scholarly journals The Relationship Between Platelet/Lymphocyte and Neutrophil/Lymphocyte Ratios and Mortality in Intensive Care Patients with Crimean-Congo Hemorrhagic Fever

Author(s):  
Onur Avcı
2020 ◽  
Vol 15 (05) ◽  
pp. 242-247 ◽  
Author(s):  
Resul Yilmaz ◽  
Erhan Karaaslan ◽  
Suleyman Ekrem Albayrak ◽  
Ali Gul ◽  
Tuba Kasap

Abstract Objective The aim of this study was to determine the clinical characteristics, course of disease, and outcomes of patients admitted to our pediatric intensive care unit (PICU) for Crimean–Congo hemorrhagic fever (CCHF). Methods Data of all patients with CCHF who were admitted to PICU during a 3-year period and whose diagnosis was confirmed by serological methods or polymerase chain reaction were retrospectively reviewed. Their presenting characteristics, treatments, and outcomes were extracted from the hospital's electronic database. Disease severity scoring was performed using the severity scoring index and severity grading score system. Results The data of 22 of 123 patients with suspected CCHF who were admitted to PICU were evaluated. Among them, 68.2% were males and mean age of all patients was 13.4 ± 2.2 years. The average length of stay of 10 patients was >10 days. On average, 3.72 units of platelet suspension per patient was transfused. In the course of the disease, the highest laboratory values were reached on day 3 of admission. Conclusion Poor CCHF outcome depends on thrombocytopenia severity, prolonged coagulation tests, high-liver enzyme levels, and disseminated intravascular coagulation. Poor outcomes can be avoided by CCHF awareness and preparedness, early diagnosis of the disease, and supportive treatment with appropriate fluid and blood product transfusion. Randomized controlled trials on prophylactic transfusion and ribavirin use are needed.


2013 ◽  
Vol 85 (10) ◽  
pp. 1794-1801 ◽  
Author(s):  
Mehmet Bakir ◽  
Sevtap Bakir ◽  
Ismail Sari ◽  
Veysel Kenan Celik ◽  
Mustafa Gokhan Gozel ◽  
...  

Author(s):  
İskender Kara ◽  
Hasan Nabi Undar ◽  
Filiz Seven ◽  
Fatma Kalem ◽  
Gaye Ural ◽  
...  

2019 ◽  
Vol 72 (2) ◽  
pp. 463-467
Author(s):  
Alessandra Soler Bastos ◽  
Lúcia Marinilza Beccaria ◽  
Daniele Cristiny da Silva ◽  
Taís Pagliuco Barbosa

ABSTRACT Objective: identify delirium and subsyndromal delirium in intensive care patients; age, hospitalization time, and mortality. Method: a retrospective, quantitative study conducted in the Intensive Care Unit, using the Richmond Agitation-Sedation Scale to evaluate sedation and the Intensive Care Delirium Screening Checklist for the identification of delirium, with the participation of 157 patients. For statistical analysis, the t-test and the Chi-square test was carried out. Results: the majority presented subsyndromal delirium (49.7%). Mortality was 21.7%. The relationship between delirium and its subsyndromal with hospitalization time was statistically significant for both (p=0.035 and p <0.001), while age was significant only in the subsyndromal delirium (p=0.009). Conclusion: the majority of the patients presented subsyndromal delirium. The length of hospital stay was statistically significant in delirium and subsyndroma delirium. Age was significant only in subsyndromal delirium. The mortality of patients with delirium was higher than the others.


Vestnik ◽  
2021 ◽  
pp. 323-329
Author(s):  
Г.Н. Абуова ◽  
Т.В. Полукчи ◽  
Ф.А. Бердалиева ◽  
Д.С. Алиев ◽  
Л.Л. Сарыпбекова ◽  
...  

Вирус Конго-Крымской геморрагической лихорадки является возбудителем тяжелой клещевой, часто смертельной, Конго-Крымской геморрагической лихорадки, которая широко распространена во всем мире. Передача вируса Конго-Крымской геморрагической лихорадки к человеку происходит через укус клеща, раздавливание зараженных клещей или контакт с инфицированной кровью человека. Миграция вируса способна через клещей с животными и перелетных птиц, в связи с чем имеется возможность исследования географического распространения посредством генетического анализа. В этом обзоре мы стремимся обобщить самые последние данные о генетическом разнообразии вирусов Конго-Крымской геморрагической лихорадки, циркулирующих в мире. Временной и пространственный анализ многообразия штаммов вируса может послужить ключевым фактором для лучшего понимания связи серопозитивности и уровня летальности. The Crimean-Congo hemorrhagic fever virus is the causative agent of severe tick-borne, often fatal, zoonotic Crimean-Congo hemorrhagic fever, which is widespread throughout the world. Transmission of the Crimean-Congo hemorrhagic fever virus to humans occurs through a tick bite, crushing of infected ticks or contact with infected host blood. The migration of the virus is possible through ticks with animals and migratory birds, and therefore it is possible to study the geographical distribution through genetic analysis. In this review, we aim to summarize the latest data on the genetic diversity of the Crimean-Congo hemorrhagic fever viruses circulating in the world. The temporal and spatial analysis of the diversity of virus strains can serve as a key factor for a better understanding of the relationship between seropositivity and the mortality rate.


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