scholarly journals Primary Testicular Failure with Unilateral Cryptorchidism

2020 ◽  
Vol 1 (1) ◽  
pp. 16-21
Author(s):  
Ahmad Ricardo Silalahi ◽  
Tjahjo Djojo Tanojo ◽  
Reny I'tishom
Keyword(s):  
Klinefelter Syndrome ◽  
First Year ◽  
Testis Size ◽  
Left Testis ◽  
Cancer Management ◽  
Testicular Failure ◽  
The Right ◽  
First Time ◽  
Unilateral Cryptorchidism ◽  
Rule Out

Background: Primary Testicular Failure (PTF) in men with unilateral cryptorchidism is a rare case, which might be the first time reported. Case: A 34-year-old man came with infertility and azoospermia. Signs of secondary sex found. FSH levels: 60.68 mIU / ml, LH levels: 15.96 mIU / ml, T levels: 336.14 ng / dl, E2 levels: 27.81 ng / dl. Ultrasound showed the left testis in the left inguinal +/- 2,4x1,1x3,6 cm in size, with decrease vascularization; +/- 4.1 cm from the base of the penis. The right testis size +/- 2,8x1,1x2,2 cm in the right scrotum accompanied by spermatocele. The patient was referred to the Urology department for orchidopexy of the left testis in the inguinal. Discussion: Primary testicular failure, in this case, may occur due to idiopathic but does not rule out the mosaic type of Klinefelter syndrome. The patient has unilateral cryptorchidism for 20 years, there will be a risk of testicular cancer. Management of cryptorchidism must be performed orchidopexy the first year after birth. After orchidopexy, monitoring is needed every year until at least 5 years. Conclusion: PTF occurs when the parenchymal tissue contained in the testes is no longer able to produce sperm or testosterone. PTF diagnosis is only possible through pathology and testicular cytology, but the combination of FSH and Inhibin B examination remains the best recommendation as a biomarker for patients with PTF.

Effects on differentiation of reproductive organs and sexual behaviour in Japanese quail by excessive embryonic ERα activation

2010 ◽  
Vol 22 (2) ◽  
pp. 416 ◽  
Author(s):  
Anna Mattsson ◽  
Björn Brunström
Keyword(s):  
Japanese Quail ◽  
Oestrogen Receptor ◽  
Reproductive Tract ◽  
Reproductive Organs ◽  
Positive Control ◽  
Reproductive Organ ◽  
Testis Size ◽  
Left Testis ◽  
The Right ◽  
Copulatory Behaviour

Exposure of Japanese quail (Coturnix japonica) embryos to oestrogenic substances disrupts sexual differentiation of the reproductive tract of both sexes and impairs the copulatory behaviour of the adult male. To examine whether these effects can be induced by selective activation of oestrogen receptor α (ERα), Japanese quail eggs were injected with various doses of the selective ERα agonist 16α-lactone-oestradiol (16α-LE2). The natural oestrogen 17β-oestradiol (E2) was used as a positive control. Both 16α-LE2 and E2 induced formation of an ovary-like cortex in the left testis (ovotestis) and reduced the size of the right testis in male embryos. The asymmetry in testis size remained in sexually mature males. Both substances induced retention and malformation of the Müllerian ducts in embryos of both sexes and malformed oviducts in juveniles. Male copulatory behaviour was suppressed by embryonic exposure to E2 and the highest dose of 16α-LE2. However, the lower dose of 16α-LE2, which markedly affected development of the reproductive organs, was without effects on behaviour. It can therefore not be excluded that the behavioural demasculinisation at the 100-fold higher dose involved cross-activation of oestrogen receptor β (ERβ). In conclusion, our results suggest that oestrogen-induced disruption of reproductive organ development in Japanese quail can be mediated via ERα, whereas the role of ERα in demasculinisation of copulatory behaviour remains to be clarified.

scholarly journals Ovotesticular Disorder of Sexual Development and Non-Palpable Testis

