Pharmacology and Phytochemistry of Coriander

Tridecanoic Acid ◽

Active Chemical ◽

The Family ◽

Coriander, named as Coriandrum sativum Linn, belongs to the family Umbelliferae and is one of the most popular and well-known spices/condiments and herbal medicines. The essential oils and fatty oils are the two major active chemical constituents present in the plant. The other minor ingredients found to be present are monoterpenes hydrocarbons i-e limonene, γ-terpinene, α-pinene, p-cymene, borneol, citronellol, camphor, geraniol, and geraniol acetate and abd heterocyclic components such as pyrazine, pyridine, thiazole, furan and tetrahudrofuran derivatives, isocoumarins, coriandrin, dihydrocoriandrin, coriandrons A-E, flavonoids. The volatile oil from the leaf contains aromatic acids such as 2-decenoic acid, E-11-tetradecenoic acid, undecyl alcohol, tridecanoic acid, capric acid, undecanoic acid, and more. The current pharmacological research reveals the application of coriander has antibacterial and antifungal activity.

Chemical constituents, in vitro antibacterial and antifungal activity of Mentha×Piperita L. (peppermint) essential oils

Journal of King Saud University - Science ◽

10.1016/j.jksus.2017.07.013 ◽

2019 ◽

Vol 31 (4) ◽

pp. 528-533 ◽

Cited By ~ 16

Author(s):

Nagarjuna Reddy Desam ◽

Abdul Jabbar Al-Rajab ◽

Mukul Sharma ◽

Mary Moses Mylabathula ◽

Ramachandra Reddy Gowkanapalli ◽

...

Keyword(s):

Antifungal Activity ◽

Essential Oils ◽

Chemical Constituents ◽

Mentha Piperita ◽

PHARMACOGNOSTICAL, PHYSICOCHEMICAL AND PHYTOCHEMICAL STUDIES OF PIPER LONGUM LINN. FRUITS

INTERNATIONAL JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (IJPER) ◽

10.37021/ijper.v1i1.15 ◽

2019 ◽

Vol 1 (1) ◽

pp. 19-24

Author(s):

Priyanka Sharma

Keyword(s):

Chemical Constituents ◽

Volatile Oil ◽

Water Soluble ◽

Phytochemical Analysis ◽

Chemical Parameters ◽

Piper Longum ◽

The Family ◽

Perennial Shrub ◽

Physical And Chemical ◽

Phytochemical Studies

Introduction: Piper longum Linn, belonging to the family Piperaceae, is a climber, perennial shrub which is commonly found in India. The dried fruits of Piper longum are widely used in Ayurvedic System of medicines since time unknown. It posses significant pharmacological properties due to presence of variety of chemical constituents in it. Objective: The present study is aimed to evaluate the pharmacognostical, physiochemical and phytochemical parameters for Piper longum fruits, as per the WHO guidelines for herbal drug standardization. Materials and Methods: WHO emphasized the use of standardized herbs and formulations for safety and best therapeutic results. Results and Discussion: Pharmacognostical studies shows that the fruits of Piper longum are found as green when fresh which turns grayish black upon drying. It posses pungent, bitter and acrid taste. The fruits are cylindrical with small petiole. The powder microscopy shows the presence of brown content, oleo resins, stone cells and calcium oxalate crystals. Physiochemical analysis shows variable extractive values in different solvents with maximum extractives of 20.6±0.021% in water and minimum extractive value of 6.6±0.036% in chloroform. Total Ash value of 8.3±0.015%, Acid Insoluble Ash- 1.16±0.025% and Water Soluble Ash- 5.5±0.01%, Foreign Matter- 1.62±0.12%, Moisture content of 15.70±0.051%, Bitterness value-1.96, Swelling Index-1.5±0.01 and Foaming Index- 102.33. Phytochemical analysis of the fruits of Piper longum shows the presence of alkaloids, volatile oil, tannins, fixed oils, and phenolics. Conclusion: The botanical, physical and chemical parameters obtained in this study can be used for establishing the identity and purity of the drug that will lead to safety and efficacy of the herb.

