scholarly journals A pilot study assessing reliability and age‐related differences in corticomuscular and intramuscular coherence in ankle dorsiflexors during walking

2020 ◽  
Vol 8 (4) ◽  
Author(s):  
Federico Gennaro ◽  
Eling D. Bruin
Keyword(s):  
Pilot Study ◽  
Age Related ◽  
Intramuscular Coherence ◽  
Ankle Dorsiflexors

Ankle dorsiflexors and plantarflexors neuromuscular electrical stimulation training impacts gait kinematics in older adults: a pilot study

2020 ◽  
Author(s):  
Antoine Langeard ◽  
Lucile Bigot ◽  
Gilles Loggia ◽  
Louis Bherer ◽  
Nathalie Chastan ◽  
...  
Keyword(s):  
Older Adults ◽  
Electrical Stimulation ◽  
Pilot Study ◽  
Neuromuscular Electrical Stimulation ◽  
Gait Kinematics ◽  
Ankle Dorsiflexors

scholarly journals Blinding in electric current stimulation in subacute neglect patients with current densities of 0.8 A/m2: a cross-over pilot study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Anna Gorsler ◽  
Ulrike Grittner ◽  
Nadine Külzow ◽  
Torsten Rackoll
Keyword(s):  
Pilot Study ◽  
Electric Fields ◽  
Standard Care ◽  
Small Sample Size ◽  
Small Sample ◽  
Related Factors ◽  
Attentional Deficits ◽  
Age Related ◽  
Current Densities ◽  
Improve Standard

Abstract Objective Neglect after stroke is a disabling disorder and its rehabilitation is a major challenge. Transcranial direct current stimulation (tDCS) seems to be a promising adjuvant technique to improve standard care neglect therapy. Since electric fields are influenced by age-related factors, higher current densities are probably needed for effective treatment in aged stroke patients. Validation of treatment efficacy requires sham-controlled experiments, but increased current densities might comprise blinding. Therefore, a pilot study was conducted to test sham adequacy when using current density of 0.8 A/m2. Whether especially neglect patients who mainly suffer from perceptual and attentional deficits are able to differentiate beyond chance active from sham tDCS was investigated in a randomized cross-over design (active/sham stimulation) in 12 early subacute patients with left-sided hemineglect. Stimulation (0.8 A/m2) was performed simultaneous to standard care neglect therapy. Results Odds ratio of correct guessing an atDCS condition compared to wrongly judge an atDCS condition as sham was 10.00 (95%CI 0.65–154.40, p = 0.099). However, given the small sample size and high OR, although likely somewhat overestimated, results require careful interpretation and blinding success in neglect studies with current densities of 0.8 A/m2 should be further confirmed.

Pilot study investigating the age-related decline in ovarian function of regularly menstruating normal women

2005 ◽  
Vol 84 (5) ◽  
pp. 1462-1469 ◽  
Author(s):  
Carmen L. Pastor ◽  
Vien H. Vanderhoof ◽  
Lony C.-L. Lim ◽  
Karim A. Calis ◽  
Ahalya Premkumar ◽  
...  
Keyword(s):  
Pilot Study ◽  
Ovarian Function ◽  
Age Related ◽  
Normal Women

scholarly journals A pilot study of clinical cell therapy for patients with vascular dementia

2021 ◽  
Vol 9 (2) ◽  
pp. 137-150
Author(s):  
Yunliang Wang ◽  
Xiaoling Guo ◽  
Yanqiu Liu ◽  
Yan Li ◽  
Ying Liu ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cell Therapy ◽  
Vascular Dementia ◽  
Clinical Dementia Rating ◽  
Double Blind ◽  
Cell Therapies ◽  
Group Patient ◽  
Verbal Recall ◽  
Human Lifespan ◽  
Age Related

Background:Vascular dementia (VD) is a series of clinical and neurophysiological manifestations caused by cerebrovascular disease. As the human lifespan increases, the number of people affected by age-related dementia is growing at an alarming pace, but no proved therapeutic methods can stop it from getting worse.Objective:To investigate the neurorestorative effects of injecting olfactory ensheathing cells (OECs), Schwann cells (SCs), and olfactory receptor neurons (ORNs) into olfactory sub-mucosa in VD patients.Methods:A pilot study of double-blind randomized controlled cell therapies was conducted in VD patients (n = 5). Cells were injected into the patients’ olfactory sub-mucosa. Two patients received OEC treatment, one received SC treatment, one ORN treatment, and one OEC combined with ORN. Mental state and cognitive function were observed before treatment and 1, 3, 6, and 12 months after treatment. magnetic resonance imaging (MRI) or computed tomography (CT) was performed before treatment and 12 months after treatment.Results:The directional function score on the Mini-Mental Status Examination (MMSE) in the patient who received SC treatment had increased slightly 1 and 3 months after treatment. The scores for orientation, attention, delayed verbal recall, and repetition increased in the ORN group patient 1 month after treatment. The orientation and repetition scores of the ORN group patient continued to increase 3 months after treatment. The scores for attention, delayed verbal recall, and phase 3 command decreased in the OEC and the OEC + ORN group patients after treatment assessment Scores on the Montreal Cognitive Assessment (MoCA) and Clinical Dementia Rating (CDR) scale also improved in the ORN group patient. Clinical and MRI or CT examinations did not find any side effects from the cell therapy or transplanting procedure.Conclusion:All of the cell transplantations were found to be safe. ORN was shown to be a promising therapy for VD patients. Phase II clinical trials of ORN, SC, and OEC therapy are required to verify their effects on VD symptoms, especially ORNs.

