Undergraduate Geography Students Define Aesthetic Maps

2012 ◽  
pp. 89-92
Author(s):  
Sven Fuhrmann
Keyword(s):  
Paradigm Shift ◽  
Spatial Representations ◽  
Web Based ◽  
Short Questionnaire ◽  
Insight Into

Several aesthetic map definition approaches aim to describe the components, concepts and aspects of aesthetic maps. While the discussion is mostly conducted by mapping professionals and researchers, one may wonder how naïve map users would define an aesthetic map. Thirty-four undergraduate geography students answered a short questionnaire in which they defined an aesthetic map, and identified the most aesthetic map along with the reasons why they liked that particular map. Preliminary findings indicate that two important concepts for aesthetic maps are clarity and being visually pleasing/attractive. Favorite aesthetic maps ranged widely from reference to thematic to imaginary maps. Questionnaire results also indicate the emerging importance of and possible aesthetic paradigm shift towards mobile and other interactive, web-based spatial representations. Naïve aesthetic map definitions could provide an important insight into current and future aesthetic map trends.

PubChem and ChEMBL Beyond Lipinski

2019 ◽  
Author(s):  
Jean-Louis Reymond ◽  
Mahendra Awale ◽  
Daniel Probst ◽  
Alice Capecchi
Keyword(s):  
Nearest Neighbor ◽  
Molecular Shape ◽  
Biological Properties ◽  
Web Based ◽  
Large Molecules ◽  
Interactive Tools ◽  
Small Molecule Drugs ◽  
Pubchem Database ◽  
Nearest Neighbor Searches ◽  
Insight Into

<p>Seven million of the currently 94 million entries in the PubChem database break at least one of the four Lipinski constraints for oral bioavailability, 183,185 of which are also found in the ChEMBL database. These non-Lipinski PubChem (NLP) and ChEMBL (NLC) subsets are interesting because they contain new modalities that can display biological properties not accessible to small molecule drugs. Unfortunately, the current search tools in PubChem and ChEMBL are designed for small molecules and are not well suited to explore these subsets, which therefore remain poorly appreciated. Herein we report MXFP (macromolecule extended atom-pair fingerprint), a 217-D fingerprint tailored to analyze large molecules in terms of molecular shape and pharmacophores. We implement MXFP in two web-based applications, the first one to visualize NLP and NLC interactively using Faerun (http://faerun.gdb.tools/), the second one to perform MXFP nearest neighbor searches in NLP (http://similaritysearch.gdb.tools/). We show that these tools provide a meaningful insight into the diversity of large molecules in NLP and NLC. The interactive tools presented here are publicly available at http://gdb.unibe.ch and can be used freely to explore and better understand the diversity of non-Lipinski molecules in PubChem and ChEMBL.</p>

Rethinking bibliographic utilities for library consortia

2020 ◽  
Vol 37 (8) ◽  
pp. 7-9
Author(s):  
Israel Odede
Keyword(s):  
Literature Review ◽  
Paradigm Shift ◽  
Design Methodology ◽  
Distributed Network ◽  
Network Resources ◽  
Content Type ◽  
Library Consortia ◽  
Individual Ownership ◽  
Insight Into

Purpose The paper aims to critically examine the bibliographic utility as a roadmap to increase library consortia and provide an insight into a new library consortia strategy that integrates librarians into a system of sharing both resources and knowledge. Design/methodology/approach This study adopted a literature review approach with a focus on bibliographic utility as a necessary prerequisite for effective library consortia, which is a paradigm shift from the concept of individual ownership to a collective access of distributed network resources and knowledge. Findings The reviewed literature indicated that significant bibliographic utilities and integrated library systems are factors that shaped and developed consortia activities in libraries. Originality/value The bibliographic utility has limited literature, and a few published scholarly studies have combined bibliographic utility and library consortia as strategies to share resources and knowledge

MetLigDB: a web-based database for the identification of chemical groups to design metalloprotein inhibitors