2021 ◽  
Vol 64 (1) ◽  
pp. 42-45
Author(s):  
Radek Štichhauer ◽  
Antonín Šafus ◽  
David Neumann ◽  
Ivo Novák ◽  
Vladana Skutilová ◽  
...  
Keyword(s):  
Sexual Development ◽  
Klinefelter Syndrome ◽  
Peer Group ◽  
Bilateral Mastectomy ◽  
Disorders Of Sexual Development ◽  
Rare Type ◽  
Left Testis ◽  
True Hermaphroditism ◽  
Disorder Of Sexual Development ◽  
The Right

Disorders of sexual development (DSD) refers to a group of diseases that links the mismatch between an individual’s genetic and gonadal development and its phenotype. Ovotesticular DSD (true hermaphroditism) is one such disease, in which both male and female gonads are present. A 15-year-old boy with a history of surgery for non-palpable testis was examined due to bilateral gynecomastia and known gonosomal mosaic of Klinefelter syndrome. The external genital was matured as male and, in the left half of the scrotum, there was a testicle of normal size. Despite uncertain resistance on the right side, however, the right testis was not palpable. Revision of the right groin revealed a surprising finding in the form of an ovary with a dilated fallopian tube, both of which were completely removed. Surgical revision of the left testis with biopsy was performed. The surgery was completed with a bilateral mastectomy. The postoperative course was uncomplicated, and the boy is content and fully integrated into his peer group. True hermaphroditism is a rare type of DSD. In the case described, DSD was not exhibited until puberty, after an examination for gynecomastia. The case also confirms the necessity of clarification and long-term follow-up of patients with unclear findings during surgery for non-palpable testis. Diagnostic laparoscopy is clearly indicated in these situations.

scholarly journals Asymmetries in reproductive anatomy: insights from promiscuous songbirds

2019 ◽  
Vol 128 (3) ◽  
pp. 569-582
Author(s):  
Sara Calhim ◽  
Stephen Pruett-Jones ◽  
Michael S Webster ◽  
Melissah Rowe
Keyword(s):  
Sperm Competition ◽  
Reproductive Tract ◽  
Fertilization Success ◽  
Directional Asymmetry ◽  
Male Reproductive Success ◽  
Testis Size ◽  
Left Testis ◽  
Malurus Melanocephalus ◽  
Gonad Size ◽  
The Right

Abstract Directional asymmetry in gonad size is commonly observed in vertebrates and is particularly pronounced in birds, where the left testis is frequently larger than the right. The adaptive significance of directional asymmetry in testis size is poorly understood, and whether it extends beyond the testes (i.e. side-correspondent asymmetry along the reproductive tract) has rarely been considered. Using the Maluridae, a songbird family exhibiting variation in levels of sperm competition and directional testis asymmetry, yet similar in ecology and life history, we investigated the relative roles of side-correspondence and sperm competition on male reproductive tract asymmetry at both inter- and intraspecific levels. We found some evidence for side-correspondent asymmetry. Additionally, sperm competition influenced directional asymmetry at each end of the reproductive tract: species experiencing higher levels of sperm competition had a relatively larger right testis and relatively more sperm in the right seminal glomerus. Within red-backed fairy-wrens (Malurus melanocephalus), auxiliary males had relatively more sperm in the left seminal glomerus, in contrast to a right-bias asymmetry throughout the reproductive tract in breeding males. Given that the number of sperm is important for competitive fertilization success, our results suggest that sperm competition shapes reproductive asymmetries beyond testis size, with likely functional consequences for male reproductive success.

scholarly journals The Importance of Physical Therapy in the Treatment of Unilateral Congenital Bell Paralysis - A Case Report

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Jelena Milosevic ◽  
Danijela Pavicevic ◽  
Katarina Parezanovic-Ilic ◽  
Zoran Milenkovic
Keyword(s):  
Facial Nerve ◽  
First Year ◽  
Nerve Lesion ◽  
Efficient Technology ◽  
The Face ◽  
Facial Nerve Lesion ◽  
The Right ◽  
First Year Of Life ◽  
First Time ◽  
Degree Of Recovery

