scholarly journals A review on potential therapeutic properties of Pomegranate (Punica granatum L.)

2020 ◽  
Vol 7 (1) ◽  
pp. 9-16 ◽  
Author(s):  
H R Puneeth ◽  
S S P Chandra

Pomegranate (Punica granatum L. formerly in Punicaceae family) considered to be super food worldwide, belongs to the family Lythraceae. It is primarily cultivated in the Middle East, north and tropical Africa, the Indian subcontinent, Asia and Latin America. The medicinal potential of pomegranate is extensively mentioned in the ancient literature and also used in different system of medicines for a variety of ailments. The chemical constituents of pomegranate have increased the research concern of this fruit in the current years. It includes a variety of bioactive compounds such as quercetin, ellagic acid, punicalagin, pedunculagin, tannic acid, anthocyanins, rutin, catechin and polyphenols. These components of pomegranate possess antioxidant, neuroprotective, anti-inflammatory, anti-angiogenic, anticancerous, anti-mutagenic, cytoprotective, cardiovascular protective, anti-diabetic, anti-ulcerogenic, hepatoprotective, antibacterial and antifungal potentials. It can enhance the male fertility and also protect from the UV induced skin damage. Furthermore, it also illustrate the inhibitory effects on vital metabolic enzymes, stimulate cell differentiation and toxicological properties. The pomegranate also impedes with numerous signalling pathways, which include Bax, Bcl-X, Bad, ERK1/2, JNK, PI3K/AKT, mTOR, PI3K, MAPK and P38. The present review will extensively discuss the above properties of pomegranate and its extracts, supporting the rich nutritive and healthy advantages of the fruit belonging to the monogeneric family.

2020 ◽  
Vol 11 (1) ◽  
pp. 1067-1072
Author(s):  
Akassh M ◽  
Fathima T ◽  
Mruthunjaya K

Natural products are the main source for an alternative system of medicine. Ziziphus mauritiana, commonly known as jujubes, belongs to the family Rhamnaceae and is majorly found in the Indian subcontinent. They are traditionally used to treat chronic bronchitis, insomnia, diabetes, diarrhoea, abscesses, wounds, liver diseases, fever, sleeplessness, constipation, urinary diseases, and abdominal pains. Over the course of many years, various parts of Ziziphus mauritiana has been found to possess hair growth stimulating, anti-platelet aggregating, anti-inflammation, wound-healing, anti-obesity, antibacterial, and antioxidant effects. Various peer-reviewed research articles were collected from SCOPUS, PubMed, Google, Research Gate, and Web of Science databases. A total of 26 papers were selected based on their relevance. Acetyljujuboside B, Mauritine A, and Jujuboside A are some of the numerous chemical constituents present in Ziziphus mauritiana. The present review is an effort to provide a comprehensive review of the literature on the health-promoting effects of Ziziphus mauritiana.


2018 ◽  
Vol 16 (4) ◽  
pp. 555-566 ◽  
Author(s):  
Mohammad Shahid ◽  
Shahid-ul-Islam ◽  
Luqman Jameel Rather ◽  
Nikhat Manzoor ◽  
Faqeer Mohammad

2017 ◽  
Vol 48 ◽  
pp. 110-117
Author(s):  
N. P. Stepanyan-Gandilyan

The issues of the taxonomy of the olygotypic family Punicaceae Bercht. et J. Presl are concerned. The study of the family in 2005–2017 indicates that the differences between two species Punica granatum L. and P. protopunica Balf. f. are insufficient to treat P. protopunica, an endemic of the Socotra Island, as a separate genus. The range of the variability of morphological features and caryological data suggest advisability to preserve the both species in the genus Punica L. The family Punicaceae, in its turn, is often considered as the subfamily Punicoideae Luerss. within the family Lythraceae J. St.-Hil. The necessity to preserve Punicaceae in the range of family is determined by its distinction in the combination of several important morphological features (such as structure of fruits, seeds, position of the cotyledons, etc.) from the members of relative families.


Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 411
Author(s):  
Camille Albrecht ◽  
Zachée Louis Evariste Akissi ◽  
Philomène Akoua Yao-Kouassi ◽  
Abdulmagid Alabdul Magid ◽  
Pascal Maurice ◽  
...  

Sialidases, also called neuraminidases, are involved in several human pathologies such as neurodegenerative disorders, cancers, as well as infectious and cardiovascular diseases. Several studies have shown that neuraminidases, such as neuraminidase 1 (NEU-1), may be promising pharmacological targets. Therefore, the discovery of new selective inhibitors of NEU-1 are necessary to better understand the biological functions of this sialidase. In the present study, we describe the isolation and characterization of nine known compounds from Olyra latifolia L. leaves. This plant, known to have several therapeutic properties, belongs to the family of Poaceae and is found in the neotropics and in tropical Africa and Madagascar. Among the purified compounds, feddeiketone B, 2,3-dihydroxy-1-(4-hydroxy-3,5-diméthoxyphényl)-l-propanone, and syringylglycerol were shown to present structural analogy with DANA, and their effects on membrane NEU-1 sialidase activity were evaluated. Our results show that they possess inhibitory effects against NEU-1-mediated sialidase activity at the plasma membrane. In conclusion, we identified new natural bioactive molecules extracted from Olyra latifolia as inhibitors of human NEU-1 of strong interest to elucidate the biological functions of this sialidase and to target this protein involved in several pathophysiological contexts.


2017 ◽  
Vol 8 (4) ◽  
pp. 656-661 ◽  
Author(s):  
K. Ali ◽  
S. Khan ◽  
N. Khan ◽  
W. Khan ◽  
I. U. Rahman ◽  
...  

