scholarly journals Chromosomal Aberrations and Spermhead Abnormalities Induced by Abamectin (Avermectin B1) and its Degradates in Male Swiss Albino Mice.

CYTOLOGIA ◽  
1995 ◽  
Vol 60 (4) ◽  
pp. 411-417 ◽  
Author(s):  
S. A. Salama ◽  
A. I. Fahmi ◽  
G. E. S. Abo El-Ghar
Keyword(s):  
Chromosomal Aberrations ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals EVALUATION OF GENOTOXICITY PROFILE OF JASADA BHASMA (A ZINC-BASED MINERAL FORMULATION) IN SWISS ALBINO MICE

2019 ◽  
Vol 12 (1) ◽  
pp. 305
Author(s):  
Ravi Bhasker ◽  
Megha A Doshi ◽  
Anjana S ◽  
Ravi M ◽  
Naveen Kumar ◽  
...  
Keyword(s):  
Comet Assay ◽  
Chromosomal Aberrations ◽  
Mutagenic Activity ◽  
Genetic Material ◽  
Safety Data ◽  
Vehicle Group ◽  
Swiss Albino Mice ◽  
Group I ◽  
Potential Risk Factors ◽  
Albino Mice

  Objective: Genotoxicity is regarded as one of the potential risk factors for causing pathological diseases. It was confirmed that many chemicals have the mutagenic activity which leads to cancer. A compound which interacts with genetic material DNA and shows adverse effects by altering its structure or function is referred to as genotoxic.Methods: The present study involved 40 Swiss albino mice weighing between 25 and 30 g body weights categorized into four different groups. Group-I (normal control) received 0.5% carboxymethyl cellulose as vehicle. Group-II (toxicant control) received 40 mg/kg/body weight cyclophosphamide on the 28th day. Group-III and IV received test drug JB 15.6 mg/kg and 78 mg/kg, respectively, for 28 consecutive days. Blood samples were collected and processed for evaluating by comet assay. The animals were sacrificed and collected the bone marrow from both the femur for chromosomal aberration and micronuclei assay.Results: JB administered at two different dose levels did not show any significant changes in the comet assay parameters, no micronucleus was found and did not produce any chromosomal aberrations both numerically and structurally when compared to positive test control group.Conclusion: The genotoxicity evaluation of JB did not show any chromosomal aberrations and presence of micronucleus. Thus, the safety data will refine therapeutic utility of JB encouraging their rationale use and translate into greater and broader utilization of JB.

scholarly journals EVALUATION OF GENOTOXICITY PROFILE OF JASADA BHASMA (A ZINC-BASED MINERAL FORMULATION) IN SWISS ALBINO MICE

2019 ◽  
Vol 12 (1) ◽  
pp. 305
Author(s):  
Ravi Bhasker ◽  
Megha A Doshi ◽  
Anjana S ◽  
Ravi M ◽  
Naveen Kumar ◽  
...  
Keyword(s):  
Comet Assay ◽  
Chromosomal Aberrations ◽  
Mutagenic Activity ◽  
Genetic Material ◽  
Safety Data ◽  
Vehicle Group ◽  
Swiss Albino Mice ◽  
Group I ◽  
Potential Risk Factors ◽  
Albino Mice

  Objective: Genotoxicity is regarded as one of the potential risk factors for causing pathological diseases. It was confirmed that many chemicals have the mutagenic activity which leads to cancer. A compound which interacts with genetic material DNA and shows adverse effects by altering its structure or function is referred to as genotoxic.Methods: The present study involved 40 Swiss albino mice weighing between 25 and 30 g body weights categorized into four different groups. Group-I (normal control) received 0.5% carboxymethyl cellulose as vehicle. Group-II (toxicant control) received 40 mg/kg/body weight cyclophosphamide on the 28th day. Group-III and IV received test drug JB 15.6 mg/kg and 78 mg/kg, respectively, for 28 consecutive days. Blood samples were collected and processed for evaluating by comet assay. The animals were sacrificed and collected the bone marrow from both the femur for chromosomal aberration and micronuclei assay.Results: JB administered at two different dose levels did not show any significant changes in the comet assay parameters, no micronucleus was found and did not produce any chromosomal aberrations both numerically and structurally when compared to positive test control group.Conclusion: The genotoxicity evaluation of JB did not show any chromosomal aberrations and presence of micronucleus. Thus, the safety data will refine therapeutic utility of JB encouraging their rationale use and translate into greater and broader utilization of JB.

Protective Effects of Prunus Avium Extract on 10 Ghz Induced Damages in the Spleen of Swiss Albino Mice

2011 ◽  
Vol 3 (8) ◽  
pp. 680-684 ◽  
Author(s):  
Faiza Rifat ◽  
◽  
Archana Sharma ◽  
Preeti Srivastava ◽  
Shikha Patni ◽  
...  
Keyword(s):  
Prunus Avium ◽  
Protective Effects ◽  
Swiss Albino Mice ◽  
Albino Mice

PROTECTIVE EFFECT OF ROSEMARY (ROSMARINUS OFFICINALIS L.) EXTRACT OVER THE GENOTOXICITY INDUCED BY CYCLOPHOSPHAMIDE IN SWISS ALBINO MICE

2016 ◽  
Vol 72 (9) ◽  
Author(s):  
Dr. Ayman Salah El-Seedy ◽  
Hany George Shalaby ◽  
Mohamed Ahmed El-Sehrigy ◽  
Madiha Mohiy El-Dein Ghoneim
Keyword(s):  
Protective Effect ◽  
Rosmarinus Officinalis ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Rosmarinus Officinalis L

HAEMATO-BIOCHEMICAL AND IMMUNOLOGICAL CHANGES IN EXPERIMENTALLY INDUCED ACETAMIPRID TOXICITY IN SWISS ALBINO MICE

2016 ◽  
Vol 12 (1) ◽  
Author(s):  
D.T. Fefar ◽  
Ankita N. Brahmbhatt ◽  
B.P. Joshi ◽  
D.J. Ghodasara
Keyword(s):  
Dose Level ◽  
Significant Rise ◽  
High Dose ◽  
Cell Mediated Immunity ◽  
Swiss Albino Mice ◽  
Mean Values ◽  
Group Iii ◽  
Treatment Groups ◽  
Immunological Effects ◽  
Albino Mice

A study was conducted on 5 weeks old 64 (32 male and 32 female) Swiss albino mice to assess the haemato-biochemical and immunological effects of acetamiprid. All the male and female mice were randomly divided into eight different groups. The groups I (male) and II (female) served as controls whereas remaining groups served as treatment groups and were administered acetamiprid at the daily dose rate of 20, 10, 5 mg/kg body weight in males(Group III, V, VII) and females (Group IV, VI,VIII),respectively for 28 days. After 28 days treatment, blood samples were collected for hematological, biochemical as well as immunological analysis. There was significant decrease in haematological parameters like Hb, TEC, TLC, neutrophils and lymphocytes count in high dose groups and revealed potential adversity of acetamiprid at rates of 20 mg/kg/day on haematopoetic system of mice. A dose dependent significant rise in mean values of AST and ALT was observed in treatment groups, whereas there was significant decrease in total protein and albumin and increase in BUN in high and mid dose treated groups, irrespective of sex of mice. Dinitroflurobenzene (DNFB) test conducted to assess the cell mediated immunity revealed the toxic effect of acetamiprid on cell mediated immunity of mice at dose level of 10 mg/kg/day. The mice of high dose group revealed a significant decrease in HA titer and indicated the immunotoxic potential of acetamiprid at dose level of 20 mg/kg/day.

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