Biology and Treatment of Acute Lymphocytic Leukemia in Adolescents and Young Adults

2013 ◽  
pp. 285-289
Author(s):  
Anjali S. Advani
Keyword(s):  
Young Adults ◽  
Clinical Research ◽  
Patient Population ◽  
Acute Lymphocytic Leukemia ◽  
Optimal Treatment ◽  
Lymphocytic Leukemia ◽  
Adolescents And Young Adults ◽  
Psychosocial Issues ◽  
The Past

The treatment of young adults (16 to 39 years of age) with acute lymphocytic leukemia (ALL) has been a focus of clinical research over the past decade. This review will focus on the biology, optimal treatment, treatment-related toxicities, and psychosocial issues in this patient population.

scholarly journals Is It Helpful to Believe That Efforts Will Lead to Positive Outcomes? Two Cross-Lagged Panel Investigations among Adolescents and Young Adults

2020 ◽  
Vol 17 (20) ◽  
pp. 7585
Author(s):  
Jacky C. K. Ng ◽  
Vince W. T. Cheung ◽  
Helen S. M. Wong ◽  
Sherry M. Y. Leung ◽  
Victor C. Y. Lau
Keyword(s):  
Life Satisfaction ◽  
Young Adults ◽  
Self Esteem ◽  
Adolescents And Young Adults ◽  
Time Lags ◽  
Positive Outcomes ◽  
The Past ◽  
Multiplicative Effect ◽  
Positive Effect

Over the past few decades, the role of self-views in life satisfaction has been extensively investigated. Recently, growing attention has been directed to the question of whether an optimistic worldview, termed “reward for application”, helps boost life satisfaction. Conceptually, the association between reward for application and life satisfaction can be paradoxical. Due to various methodological and theoretical shortfalls, previous investigations were unable to draw a robust conclusion on this association. To address these shortfalls, two cross-lagged panel studies were conducted with different time lags. Over and above the potential confounds of self-views (namely, self-esteem and self-rated personality traits), reward for application had a positive effect on lagged life satisfaction among both adolescents and young adults, while the reverse effect was not found. Moreover, we found support for the multiplicative effect between worldviews and self-views, in which the positive effect of reward for application on life satisfaction was attenuated by high self-esteem.

scholarly journals Age- and Sex-Related Differences in Nonfatal Dog Bite Injuries Among Persons Aged 0-19 Treated in Hospital Emergency Departments, United States, 2001-2017

2020 ◽  
Vol 135 (2) ◽  
pp. 238-244
Author(s):  
Adelaide Newman Basco ◽  
Emma Reiss McCormack ◽  
William T. Basco
Keyword(s):  
Young Adults ◽  
Emergency Departments ◽  
Adolescents And Young Adults ◽  
Dog Bite ◽  
The Past ◽  
Adjusted Rate ◽  
Hospital Emergency Departments ◽  
Year 2000 ◽  
Bite Injuries ◽  
Age And Sex

Objective: No studies using national data have evaluated changes in nonfatal dog bite injuries among children, adolescents, and young adults during the past 2 decades. We examined estimates of annual nonfatal dog bite injuries among persons aged 0-19 treated in US emergency departments (EDs) from 2001 through 2017. Methods: We examined data from the Web-based Injury Statistics Query and Reporting System to compare estimates of the annual rates of nonfatal dog bite injuries in EDs among all persons aged 0-19, by age group (0-4, 5-9, 10-14, and 15-19), and by sex. We determined significance by comparing 95% confidence intervals (CIs), and we standardized rate calculations to the year 2000 population. Results: During 2001-2017, an estimated 2 406 109 (95% CI, 2 102 643-2 709 573) persons aged 0-19 were treated in EDs for nonfatal dog bite injuries (age-adjusted rate of 173.1 per 100 000 persons aged 0-19). The estimated number of nonfatal dog bite injuries declined significantly, from 181 090 (95% CI, 158 315-203 864) in 2001 to 118 800 (95% CI, 97 933-139 667) in 2017. The highest rate was among children aged 5-9. Male children, adolescents, and young adults were significantly more likely than female children, adolescents, and young adults to be treated in the ED for nonfatal dog bite injuries, driven by male–female differences in children and adolescents aged 5-14. Conclusions: Although the estimated number of nonfatal dog bite injuries among persons aged 0-19 declined significantly in the past 2 decades, additional regulatory and educational efforts specific to age and sex may lead to further reductions in nonfatal dog bite injuries.

Grocery Shopping, Dinner Preparation, and Dietary Habits among Adolescents and Young Adults in Canada

2018 ◽  
Vol 79 (4) ◽  
pp. 157-163 ◽  
Author(s):  
Lana Vanderlee ◽  
Erin P Hobin ◽  
Christine M White ◽  
David Hammond
Keyword(s):  
Young Adults ◽  
Online Survey ◽  
Dietary Habits ◽  
Eating Habits ◽  
Adolescents And Young Adults ◽  
Grocery Shopping ◽  
Fruit Consumption ◽  
Chi Square ◽  
Cross Sectional ◽  
The Past

