Association between homocysteine, vitamin B6 concentrations and inflammation

2007 ◽  
Vol 45 (12) ◽  
Author(s):  
Anna Maria Gori ◽  
Francesco Sofi ◽  
Rossella Marcucci ◽  
Betti Giusti ◽  
Gian Franco Gensini ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Vitamin B6 ◽  
Present Review ◽  
Vitamin B ◽  
Growing Body ◽  
Arterial Occlusive Diseases ◽  
Artery Disease

AbstractDuring the last years, a growing body of evidence has been accumulated on the role of hyperhomocysteinemia in the occurrence of coronary artery disease and other arterial occlusive diseases. The mechanism by which high circulating homocysteine concentrations are a risk factor for atherothrombosis is incompletely understood. The present review is aimed to evaluate the role of inflammation in influencing homocysteine (Hcy) and vitamin BClin Chem Lab Med 2007;45:1728–36.

ROLE OF HS CRP AND LIPID ABNORMALITIES AS RISK FACTOR IN CORONARY ARTERY DISEASE

2021 ◽  
pp. 37-39
Author(s):  
Dipankar Kundu ◽  
Aniket Paul ◽  
Sourish Ghosh
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Study Results ◽  
Hs Crp ◽  
Artery Disease ◽  
Lipid Abnormalities

BACKGROUND: In recent years, data suggesting that certain markers of inammation play a key role in the development and progression of atherosclerosis. hsCRP has shown promising results as a predictor of Coronary Artery Disease(CAD). OBJECTIVES: To evaluate the signicance of CRP as one of the most reliable markers in coronary artery disease and to study the role of lipid abnormalities as a risk factor in coronary artery disease. MATERIALS AND METHODS: Study was conducted at MedicalCollege, Kolkata.30 cases and 30 controls were studied. Angiographically proven cases of CAD aged between 40- 60 years of both sexes were included in the study as cases. Age and sex matched individuals without CAD weSre considered as cases. Patients with recent myocardial infarction, unstable angina (<6months).and with other inammatory conditions were excluded from the study. RESULTS: hsCRP was signicantly higher in CAD cases2.0±1.4 compared with controls0.8±0.7 and this was statistically signicant <0.001.Lipid parameters such as Total Cholesteol,Triglycerides and Low density lipoprotein were elevated in cases compared with controls and was found to be statistically signicant. Blood glucose parameters both in fasting and post-prandial conditions were found to be elevated in cases compared with controls. CONCLUSION: The study thus suggests that hsCRP level appears to be a dependable marker of CAD.Thus, hsCRP can be used as a sensitive predictor of CAD.

scholarly journals Role of Kozak sequence polymorphism of platelet glycoprotein Ibα as a risk factor for coronary artery disease and catheter interventions

2001 ◽  
Vol 38 (4) ◽  
pp. 1023-1027 ◽  
Author(s):  
Christian Meisel ◽  
Vahid Afshar-Kharghan ◽  
Ingolf Cascorbi ◽  
Michael Laule ◽  
Verena Stangl ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Sequence Polymorphism ◽  
Platelet Glycoprotein ◽  
Kozak Sequence ◽  
Artery Disease

scholarly journals Assessment of the role of IL6 and IL10 gene polymorphisms as a risk factor for the development of restenosis in patients after implantation of drug-eluting stents

2021 ◽  
Vol 25 (1) ◽  
pp. 48-54
Author(s):  
K. B. Timizheva ◽  
A. V. Aghajanyan ◽  
L. V. Tskhovrebova ◽  
Z. Kh. Shugushev ◽  
M. M. Azova
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Drug Eluting Stents ◽  
Il10 Gene ◽  
Drug Eluting ◽  
Artery Disease ◽  
Il6 Gene

Relevance. Currently, the number of percutaneous coronary interventions continues to increase, which leads to an increase in the absolute number of restenosis cases, which is the main complication of the long-term postoperative period. The search for risk factors responsible for restenosis and artery re-narrowing mechanisms in order to prevent this complication is an important goal in interventional cardiology. Risk factors for the restenosis development include clinical, angiographic and genetic factors. An active search for biomolecular markers associated with the coronary artery restenosis is currently underway. Objective: to study the role of polymorphic variants C-174G of the IL6 gene and C-819T of the IL10 gene as a risk factor for the development of restenosis in patients after stent implantation. Materials and Methods : The study included 113 patients with stable coronary artery disease, who had previously undergone balloon angioplasty and implantation of drug-eluting stents, and 62 patients with intact arteries that were included to the control group. Statistical data processing was carried out using the R-language program and the SPSS Statistics 20 software package. Results: GG genotype for IL6 gene was associated with the development of coronary artery disease. In the subgroup of patients over 65 years of age and instent restenosis, the GG genotype was significantly less frequent. The homozygous CC genotype for IL10 gene was associated with rapid angiographic in-stent restenosis progression.

The Role of Insulin Resistance as a Risk Factor of Coronary Artery Disease

1996 ◽  
Vol 26 (1) ◽  
pp. 35 ◽  
Author(s):  
Sung Ae Jung ◽  
Si-Hoon Park ◽  
Gil Ja Shin ◽  
Woo Hyung Lee
Keyword(s):  
Insulin Resistance ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Artery Disease
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