scholarly journals Intraoperative biophotonic imaging systems for image-guided interventions

Nanophotonics ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. 99-116 ◽  
Author(s):  
Salar Sajedi ◽  
Hamid Sabet ◽  
Hak Soo Choi
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
Imaging System ◽  
Nuclear Imaging ◽  
Imaging Systems ◽  
Quantitative Detection ◽  
Depth Information ◽  
Image Guided ◽  
Nir Fluorescence ◽  
Biophotonic Imaging

AbstractBiophotonic imaging has revolutionized the operation room by providing surgeons intraoperative image-guidance to diagnose tumors more efficiently and to resect tumors with real-time image navigation. Among many medical imaging modalities, near-infrared (NIR) light is ideal for image-guided surgery because it penetrates relatively deeply into living tissue, while nuclear imaging provides quantitative and unlimited depth information. It is therefore ideal to develop an integrated imaging system by combining NIR fluorescence and gamma-positron imaging to provide surgeons with highly sensitive and quantitative detection of diseases, such as cancer, in real-time without changing the look of the surgical field. The focus of this review is to provide recent progress in intraoperative biophotonic imaging systems, NIR fluorescence imaging and intraoperative nuclear imaging devices, and their future perspectives for image-guided interventions.

Image-guided near-infrared fluorescent sentinel lymph node mapping in human breast cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e11591-e11591
Author(s):  
S. Troyan ◽  
S. Gibbs-Strauss ◽  
S. Gioux ◽  
R. Oketokoun ◽  
F. Azar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Optical Imaging ◽  
Real Time ◽  
Near Infrared ◽  
Imaging System ◽  
Sulfur Colloid ◽  
Guided Surgery ◽  
Image Guided ◽  
Nir Fluorescence ◽  
Surgical Field

e11591 Background: Breast cancer surgery is presently performed without real-time image-guidance. We have developed a novel optical imaging system for image-guided surgery that uses invisible near-infrared (NIR) fluorescent light to highlight structures on the surgical field with high sensitivity, specificity, and contrast. We have also performed the first human clinical trial of the imaging system in women undergoing SLN mapping for breast cancer. Methods: We used a portable imaging system with an articulating arm that has 6 degrees of freedom, high power LED light source, custom optics, custom software, and sterile drape. The imaging system provided simultaneous and real-time imaging of color video and NIR fluorescence at up to 15 frames per second. N = 6 women with biopsy- confirmed breast cancer undergoing SLN mapping gave informed consent. All subjects received conventional mapping with Tc-99m sulfur colloid using a handheld gamma probe as well as NIR fluorescence-guided SLN mapping using a mixture of indocyanine green (ICG) diluted to a final concentration of 10 μM in human serum albumin (ICG:HSA). Results: The imaging system was easy to position in the operating room, with the articulating arm providing 50” horizontal reach and 70” vertical reach. Working distance to the patient was 18”. NIR fluorescence excitation was 20 mW/cm2 at 760 nm. NIR-depleted white light was 40,000 lux. A total of 1.6 ml of ICG:HSA was injected intra-tumorally and peri-tumorally and the site massaged for 5 min. 8 of 9 SLNs identified by Tc- 99m sulfur colloid were also identified by NIR fluorescence. However, NIR fluorescence identified an SLN, confirmed to have cancer in it, that was not identified by Tc-99m sulfur colloid. These differences were consistent with asynchrony in the injection techniques. Unlike the gamma-ray probe, NIR fluorescence provided high-resolution, large area optical imaging of the surgical field, and helped guide surgical resection. Conclusions: In this 6-patient pilot study, a novel NIR fluorescence optical imaging system was used for the first time, and provided real-time image-guided surgery for SLN mapping of breast cancer. No significant financial relationships to disclose.

