Plasma thiol/disulphide homeostasis changes in patients with restless legs syndrome

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ertan Kucuksayan ◽  
Serkan Ozben ◽  
Selma Topaloglu Tuac ◽  
Mesrure Koseoglu ◽  
Ozcan Erel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Restless Legs Syndrome ◽  
Rating Scales ◽  
Spectrophotometric Analysis ◽  
Healthy Controls ◽  
Restless Legs ◽  
Severity Rating ◽  
Total Thiol ◽  
Disease Rating ◽  
Positive Correlations

Abstract Objectives Restless legs syndrome (RLS) is a common neurological condition. Oxidative stress plays an important role in its pathogenesis. Thiol-disulphide homeostasis (TDH) is a new biomarker of oxidative stress. We studied plasma TDH to determine whether TDH could be used as a new biomarker for RLS and evaluated correlations between TDH and various disease severity rating scales. Methods A total of 25 RLS patients and 25 healthy controls were included into the study. TDH status was determined using an automated spectrophotometric analysis method and correlations were analyzed between the TDH status and various disease rating scales in the RLS patients. Results Plasma total (401 ± 27 μmol/L) and native thiol (354 ± 30 μmol/L) levels were significantly lower, but disulphide level (24 ± 6 μmol/L) was significantly (<0.0001) higher in the RLS patients compared to the controls (455 ± 36, 424 ± 37, 15 ± 5 μmol/L, respectively). The disulphide/native thiol and disulphide/total thiol ratios increased, in contrast, native thiol/total thiol ratio decreased significantly in the RLS patients compared to the healthy controls (<0.0001). The disulphide levels correlated positively with age and various rating scores of the RLS patients. International Restless Legs Syndrome Study Group (IRLSSG) rating score and age correlated negatively with the total and native thiol levels. Conclusions Our findings indicate increased oxidative stress in the RLS patients reflected by decreased native and total thiol, and increased disulphide levels and positive correlations between the disulphide levels and various rating scores. We suggest dynamic TDH status to be used as a novel biomarker for the diagnosis and follow-up of the RLS patients.

scholarly journals Review of Severity Rating Scales for Restless Legs Syndrome: Critique and Recommendations

2014 ◽  
Vol 1 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Arthur S. Walters ◽  
Birgit Frauscher ◽  
Richard Allen ◽  
Heike Benes ◽  
K. Ray Chaudhuri ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Rating Scales ◽  
Restless Legs ◽  
Severity Rating

Prevalence of restless legs syndrome and REM sleep behavior disorder in multiple sclerosis

2007 ◽  
Vol 13 (6) ◽  
pp. 805-808 ◽  
Author(s):  
M.J. Gómez-Choco ◽  
A. Iranzo ◽  
Y. Blanco ◽  
F. Graus ◽  
J. Santamaria ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Restless Legs Syndrome ◽  
Rem Sleep ◽  
Neurological Disease ◽  
Age Distribution ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Healthy Controls ◽  
Sleep Behavior ◽  
Restless Legs

A total of 135 consecutive, unrelated, multiple sclerosis (MS) patients were interviewed for symptoms suggestive of restless legs syndrome (RLS) and REM sleep behavior disorder (RBD), using semi-structured questionnaires. Some 118 unrelated healthy controls of similar sex and age distribution were included for comparison. Patients and controls with equivocal symptoms were re-evaluated by a sleep disorders specialist and video-polisomnography in those who fulfilled the criteria for RBD. We did not find significant differences in frequency (13.3 versus 9.3%), proportion of females (66.7 versus 58.5%), and mean age (42.1±12.6 versus 43±7.8 years) among MS patients and controls with RLS. RBD was found in three patients (1.4%), one associated with antidepressant intake, but in none of the controls. Our study shows that RLS in MS is not more frequent than in the general population, and that RBD, although uncommon, may occur in the setting of this neurological disease. Multiple Sclerosis 2007; 13: 805-808. http://msj.sagepub.com

scholarly journals Polysomnography Findings in Patients with Restless Legs Syndrome and in Healthy Controls: A Comparative Observational Study

SLEEP ◽  
2007 ◽  
Vol 30 (7) ◽  
pp. 861-865 ◽  
Author(s):  
Magdolna Hornyak ◽  
Bernd Feige ◽  
Ulrich Voderholzer ◽  
Alexandra Philipsen ◽  
Dieter Riemann
Keyword(s):  
Observational Study ◽  
Restless Legs Syndrome ◽  
Healthy Controls ◽  
Restless Legs

scholarly journals 0790 The Clinical Significance of Hepcidin as a Predictive Value for Treatment Responses in Restless Legs Syndrome

