scholarly journals Ovotesticular Disorder of Sexual Development and Non-Palpable Testis

2021 ◽  
Vol 64 (1) ◽  
pp. 42-45
Author(s):  
Radek Štichhauer ◽  
Antonín Šafus ◽  
David Neumann ◽  
Ivo Novák ◽  
Vladana Skutilová ◽  
...  
Keyword(s):  
Sexual Development ◽  
Klinefelter Syndrome ◽  
Peer Group ◽  
Bilateral Mastectomy ◽  
Disorders Of Sexual Development ◽  
Rare Type ◽  
Left Testis ◽  
True Hermaphroditism ◽  
Disorder Of Sexual Development ◽  
The Right

Disorders of sexual development (DSD) refers to a group of diseases that links the mismatch between an individual’s genetic and gonadal development and its phenotype. Ovotesticular DSD (true hermaphroditism) is one such disease, in which both male and female gonads are present. A 15-year-old boy with a history of surgery for non-palpable testis was examined due to bilateral gynecomastia and known gonosomal mosaic of Klinefelter syndrome. The external genital was matured as male and, in the left half of the scrotum, there was a testicle of normal size. Despite uncertain resistance on the right side, however, the right testis was not palpable. Revision of the right groin revealed a surprising finding in the form of an ovary with a dilated fallopian tube, both of which were completely removed. Surgical revision of the left testis with biopsy was performed. The surgery was completed with a bilateral mastectomy. The postoperative course was uncomplicated, and the boy is content and fully integrated into his peer group. True hermaphroditism is a rare type of DSD. In the case described, DSD was not exhibited until puberty, after an examination for gynecomastia. The case also confirms the necessity of clarification and long-term follow-up of patients with unclear findings during surgery for non-palpable testis. Diagnostic laparoscopy is clearly indicated in these situations.

scholarly journals Primary Testicular Failure with Unilateral Cryptorchidism

2020 ◽  
Vol 1 (1) ◽  
pp. 16-21
Author(s):  
Ahmad Ricardo Silalahi ◽  
Tjahjo Djojo Tanojo ◽  
Reny I'tishom
Keyword(s):  
Klinefelter Syndrome ◽  
First Year ◽  
Testis Size ◽  
Left Testis ◽  
Cancer Management ◽  
Testicular Failure ◽  
The Right ◽  
First Time ◽  
Unilateral Cryptorchidism ◽  
Rule Out

Background: Primary Testicular Failure (PTF) in men with unilateral cryptorchidism is a rare case, which might be the first time reported. Case: A 34-year-old man came with infertility and azoospermia. Signs of secondary sex found. FSH levels: 60.68 mIU / ml, LH levels: 15.96 mIU / ml, T levels: 336.14 ng / dl, E2 levels: 27.81 ng / dl. Ultrasound showed the left testis in the left inguinal +/- 2,4x1,1x3,6 cm in size, with decrease vascularization; +/- 4.1 cm from the base of the penis. The right testis size +/- 2,8x1,1x2,2 cm in the right scrotum accompanied by spermatocele. The patient was referred to the Urology department for orchidopexy of the left testis in the inguinal. Discussion: Primary testicular failure, in this case, may occur due to idiopathic but does not rule out the mosaic type of Klinefelter syndrome. The patient has unilateral cryptorchidism for 20 years, there will be a risk of testicular cancer. Management of cryptorchidism must be performed orchidopexy the first year after birth. After orchidopexy, monitoring is needed every year until at least 5 years. Conclusion: PTF occurs when the parenchymal tissue contained in the testes is no longer able to produce sperm or testosterone. PTF diagnosis is only possible through pathology and testicular cytology, but the combination of FSH and Inhibin B examination remains the best recommendation as a biomarker for patients with PTF.

scholarly journals Why are there no platypuses at the Olympics?: A teleological case for athletes with disorders of sexual development to compete within their sex category

2020 ◽  
Vol 32 (1) ◽  
pp. 1-2
Author(s):  
Nathan Gamble ◽  
Michal Pruski
Keyword(s):  
Medical Treatment ◽  
South African ◽  
Sexual Development ◽  
Phenotypic Traits ◽  
Disorders Of Sexual Development ◽  
Male And Female ◽  
Testosterone Levels ◽  
Disorder Of Sexual Development ◽  
A Performance

