Spirometry in adult hypothyroid patients: a comparative study

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Rasha N. Mohammed ◽  
Haithem J. Kadhum ◽  
Ali R. Hashim
Keyword(s):  
Comparative Study ◽  
Pulmonary Function ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Thyroxine Therapy ◽  
Function Test ◽  
South Of Iraq ◽  
And Control ◽  
Hypothyroid Patients ◽  
Abnormal Pulmonary Function

AbstractObjectivesHypothyroidism adversely affects pulmonary function, which may improve by thyroxine therapy. Limited studies about the effect of hypothyroidism on spirometric parameters in adult patients were conducted in Basra, south of Iraq. Moreover, the effect of thyroxine therapy on spirometric parameters was not covered by these studies. In this study, pulmonary function in adult’s hypothyroid patients was evaluated by spirometry to detect any impairment, type of impairment, and to evaluate the effect of thyroxine therapy.MethodsA comparative study was conducted in Al-Faiha Specialized Diabetes, Endocrine, and Metabolism Center (FDEMC) in Al-Faiha teaching hospital, Basrah, Iraq. Subjects are divided into four groups: uncontrolled hypothyroid group (n=72), controlled hypothyroid group (n=60), newly diagnosed hypothyroid group (n=52), and control group (n=110). Spirometry was done to all subjects in sitting position, it’s repeated at least three times and the best result was recorded.ResultsA significantly (p<0.05) less spirometric parameters and more abnormal pulmonary function test (PFT) were noticed in hypothyroid groups, the reduction were more pronounced in the uncontrolled hypothyroid group. The abnormality in PFT was mostly of restrictive type. A significantly (p<0.05) negative correlation has been found between thyroid-stimulating hormone (TSH) and spirometric parameters, while the correlation of fT4 is significantly (p<0.05) positive with FVC% and FEV%.ConclusionIn hypothyroidism, high TSH and low fT4 are recognized causes of a reduction in spirometric parameters. Therefore, spirometry can be used to detect pulmonary function changes in hypothyroidism.

scholarly journals Comparison of Urinary Iodine, Urinary Arsenic, Radioiodine Uptake, Thyroid Stimulating Hormone (TSH) and Free Thyroxin (FT4) Levels, Between Experimental Group with Simple Diffuse Goiter and Control Group

1970 ◽  
Vol 7 (1) ◽  
pp. 89-98 ◽  
Author(s):  
Md Sharif Hossain ◽  
Fatema Begum
Keyword(s):  
Urinary Iodine ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Control Groups ◽  
Arsenic Level ◽  
Radioiodine Uptake ◽  
Urinary Arsenic ◽  
Diffuse Goiter ◽  
And Control ◽  
Experimental Group

In Bangladesh some researchers have done several studies to find the correlation of simple diffuse goiter with arsenic level but no one conducted any study to find the differences of urinary iodine, urinary arsenic, radioiodine uptake, the thyroid stimulating hormone (TSH) and free thyroxin (FT4) levels between goitrous and non goitrous. That is why, in this research an attempt has been made to compare the urinary iodine, urinary arsenic, radioiodine uptake, TSH and FT4 levels between experimental group with simple diffuse goiter and healthy control group. In this study another purpose has also been made to find the associations between different pairs of variables for both experimental and control group. In this study we have tried to find the impacts of arsenic level on simple diffuse goiter. This is a case-control analytical study. The study is carried out in the Institute of Nuclear Medicine and Ultrasound, in collaboration with the thyroid out patient department of Bangabandhu Sheikh Mujib Medical University. A total of eighty five (85) subjects are included in the study. Among the 85 subjects, a sample of forty five is considered for experimental group with simple diffuse goiter and another sample of forty is considered for healthy control group without any thyroid disease. From the experimental results it has been found that, the arsenic levels, FT4 and radioiodine uptake levels at 2 hours between the experimental and control groups are significantly different but the urinary iodine levels, TSH levels and radioiodine uptake levels at 24 hours between the experimental and control groups are not statistically different. From the experimental results it has also been found that there is significant differentiation between experimental and controls groups in respect of association between different pairs of variables. In this study, another significant finding is that iodine deficiency is not only the factor of causing simple diffuse goiter, but arsenic level is also one of the most important factor of causing simple diffuse goiter. Key words: Iodine deficiency, Simple diffuse goiter, Urinary arsenic, Statistical analysis, Association, Experimental and Control groups  DOI = 10.3329/dujps.v7i1.1224 Dhaka Univ. J. Pharm. Sci. 7(1): 89-98, 2008 (June)