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A300-A301
Author(s):  
H Im
Keyword(s):  
Restless Legs Syndrome ◽  
Iron Homeostasis ◽  
Dependent Manner ◽  
Healthy Controls ◽  
Restless Legs ◽  
Inflammatory Processes ◽  
Drug Naïve ◽  
Therapeutic Responses

Abstract Introduction Restless legs syndrome (RLS) is a common sensory motor neurological disorder that is related to iron-dopamine dysregulation and immune system alteration. Hepcidin is the key regulatory hormone of systemic iron homeostasis and is related to inflammatory processes. We aimed to evaluate the clinical utility of hepcidin as a diagnostic biomarker and index of therapeutic responses in RLS patients after dopaminergic treatment. Methods Non-anemic and drug-naive RLS patients (n=18) and healthy controls (n=15) were enrolled. Hepcidin (pre-prohepcidin) and iron-related values in serum were measured upon the first visit in both groups and 12 weeks later after dopaminergic treatment in 12 RLS patients. Information about sociodemographic characteristics, sleep-related profiles, mood, and anxiety was obtained upon the first visit in all participants as well as after treatment in RLS patients. Results Hepcidin levels exhibited no significant differences between patients with drug-naïve RLS and healthy controls at a diagnosis (7.1 ± 2.4 vs. 7.0 ± 3.2 ng/ml, p = 0.978). Decreased hepcidin levels were significantly associated with decreased RLS severity (β = 0.002, 95% CI = 0.00−0.00, p = 0.005) and improved quality of life (β = 0.002, 95% CI = 0.00−7.01, p = 0.044) in a dose-dependent manner after 12 weeks of treatment with a dopamine agonist. This association was independent of age, sex, inflammatory markers, sleep quality, insomnia, daytime sleepiness, depression, and anxiety. Conclusion This study demonstrates a role of hepcidin as a predictor of therapeutic responses in RLS patients. Support This work was supported by the Korea Health technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, South Korea [grant number HI17C2072].

International Restless Legs Syndrome Study Group Severity Rating Scale

2019 ◽  
Author(s):  
Denise Sharon ◽  
◽  
Richard P. Allen ◽  
Pablo Martinez-Martin ◽  
Arthur S. Walters ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Rating Scale ◽  
Study Group ◽  
Restless Legs ◽  
Severity Rating

scholarly journals Restless Legs Syndrome in Pediatric Patients With Nephrotic Syndrome

2015 ◽  
Vol 2 ◽  
pp. 2333794X1558599
Author(s):  
Victoria Cheung ◽  
Sara Wertenteil ◽  
Susan Sasson ◽  
Suzanne Vento ◽  
Sanjeev Kothare ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Nephrotic Syndrome ◽  
Kidney Disease ◽  
Restless Legs Syndrome ◽  
Daytime Sleepiness ◽  
Pediatric Patients ◽  
Glomerular Disease ◽  
Healthy Controls ◽  
Restless Legs ◽  
Pediatric Sleep Questionnaire

Background. Restless legs syndrome (RLS) is a sleep disorder characterized by an urge to move or the presence of unpleasant sensations in the extremities. The prevalence of RLS is higher in children and adults with chronic kidney disease and in adults with glomerular disease. Objective. To determine the prevalence of RLS in children with nephrotic syndrome. Methods. We studied 50 children with nephrotic syndrome and 22 controls. The following surveys were administered: Pediatric Emory RLS questionnaire, Pediatric Daytime Sleepiness Scale, and Pediatric Sleep Questionnaire. Results. Children with nephrotic syndrome were 9.0 ± 4.4 years old, 27 were male, and 27 were in remission. The prevalence of RLS was similar in the nephrotic syndrome cases and controls, whether or not indeterminate cases were considered positive: 14.0% versus 13.6% including indeterminate cases, and 8.0% versus 9.1% excluding indeterminate cases. Conclusion. RLS is not more common in children with glomerular disease compared to healthy controls.

scholarly journals Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients

2020 ◽  
Vol 9 (12) ◽  
pp. 4115
Author(s):  
Hee-Jin Im ◽  
Jee Hyun Kim ◽  
Chang-Ho Yun ◽  
Dong Wook Kim ◽  
Jeeyoung Oh
Keyword(s):  
Dopamine Agonist ◽  
Clinical Improvement ◽  
Restless Legs Syndrome ◽  
Serum Levels ◽  
Dependent Manner ◽  
Healthy Controls ◽  
Restless Legs ◽  
Serum Hepcidin ◽  
Drug Naïve