Abstract Peripheral paralysis of facial nerve in the newly-born can be congenital and developed. In clinical sense, paralysis of facial nerve is characterised by paralysis of mimic face muscles that are controlled by a facial nerve. A female newly-born, delivered by Caesarean section was clinically diagnosed weakness on the right side of the face. Thirteen days after the birth the newly-born was examined by a physiatrist for the first time due to the weakness of the right facial side. During the first year of life a severe congenital lesion of facial nerve was diagnosed. Rehabilitation treatments were administered during the first year of life, with partial clinical improvement. The seriousness of facial nerve lesion has a significant influence on the degree of recovery. It is very important to identify the type of lesion by using efficient technology, since it is the only way to provide early and adequate therapy.

scholarly journals Y/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice

Life ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1219
Author(s):  
Chengqing Hu ◽  
Jiangcheng Shi ◽  
Yujing Chi ◽  
Jichun Yang ◽  
Qinghua Cui
Keyword(s):  
Flow Cytometry ◽  
X Chromosome ◽  
Sequencing Data ◽  
Left Testis ◽  
Mirna Sequencing ◽  
The Right ◽  
Almost All ◽  
Multicellular Organisms ◽  
First Time ◽  
Lower Expression

The sex chromosomes play central roles in determining the sex of almost all of the multicellular organisms. It is well known that meiosis in mammalian spermatogenesis produces ~50% Y- and ~50% X-chromosome-bearing sperm, a 1:1 ratio. Here we first reveal that the X-chromosome-encoded miRNAs show lower expression levels in the left testis than in the right testis in healthy mice using bioinformatics modeling of miRNA-sequencing data, suggesting that the Y:X ratio could be unbalanced between the left testis and the right testis. We further reveal that the Y:X ratio is significantly elevated in the left testis but balanced in the right testis using flow cytometry. This study represents the first time the biased Y:X ratio in the left testis but not in the right testis is revealed.

Variation in testis weight of the Tibetan toad Scutiger boulengeri along a narrow altitudinal gradient

2018 ◽  
Vol 68 (4) ◽  
pp. 429-439 ◽  
Author(s):  
Lixia Zhang ◽  
Dong An ◽  
Yuxiao He ◽  
Zhibing Li ◽  
Bohao Fang ◽  
...  
Keyword(s):  
Life History Theory ◽  
Reproductive Investment ◽  
Harsh Environments ◽  
The Tibetan Plateau ◽  
Testis Weight ◽  
Testis Size ◽  
Left Testis ◽  
Using Data ◽  
The Right ◽  
Small Testis

Abstract Life-history theory predicts that organisms inhabiting harsh environments such as high altitudes should invest less in reproduction and more in survival. Testis size is associated with the intensity of male-male competition for mating and thus may be treated as an indicator of male reproductive investment. Hence, it may be expected that organisms will reduce their testis size with increasingly harsh environments. Here we test this prediction in a toad species, Scutiger boulengeri, endemic to the Tibetan plateau using data from three populations located at altitudes of 4078, 4276, and 4387 m. Consistent with the prediction, male toads exhibited smaller testes at higher altitudes, despite the relatively narrow altitudinal span. It is likely that cold climates and strong seasonality constrain the ability of high-altitude male toads to allocate more energy into reproduction, thereby leading to small testis size. In addition, the left testis was significantly heavier than the right one and the degree of size asymmetry was unrelated to either altitude or body condition.