2011 ◽  
Vol 44 (4) ◽  
pp. 878-881 ◽  
Author(s):  
Hwanho Choi ◽  
Hongsuk Kang ◽  
Hwangseo Park
Keyword(s):  
Drug Discovery ◽  
Metal Ions ◽  
Metal Ion ◽  
Central Metal ◽  
Amino Acid Residues ◽  
Web Based ◽  
Additional Information ◽  
Chemical Groups ◽  
Insight Into ◽  
Chelating Groups

MetLigDB (http://silver.sejong.ac.kr/MetLigDB) is a publicly accessible web-based database through which the interactions between a variety of chelating groups and various central metal ions in the active site of metalloproteins can be explored in detail. Additional information can also be retrieved, including protein and inhibitor names, the amino acid residues coordinated to the central metal ion, and the binding affinity of the inhibitor for the target metalloprotein. Although many metalloproteins have been considered promising targets for drug discovery, it is difficult to discover new inhibitors because of the difficulty in designing a suitable chelating moiety to impair the catalytic activity of the central metal ion. Because both common and specific chelating groups can be identified for varying metal ions and the associated coordination environments, MetLigDB is expected to give users insight into designing new inhibitors of metalloproteins for drug discovery.

scholarly journals A new insight into root responses to external cues: Paradigm shift in nutrient sensing

2015 ◽  
Vol 10 (12) ◽  
pp. e1049791 ◽  
Author(s):  
Deepak Bhardwaj ◽  
Anna Medici ◽  
Alain Gojon ◽  
Benoît Lacombe ◽  
Narendra Tuteja
Keyword(s):  
Paradigm Shift ◽  
Nutrient Sensing ◽  
External Cues ◽  
Root Responses ◽  
Insight Into

Insight into interface design of web-based case-based reasoning retrieval systems

2009 ◽  
Vol 36 (3) ◽  
pp. 7280-7287 ◽  
Author(s):  
Wu He ◽  
Feng-Kwei Wang ◽  
Tawnya Means ◽  
Li Da Xu
Keyword(s):  
Interface Design ◽  
Case Based Reasoning ◽  
Web Based ◽  
Retrieval Systems ◽  
Insight Into ◽  
Case Based

Measuring the Conceptual Variables for E-Services Acceptance

2013 ◽  
pp. 302-309
Author(s):  
Kamaljeet Sandhu
Keyword(s):  
User Experience ◽  
Service System ◽  
Descriptive Data ◽  
Web Based ◽  
Electronic Service ◽  
Insight Into ◽  
The Web ◽  
Service Framework

This case study examines the Web Electronic Service framework for a University in Australia. The department is in the process of developing and implementing a Web-based e-service system. The user experience to use e-services requires insight into the attributes that shape the experience variable. The descriptive data about the attributes that form the experience variable is provided in this study.

Open Innovation through Customers

2014 ◽  
pp. 335-374
Author(s):  
Barbara Aquilani ◽  
Tindara Abbate
Keyword(s):  
Literature Review ◽  
Open Innovation ◽  
Paradigm Shift ◽  
Review Process ◽  
Organizational Changes ◽  
Hybrid Mode ◽  
Web Based ◽  
Organizational Issues ◽  
Areas Of Interest

This chapter aims at analyzing how firms can successfully embrace an Open Innovation (OI) process through customers, involving them, individually or in communities, in the co-creation of ideas, knowledge, products, services, processes, putting into action and integrating their creativity with firms' resources. Three main areas of interest are analyzed through a literature review process, to create a framework able to show the challenges organizations have to meet simultaneously externally (i.e. consumerism) and internally (i.e. organizational changes) in this shift of the innovation paradigm: consumerism features and challenges, OI approach and web-based platforms, and organizational issues involved in the OI paradigm shift. This chapter affords consumerism and OI approach, while the next, which is the sequel of this one, discusses OI platforms and organizational changes as well as the resulting framework. Four contributions distinguish this study: (i) the link between consumerism and OI; (ii) the focus on customers as a source of external innovation; (iii) the identification of alternative ways to access OI with customers and their features; (iv) the disclosure of a “hybrid” mode to develop OI through customers.