Synthesis of some new 6-aryl-3-(4-isopropylphenyl)[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles and its anti-microbial study

Current Chemistry Letters ◽

10.5267/j.ccl.2021.4.003 ◽

2021 ◽

Vol 10 (4) ◽

pp. 479-488 ◽

Cited By ~ 1

Author(s):

K. A. Joshi ◽

J. M. Dhalani ◽

H. B. Bhatt ◽

K. M. Kapadiya

Keyword(s):

Antifungal Activity ◽

Spectroscopic Techniques ◽

Aromatic Acids ◽

Reference Standard ◽

Essential Step ◽

Step Procedure ◽

Antibacterial And Antifungal ◽

Microbial Study

New series of fused 1,2,4-triazoles, i.e., 3-(4-isopropylphenyl)-6-substituted phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (5a-5j) have been synthesized via a four-step procedure and using eco-friendly reaction condition at some steps of the synthesis. It was adopted by the formation of hydrazide of methyl 4-isopropylbenzoate (1) followed by reaction with CS2 in basic media to afford potassium salt, which on cyclized to our essential step, 4-amino-5-(4-isopropylphenyl)-4H-1,2,4-triazole-3-thiol (4). The desired adducts (5a-5j) were formed by (4) on reaction with various aromatic acids in POCl3 media. The newly synthesized triazolo- thiadiazoles have been characterized by different spectroscopic techniques and investigated for their in vitro antibacterial and antifungal activity. It was revealed that the compounds 5a, 5c, 5h, and 5i showed interesting antibacterial and antifungal activity compared to the used reference standard.

Bioactive Chemical Constituents and Comparative Antimicrobial Activity of Callus Culture and Adult Plant Extracts from Alternanthera tenella

Zeitschrift für Naturforschung C ◽

10.1515/znc-2009-5-612 ◽

2009 ◽

Vol 64 (5-6) ◽

pp. 373-381 ◽

Cited By ~ 5

Author(s):

Marcos J. Salvador ◽

Paulo S. Pereira ◽

Suzelei C. França ◽

Regina C. Candido ◽

Izabel Y. Ito ◽

...

Keyword(s):

Antimicrobial Activity ◽

Antifungal Activity ◽

Callus Culture ◽

Culture Media ◽

Chemical Constituents ◽

Adult Plant ◽

Crude Extracts ◽

Antibacterial And Antifungal ◽

Adult Plants

Crude extracts of a callus culture (two culture media) and adult plants (two collections) from Alternanthera tenella Colla (Amaranthaceae) were evaluated for their antibacterial and antifungal activity, in order to investigate the maintenance of antimicrobial activity of the extracts obtained from plants in vivo and in vitro. The antibacterial and antifungal activity was determined against thirty strains of microorganisms including Gram-positive and Gram-negative bacteria, yeasts and dermatophytes. Ethanolic and hexanic extracts of adult plants collected during the same period of the years 1997 and 2002 [Ribeirão Preto (SP), collections 1 and 2] and obtained from plant cell callus culture in two different hormonal media (AtT43 and AtT11) inhibited the growth of bacteria, yeasts and dermatophytes with inhibition halos between 6 and 20 mm. For the crude extracts of adult plants bioassay-guided fractionation, purification, and isolation were performed by chromatographic methods, and the structures of the isolated compounds were established by analysis of chemical and spectral evidences (UV, IR, NMR and ES-MS). Steroids, saponins and flavonoids (aglycones and C-glycosides) were isolated. The minimum inhibitory concentration (MIC) of the isolated compounds varied from 50 to 500 μg/mL

Chemical constituents and their antibacterial and antifungal activity from the Egyptian herbal medicine Chiliadenus montanus

Phytochemistry ◽

10.1016/j.phytochem.2014.03.027 ◽

2014 ◽

Vol 103 ◽

pp. 154-161 ◽

Cited By ~ 13

Author(s):

Mohamed-Elamir F. Hegazy ◽

Hisashi Matsuda ◽

Seikou Nakamura ◽

Taha A. Hussein ◽

Masayuki Yoshikawa ◽

...

Keyword(s):

Antifungal Activity ◽

Herbal Medicine ◽

Chemical Constituents ◽

A review on potential therapeutic properties of Pomegranate (Punica granatum L.)

