Congenital hyperinsulinism
Keyword(s):
Β Cells
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Congenital hyperinsulinism (CHI) is one of the main causes underlying the development of persistent hypoglycemic conditions in children. Biochemically, CHI is characterized by inadequate insulin secretion from pancreatic β-cells. CHI is a heterogeneous pathology in terms of clinical manifestations, morphological features, and molecular-genetic defects contributing to its development. The present paper is focused on the current views of CHI pathogenesis; the clinical characteristic of the disease is given and the internationally accepted protocols for the examination and treatment of children with congenital hyperinsulinism are described.
2020 ◽
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pp. 671-674
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pp. 30368-30375
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pp. 799-814
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pp. 2039-2047
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2005 ◽
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pp. 1181-1184
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