Low dose radiation for subfoveal choroidal neovascularization in age-related macular degeneration. A pilot study

1997 ◽  
Vol 93 (4) ◽  
pp. 317-326 ◽  
Author(s):  
C. Valmaggia ◽  
P. Bischoff ◽  
G. Ries ◽  
W. Seelentag ◽  
H. Niederberger ◽  
...  
Keyword(s):  
Pilot Study ◽  
Macular Degeneration ◽  
Choroidal Neovascularization ◽  
Low Dose ◽  
Age Related Macular Degeneration ◽  
Low Dose Radiation ◽  
Age Related ◽  
Subfoveal Choroidal Neovascularization ◽  
Dose Radiation

Effects of exercise programs on balance in older women with age-related visual problems: A pilot study

2012 ◽  
Vol 55 (2) ◽  
pp. 446-452 ◽  
Author(s):  
Éva Kovács ◽  
Klára Tóth ◽  
Lívia Dénes ◽  
Tamás Valasek ◽  
Klára Hazafi ◽  
...  
Keyword(s):  
Pilot Study ◽  
Older Women ◽  
Exercise Programs ◽  
Age Related ◽  
Visual Problems

scholarly journals Effects of Exercise Combined with a Healthy Diet or Calanus finmarchicus Oil Supplementation on Body Composition and Metabolic Markers—A Pilot Study

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2139
Author(s):  
Paulina Wasserfurth ◽  
Josefine Nebl ◽  
Jan Philipp Schuchardt ◽  
Mattea Müller ◽  
Tim Konstantin Boßlau ◽  
...  
Keyword(s):  
Body Composition ◽  
Pilot Study ◽  
Glucose Metabolism ◽  
Blood Lipids ◽  
Healthy Diet ◽  
Calanus Finmarchicus ◽  
Control Group ◽  
Low Grade ◽  
Age Related ◽  
Exercise Routine

Aging is accompanied by a progressive decline in muscle mass and an increase in fat mass, which are detrimental changes associated with the development of health conditions such as type-2 diabetes mellitus or chronic low-grade inflammation. Although both exercise as well as nutritional interventions are known to be beneficial in counteracting those age-related changes, data to which extent untrained elderly people may benefit is still sparse. Therefore, a randomized, controlled, 12-week interventional trial was conducted in which 134 healthy untrained participants (96 women and 38 men, age 59.4 ± 5.6 years, body mass index (BMI) 28.4 ± 5.8 kg/m2) were allocated to one of four study groups: (1) control group with no intervention (CON); (2) 2×/week aerobic and resistance training only (EX); (3) exercise routine combined with dietary counseling in accordance with the guidelines of the German Nutrition Society (EXDC); (4) exercise routine combined with intake of 2 g/day oil from Calanus finmarchicus (EXCO). Body composition (bioelectrical impedance analysis), as well as markers of glucose metabolism and blood lipids, were analyzed at the beginning and the end of the study. The highest decreases in body fat were observed within the EXCO group (−1.70 ± 2.45 kg, p < 0.001), and the EXDC (−1.41 ± 2.13 kg, p = 0.008) group. Markers of glucose metabolism and blood lipids remained unchanged in all groups. Taken together results of this pilot study suggest that a combination of moderate exercise and intake of oil from Calanus finmarchicus or a healthy diet may promote fat loss in elderly untrained overweight participants.

scholarly journals Topical dorzolamide increases pericentral visual function in age-related maculopathy: pilot study findings with short-wavelength automated perimetry

2005 ◽  
Vol 83 (2) ◽  
pp. 154-160 ◽  
Author(s):  
Andreas Remky ◽  
Anke Weber ◽  
Oliver Arend ◽  
William Eric Sponsel
Keyword(s):  
Pilot Study ◽  
Visual Function ◽  
Short Wavelength ◽  
Automated Perimetry ◽  
Age Related ◽  
Topical Dorzolamide

Pilot study of homeostatic alterations of mineral elements in serum of patients with age-related macular degeneration via elemental and isotopic analysis using ICP-mass spectrometry

2020 ◽  
Vol 177 ◽  
pp. 112857 ◽  
Author(s):  
Marta Aranaz ◽  
Marta Costas-Rodríguez ◽  
Lara Lobo ◽  
Héctor González-Iglesias ◽  
Frank Vanhaecke ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Pilot Study ◽  
Macular Degeneration ◽  
Isotopic Analysis ◽  
Mineral Elements ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Icp Mass Spectrometry

scholarly journals Age-related prefrontal cortex activation in associative memory: An fNIRS pilot study

NeuroImage ◽  
2020 ◽  
Vol 222 ◽  
pp. 117223
Author(s):  
Deborah Talamonti ◽  
Catharine A. Montgomery ◽  
Dan P.A. Clark ◽  
Davide Bruno
Keyword(s):  
Prefrontal Cortex ◽  
Pilot Study ◽  
Associative Memory ◽  
Age Related
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