Background: Restless legs syndrome (RLS) is a common sensory motor neurological disorder that is related to iron–dopamine dysregulation and immune system alteration. We aimed to assess the effects of serum hepcidin, an iron-regulating hormone, in drug-naive RLS patients compared to healthy controls and to evaluate its role in helping to predict clinical improvement after treatment with dopamine agonist. Methods: Nonanemic and drug-naive RLS patients (n = 18) and healthy controls (n = 15) were enrolled. The serum hepcidin and iron-related values in the serum were measured upon the first visit in both groups and 12 weeks later after dopaminergic treatment in 12 patients. Information about sociodemographic characteristics, sleep-related profiles, mood and anxiety was obtained upon the first visit in all participants as well as after treatment in RLS patients. Results: Serum hepcidin levels exhibited no significant differences between patients with drug-naïve RLS and healthy controls at diagnosis (7.1 ± 2.4 vs. 7.0 ± 3.2 ng/mL, p = 0.357). Decreased hepcidin levels were significantly associated with decreased RLS severity (β = 0.002, 95% CI = 0.00−0.00, p = 0.005) and improved quality of life (β = 0.002, 95% CI = 0.00−7.01, p = 0.044) in a dose-dependent manner after 12 weeks of treatment with a dopamine agonist. This association was independent of age, sex, inflammatory markers, sleep quality, insomnia, daytime sleepiness, depression and anxiety. Conclusions: This study demonstrates the role of hepcidin in evaluating the positive therapeutic response in RLS.

Correlation between rating scales and sleep laboratory measurements in restless legs syndrome

2004 ◽  
Vol 5 (6) ◽  
pp. 561-565 ◽  
Author(s):  
D GARCIABORREGUERO ◽  
O LARROSA ◽  
Y DELALLAVE ◽  
J JOSEGRANIZO ◽  
R ALLEN
Keyword(s):  
Restless Legs Syndrome ◽  
Rating Scales ◽  
Sleep Laboratory ◽  
Laboratory Measurements ◽  
Restless Legs

scholarly journals Increased blood pressure during the suggested immobilization test in Restless Legs Syndrome

SLEEP ◽  
2019 ◽  
Vol 43 (4) ◽  
Author(s):  
Anna Laura Rassu ◽  
Sofiène Chenini ◽  
Lucie Barateau ◽  
Regis Lopez ◽  
Elisa Evangelista ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Restless Legs Syndrome ◽  
Repeated Measures ◽  
Blood Pressure Monitoring ◽  
Autonomic Response ◽  
Healthy Controls ◽  
Restless Legs ◽  
Autonomic Activation ◽  
Mixed Regression ◽  
Motor Component

Abstract Objective To investigate the relationship between sensory discomfort/motor component and cardiovascular autonomic response by continuous beat-to-beat blood pressure monitoring (CBPM) during the suggested immobilization test (SIT) in patients with restless legs syndrome (RLS). Methods Thirty-two drug-free patients with primary RLS (10 men; mean age 60.29 ± 10.81 years) and 17 healthy controls (2 men; mean age 58.82 ± 11.86 years) underwent a 1-hour SIT starting at 8 pm with concomitant CBPM to measure the heart rate (HR) and systolic/diastolic blood pressure (SBP, DBP). In all subjects, the presence of sensory discomfort and motor component during the SIT (S-SIT+ and M-SIT+, respectively) was quantified. Mixed regression models were used to compare the SBP, DBP, and HR profiles during the SIT by taking into account the repeated measures (6 time periods of 10 minutes). Results In patients with S-SIT+ (n = 17), SBP (p &lt; 0.0001), DBP (p = 0.0007), and HR (p = 0.03) increased during the SIT compared with other patients and controls. Seventeen patients had M-SIT+ (none among healthy controls). Classifying patients in 4 groups in function of the presence/absence of the SIT sensory and motor components revealed that SDB and DBP increased throughout the SIT in patients with S-SIT+, independently of the motor component (p &lt; 0.0001 and p = 0.0008 for SBD; p &lt; 0.0001 and p = 0.01 for DBP in the S-SIT+/M-SIT− and S-SIT+/M-SIT+ groups, respectively). Conclusion During the SIT, BP concomitantly increased only in patients with RLS and sensory discomfort, with or without motor component. This highlights the link between evening sensory RLS symptoms, autonomic activation, and potential long-term cardiovascular consequences.

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