scholarly journals Association of predicted lean body mass and fat mass with cardiovascular events in patients with type 2 diabetes mellitus

2019 ◽  
Vol 191 (38) ◽  
pp. E1042-E1048 ◽  
Author(s):  
Zhenhua Xing ◽  
Liang Tang ◽  
Jian Chen ◽  
Junyu Pei ◽  
Pengfei Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lean Body Mass ◽  
Body Mass ◽  
Fat Mass ◽  
Cardiovascular Events

scholarly journals A CROSS SECTIONAL STUDY OF TYPE 2 DIABETES MELLITUS COMPARING DIFFERENT FACTORS BETWEEN LEAN BODY WEIGHT, NON OBESE AND OBESE PATIENTS IN WESTERN UTTAR PRADESH

2020 ◽  
Vol 3 (01) ◽  
pp. 404-407
Author(s):  
Manish Shrivastav ◽  
Nihit Kharkwal ◽  
Alankar Tiwari ◽  
Keshav Kumar Gupta
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Lean Body Mass ◽  
Body Mass ◽  
Glycosylated Hemoglobin ◽  
Uttar Pradesh ◽  
Lean Body Weight

Introduction- Incidence and prevalence of diabetes mellitus has been increased quite rapidly from last decade. It was thought previously that obesity is one of the major predisposing risk factor and complications of diabetes would be more common and fatal in obese persons with diabetes, but it has been shown in more recent studies that some of the factors and peculiarities are much more common in patients with lean body mass. Material and methods- This study was done in a tertiary care centre of western Uttar Pradesh over 240 cases of type 2 diabetes mellitus that were divided into three categories in equal proportion considering their body mass index (lean , non obese and obese ). Some of the factors like urine microscopy, fasting and post prandial glucose level, glycosylated hemoglobin, lipid profile and kidney functions were studied to find out the difference in level of above mentioned factors in these groups. Results- Fasting blood glucose, post prandial blood glucose, glycosylated hemoglobin level, and triglyceride level came to be signinifiacntly higher in lean body mass group as compared to other two groups. As far as renal status is concerned there was no significant variation in different groups of diabetes mellitus. Conclusion- Present study showed that lean body weight type of type 2 diabetes mellitus are definitely different subset of population of type 2 diabetes mellitus with clinical characteristics different from other subtype i.e. non obese and obese in this region of country.   Introduction- Incidence and prevalence of diabetes mellitus has been increased quite rapidly from last decade. It was thought previously that obesity is one of the major predisposing risk factor and complications of diabetes would be more common and fatal in obese persons with diabetes, but it has been shown in more recent studies that some of the factors and peculiarities are much more common in patients with lean body mass. Material and methods- This study was done in a tertiary care centre of western Uttar Pradesh over 240 cases of type 2 diabetes mellitus that were divided into three categories in equal proportion considering their body mass index (lean , non obese and obese ). Some of the factors like urine microscopy, fasting and post prandial glucose level, glycosylated hemoglobin, lipid profile and kidney functions were studied to find out the difference in level of above mentioned factors in these groups. Results- Fasting blood glucose, post prandial blood glucose, glycosylated hemoglobin level, and triglyceride level came to be signinifiacntly higher in lean body mass group as compared to other two groups. As far as renal status is concerned there was no significant variation in different groups of diabetes mellitus. Conclusion- Present study showed that lean body weight type of type 2 diabetes mellitus are definitely different subset of population of type 2 diabetes mellitus with clinical characteristics different from other subtype i.e. non obese and obese in this region of country.   Introduction- Incidence and prevalence of diabetes mellitus has been increased quite rapidly from last decade. It was thought previously that obesity is one of the major predisposing risk factor and complications of diabetes would be more common and fatal in obese persons with diabetes, but it has been shown in more recent studies that some of the factors and peculiarities are much more common in patients with lean body mass. Material and methods- This study was done in a tertiary care centre of western Uttar Pradesh over 240 cases of type 2 diabetes mellitus that were divided into three categories in equal proportion considering their body mass index (lean , non obese and obese ). Some of the factors like urine microscopy, fasting and post prandial glucose level, glycosylated hemoglobin, lipid profile and kidney functions were studied to find out the difference in level of above mentioned factors in these groups. Results- Fasting blood glucose, post prandial blood glucose, glycosylated hemoglobin level, and triglyceride level came to be signinifiacntly higher in lean body mass group as compared to other two groups. As far as renal status is concerned there was no significant variation in different groups of diabetes mellitus. Conclusion- Present study showed that lean body weight type of type 2 diabetes mellitus are definitely different subset of population of type 2 diabetes mellitus with clinical characteristics different from other subtype i.e. non obese and obese in this region of country.  

Insulin-resistant patients with type 2 diabetes mellitus have higher serum leptin levels independently of body fat mass

2002 ◽  
Vol 39 (3) ◽  
pp. 105-110 ◽  
Author(s):  
S. Fischer ◽  
M. Hanefeld ◽  
S. M. Haffner ◽  
C. Fusch ◽  
U. Schwanebeck ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Serum Leptin ◽  
Insulin Resistant

The Cardiovascular Events in Metabolic Surgery Compared to the New Classes of Glucose-Lowering Agents in Patients with T2DM

2021 ◽  
Author(s):  
Najla Shamsi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Metabolic Surgery ◽  
Cardiovascular Events ◽  
Controlled Trials ◽  
Glucose Lowering ◽  
Randomized Controlled ◽  
History Of