Thyroid Nodules in Patients with Acromegaly: Frequency According to the ACR TI-RADS Classification and its Relationship with Disease Activity

2021 ◽  
Author(s):  
Mustafa Can ◽  
Muhammet Kocabaş ◽  
Melia Karakose ◽  
Hatice Caliskan Burgucu ◽  
Zeliha Yarar ◽  
...  
Keyword(s):  
Disease Activity ◽  
Thyroid Nodules ◽  
Thyroid Volume ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Control Subjects ◽  
Number Of Patients ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Abstract Purpose: In our study, we aimed to determine the frequency of thyroid nodules in patients with acromegaly according to the American College of Radiology (ACR) Thyroid Imaging, Reporting and Data System (TI-RADS) classification and its relationship with acromegaly disease activity. Methods: A total of 56 patients with acromegaly and age, sex, and body mass index matched with 56 healthy control subjects were included in our study. Thyroid-stimulating hormone, free thyroxine, and anti-thyroperoxidase antibody levels of patients and control subjects were measured. In addition, patients and healthy controls were evaluated by ultrasonography to determine thyroid structure, thyroid volume, and thyroid nodules and to make ACR TI-RADS classification. Results: Thyroid nodules were present in 31 (55.4%) of 56 patients in the acromegaly group and 20 (35.7%) of 56 subjects in the control group, and the frequency of thyroid nodules was significantly higher in the acromegaly group (p=0.038). The mean number of nodules in the acromegaly group and control group was 1.27±1.43 and 0.48±0.73, respectively, and the mean number of nodules was significantly higher in the acromegaly group (p=0.003). The number of patients with TI-RADS 1, TI-RADS 2, and TI-RADS 4 nodules in the acromegaly group was higher than the control group (p=0.026, p=0.049, p=0.007, respectively). No difference was found in terms of cytological findings between those who have undergone FNAB in the acromegaly group and control group. Conclusion: In our study, we found that the frequency of thyroid nodules, the number of thyroid nodules, and the number of TI-RADS 1, TI-RADS 2, and TI-RADS 4 nodules increased in patients with acromegaly. There was no significant difference between acromegaly disease activity and thyroid nodule frequency, number of thyroid nodules, and TI-RADS classifications.

Central and Peripheral Nerve Conduction in Thyroid Dysfunction: The Influence of l-Thyroxine Therapy Compared with Warming upon the Conduction Abnormalities of Primary Hypothyroidism

1983 ◽  
Vol 64 (6) ◽  
pp. 617-622 ◽  
Author(s):  
R. J. Abbott ◽  
B. P. O'Malley ◽  
D. B. Barnett ◽  
L. Timson ◽  
F. D. Rosenthal
Keyword(s):  
Peripheral Nerve ◽  
Nerve Conduction ◽  
Primary Hypothyroidism ◽  
Control Group ◽  
Conduction Delay ◽  
Evoked Responses ◽  
Visual Evoked Responses ◽  
Thyroxine Therapy ◽  
Hypothyroid Patients ◽  
Visual Evoked

1. The latencies of the visual evoked responses, indices of central nerve conduction, and peripheral nerve conduction were slowed in patients with primary hypothyroidism compared with controls. 2. in thyrotoxic patients, there was no change in the latencies of the visual evoked responses and peripheral nerve conduction compared with the control group. 3. The abnormalities seen in hypothyroidism were reversed by L-thyroxine therapy. 4. Warming untreated hypothyroid patients significantly improved both central and peripheral nerve conduction. 5. The conduction delay found in hypothyroidism is to a large extent dependent upon a subnormal body temperature.