The near infrared imaging system for the real-time protection of the JET ITER-like wall

2017 ◽  
Vol T170 ◽  
pp. 014027 ◽  
Author(s):  
A Huber ◽  
D Kinna ◽  
V Huber ◽  
G Arnoux ◽  
I Balboa ◽  
...  
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Imaging System ◽  
Near Infrared Imaging ◽  
The Real ◽  
Infrared Imaging System

scholarly journals Development of an X-ray real-time stereo imaging technique using synchrotron radiation

2011 ◽  
Vol 18 (4) ◽  
pp. 569-574 ◽  
Author(s):  
Masato Hoshino ◽  
Kentaro Uesugi ◽  
James Pearson ◽  
Takashi Sonobe ◽  
Mikiyasu Shirai ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Real Time ◽  
Imaging System ◽  
Silicon Crystal ◽  
Three Dimensional ◽  
Stereo Image ◽  
Large Field ◽  
Depth Information ◽  
Stereo Imaging ◽  
X Ray

An X-ray stereo imaging system with synchrotron radiation was developed at BL20B2, SPring-8. A portion of a wide X-ray beam was Bragg-reflected by a silicon crystal to produce an X-ray beam which intersects with the direct X-ray beam. Samples were placed at the intersection point of the two beam paths. X-ray stereo images were recorded simultaneously by a detector with a large field of view placed close to the sample. A three-dimensional wire-frame model of a sample was created from the depth information that was obtained from the lateral positions in the stereo image. X-ray stereo angiography of a mouse femoral region was performed as a demonstration of real-time stereo imaging. Three-dimensional arrangements of the femur and blood vessels were obtained.

Development of Real Time High Energy X-Ray Imaging System for Use in Dynamic Fluoroscopy of Aero Gas Turbines

1975 ◽  
Author(s):  
A. E. Stewart
Keyword(s):  
Real Time ◽  
Gas Turbines ◽  
Imaging System ◽  
High Energy ◽  
Cesium Iodide ◽  
Imaging Systems ◽  
X Ray ◽  
X Ray Imaging ◽  
Different Types

This paper discusses the development of a real-time high energy x-ray imaging system for use in dynamic fluoroscopy of aero gas turbines. In order to cover the range of subjects on gas turbines, over ten combinations of film and screen types are used. Three different types of x-ray imaging systems were considered for use: direct type intensifiers (cesium iodide phosphors), and indirect type intensifiers — Marconi “Marionette” and the Oude Delft “Delcalix.”

A Hyperspectral Imaging System for Identification of Faecal and Ingesta Contamination on Poultry Carcasses

2003 ◽  
Vol 11 (4) ◽  
pp. 269-281 ◽  
Author(s):  
Kurt C. Lawrence ◽  
William R. Windham ◽  
Bosoon Park ◽  
R. Jeff Buhr
Keyword(s):  
Real Time ◽  
Hyperspectral Imaging ◽  
Near Infrared ◽  
Imaging System ◽  
Principal Component ◽  
Ccd Camera ◽  
Sample Population ◽  
Multivariate System ◽  
Ratio Image ◽  
On Line

A method and system for detecting faecal and ingesta contaminants on poultry carcasses were demonstrated. A visible/near infrared monochromator, which measured reflectance and principal component analysis were first used to identify key wavelengths from faecal and uncontaminated skin samples. Measurements at 434, 517, 565 and 628 nm were identified and used for evaluation with a hyperspectral imaging system. The hyperspectral imaging system, which was a line-scan (pushbroom) imaging system, consisted of a hyperspectral camera, fibre-optic line lights, a computer and frame grabber. The hyperspectral imaging camera consisted of a high-resolution charge coupled device (CCD) camera, a prism-grating-prism spectrograph, focusing lens, associated optical hardware and a motorised controller. The imaging system operated from about 400 to 900 nm. The hyperspectral imaging system was calibrated for wavelength, distance and percent reflectance and analysis of calibrated images at the key wavelengths indicated that single-wavelength images were inadequate for detecting contaminants. However, a ratio of images at two of the key wavelengths was able to identify faecal and ingesta contaminants. Specifically, the ratio of the 565-nm image divided by the 517-nm image produced good results. The ratio image was then further processed by masking the background and either enhancing the image contrast with a non-linear histogram stretch, or applying a faecal threshold. The results indicated that, for the limited sample population, more than 96% of the contaminants were detected. Thus, the hyperspectral imaging system was able to detect contaminants and showed feasibility, but was too slow for real-time on-line processing. Therefore, a multivariate system operating at 565 and 517 nm, which should be capable of operating at real-time on-line processing speed, should be used. Further research with such a system needs to be conducted.

