Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis

Testosterone’s role in female depression is not well understood, with studies reporting conflicting results. Here, we use meta-analytical and Mendelian randomization techniques to determine whether serum testosterone levels differ between depressed and healthy women and whether such a relationship is casual. Our meta-analysis shows a significant association between absolute serum testosterone levels and female depression, which remains true for the premenopausal group while achieving borderline significance in the postmenopausal group. The results from our Mendelian randomization analysis failed to show any causal relationship between testosterone and depression. Our results show that women with depression do indeed display significantly different serum levels of testosterone. However, the directions of the effect of this relationship are conflicting and may be due to menopausal status. Since our Mendelian randomization analysis was insignificant, the difference in testosterone levels between healthy and depressed women is most likely a manifestation of the disease itself. Further studies could be carried out to leverage this newfound insight into better diagnostic capabilities culminating in early intervention in female depression.

Download Full-text

Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population

SLEEP ◽

10.1093/sleep/zsz046 ◽

2019 ◽

Vol 42 (6) ◽

Cited By ~ 5

Author(s):

Takeshi Nishiyama ◽

Masahiro Nakatochi ◽

Atsushi Goto ◽

Motoki Iwasaki ◽

Tsuyoshi Hachiya ◽

...

Keyword(s):

Japanese Population ◽

Mendelian Randomization ◽

Meta Analysis ◽

Genome Wide Association ◽

Mendelian Randomization Analysis ◽

Genome Wide ◽

Randomization Analysis

Download Full-text

P42.08 Association Between the Age at First-Live Birth and Lung Cancer Risk: Meta-Analysis and Mendelian Randomization Analysis

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2021.01.1647 ◽

2021 ◽

Vol 16 (3) ◽

pp. S480-S481

Author(s):

Y. Ao ◽

Y. Li ◽

Y. Wen ◽

H. Liang ◽

W. Liang ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Live Birth ◽

Lung Cancer Risk ◽

Mendelian Randomization ◽

Meta Analysis ◽

Mendelian Randomization Analysis ◽

Randomization Analysis

Download Full-text

Mendelian randomization analysis of Circulating adiponectin levels on prostate cancer

10.21203/rs.3.rs-319125/v1 ◽

2021 ◽

Author(s):

Liangliang Ren ◽

Chenhao Yu ◽

Zhenwei Zhou ◽

Gonghui Li

Keyword(s):

Prostate Cancer ◽

Protective Effect ◽

Genome Wide Association Study ◽

Mendelian Randomization ◽

Meta Analysis ◽

Causal Effects ◽

Nucleotide Polymorphisms ◽

Genetic Associations ◽

Mendelian Randomization Analysis ◽

Randomization Analysis

Abstract Background: Previous observational studies showed a conflict with the correlation between circulating adiponectin levels and prostate cancer. Methods: In this study, we employed Mendelian randomization analysis to identify the causal effects between them. 14 single nucleotide polymorphisms were screened from the largest-scale genome-wide association study meta-analysis of adiponectin in a multi-ethnic population. The SNP outcome effects were obtained from Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome and Japanese Encyclopedia of Genetic Associations by Riken. Inverse variance weighted model with random-effects was the main effect estimation in our study, alongside weighted median, MR-Egger, and weighted mode models.Results: The results showed no significant causal estimate but a potential protective effect of adiponectin on prostate cancer. In addition, two other research of adiponectin repeated the analysis to avoid the bias of human species showing the similar results. Conclusion: Our study did not provide significant evidence to support the causal effects of circulating adiponectin levels on prostate cancer, but most of our results showed a potential protective effect requiring larger-scale MR analysis to confirm.

Download Full-text

Association between systemic lupus erythematosus and cancer: findings from cohort studies and Mendelian randomization analysis

10.21203/rs.3.rs-841744/v1 ◽

2021 ◽

Author(s):

Dongqing Gu ◽

Mingshuang Tang ◽

Huijie Cui ◽

Min Zhang ◽

Yutong Wang ◽

...

Keyword(s):

Cohort Studies ◽

Lupus Erythematosus ◽

Odds Ratio ◽

Observational Studies ◽

Mendelian Randomization ◽

Meta Analysis ◽

European Ancestry ◽

Mendelian Randomization Analysis ◽

Increased Risk ◽

Randomization Analysis

Abstract Background Observational studies suggested that systemic lupus erythematosus (SLE) was associated with an increased risk of cancer, however, the causal effect remains unclear. We aim to determine the causality between SLE and cancer using a meta-analysis and Mendelian randomization (MR) approach. Methods A systematic search was conducted using PubMed to identify cohort studies published before January 21, 2021. Meta-analysis was performed to calculate relative risk (RR) and corresponding 95% confidence intervals (CI), and the potentially causal relationships identified by observational studies were further validated using two-sample Mendelian randomization. Results Through meta-analysis of 43 cohort studies involving 231,499 patients, we observed an increased overall cancer risk among SLE patients (RR = 1.62, 95% CI, 1.47–1.79). Site-specific analysis suggested that SLE patients were associated with an increased risk of 17 cancers. Mendelian randomization analysis indicated that genetically predisposed SLE was causally associated with an increased risk of lymphoma (odds ratio = 1.0004, 95% CI, 1.0001–1.0007, P = 0.0035), whereas a decreased risk of bladder cancer (odds ratio = 0.9996, 95% CI, 0.9994–0.9998, P = 0.00004) in European ancestry. However, no relationship was observed between genetically predisposed SLE and risk of colon, pancreatic, lung, cervical and Non-melanoma skin cancer in European ancestry, liver cancer and lung cancer in Asian ancestry. Conclusions Findings from meta-analysis and Mendelian randomization analysis suggested that SLE might be causally associated with an increased risk of lymphoma. However, inconsistent results were observed between SLE and risk of bladder cancer.

Download Full-text