362: The right and the left Testis Migrates at the same time? Analisys in 144 human fetuses

2007 ◽  
Vol 177 (4S) ◽  
pp. 121-121
Author(s):  
Luciano A. Favorito ◽  
Francisco J.B. Sampaio
Keyword(s):  
Human Fetuses ◽  
Left Testis ◽  
The Right

Evaluation of 99mTc-Label led Vitamin K4 as an Agent for Testicular Imaging

1991 ◽  
Vol 30 (01) ◽  
pp. 35-39 ◽  
Author(s):  
H. S. Durak ◽  
M. Kitapgi ◽  
B. E. Caner ◽  
R. Senekowitsch ◽  
M. T. Ercan
Keyword(s):  
Soft Tissue ◽  
Room Temperature ◽  
Normal Subjects ◽  
Left Testis ◽  
Wide Range ◽  
Activity Ratios ◽  
The Right ◽  
Radioactivity Levels

Vitamin K4 was labelled with 99mTc with an efficiency higher than 97%. The compound was stable up to 24 h at room temperature, and its biodistribution in NMRI mice indicated its in vivo stability. Blood radioactivity levels were high over a wide range. 10% of the injected activity remained in blood after 24 h. Excretion was mostly via kidneys. Only the liver and kidneys concentrated appreciable amounts of radioactivity. Testis/soft tissue ratios were 1.4 and 1.57 at 6 and 24 h, respectively. Testis/blood ratios were lower than 1. In vitro studies with mouse blood indicated that 33.9 ±9.6% of the radioactivity was associated with RBCs; it was washed out almost completely with saline. Protein binding was 28.7 ±6.3% as determined by TCA precipitation. Blood clearance of 99mTc-l<4 in normal subjects showed a slow decrease of radioactivity, reaching a plateau after 16 h at 20% of the injected activity. In scintigraphic images in men the testes could be well visualized. The right/left testis ratio was 1.08 ±0.13. Testis/soft tissue and testis/blood activity ratios were highest at 3 h. These ratios were higher than those obtained with pertechnetate at 20 min post injection.99mTc-l<4 appears to be a promising radiopharmaceutical for the scintigraphic visualization of testes.

Implementation of the Second-year course in an Engineering Professional Spine

2018 ◽  
Author(s):  
Umar Iqbal ◽  
Deena Salem ◽  
David Strong
Keyword(s):  
Learning Outcomes ◽  
Research University ◽  
Engineering Students ◽  
Employability Skills ◽  
First Year ◽  
Computer Engineering ◽  
Core Courses ◽  
Second Year ◽  
First Time ◽  
Academic Year

The objective of this paper is to document the experience of developing and implementing a second-year course in an engineering professional spine that was developed in a first-tier research university and relies on project-based core courses. The main objective of this spine is to develop the students’ cognitive and employability skills that will allow them to stand out from the crowd of other engineering graduates.The spine was developed and delivered for the first time in the academic year 2010-2011 for first-year general engineering students. In the year 2011-2012, those students joined different programs, and accordingly the second-year course was tailored to align with the different programs’ learning outcomes. This paper discusses the development and implementation of the course in the Electrical and Computer Engineering (ECE) department.

Breast cancer associated with pregnancy: a clinical case

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (1) ◽  
pp. 102-108
Author(s):  
Yu E Dobrokhotova ◽  
S E Arakelov ◽  
S Zh Danelyan ◽  
E I Borovkova ◽  
A E Zykov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Clinical Case ◽  
First Trimester ◽  
First Year ◽  
Total Mastectomy ◽  
First Time

Associated with pregnancy is breast cancer, which was first detected during pregnancy, during the first year after childbirth or at any time against lactation. Diagnosis of the disease in the first trimester is an indication for abortion. The detection of the disease after 20 weeks and the desire of the woman to maintain pregnancy is the basis for conducting a total mastectomy followed by polychemotherapy with doxorubicin with cyclophosphamide or with fluorouracil. Radiation therapy during pregnancy is not applied. The timing and method of delivery are determined individually and depend on the stage of the process and the period of pregnancy, when it was identified. A clinical case of a patient with edematous-infiltrative form of breast cancer of the IV stage, diagnosed for the first time in 22 weeks of pregnancy, is presented.

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