scholarly journals Towards clinical photoacoustic and ultrasound imaging: Probe improvement and real-time graphical user interface

2020 ◽  
Vol 245 (4) ◽  
pp. 321-329 ◽  
Author(s):  
Jeesu Kim ◽  
Eun-Yeong Park ◽  
Byullee Park ◽  
Wonseok Choi ◽  
Ki J Lee ◽  
...  
Keyword(s):  
User Interface ◽  
Real Time ◽  
Ultrasound Imaging ◽  
Graphical User Interface ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Clinical Applications ◽  
Imaging Systems ◽  
Imaging Probe ◽  
Conventional Ultrasound

Photoacoustic imaging is a non-invasive and non-ionizing biomedical technique that has been investigated widely for various clinical applications. By taking the advantages of conventional ultrasound imaging, hand-held operation with a linear array transducer should be favorable for successful clinical translation of photoacoustic imaging. In this paper, we present new key updates contributed to the previously developed real-time clinical photoacoustic and ultrasound imaging system for improving the clinical usability of the system. We developed a seamless image optimization platform, designed a real-time parameter control software with a user-friendly graphical user interface, performed Monte Carlo simulation of the optical fluence in the imaging plane, and optimized the geometry of the imaging probe. The updated system allows optimizing of all imaging parameters while continuously acquiring the photoacoustic and ultrasound images in real-time. The updated system has great potential to be used in a variety of clinical applications such as assessing the malignancy of thyroid cancer, breast cancer, and melanoma. Impact statement Photoacoustic imaging is a promising biomedical imaging modality that can visualize both structural and functional information of biological tissue. Because of its easiness to be integrated with conventional ultrasound imaging systems, numerous studies have been conducted to develop and apply clinical photoacoustic imaging systems. However, most of the systems were not suitable for general-purpose clinical applications due to one of the following reasons: target specific design, immobility, inaccessible operation sequence, and lack of hand-held operation. This study demonstrates a real-time clinical photoacoustic and ultrasound imaging system, which can overcome the limitations of the previous systems for successful clinical translation.

Wavefront Coded Imaging Systems for MEMS Analysis

2002 ◽  
Author(s):  
Daniel L. Barton ◽  
Jeremy A. Walraven ◽  
Edward R. Dowski ◽  
Rainer Danz ◽  
Andreas Faulstich ◽  
...  
Keyword(s):  
Signal Processing ◽  
Real Time ◽  
High Performance ◽  
Imaging System ◽  
Three Dimensional ◽  
Imaging Systems ◽  
Depth Of Field ◽  
Real Time Imaging ◽  
Large Depth ◽  
Wavefront Coding

Abstract A new imaging technique called Wavefront Coding allows real-time imaging of three-dimensional structures over a very large depth. Wavefront Coding systems combine aspheric optics and signal processing to achieve depth of fields ten or more times greater than that possible with traditional imaging systems. Understanding the relationships between traditional and modern imaging system design through Wavefront Coding is very challenging. In high performance imaging systems nearly all aspects of the system that could reduce image quality are carefully controlled. Modifying the optics and using signal processing can increase the amount of image information that can be recorded by microscopes. For a number of applications this increase in information can allow a single image to be used where a number of images taken at different object planes had been used before. Having very large depth of field and real-time imaging capability means that very deep structures such as surface micromachined MEMS can be clearly imaged with one image, greatly simplifying defect and failure analysis.

scholarly journals Compact wearable dual-mode imaging system for real-time fluorescence image-guided surgery

2015 ◽  
Vol 20 (9) ◽  
pp. 096010 ◽  
Author(s):  
Nan Zhu ◽  
Chih-Yu Huang ◽  
Suman Mondal ◽  
Shengkui Gao ◽  
Chongyuan Huang ◽  
...  
Keyword(s):  
Real Time ◽  
Imaging System ◽  
Image Guided Surgery ◽  
Dual Mode ◽  
Fluorescence Image ◽  
Guided Surgery ◽  
Image Guided
Sign in / Sign up

Export Citation Format

Share Document