In mid-2019, the controversy regarding South African runner Caster Semenya’s eligibility to participate in competitions against other female runners culminated in a Court of Arbitration for Sport judgement. Semenya possessed high endogenous testosterone levels (arguably a performance advantage), secondary to a disorder of sexual development. In this commentary, Aristotelean teleology is used to defend the existence of ‘male’ and ‘female’ as discrete categories. It is argued that once the athlete’s sex is established, they should be allowed to compete in the category of their sex without obligatory medical treatment. Indeed, other athletes who possess advantageous genetic or phenotypic traits that fall outside of the human norm have been allowed to compete as humans without restraint. In both cases, if an athlete possesses the essential attributes of being a human or being male or female they should be permitted to compete in those respective categories; athletes’ eligibilities should not be based upon accidental attributes.

Ovotesticular Disorder of Sexual Development (True Hermaphroditism)

Urology ◽  
2009 ◽  
Vol 73 (2) ◽  
pp. 293-296 ◽  
Author(s):  
Ann-Leslie Berger-Zaslav ◽  
Lakshmi Mehta ◽  
Jessy Jacob ◽  
Theresa Mercado ◽  
Inder Gadi ◽  
...  
Keyword(s):  
Sexual Development ◽  
True Hermaphroditism ◽  
Disorder Of Sexual Development

362: The right and the left Testis Migrates at the same time? Analisys in 144 human fetuses

2007 ◽  
Vol 177 (4S) ◽  
pp. 121-121
Author(s):  
Luciano A. Favorito ◽  
Francisco J.B. Sampaio
Keyword(s):  
Human Fetuses ◽  
Left Testis ◽  
The Right

Evaluation of 99mTc-Label led Vitamin K4 as an Agent for Testicular Imaging

1991 ◽  
Vol 30 (01) ◽  
pp. 35-39 ◽  
Author(s):  
H. S. Durak ◽  
M. Kitapgi ◽  
B. E. Caner ◽  
R. Senekowitsch ◽  
M. T. Ercan
Keyword(s):  
Soft Tissue ◽  
Room Temperature ◽  
Normal Subjects ◽  
Left Testis ◽  
Wide Range ◽  
Activity Ratios ◽  
The Right ◽  
Radioactivity Levels

Vitamin K4 was labelled with 99mTc with an efficiency higher than 97%. The compound was stable up to 24 h at room temperature, and its biodistribution in NMRI mice indicated its in vivo stability. Blood radioactivity levels were high over a wide range. 10% of the injected activity remained in blood after 24 h. Excretion was mostly via kidneys. Only the liver and kidneys concentrated appreciable amounts of radioactivity. Testis/soft tissue ratios were 1.4 and 1.57 at 6 and 24 h, respectively. Testis/blood ratios were lower than 1. In vitro studies with mouse blood indicated that 33.9 ±9.6% of the radioactivity was associated with RBCs; it was washed out almost completely with saline. Protein binding was 28.7 ±6.3% as determined by TCA precipitation. Blood clearance of 99mTc-l<4 in normal subjects showed a slow decrease of radioactivity, reaching a plateau after 16 h at 20% of the injected activity. In scintigraphic images in men the testes could be well visualized. The right/left testis ratio was 1.08 ±0.13. Testis/soft tissue and testis/blood activity ratios were highest at 3 h. These ratios were higher than those obtained with pertechnetate at 20 min post injection.99mTc-l<4 appears to be a promising radiopharmaceutical for the scintigraphic visualization of testes.