Type 2 Diabetes Mellitus is a prevalent chronic disease with several macrovascular and microvascular complications. Cardiovascular diseases including coronary artery disease and stroke are common macrovascular complication that reduces the quality of life and lead to early mortality. Additionally, they pose enormous socioeconomic burden on the societies and the governments. Therefore, any intervention that reduces the cardiovascular events in patients with diabetes will have positive impact of the patients and the society. Thus, this systematic review aimed to evaluate the cardiovascular events after metabolic surgery in comparison with the new classes of glucose lowering agents in patients with type 2 diabetes mellitus. The review included 11 randomized controlled trials to both GLP-1 RA and SGLT-2 i groups. It also included 7 metabolic surgery studies, 2 of these are randomized controlled trials and the other 5 are observational studies. These studies were the most relevant studies to the research question. The results revealed different baseline demographic and clinical characteristics between the medication trials and metabolic surgery studies. Moreover, it revealed significant reduction in cardiovascular events in metabolic surgery studies when compared to medication trials. It also showed significant HbA1c and weight reduction in the metabolic surgery group. The remission of diabetes was very high in the metabolic surgery group while none of medication trials accomplished diabetes recovery. However, both medication and surgery groups had adverse events. In conclusion, the review is consistent with previous literature. It suggests that metabolic surgery is more effective than medical therapy in reducing cardiovascular events. Although this conclusion should be interpreted with caution due to the differences in baseline characteristics between studies. In general, the review recommends younger adult diabetic patients with obesity and history of established cardiovascular diseases to undergo metabolic surgery. Whereas, older patients with history of cardiovascular disease should be advised to take one of the medications that has been proved to reduce cardiovascular events. Future studies that compare metabolic surgery and the new classes of the glucose lowering agents is recommended to confirm the findings in this review.

scholarly journals Incongruence in body image and body mass index: A surrogate risk marker in Black women for type 2 diabetes mellitus

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Rynal Devanathan ◽  
Viveka Devanathan ◽  
Tonya M. Esterhuizen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Body Image ◽  
Type 2 Diabetes Mellitus ◽  
Black Women ◽  
Body Mass ◽  
Risk Marker ◽  
Diabetes Group

Background: Excess weight contributes to the development and progression of Type 2 diabetes mellitus (T2DM). Distorted body image amongst urban Black women and the perception that thinness is linked with HIV, may however be compounding the problem, particularly in areas with a high HIV burden.Objectives: This study aimed to compare the perception of body image in urban Black women with and without T2DM.Methods: A cross-sectional comparative study was conducted on 328 Black women systematically sampled into two groups (with and without T2DM). Body mass index (BMI) (weight [kg]/height[m2]) was determined and the adapted Stunkard Body Image Silhouettes for Black women was used to determine perceived body image (PBI).Results: Seventy-two per cent had T2DM and in this group 89% were obese, with a mean BMI of 39.5 kg/m2 (s.d. ± 8.5). In the non-diabetes group (NDG) 44% were obese, with a mean BMIof 31.3 kg/m2 (s.d. ± 9.0) Black women underestimated their body image across all weight categories (p < 0.05). Both groups (99% of the study group) also perceived thinness as being associated with HIV.Conclusions: This study identified an incongruence between PBI and actual BMI amongst urban Black women. This, combined with their belief that thinness is associated with HIV, places those with T2DM at risk of secondary complications arising from diabetes mellitus, and those without diabetes mellitus at a higher risk of developing T2DM. A discrepancy between PBI and BMI may therefore serve as a risk marker to alert clinicians to use a more ethno-cultural specific approach in engaging with urban Black women regarding weight loss strategies in the future.

scholarly journals New clusters of type 2 diabetes mellitus and their outcomes: relation between pharmacological treatment and previous cardiovascular events

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
Claudio Santos ◽  
Sonia Brito-Costa ◽  
Luis Margalho ◽  
Pedro Monteiro
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pharmacological Treatment ◽  
Cardiovascular Events ◽  
Glycated Haemoglobin ◽  
Research Unit ◽  
Clinical Research Unit ◽  
History Of

Abstract Background Type 2 Diabetes Mellitus (T2DM) is the most common form of diabetes in adults, with 90% to 95% of cases. This study aims to establish clusters and have knowledge about the relationship between previous cardiovascular events and pharmacological treatment for T2DM. Methods 191 participants (EG) with T2DM with the average of 70.3 years (SD = 8.3) and 36 with pre-diabetes (CG) with an average of 62 years (SD = 10.3) who participated in clinical trials at Clinical Research Unit in Cardiology of Coimbra Hospital and Universitary Centre without cognitive difficulties, were divided in 5 different clusters. These were established based on six different variables: body mass index (BMI), age of each individual, age at diagnosis of DMT2, glycated haemoglobin value (HbA1c), homeostatic model that estimates the function of β cells (HOMA2-B) and insulin resistance (HOMA2-IR). Results Cluster 1 presented pre-diabetic individuals (15.9%), while diabetic individuals were divided into clusters 2 (1.8%), 3 (17.6%), 4 (21.1%) and 5 (43.6%). Regarding the study of the prevalence of previous cardiovascular events, the majority of individuals present in the different clusters had history of acute myocardial infarction (AMI). As for the prevalence of pharmacological treatment for DMT2, it was found that metformin was the most used drug. It was observed a relationship between previous AMI and metformin administration in clusters 3 (P = 0.0027; P &lt; 0.05) and 5 (P = 0.0059; P &lt; 0.05). Conclusions It was possible to create different clusters in a sample of the Portuguese population and to observe the existence of dependency relationships between different previous cardiovascular events and pharmacological treatment.

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