Plant Science Today ◽

10.14719/pst.2020.7.1.619 ◽

2020 ◽

Vol 7 (1) ◽

pp. 9-16 ◽

Cited By ~ 1

Author(s):

H R Puneeth ◽

S S P Chandra

Keyword(s):

Indian Subcontinent ◽

Chemical Constituents ◽

Punica Granatum ◽

Skin Damage ◽

Inhibitory Effects ◽

The Family ◽

Therapeutic Properties ◽

The Rich ◽

Antibacterial And Antifungal ◽

Punica Granatum L

Pomegranate (Punica granatum L. formerly in Punicaceae family) considered to be super food worldwide, belongs to the family Lythraceae. It is primarily cultivated in the Middle East, north and tropical Africa, the Indian subcontinent, Asia and Latin America. The medicinal potential of pomegranate is extensively mentioned in the ancient literature and also used in different system of medicines for a variety of ailments. The chemical constituents of pomegranate have increased the research concern of this fruit in the current years. It includes a variety of bioactive compounds such as quercetin, ellagic acid, punicalagin, pedunculagin, tannic acid, anthocyanins, rutin, catechin and polyphenols. These components of pomegranate possess antioxidant, neuroprotective, anti-inflammatory, anti-angiogenic, anticancerous, anti-mutagenic, cytoprotective, cardiovascular protective, anti-diabetic, anti-ulcerogenic, hepatoprotective, antibacterial and antifungal potentials. It can enhance the male fertility and also protect from the UV induced skin damage. Furthermore, it also illustrate the inhibitory effects on vital metabolic enzymes, stimulate cell differentiation and toxicological properties. The pomegranate also impedes with numerous signalling pathways, which include Bax, Bcl-X, Bad, ERK1/2, JNK, PI3K/AKT, mTOR, PI3K, MAPK and P38. The present review will extensively discuss the above properties of pomegranate and its extracts, supporting the rich nutritive and healthy advantages of the fruit belonging to the monogeneric family.

Temulawak (Curcuma xanthorrhizaRoxb.) belongs to the family Zingiberaceae, has been empirically used as herbal medicines. The research was aimed to evaluate three promising lines of Temulawak based on their high bioactive contents (xanthorrhizol and curcuminoid) and its in vitro bioactivity (antioxidant and toxicity), and to obtain information on agrobiophysic environmental condition which produced high bioactive compounds. The xanthorrhizol and curcuminoid contents were measured by HPLC. In vitro antioxidant and toxicity were determined by DPPH (1,1-diphenyl-2-picryl-hydrazyl) method and BSLT (Brine Shrimp Lethality Test). The result showed that promising line A produced the highest yield of bioactive and bioactivity, i.e. 0.157 and 0.056 g plant-1of xanthorrizol and curcuminoid respectively. The IC50 of antioxidant activity was 65.09 mg L-1and LC50of toxicity was 69.05 mg L-1. In this study, Cipenjo had the best temulawak performance than two other locations. According to the agrobiophysic parameters, Cipenjo environmental condition was suitable for temulawak cultivation with temperature 28-34 ºC, rainfall ± 223.97 mm year-1 and sandy clay soil. Keywords: antioxidant, curcuminoid, promising lines, temulawak, xanthorrhizol

Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) ◽

10.24831/jai.v40i2.6383 ◽

1970 ◽

Vol 40 (2) ◽

Author(s):

Waras Nurcholis ◽

Edy Djauhari Purwakusumah ◽

Mono Rahardjo ◽

Latifah K. Darusman

Keyword(s):

Antioxidant Activity ◽

Bioactive Compounds ◽

Brine Shrimp ◽

Clay Soil ◽

Herbal Medicines ◽

Environmental Condition ◽

In Vitro Bioactivity ◽

The Family ◽

Promising Line

Temulawak (Curcuma xanthorrhizaRoxb.) belongs to the family Zingiberaceae, has been empirically used as herbal medicines. The research was aimed to evaluate three promising lines of Temulawak based on their high bioactive contents (xanthorrhizol and curcuminoid) and its in vitro bioactivity (antioxidant and toxicity), and to obtain information on agrobiophysic environmental condition which produced high bioactive compounds. The xanthorrhizol and curcuminoid contents were measured by HPLC. In vitro antioxidant and toxicity were determined by DPPH (1,1-diphenyl-2-picryl-hydrazyl) method and BSLT (Brine Shrimp Lethality Test). The result showed that promising line A produced the highest yield of bioactive and bioactivity, i.e. 0.157 and 0.056 g plant-1of xanthorrizol and curcuminoid respectively. The IC50 of antioxidant activity was 65.09 mg L-1and LC50of toxicity was 69.05 mg L-1. In this study, Cipenjo had the best temulawak performance than two other locations. According to the agrobiophysic parameters, Cipenjo environmental condition was suitable for temulawak cultivation with temperature 28-34 ºC, rainfall ± 223.97 mm year-1 and sandy clay soil. Keywords: antioxidant, curcuminoid, promising lines, temulawak, xanthorrhizol

