjusted for age, sex, baseline Expanded Disability Status Scale, IgG oligoclonal bands and disease-modifying treatment exposure), relapsing-remitting multiple sclerosis (MS) patients with ITMS were at higher risk to experience a second clinical attack (adjusted hazard ratio (aHR) = 6.3, 95% confidence interval (CI) = 2.1–18.4, p = 0.001). Conclusion: Together with previous studies, our findings support the role of ITMS as a prognostic biomarker in MS.

scholarly journals REVIEW ON UNDERSTANDING DYSLIPIDEMIA AND ITS MANAGEMENT IN AYURVEDA: A CONCEPTUAL PERSPECTIVE

2021 ◽  
Vol 12 (1) ◽  
pp. 150-153
Author(s):  
Lolashri S J ◽  
Kiran M Goud
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Lipid Level ◽  
Lifestyle Changes ◽  
Treatment Modalities ◽  
Cardiovascular Disorders ◽  
Metabolic Derangement

Lifestyle changes and alteration in diet brings about metabolic derangement eventually leading to conditions like Dyslipidemia. Raise in lipid level is the major cause and risk factor for Cardiovascular disorders, Diabetes mellitus etc. Globally one-third of incidence of Cardiovascular diseases are attributing by Dyslipidemia. In Ayurveda, this condition falls under the category of Santarpanotthavikara, which starts its pathology from the vitiation of kapha dosha, rasa and Medo dhatu. The prime Nidanas involved in this pathogenesis are Shleshmala ahara sevana, Adhyashana, avyayama and divaswapna. Considering these Nidana s and dosha-dushya vivechana our Acharya s mentioned about the administration of Guru-Atarpana dravyas, Vataghna annapana, Katu, Tikta, Kashaya rasa pradhana, Ruksha Ushna guna lines, treatment modalities like Vamana karma, Ruksha ushna Basti, Lekhana Basti, Ruksha Udvartana to tackle this condition.

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