Purpose: The current study aimed to characterize grocery shopping and dinner preparation behaviours among young people in Canada and to examine associations with eating habits. Methods: A cross-sectional online survey was conducted with 2008 participants aged 16–24 from across Canada. The survey measured self-reported grocery shopping and dinner preparation behaviours, frequency of eating breakfast and eating meals prepared away from home, frequency of vegetable and fruit intake, and socio-demographic characteristics. Chi-square tests examined differences in proportions; logistic and linear regressions examined dietary habits, including covariates for grocery shopping and dinner preparation and socio-demographics. Results: Overall, 37.3% had helped with grocery shopping in the past week, and 84.3% had participated in dinner preparation at least 1 day in the past week. Engaging in shopping at least once weekly was associated with increased vegetable and fruit consumption only, whereas more frequent engagement in dinner preparation was associated with increased vegetable and fruit consumption, more frequent breakfast consumption, and fewer meals consumed that were prepared away from home (P < 0.001 for all). Conclusions: Increased participation in grocery shopping and dinner preparation were associated with healthier dietary habits. Interventions that increase these behaviours may contribute to improving dietary behaviours among adolescents and young adults.

scholarly journals Smoking prevalence, core/periphery network positions, and peer influence: Findings from five datasets on US adolescents and young adults

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248990
Author(s):  
Cheng Wang
Keyword(s):  
Young Adults ◽  
Young Adult ◽  
Peer Influence ◽  
Smoking Prevalence ◽  
Random Network ◽  
Smoking Behavior ◽  
The Other ◽  
Adolescents And Young Adults ◽  
Adolescent And Young Adult ◽  
The Past

Smoking prevalence has decreased significantly among US adolescents and young adults in the past 20 years. It is possible that adolescent and young adult smokers were moving from core to peripheral positions in social networks and thus less influential as suggested in previous research on adult smokers. We construct five sample datasets to test these hypotheses but none of them receives much support. When the proportion of smokers is relatively higher in two sample datasets, smokers tended to be at more marginal network positions than nonsmokers, both smokers and nonsmoker could exert peer influence, and the magnitude of peer influence from smokers was even greater than that from nonsmokers. When smoking was less frequent in the other three sample datasets, smokers and nonsmokers were at random network positions and no peer influence on smoking behavior was detected. Therefore, core/periphery network positions are still the key linking smoking prevalence and peer influence among US adolescents and young adults but operating through a different mechanism from their adult counterparts. When scientists design and conduct prevention programs against adolescent and young adult smoking behavior, core/periphery network positions, smoking prevalence, and peer influence should all be taken into consideration.

Preconception Counseling for Adolescents and Young Adults with Diabetes: a Literature Review of the Past 10 Years

2018 ◽  
Vol 18 (3) ◽  
Author(s):  
Frances Peterson-Burch ◽  
Hiba Abujaradeh ◽  
Nicole Charache ◽  
Andrea Fischl ◽  
Denise Charron-Prochownik
Keyword(s):  
Young Adults ◽  
Literature Review ◽  
Adolescents And Young Adults ◽  
Preconception Counseling ◽  
The Past

scholarly journals The Significance of Bone Marrow Lymphocytosis of Acute Leukemia Patients in Remission

Blood ◽  
1968 ◽  
Vol 32 (5) ◽  
pp. 767-773 ◽  
Author(s):  
ROLAND T. SKEEL ◽  
EDWARD S. HENDERSON ◽  
JOHN M. BENNETT
Keyword(s):  
Bone Marrow ◽  
Complete Remission ◽  
Acute Leukemia ◽  
Median Survival ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
The Past ◽  
Remission Status ◽  
Remission Duration ◽  
Subsequent Relapse

Abstract Bone marrow lymphocytosis (BML) 20 per cent or greater occurring during remission of acute leukemia has been looked upon in the past as an unfavorable sign that may presage early subsequent relapse. Seventy-four patients with acute lymphocytic leukemia were studied to evaluate the significance of BML in remission. It was found that 14 patients with less than 20 per cent bone marrow lymphocytes at any time in remission had a median remission duration of 3 months and a median survival of 21 months, while 60 patients with 20 per cent or more bone marrow lymphocytes at any time in remission had a median remission duration of 14 months and a median survival time of 34 months. Patients with AGL and lymphocytosis had remissions and survivals not significantly longer than those without lymphocytosis It is concluded that there is no justification for excluding a patient from complete remission status because of bone marrow lymphocytosis.

How I treat acute lymphocytic leukemia in adults

Blood ◽  
2007 ◽  
Vol 110 (7) ◽  
pp. 2268-2275 ◽  
Author(s):  
Jacob M. Rowe ◽  
Anthony H. Goldstone
Keyword(s):  
Acute Lymphocytic Leukemia ◽  
Residual Disease ◽  
Allogeneic Transplantation ◽  
Current Approach ◽  
Molecular Techniques ◽  
Lymphocytic Leukemia ◽  
Newly Diagnosed ◽  
Childhood All ◽  
The Past ◽  
Collaborative Studies

The treatment of newly diagnosed acute lymphocytic leukemia (ALL) in adults remains unsatisfactory. Not withstanding the outstanding progress in curing childhood ALL, only approximately one third of adults younger than 60 years can be cured, and the overall published survival curves have not changed significantly during the past 15 years. Recent therapeutic advances in allogeneic transplantation through the conduct of large collaborative studies, better understanding of the relevance of cytogenetics, improved molecular techniques for the detection of minimal residual disease, and clinical research into novel biologic and targeted therapies have all combined to offer potentially a better hope for an improved outcome in this disease. The current approach in 2007 to the management of this disease is presented by way of a discussion of illustrative cases. In this uncommon and difficult disease, well-structured intergroup studies will remain vital for future progress.

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