Punica granatum L. (wild) belongs to family Punicaceae, a woody plant, predominantly found on calcareous and alkaline soils. The species is extensively utilized as food and firewood and for the extraction of various chemicals due to its therapeutic properties. To understand the ethno-botanical and ecological status of the species on a regional scale, a questionnaire survey was conducted in the Dir (L) area using close and open-ended questionnaires. Data collected from 124 respondents were analysed quantitatively using statistical analysis to calculate indices like Relative Frequency of Citation (RFC), Use value (UV) and multivariate analysis. GPS data used for the presence data of the plants were used to develop GIS thematic maps. Geo-referenced data on P. granatum was collected from the study area, using GPS. Results suggest that the plant is mostly used as a remedy for dry cough, as an astringent, people used powder form of fruit peelings. It was documented in the present investigation that P. granatum is mainly eradicated due to its extensive use as firewood. The study also evaluated on the major aspect of how the P. granatum can be conserved naturally. It was found out that the plant is conserved in areas inaccessible to humans. The status of the vegetation community around this plant was also explored, it is found out that specific shrub and tree communities were major flora growing in proximity to P. granatum. The finding of this survey has concluded that wild P. granatum is an endangered species due to its extensive and uncontrollable use for firewood, curing diseases and its economic potential. These findings could be exploited to take necessary steps for the conservation of this species. 


2022 ◽  
pp. 711-734
Author(s):  
Sonia Singh ◽  
Nitin Agrawal ◽  
Isha Mishra

Coriander, named as Coriandrum sativum Linn, belongs to the family Umbelliferae and is one of the most popular and well-known spices/condiments and herbal medicines. The essential oils and fatty oils are the two major active chemical constituents present in the plant. The other minor ingredients found to be present are monoterpenes hydrocarbons i-e limonene, γ-terpinene, α-pinene, p-cymene, borneol, citronellol, camphor, geraniol, and geraniol acetate and abd heterocyclic components such as pyrazine, pyridine, thiazole, furan and tetrahudrofuran derivatives, isocoumarins, coriandrin, dihydrocoriandrin, coriandrons A-E, flavonoids. The volatile oil from the leaf contains aromatic acids such as 2-decenoic acid, E-11-tetradecenoic acid, undecyl alcohol, tridecanoic acid, capric acid, undecanoic acid, and more. The current pharmacological research reveals the application of coriander has antibacterial and antifungal activity.


Author(s):  
Sonia Singh ◽  
Nitin Agrawal ◽  
Isha Mishra

Coriander, named as Coriandrum sativum Linn, belongs to the family Umbelliferae and is one of the most popular and well-known spices/condiments and herbal medicines. The essential oils and fatty oils are the two major active chemical constituents present in the plant. The other minor ingredients found to be present are monoterpenes hydrocarbons i-e limonene, γ-terpinene, α-pinene, p-cymene, borneol, citronellol, camphor, geraniol, and geraniol acetate and abd heterocyclic components such as pyrazine, pyridine, thiazole, furan and tetrahudrofuran derivatives, isocoumarins, coriandrin, dihydrocoriandrin, coriandrons A-E, flavonoids. The volatile oil from the leaf contains aromatic acids such as 2-decenoic acid, E-11-tetradecenoic acid, undecyl alcohol, tridecanoic acid, capric acid, undecanoic acid, and more. The current pharmacological research reveals the application of coriander has antibacterial and antifungal activity.


2015 ◽  
Vol 18 (9) ◽  
pp. 1007-1012 ◽  
Author(s):  
Abdelaziz Souli ◽  
Hichem Sebai ◽  
Kais Rtibi ◽  
Latifa Chehimi ◽  
Mohsen Sakly ◽  
...  

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (10) ◽  
pp. 5-23
Author(s):  
D Swetha ◽  
◽  
G Krishna Mohan

Pomegranate, Punica granatum L. (Punicacece), is designated as a plant used in folklore and in several systems of medicine like ayurvedic, unani and siddha for treatment of variety of ailments, as it is believed to possess the powers of fertility, abundance and good luck. The last decade had seen virtual explosion of publications on research dealing with the potentials of pomegranate than the preceding years. Findings showed that almost all parts of pomegranate plant comprise several biochemical constituents (polyphenols, anthocyanins, tannins, alkaloids,. etc.) possessing nutritional and medicinal value. Particularly fruit exhibited potential antioxidant, anti-inflammatory, anti-carcinogenic activities and probable mechanisms are also explained. Many of these effects are related to the presence of ellagic acid, ellagitannins (punicalin, punicalagin), punicic acid, others include fatty acids, anthocyanins, flavonoids, phenols, sterols, estrogenic flavonols and minerals. However, the synergistic action of these constituents appeared to be superior than individual constituents. Promising clinical applications include treatment of cancer, obesity, diabetes, infertility, intestinal inflammation, dental conditions and dermatology. Though moderate consumption of pomegranate doesn’t result any adverse effects, some drug interactions are seen (anti-hypertensives, statins and anticoagulants like warfarin), as it inhibits CYP2C9 and CYP3A mediated drug metabolism. Aim of this review is to understand the historical background, nutritional value, chemical constituents, pharmacological activities, safety assessment (acute and sub-chronic toxicity) and drug interactions of fruit with their clinical applications. We have summarized past to current research (past 10 years) done based on antioxidant, anti-inflammatory and anti-cancer activities and tried to establish the mechanisms of action, and also thrown light on ongoing clinical trials.


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