Psychological Problem in Pediatric Disorder of Sex Development Patient and Relatives

2021 ◽  
Vol 1 (2) ◽  
pp. 24-27
Author(s):  
Erlangga Danu Saputro
Keyword(s):  
Sexual Development ◽  
Psychosocial Problems ◽  
Psychological Problem ◽  
Systematic Search ◽  
Basic Data ◽  
Disorder Of Sex Development ◽  
Sex Development ◽  
Disorder Of Sexual Development ◽  
Counselling Program

Disorder of sexual development (DSD) is one of challenging disorder that has to be done clinically and physiologically. The patients and relatives may experience various psychosocial problems that have an impact on their live. The aim of this study is to look at psychological problem in children with DSD and their relatives. A systematic search was conducted in PubMed for articles representing information on psychological problem to the patient and their relatives. Relevant data were extracted and narratively reviewed. The result of this review can be used as basic data in the development of counselling program for the patients and their relatives.

scholarly journals Comorbidity between Klinefelter syndrome and diaphragmatic hernia. A case report

2014 ◽  
Vol 132 (5) ◽  
pp. 311-313
Author(s):  
Carolina Melendez Valdez ◽  
Stephan Philip Leonhardt Altmayer ◽  
Adyr Eduardo Virmond Faria ◽  
Aline Weiss ◽  
Jorge Alberto Bianchi Telles ◽  
...  
Keyword(s):  
Diaphragmatic Hernia ◽  
Ultrasound Examination ◽  
Klinefelter Syndrome ◽  
Age Groups ◽  
Left Lung ◽  
Left Lobe ◽  
Imaging Studies ◽  
Left Hemithorax ◽  
Prenatal Imaging ◽  
The Right

CONTEXT: Intrathoracic cystic lesions have been diagnosed in a wide variety of age groups, and the increasing use of prenatal imaging studies has allowed detection of these defects even in utero.CASE REPORT: A 17-year-old pregnant woman in her second gestation, at 23 weeks of pregnancy, presented an ultrasound with evidence of a cystic anechoic image in the fet al left hemithorax. A morphological ultrasound examination performed at the hospital found that this cystic image measured 3.7 cm x 2.1 cm x 1.6 cm. Polyhydramnios was also present. At this time, the hypothesis of cystic adenomatoid malformation was raised. Fet al echocardiography showed only a dextroposed heart. Fet al magnetic resonance imaging produced an image compatible with a left diaphragmatic hernia containing the stomach and at least the first and second portions of the duodenum, left lobe of the liver, spleen, small intestine segments and portions of the colon. The stomach was greatly distended and the heart was shifted to the right. There was severe volume reduction of the left lung. Fet al karyotyping showed the chromosomal constitution of 47,XXY, compatible with Klinefelter syndrome. In our review of the literature, we found only one case of association between Klinefelter syndrome and diaphragmatic hernia.CONCLUSIONS: We believe that the association observed in this case was merely coincidental, since both conditions are relatively common. The chance of both events occurring simultaneously is estimated to be 1 in 1.5 million births.

Disorders of Sexual Development in Newborns

Neonatology ◽  
2017 ◽  
pp. 1-25
Author(s):  
Antonio Balsamo ◽  
Paolo Ghirri ◽  
Silvano Bertelloni ◽  
Rosa T. Scaramuzzo ◽  
Franco D’Alberton ◽  
...  
Keyword(s):  
Sexual Development ◽  
Disorders Of Sexual Development

Ethical Aspects in the Care of Intersex Patients

2015 ◽  
Author(s):  
Timothy F. Murphy
Keyword(s):  
Sexual Development ◽  
Well Being ◽  
Psychological Effects ◽  
Adult Patients ◽  
Ethical Aspects ◽  
Disorders Of Sexual Development ◽  
Intersex Condition ◽  
Body Modifications ◽  
Health And Well Being

People with intersex conditions have male-typical and female-typical traits, to varying degrees in genetics and anatomy. Because of these variations, people with intersex conditions or disorders of sexual development can face difficulties related to their identities and relationships. As a matter of ethics, clinicians should exhibit humane behavior toward patients of all ages as they explore the meaning of their intersex condition for their health and well-being. Clinicians can also help families understand the meaning of that condition for their children and themselves. Clinicians will also have responsibilities toward child, adolescent, and adult patients bearing on the psychological effects of body modifications taken to normalize their sexual appearance. In addition, clinicians will have the responsibility to address the effects of body modifications hoped for by the patient. Observance of confidentiality is key in relationships with intersex patients.

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