Polymorphism of MMP1 and MMP3 promoter regions and HR-HPV infection in women from Burkina Faso and Côte d‘Ivoire

AbstractThe single nucleotide polymorphism (SNP) of the promoter region of MMP-1 (at 1607 bp) and MMP-3 (at 1171 bp) create Ets binding sites. Correlations between these SNPs and sensitivity to several biological processes such as metastasis and recurrence of cancer have been reported in several studies.In this case-control study, we looked for these SNPs in women infected with or not with high-risk human papillomaviruses (HR-HPV). The frequency, distribution and correlation of these SNPs with the presence or absence of HR-HPV infection were evaluated.Genotypes 1G1G, 1G2G and 2G2G for MMP1 and genotypes 5A5A, 5A6A, 6A6A for MMP3 were found in our study population. In general, we noted that the 1G (40.8%) and 2G (64.8%) alleles were more frequent in non-infected women and infected women, respectively, and more specifically this difference was significant in women from Côte d‘Ivoire.These results, although yet to be reaffirmed with assays for quantifying the mRNA of these genes, suggest that the SNP of the MMP-1 promoter could promote infection with HR-HPV.

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Erratum to “Polymorphism of MMP1 and MMP3 promoter regions and HR-HPV infection in women from Burkina Faso and Côte d‘Ivoire”

BioMolecular Concepts ◽

10.1515/bmc-2020-0013 ◽

2020 ◽

Vol 11 (1) ◽

pp. 142

Author(s):

Prosper Bado ◽

Florencia Wendkuuni Djigma ◽

Théodora Mahoukèdè Zohoncon ◽

Dorcas Obiri-Yeboah ◽

Esther Mah Alima Traoré ◽

...

Keyword(s):

Burkina Faso ◽

Cote D'ivoire ◽

Côte D’Ivoire ◽

Hpv Infection ◽

Promoter Regions ◽

Cote D’Ivoire ◽

Côte D'ivoire

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Human papilloma viruses infection among adolescent females perinatally infected with HIV in Côte d’Ivoire

Sexually Transmitted Infections ◽

10.1136/sextrans-2019-054420 ◽

2020 ◽

pp. sextrans-2019-054420

Author(s):

Boris Tchounga ◽

Apollinaire Horo ◽

Simon Boni ◽

Aristophane Tanon ◽

Madeleine Amorissani Folquet ◽

...

Keyword(s):

Cote D'ivoire ◽

Côte D’Ivoire ◽

Sexual Debut ◽

Hpv Infection ◽

Adolescent Females ◽

Childbearing Age ◽

Cross Sectional Survey ◽

Cote D’Ivoire ◽

Côte D'ivoire ◽

Prospective Longitudinal

BackgroundCervical cancer prevention strategies recommend human papilloma virus (HPV) vaccination for female adolescents prior to their sexual debut. While HIV is a major risk factor for HPV infection in women of childbearing age, its prevalence among HIV-infected adolescent female is mostly unknown. This study aimed to describe the HPV prevalence and correlates among perinatally HIV-infected adolescent females prior to HPV immunisation.MethodsA cross-sectional survey was conducted from January to June 2016, in the four major paediatric HIV clinics of Abidjan, Côte d’Ivoire. All HIV-infected females aged 11–16 years were approached to participate in the study. A questionnaire assessing sexual behaviours and genital hygiene practices was administered to participants completed with a systematic vaginal swab collection. HPV genotyping was performed using the Anyplex II HPV28 Detection (Seegene). A logistic regression analysis was performed to identify factors associated with the presence of HPV infection. HPV immunisation was proposed free of charge to all participants.ResultsA total of 250 participants were included, with a median age of 13 years (IQR 11–14). Among them, 237 (94.8%) were on antiretroviral treatment with a median CD4 count of 660 (IQR 439–914) cells/mm3. The overall prevalence of at least one HPV was 3.6% (95% CI 1.6 to 6.7) and the prevalence of at least one carcinogenic HPV was 2.8% (95% CI 0.7 to 4.8). Vaginal cleansing was reported by 75 (30%) of participants, with a median age at initiation of 12 years (IQR 10–13). Sexual activity was self-reported by 12 (4.8%) participants with a median age at sexual debut of 11 years (IQR 10–14). HPV infection was associated with vaginal cleansing (adjusted OR=7.0 (95% CI 1.4 to 31.6)).ConclusionThe reported low prevalence of carcinogenic HPV infections supports the appropriateness of HPV immunisation in this population. The reported association between cleansing practices and HPV infection deserves further prospective longitudinal studies.

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PROGRESSION OF AUTOANTIBODIES ANTI-GAD AND ANTI-IA2 IN TYPE 1A DIABETICS AGED OF 5 TO 21 YEARS IN CÔTE D’IVOIRE

10.1101/551473 ◽

2019 ◽

Author(s):

Aïssé Florence Judith Trébissou ◽

Chiayé Claire Antoinette Yapo-Crezoit ◽

Pascal Sibailly ◽

Mamadou Sanogo ◽

Amos Ankotché ◽

...

Keyword(s):

Cote D'ivoire ◽

Côte D’Ivoire ◽

Cell Mass ◽

Mean Value ◽

Cote D’Ivoire ◽

Gad Autoantibodies ◽

A Value ◽

Côte D'ivoire ◽

Study Population ◽

The Mean

AbstractBackgroundDiabetes autoantibodies are indispensable markers of diabetes classification.Objectiveto research autoantibodies anti-GAD and anti-IA2 in type 1A diabetics (T1D) aged 5 to 21 years, and to follow the progression of these autoantibodies in T1D patients, in Côte d’Ivoire.MethodsThe study population composed of 28 T1D patients, aged 5 to 21 years. T1D were followed up in two diabetes care centers in Abidjan district, Endocrinology departments of U.H.C of Yopougon and Treichville. Anti-GAD and anti-IA2 autoantibodies were researched by ELISA.Resultsanti-GAD and anti-IA2 were present in T1D and their siblings. After 2 years of diabetes, the titer of the anti-GAD autoantibodies increased to the mean value of 677.10 ± 353.20 IU / ml. Then, a fall of the anti-GAD autoantibodies until the cancellation was observed from the 8th to the 9th with values of 117 IU / ml to 10.14 IU / ml. Anti-IA2 autoantibodies fall at 9th year of diabetes with a value of 55.10 IU / ml.Conclusionanti-GAD and anti-IA2 autoantibodies persist after 9 years of diabetes, causing total destruction over time of the pancreatic β-cell mass in patients from Côte d’Ivoire, leading them to the death.

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