Pulmonary Function Test and Diffusion Lung Capacity in Hypothyroid Patients

2014 ◽  
Vol 2 (2) ◽  
pp. 111
Author(s):  
RM Yadav ◽  
M Bhatnagar ◽  
S Nandwani ◽  
M Saluja ◽  
A Rastogi ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Test ◽  
Lung Capacity ◽  
Function Test ◽  
And Diffusion ◽  
Hypothyroid Patients

scholarly journals Can Machine Translation Assist to Prepare for Simultaneous Interpretation?

2020 ◽  
Vol 15 (16) ◽  
pp. 230
Author(s):  
Ying Qin ◽  
Chunqing Wang
Keyword(s):  
Comparative Study ◽  
Machine Translation ◽  
Rapid Development ◽  
Experimental Results ◽  
The Other ◽  
Control Group ◽  
Simultaneous Interpretation ◽  
Simultaneous Interpreting ◽  
And Control ◽  
Experimental Group

With the rapid development of machine translation, the research of man-machine coordinated translation is drawing much concern. This paper explores roles of machine translation on advance preparation for simultaneous interpreting. We carry out a comparative study on 14 student interpreters, which are divided into experimental group and control group. The students in experimental group are allowed to use machine translation to prepare for a simultaneous interpreting, while the students in control group are not. The experimental results show that errors in machine translation might mislead the student interpreters in the simultaneous interpreting practice. On the other hand, if the time of preparation is limited, it is better not to resort to machine to make preparation because of time-consuming proofreading, or twice the effort would achieve half the result.

scholarly journals The study of pulmonary function tests in patients with hypothyroidism

2019 ◽  
Vol 6 (6) ◽  
pp. 1774
Author(s):  
Sivaranjani H. ◽  
Chaitra K. R.
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Test ◽  
The Body ◽  
Exercise Intolerance ◽  
Control Group ◽  
P Value ◽  
Common Disease ◽  
Respiratory Dysfunction ◽  
Organ Systems ◽  
Function Test

Background: Hypothyroidism is a common disease with a prevalence rate of 11% in India. It affects all organ systems in the body. Patients with hypothyroidism frequently have symptoms of fatigue and exercise intolerance. These symptoms could arise from a reduced pulmonary reserve, cardiac reserve or decreased muscle strength or increased muscle fatigue. This study aims to study the pulmonary function test in patients with hypothyroidism.Methods: This is a cross sectional study conducted on 100 patients divided into 2 groups (a) newly detected hypothyroids (b) normal control group. Cases were matched with controls in having similar environment exposure and age group. All patients had routine symptom and clinical assessment. Laboratory investigations such as complete blood picture, pulmonary function test, chest x ray and thyroid function test were done. Data was entered and analysed.Results: In this study conducted on 100 patients, case group had symptoms of easy fatiguability (36%), breathlessness (20%), menstrual abnormality (20%), weight gain (7%) and generalised body aches (5%). Mean FEV1 levels between cases and controls were 1.34 and 1.72 (p value 0.00), mean FVC were 1.88 and 2.09 (p value 0.114), FEV1/FVC ratio of 70.56, 81.98 respectively (p value 0.00). The distribution of PFT pattern was 32% obstructive, 28% mixed pattern and 22% restrictive pattern.Conclusions: This study shows that hypothyroidism causes significant decrease in FEV1 and FEV1/FVC ratio, thereby suggesting obstructive patterns of lung involvement .Therefore PFT can be used routinely as a screening test for all hypothyroid patients to detect early respiratory dysfunction and thereby optimise treatment especially in obese patients and patients with pre-existing lung disease as hypothyroidism adds to their respiratory dysfunction.

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