Evaluation of the effect of vacuum heat treatment on the visible light remote-controlled drug release and antimicrobial activity of gold nanoparticle coated titania nanotubes

2021 ◽  
Vol 48 (1) ◽  
pp. 41-51
Author(s):  
Kyung-Suk Moon ◽  
Ji-Myung Bae ◽  
Seunghan Oh
Keyword(s):  
Heat Treatment ◽  
Antimicrobial Activity ◽  
Drug Release ◽  
Visible Light ◽  
Gold Nanoparticle ◽  
Controlled Drug Release ◽  
Titania Nanotubes ◽  
Vacuum Heat Treatment

scholarly journals Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

2020 ◽  
Vol 22 (1) ◽  
pp. 154
Author(s):  
Fasih Bintang Ilhami ◽  
Kai-Chen Peng ◽  
Yi-Shiuan Chang ◽  
Yihalem Abebe Alemayehu ◽  
Hsieh-Chih Tsai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Visible Light ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Controlled Drug Release ◽  
Grand Challenge ◽  
Supramolecular System ◽  
Oxygen Species

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1–2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer.

scholarly journals Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

2016 ◽  
Vol 52 (69) ◽  
pp. 10525-10528 ◽  
Author(s):  
Saemi O. Poelma ◽  
Seung Soo Oh ◽  
Sameh Helmy ◽  
Abigail S. Knight ◽  
G. Leslie Burnett ◽  
...  
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Small Molecules ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Micellar System ◽  
On Demand ◽  
System P

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules.

scholarly journals A visible-light-controlled platform for prolonged drug release based on Ag-doped TiO2 nanotubes with a hydrophobic layer

2018 ◽  
Vol 9 ◽  
pp. 1793-1801 ◽  
Author(s):  
Caihong Liang ◽  
Jiang Wen ◽  
Xiaoming Liao
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Controlled Drug Release ◽  
Photocatalytic Decomposition ◽  
Light Illumination ◽  
Visible Light Illumination ◽  
Delivery Platform ◽  
Promising Application ◽  
Hydrophobic Layer ◽  
Prolonged Drug Release

In this work, a visible-light-controlled drug release platform was constructed for localized and prolonged drug release based on two-layer titania nanotubes (TNTs) fabricated using by an in situ voltage up-anodization process. The visible-light photocatalytic activity is improved by loading Ag onto the TNTs by NaBH4 reduction. Then, the TNTs containing Ag nanoparticles were modified with dodecanethiol (NDM) to create a hydrophobic layer. To demonstrate the visible-light-controlled drug release, the Zn2+ release behavior of the samples was investigated. In the initial 12 h, TNTs without NDM displayed a faster release rate with 29.4% Zn2+ release, which was more than three times that of the TNTs with NDM (8.7% Zn2+ release). Upon visible-light illumination, drug release from the sample coated with NDM was shown to increase due to the photocatalytic decomposition of NDM. The amount of released Zn2+ for this sample increased up to 71.9% within 12 h, indicating visible-light-controlled drug release. This drug release system may exhibit promising application as a localized, prolonged drug delivery platform.

scholarly journals Heat Treatment Induced Specified Aggregation Morphology of Metoprolol Tartrate in Poly(ε-caprolactone) Matrix and the Drug Release Variation

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3076
Author(s):  
Zhiyu Liu ◽  
Hangling Song ◽  
Xia Chen ◽  
Aichun Han ◽  
Guiting Liu ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Treatment Method ◽  
Melt Processing ◽  
Metoprolol Tartrate ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Phosphate Buffered Saline ◽  
Hot Melt

Hot-melt blending has been widely used in the pharmaceutical industry to produce drug delivery systems, however, realizing the controlled drug release behavior of a hot-melt blended medicament it is still a tough challenge. In this study, we developed a simple and effective heat treatment method to adjust the drug release behavior, without the addition of any release modifiers. Thin metoprolol tartrate (MPT)/poly(ε-caprolactone) (PCL) tablets were prepared through hot-melt processing, and different morphologies of MPT were obtained by altering processing temperatures and the following heat treatment. MPT particles with different particle sizes were obtained under different processing temperatures, and fibrous crystals of MPT were fabricated during the following heat treatment. Different morphological structures of MPT adjusted the drug diffusion channel when immersed in phosphate-buffered saline (PBS), and various drug release behaviors were approached. After being immersed for 24 h, 7% of the MPT was released from the blend processed at 130 °C, while more than 95% of the MPT were released after the following heat treatment of the same sample. Thus, flexible drug release behaviors were achieved using this simple and effective processing manufacture, which is demonstrated to be of profound importance for biomedical applications.

A tumor mRNA-dependent gold nanoparticle–molecular beacon carrier for controlled drug release and intracellular imaging

2011 ◽  
Vol 47 (26) ◽  
pp. 7458 ◽  
Author(s):  
Guangming Qiao ◽  
Linhai Zhuo ◽  
Yuan Gao ◽  
Lijuan Yu ◽  
Na Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Gold Nanoparticle ◽  
Molecular Beacon ◽  
Controlled Drug Release ◽  
Intracellular Imaging ◽  
Tumor Mrna

scholarly journals Visible-light-triggered supramolecular valves based on β-cyclodextrin-modified mesoporous silica nanoparticles for controlled drug release

RSC Advances ◽  
2019 ◽  
Vol 9 (30) ◽  
pp. 17179-17182 ◽  
Author(s):  
Qing Bian ◽  
Zhaolu Xue ◽  
Po Sun ◽  
Kejing Shen ◽  
Shangbing Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Visible Light ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release

Visible-light triggered drug delivery system based on tetra-ortho-methoxy-substituted azobenzene (mAzo) and β-cyclodextrin (β-CD) modified mesoporous silica nanoparticles (MSNs-CD).

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