Web-Based Instructions

2010 ◽  
pp. 302-326
Author(s):  
Mohammed Saleh Al Balawi
Keyword(s):  
Higher Education ◽  
Faculty Attitudes ◽  
Faculty Members ◽  
Current Status ◽  
Critical Factors ◽  
Web Based ◽  
Factors Affecting ◽  
Higher Education System ◽  
Based Instruction ◽  
Insight Into

Factors affecting faculty decisions in the conventional university setup in Saudi Arabia for participating or not participating sin Web-based instruction (WBI) were investigated in this study. Incentives and barriers to WBI, faculty attitudes, and participants’ demographic information were also explored. The study was aimed to investigate the attitudes of the faculty members at three Saudi universities toward WBI in an effort to describe the current status of WBI in the Saudi higher education system. In addition, results of the study could also provide the Saudi universities and the faculty with insight into factors affecting adoption of WBI. Finally, since there have been few implementations of WBI across the country, it was important to explore how WBI is currently used in Saudi universities and to determine critical factors that could affect the implementation of WBI.

A Study of Perceptions, Usability and Future Adoption of a Web-based Learning Tool

2014 ◽  
Vol 5 (3) ◽  
pp. 69-90
Author(s):  
Romina L. Bot ◽  
Maria del Rosario Uribe ◽  
Alejandra J. Magana ◽  
Thomas Mustillo ◽  
John A. Springer
Keyword(s):  
Technology Acceptance ◽  
Perceived Usefulness ◽  
Learning Tool ◽  
Web Based ◽  
Intention To Adopt ◽  
Qualitative Approaches ◽  
Actual Use ◽  
Political Science Education ◽  
Innovation Attributes ◽  
Insight Into

Studies of technology acceptance suggest that individuals' perceptions of usage might be antecedents to predict their adoption. This research study explored students' and professors' perceptions regarding a web-based tool for political science education; the ultimate goal was to identify students and professors' perceived usefulness and usability and thus their intention to adopt the solution as a learning tool. Forty participants answered a survey questionnaire, and quantitative and qualitative approaches were followed to uncover the relationships between usability principles, innovation attributes, and perceptions of usage. The results of the study provide new insight into the factors that may contribute to the acceptance of the learning tool, and ultimately to its actual use.

Thrombotic Thrombocytopenic Purpura: A Paradigm Shift?

2000 ◽  
Vol 84 (10) ◽  
pp. 528-535 ◽  
Author(s):  
Barbara Konkle ◽  
Miha Furlan ◽  
Douglas Cines
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Paradigm Shift ◽  
Capillary Endothelium ◽  
Healthy Individuals ◽  
Thrombocytopenic Purpura ◽  
Autoimmune Attack ◽  
Sudden Appearance ◽  
Thrombotic Diseases ◽  
Insight Into ◽  
New Strategies

SummaryThe pathophysiology of thrombotic thrombocytopenic purpura (TTP) has fascinated hematologists for decades. What causes seemingly healthy individuals to suddenly develop widespread platelet-rich microthrombi in specific microvascular beds while sparing other vascular sites completely? Is the disorder caused by the sudden appearance of a novel platelet-agglutinating factor or do platelet-rich thrombi form as a consequence of insult to the capillary endothelium? Is the disease self-limiting, does plasma exchange fundamentally alter the pathophysiology of an autoimmune attack on a normal endothelium, or does the immune response develop to microvasculature that has been perturbed and, if so, by what? It has been thought by many of us that the answers to these questions will provide insight into how platelet-vessel wall interactions are normally regulated in the microvasculature and the differences that characterize the behavior of microvascular, arterial and venous systems in various organs. The corollary to these scientific issues is the anticipation that such answers would also lead to new strategies for intervention in other, more common thrombotic diseases.

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