Current Advances in the Biological Activity of Polysaccharides in Dendrobium with Intriguing Therapeutic Potential

Current Medicinal Chemistry ◽

10.2174/0929867324666170227114648 ◽

2018 ◽

Vol 25 (14) ◽

pp. 1663-1681 ◽

Cited By ~ 9

Author(s):

Chun-Ting Lee ◽

Heng-Chun Kuo ◽

Yung-Hsiang Chen ◽

Ming-Yen Tsai

Keyword(s):

Biological Activity ◽

Therapeutic Potential ◽

Biological Activities ◽

Biological Effects ◽

Herbal Medicines ◽

Research Field ◽

Protective Effects ◽

Pharmacological Effects ◽

The Family ◽

Anti Tumor Activity

The polysaccharides in many plants are attracting worldwide attention because of their biological activities and medical properties, such as anti-viral, anti-oxidative, antichronic inflammation, anti-hypertensive, immunomodulation, and neuron-protective effects, as well as anti-tumor activity. Denodrobium species, a genus of the family orchidaceae, have been used as herbal medicines for hundreds of years in China due to their pharmacological effects. These effects include nourishing the Yin, supplementing the stomach, increasing body fluids, and clearing heat. Recently, numerous researchers have investigated possible active compounds in Denodrobium species, such as lectins, phenanthrenes, alkaloids, trigonopol A, and polysaccharides. Unlike those of other plants, the biological effects of polysaccharides in Dendrobium are a novel research field. In this review, we focus on these novel findings to give readers an overall picture of the intriguing therapeutic potential of polysaccharides in Dendrobium, especially those of the four commonly-used Denodrobium species: D. huoshanense, D. offininale, D. nobile, and D. chrysotoxum.

Substituted 4-Formyl-2H-chromen-2-ones: Their Reaction with N-(2,3,4,6-Tetra-Oacetyl- β-D-galactopyranosyl)thiosemicarbazide, Antibacterial and Antifungal Activity of Their Thiosemicarbazone Products

Current Organic Chemistry ◽

10.2174/1385272824999200812132256 ◽

2020 ◽

Vol 24 (19) ◽

pp. 2272-2282

Author(s):

Vu Ngoc Toan ◽

Nguyen Minh Tri ◽

Nguyen Dinh Thanh

Keyword(s):

Escherichia Coli ◽

Staphylococcus Aureus ◽

Candida Albicans ◽

Selenium Dioxide ◽

E Coli ◽

Antibacterial And Antifungal Activities ◽

Alkyl Ethers ◽

Several 6- and 7-alkoxy-2-oxo-2H-chromene-4-carbaldehydes were prepared from corresponding alkyl ethers of 6- and 7-hydroxy-4-methyl-2-oxo-2H-chromen-2-ones by oxidation using selenium dioxide. 6- and 7-Alkoxy-4-methyl-2H-chromenes were obtained with yields of 57-85%. Corresponding 4-carbaldehyde derivatives were prepared with yields of 41-67%. Thiosemicarbazones of these aldehydes with D-galactose moiety were synthesized by reaction of these aldehydes with N-(2,3,4,6-tetra-O-acetyl-β-Dgalactopyranosyl) thiosemicarbazide with yields of 62-74%. These thiosemicarbazones were screened for their antibacterial and antifungal activities in vitro against bacteria, such as Staphylococcus aureus, Escherichia coli, and fungi, such as Aspergillus niger, Candida albicans. Several compounds exhibited strong inhibitory activity with MIC values of 0.78- 1.56 μM, including 8a (against S. aureus, E. coli, and C. albicans), 8d (against E. coli and A. niger), 9a (against S. aureus), and 9c (against S. aureus and C. albicans).